2026-10-14
AI summary pending
View Full Filing (SEC EDGAR)Karyopharm Therapeutics Inc
$0.32-26.2%
+$48.6M
Net Activity
-9.55% total shares
Institutions Holding
102
Popularity Rank
#4556
Avg Weight
0.13%
Total Value
$223.6M
Market Cap
$3.4K
102 institutions currently hold KPTI, with 70 net buyers and 35 net sellers this quarter.
Institutional Moves (Q2 2026)
Majority Increased
Based on recent trading activity
Net Selling Institutions
35
Net Buying Institutions
70
Top 5 by Value
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Across its top 20 institutional holders, KPTI's holder base skews toward low-concentration, high-turnover investors on average (avg. concentration score 16/100, avg. turnover score 51/100).
KPTI ranks #4556 out of 37696 tracked stocks by institutional interest, inside the more closely watched half of our coverage.
102 institutions disclose a position in KPTI, but none treat it as a major bet — even Acorn Capital Advisors, LLC, its most concentrated holder, allocates just 4.0% of its own portfolio to it.
KPTI is down 26.2% today, but institutions show net buying of $48.6M this quarter — a divergence between today's price move and the underlying institutional flow.
KPTI reported a net loss of $224.7M over the trailing twelve months.
+$100.8M
Total Buy Value
$87.6M
Total Sell Value
70
Net Buyers
35
Net Sellers
KPTI
Q2 2026
Top 5 Institutional Movers
-$14.3M
+$13.2M
+$12.5M
-$10.9M
+$8.6M
KPTI does not currently have enough recent insider (Form 4) trading activity to compute a convergence signal against its 13F institutional flows.
13F data as of 2026-09-30 quarterly filings. Note: many large institutions file close to the 45-day post-quarter deadline, so early-quarter flow figures can shift substantially as more filings arrive.
| Action | Member | Trade Date | Amount |
|---|---|---|---|
| Sell (Full) | Ashley Moody Senate | 2025-02-20 | $1K–$15K |
No Form 144 planned sale filings in the last 90 days
3
Active 5%+ Holders
| Reporting Person | Type | Filing Date | % of Class |
|---|---|---|---|
| ACORN BIOVENTURES, L.P. | 13G/A | 2026-10-08 | 4.5% |
| ACORN BIOVENTURES, L.P. | 13G/A | 2026-09-25 | 5.7% |
| ACORN BIOVENTURES, L.P. | 13G/A | 2026-09-25 | 5.7% |
| RA Capital Management, L.P. | 13G/A | 2026-08-14 | 9.9% |
| Commodore Capital LP | 13G/A | 2026-08-14 | 0.0% |
| Adage Capital Management, L.P. | 13G/A | 2026-08-12 | 6.8% |
| THE GOLDMAN SACHS GROUP, INC. | 13G/A | 2026-08-11 | 6.3% |
6
Filings (14d)
AI summary pending
View Full Filing (SEC EDGAR)AI summary pending
View Full Filing (SEC EDGAR)AI summary pending
View Full Filing (SEC EDGAR)No AI summary for this filing type
View Full Filing (SEC EDGAR)AI summary pending
View Full Filing (SEC EDGAR)Karyopharm (KPTI) announced on July 30 that selinexor missed the primary endpoint of progression-free survival (PFS) in its Phase 3 XPORT-EC-042 trial for advanced or recurrent endometrial cancer. In the modified intent-to-treat (mITT) population (n=236), median PFS was 12.75 months with selinexor versus 7.43 months with placebo (HR=0.76; one-sided p=0.0791), a favorable trend but not statistically significant. The company also plans to submit an sNDA to the FDA in August for selinexor plus ruxolitinib in myelofibrosis, seeking accelerated approval, though the FDA has asked for more discussion on the supporting data. Karyopharm is also exploring financing and strategic alternatives to extend its cash runway, with no assurance any deal will happen.
View Full Filing (SEC EDGAR)48576U205
The most-added stocks by 13F institutions this quarter
Institutions Holding
6,278
Total reported value
$2.2T
3254 13F institutions increased their position this quarter
Institutions Holding
6,025
Total reported value
$3.6T
3054 13F institutions increased their position this quarter
Institutions Holding
6,188
Total reported value
$1.8T
2995 13F institutions increased their position this quarter
The most widely held stocks tracked across all 13F institutions
Institutions Holding
4,134
Total reported value
$712.8B
Held by 4134 institutions — one of the most-tracked stocks on AlphaSMO
Institutions Holding
4,112
Total reported value
$390.3B
Held by 4112 institutions — one of the most-tracked stocks on AlphaSMO
Institutions Holding
4,086
Total reported value
$377.7B
Held by 4086 institutions — one of the most-tracked stocks on AlphaSMO
Access KPTI's institutional ownership data programmatically:
REST API
curl https://alphasmo.com/api/v1/market/stock/KPTICLI
npx alphasmo stocks get KPTI