| Darwin Global Management, Ltd. | US$4.6億 | 12.10% |
| Paradigm Biocapital Advisors LP | US$1.8億 | 3.63% |
| UBS Group AG | US$1.2億 | 0.02% |
| RTW INVESTMENTS, LP | US$1.1億 | 1.13% |
| MILLENNIUM MANAGEMENT LLC | US$9089.5萬 | 0.04% |
| Holocene Advisors, LP | US$7884.2萬 | 0.19% |
| EVENTIDE ASSET MANAGEMENT, LLC | US$5702.4萬 | 0.94% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | US$4847.2萬 | 0.57% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$4493.1萬 | 0.01% |
| MORGAN STANLEY | US$3211.3萬 | 0.00% |
| PERCEPTIVE ADVISORS LLC | US$2423.2萬 | 0.47% |
| Patient Square Capital LP | US$1860.4萬 | 3.30% |
| Duquesne Family Office LLC | US$1691.7萬 | 0.50% |
| GOLDMAN SACHS GROUP INC | US$1682.2萬 | 0.00% |
| MPM BIOIMPACT LLC | US$1403.8萬 | 1.08% |
| Affinity Asset Advisors, LLC | US$1036.4萬 | 0.54% |
| FRED ALGER MANAGEMENT, LLC | US$997.7萬 | 0.04% |
| PFM Health Sciences, LP | US$947.6萬 | 0.86% |
| RENAISSANCE TECHNOLOGIES LLC | US$829.1萬 | 0.01% |
| Longaeva Partners L.P. | US$534.0萬 | 0.20% |
| TD Asset Management Inc | US$532.7萬 | 0.00% |
| ADAR1 Capital Management, LLC | US$428.6萬 | 0.25% |
| Artia Global Partners LP | US$398.4萬 | 0.80% |
| Quadrature Capital Ltd | US$378.0萬 | 0.04% |
| Aquatic Capital Management LLC | US$323.6萬 | 0.09% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$312.5萬 | 0.00% |
| Squarepoint Ops LLC | US$270.7萬 | 0.00% |
| STATE STREET CORP | US$255.9萬 | 0.00% |
| BANK OF MONTREAL /CAN/ | US$254.8萬 | 0.00% |
| Trexquant Investment LP | US$240.3萬 | 0.02% |
| XTX Topco Ltd | US$240.1萬 | 0.04% |
| BALANCE CAPITAL PARTNERS L.P. | US$231.2萬 | 2.63% |
| Verdad Advisers, LP | US$220.2萬 | 2.48% |
| JANE STREET GROUP, LLC | US$194.9萬 | 0.00% |
| HRT FINANCIAL LP | US$174.1萬 | 0.00% |
| Blackstone Inc. | US$170.5萬 | 0.01% |
| GEODE CAPITAL MANAGEMENT, LLC | US$166.2萬 | 0.00% |
| HighVista Strategies LLC | US$128.1萬 | 0.35% |
| Voleon Capital Management LP | US$125.7萬 | 0.03% |
| BARCLAYS PLC | US$108.8萬 | 0.00% |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | US$95.7萬 | 0.85% |
| Amundi | US$67.1萬 | 0.00% |
| SmartHarvest Portfolios, LLC | US$66.8萬 | 0.28% |
| BANK OF AMERICA CORP /DE/ | US$60.2萬 | 0.00% |
| High Net Worth Advisory Group LLC | US$55.8萬 | 0.13% |
| Convergence Financial, LLC | US$47.3萬 | 0.05% |
| AMERIPRISE FINANCIAL INC | US$44.1萬 | 0.00% |
| Engineers Gate Manager LP | US$39.7萬 | 0.00% |
| AXQ CAPITAL, LP | US$37.8萬 | 0.05% |
| ROYAL BANK OF CANADA | US$36.0萬 | 0.00% |
| SG Americas Securities, LLC | US$34.2萬 | 0.00% |
| CITADEL ADVISORS LLC | US$32.0萬 | 0.00% |
| Virtus Investment Advisers, LLC | US$30.8萬 | 0.08% |
| DYMON ASIA CAPITAL (SINGAPORE) PTE. LTD. | US$30.3萬 | 0.03% |
| GAMMA Investing LLC | US$27.2萬 | 0.01% |
| GSA CAPITAL PARTNERS LLP | US$26.2萬 | 0.02% |
| EverSource Wealth Advisors, LLC | US$25.6萬 | 0.01% |
| TUDOR INVESTMENT CORP ET AL | US$25.4萬 | 0.00% |
| Merit Financial Group, LLC | US$22.6萬 | 0.00% |
| Independent Advisor Alliance | US$21.0萬 | 0.00% |
| FARALLON CAPITAL MANAGEMENT LLC | US$20.7萬 | 0.00% |
| Mirae Asset Global Investments Co., Ltd. | US$10.5萬 | 0.00% |
| Caitong International Asset Management Co., Ltd | US$5.6萬 | 0.01% |
| BNP PARIBAS FINANCIAL MARKETS | US$5.2萬 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$2.0萬 | 0.00% |
| E Fund Management (Hong Kong) Co., Ltd. | US$1.3萬 | 0.01% |
| TD Waterhouse Canada Inc. | US$1.2萬 | 0.00% |
| Rossby Financial, LCC | US$9199.0 | 0.00% |
| SBI Securities Co., Ltd. | US$3508.0 | 0.00% |
| Farther Finance Advisors, LLC | US$2509.0 | 0.00% |
| NISA INVESTMENT ADVISORS, LLC | US$2073.0 | 0.00% |
| JONES FINANCIAL COMPANIES LLLP | US$912.0 | 0.00% |
| Bell Investment Advisors, Inc | US$638.0 | 0.00% |
| JPMORGAN CHASE & CO | US$448.0 | 0.00% |
| CITIGROUP INC | US$159.0 | 0.00% |