2026-08-31
No AI summary for this filing type
View Full Filing (SEC EDGAR)Karyopharm Therapeutics Inc
$1.94-1%
+$48.6M
Net Activity
-9.55% total shares
Institutions Holding
102
Popularity Rank
#4550
Avg Weight
0.13%
Total Value
$223.6M
Market Cap
$21.2K
102 institutions currently hold KPTI, with 69 net buyers and 35 net sellers this quarter.
Institutional Moves (Q2 2026)
Majority Increased
Based on recent trading activity
Net Selling Institutions
35
Net Buying Institutions
69
Top 5 by Value
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Across its top 20 institutional holders, KPTI's holder base skews toward low-concentration, high-turnover investors on average (avg. concentration score 16/100, avg. turnover score 51/100).
KPTI ranks #4550 out of 37501 tracked stocks by institutional interest, inside the more closely watched half of our coverage.
102 institutions disclose a position in KPTI, but none treat it as a major bet — even Acorn Capital Advisors, LLC, its most concentrated holder, allocates just 4.0% of its own portfolio to it.
Adage Capital Partners Gp, L.l.c. has added to its KPTI position for two straight quarters, increasing it by $11.8M to reach $14.9M today.
T. Rowe Price has trimmed its KPTI position for two straight quarters, cutting it by $3.3M while still holding $7.7M.
KPTI is down 1% today, but institutions show net buying of $48.6M this quarter — a divergence between today's price move and the underlying institutional flow.
KPTI reported a net loss of $224.7M over the trailing twelve months.
+$98.4M
Total Buy Value
$87.6M
Total Sell Value
69
Net Buyers
35
Net Sellers
KPTI
Q2 2026
Top 5 Institutional Movers
-$14.3M
+$13.2M
+$12.5M
-$10.9M
+$8.6M
KPTI does not currently have enough recent insider (Form 4) trading activity to compute a convergence signal against its 13F institutional flows.
13F data as of 2026-06-30 quarterly filings. Note: many large institutions file close to the 45-day post-quarter deadline, so early-quarter flow figures can shift substantially as more filings arrive.
| Action | Member | Trade Date | Amount |
|---|---|---|---|
| Sell (Full) | Ashley Moody Senate | 2025-02-20 | $1K–$15K |
No Form 144 planned sale filings in the last 90 days
3
Active 5%+ Holders
| Reporting Person | Type | Filing Date | % of Class |
|---|---|---|---|
| RA Capital Management, L.P. | 13G/A | 2026-08-14 | 9.9% |
| Commodore Capital LP | 13G/A | 2026-08-14 | 0.0% |
| Adage Capital Management, L.P. | 13G/A | 2026-08-12 | 6.8% |
| THE GOLDMAN SACHS GROUP, INC. | 13G/A | 2026-08-11 | 6.3% |
4
Filings (14d)
No AI summary for this filing type
View Full Filing (SEC EDGAR)AI summary pending
View Full Filing (SEC EDGAR)Karyopharm (KPTI) announced on July 30 that selinexor missed the primary endpoint of progression-free survival (PFS) in its Phase 3 XPORT-EC-042 trial for advanced or recurrent endometrial cancer. In the modified intent-to-treat (mITT) population (n=236), median PFS was 12.75 months with selinexor versus 7.43 months with placebo (HR=0.76; one-sided p=0.0791), a favorable trend but not statistically significant. The company also plans to submit an sNDA to the FDA in August for selinexor plus ruxolitinib in myelofibrosis, seeking accelerated approval, though the FDA has asked for more discussion on the supporting data. Karyopharm is also exploring financing and strategic alternatives to extend its cash runway, with no assurance any deal will happen.
View Full Filing (SEC EDGAR)Karyopharm Therapeutics announced a retention program for its top executives, awarding lump-sum cash payments totaling over $3.7 million in place of the 2026 annual bonus. The payments are subject to clawback if the executive leaves voluntarily or is fired for cause within 12 months. The program aims to keep key talent during a period of expected catalysts.
View Full Filing (SEC EDGAR)48576U205
The most-added stocks by 13F institutions this quarter
Institutions Holding
6,242
Total reported value
$2.2T
3229 13F institutions increased their position this quarter
Institutions Holding
5,990
Total reported value
$3.6T
3033 13F institutions increased their position this quarter
Institutions Holding
6,153
Total reported value
$1.8T
2971 13F institutions increased their position this quarter
The most widely held stocks tracked across all 13F institutions
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Total reported value
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Held by 4110 institutions — one of the most-tracked stocks on AlphaSMO
Institutions Holding
4,088
Total reported value
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Institutions Holding
4,062
Total reported value
$377.6B
Held by 4062 institutions — one of the most-tracked stocks on AlphaSMO
Access KPTI's institutional ownership data programmatically:
REST API
curl https://alphasmo.com/api/v1/market/stock/KPTICLI
npx alphasmo stocks get KPTI