CC
Catalio Capital Management, LP 13F Portfolio & Top Holdings (Q2 2026)
Catalio Capital Management, LPCIK: 0001958125
High-turnover traderSector-focusedContrarian
Total reported value
$532.1M
Reporting period: 2026-06-30 · Number of holdings: 39
Catalio Capital Management, LP disclosed 39 holdings in its latest 13F filing for the period ending 2026-06-30, with total reported value of $532.1M and a quarterly turnover rate of 92.1%.
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Personality snowflake
- Concentration
- 17.96
- Portfolio Stability
- 92.15
- Momentum
- 0
- Sector conviction
- 100
- Diversification
- 78
- Sizing Uniformity
- 91.22
Catalio Capital Management, LP's disclosed holdings carry a Herfindahl concentration index of 0.045 — mathematically equivalent to about 22 equally-sized positions, well below its 39 actual disclosed holdings. That gap points to a strategy built around a small core of high-conviction bets rather than broad diversification.
Position sizes are fairly uniform across the portfolio (a coefficient of variation of 0.88), suggesting a disciplined, rules-based approach to how much capital goes into each idea.
No strong tilt toward either adding to existing winners or initiating outsized new positions was observed in the latest reported quarter.
Sector classification currently covers about 36% of this portfolio's disclosed value; the remainder includes holdings (e.g. unmapped tickers, options, or other security types) not yet covered by our sector mapping.
Source and citation information
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Recent moves
View source Form 13F filing on SEC.govNew buy 05348Y105
Trim DNTH
-94.1% -$43.8M
New buy JNJ
Sold out ASND
Sold out 430
New buy 698955101
Holdings Map
New buyAddUnchangedTrim
Top 10 holdings by weight
Full holdings list this quarter
| # | Ticker | Issuer | Asset Subclass | Weight | Weight Change | Shares Change | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | ✓ | Stock-Other | 10.37% | +10.37% | NEW | ||
| 2 | JNJ | Johnson & Johnson | Stock-Healthcare | 6.63% | +6.63% | NEW | |
| 3 | GILD | Gilead Sciences Inc | Stock-Healthcare | 6.39% | +1.62% | +64.31% | |
| 4 | BBIO | Bridgebio Pharma Inc | Stock-Healthcare | 6.37% | -0.33% | +5.33% | |
| 5 | SNDX | Syndax Pharmaceuticals Inc | Stock-Other | 4.99% | -0.10% | +16.48% | |
| 6 | DFTX | Definium Therapeutics Inc | Stock-Other | 4.97% | +0.87% | -45.79% | |
| 7 | BMY | Bristol-myers Squibb Co | Stock-Healthcare | 4.47% | -0.86% | -1.85% | |
| 8 | ✓ | Stock-Other | 4.24% | +4.24% | NEW | ||
| 9 | NTRA | Natera Inc | Stock-Healthcare | 4.19% | +1.23% | +15.90% | |
| 10 | INCY | Incyte CORP | Stock-Healthcare | 4.08% | +0.50% | +5.23% | |
| 11 | SEPN | Septerna Inc | Stock-Other | 3.37% | +1.89% | +82.14% | |
| 12 | MLYS | Mineralys Therapeutics Inc | Stock-Other | 3.29% | +0.81% | +47.76% | |
| 13 | HTFL | Heartflow Inc | Stock-Other | 3.21% | +1.17% | +44.47% | |
| 14 | CRVS | Corvus Pharmaceuticals Inc | Stock-Other | 3.03% | +0.30% | +21.18% | |
| 15 | GPCR | Structure Therapeutics Inc | Stock-Other | 2.79% | +0.22% | +8.29% | |
| 16 | PTGX | Protagonist Therapeutics Inc | Stock-Other | 2.46% | +2.46% | NEW | |
| 17 | IRON | Disc Medicine Inc | Stock-Other | 2.19% | +0.55% | +29.60% | |
| 18 | EW | Edwards Lifesciences CORP | Stock-Healthcare | 2.12% | -0.30% | -13.71% | |
| 19 | AXSM | Axsome Therapeutics Inc | Stock-Healthcare | 1.99% | +1.99% | NEW | |
| 20 | RARE | Ultragenyx Pharmaceutical In | Stock-Other | 1.98% | -1.74% | -62.83% | |
| 21 | ✓ | Stock-Other | 1.94% | +1.94% | NEW | ||
| 22 | KPTI | Karyopharm Therapeutics Inc | Stock-Other | 1.73% | +0.69% | +4.81% | |
| 23 | ✓ | Stock-Other | 1.61% | +1.61% | NEW | ||
| 24 | ✓ | Ascendis Pharma A/s | Stock-Other | 1.59% | +1.59% | NEW | |
| 25 | ✓ | Stock-Other | 1.40% | +1.40% | NEW | ||
| 26 | ELDN | Eledon Pharmaceuticals Inc | Stock-Other | 1.26% | +0.20% | +3.37% | |
| 27 | FDMT | 4d Molecular Therapeutics In | Stock-Other | 1.18% | +1.18% | NEW | |
| 28 | MANE | Veradermics Inc | Stock-Other | 1.06% | -1.23% | -73.58% | |
| 29 | DYN | Dyne Therapeutics Inc | Stock-Other | 1.02% | -0.05% | -13.44% | |
| 30 | GUTS | Fractyl Health Inc | Stock-Other | 0.92% | +0.39% | +12.33% | |
| 31 | IMCR | Immunocore Holdings Plc-adr | Stock-Other | 0.88% | +0.35% | +75.51% | |
| 32 | DNTH | Dianthus Therapeutics Inc | Stock-Other | 0.60% | -9.22% | -94.12% | |
| 33 | BBOT | Bridgebio Oncology Therapeut | Stock-Other | 0.46% | +0.46% | NEW | |
| 34 | TARA | Protara Therapeutic Inc | Stock-Other | 0.37% | -0.26% | -10.32% | |
| 35 | HYPR | Hyperfine Inc | Stock-Other | 0.33% | +0.03% | — | |
| 36 | ATAI | Ataibeckley Inc | Stock-Other | 0.19% | +0.05% | — | |
| 37 | MGX | Metagenomi Therapeutics Inc | Stock-Other | 0.12% | -0.03% | — | |
| 38 | OM | Outset Medical Inc | Stock-Other | 0.10% | +0.01% | — | |
| 39 | FTH | Faeth Therapeutics Inc | Stock-Other | 0.07% | -0.03% | — |
* This report is exclusively curated by the AlphaSMO team. AlphaSMO is the web's most authoritative 13F / Inside Trader database, delivering precise insider trading and institutional holdings insights.
Portfolio Performance
Performance for Q3 2026
+1.2%
Performance Last 4 Quarters
+35.6%
Based on 79% of reported portfolio value with available pricing
- Stdev
- +21.8%
- Beta
- +0.12
- Alpha
- +31.3%
- Max Drawdown
- -7.6%
- Annualized Perf
- +36.2%
- Batting Avg vs S&P
- +52.6%
- Sortino
- +3.94
- Stutzer
- +0.48
- Treynor
- +2.84
- Sterling
- +2.06
- Calmar
- +4.79
- Information Ratio
- +0.63
- Tracking Error
- +24.6%
- Stdev Down
- +8.5%
- Winning Months %
- +68.4%
- Losing Months %
- +31.6%
- Best 12 Months
- +64.4%
- Worst 12 Months
- +35.6%
- Efficiency Ratio
- +0.63
- Sharpe
- +1.53
- Stdev Sectors
- 0%
- Skewness
- +0.43
- Kurtosis
- -0.59
- Upside Potential
- +5.67
Reported value over time
Sector allocation
Sector allocation over time
Quarterly history
Holding changes this quarter
Catalio Capital Management, LP's most significant position changes for 2026-06-30: New buy: ; New buy: Johnson & Johnson (JNJ); Sold out: Ascendis Pharma A/S (ASND); New buy: ; Sold out: Terns Pharmaceuticals Inc (430).
| # | Ticker | Issuer | Weight Change | Shares Change | Action |
|---|---|---|---|---|---|
| 1 | ✓ | +10.4% | NEW | New buy | |
| 2 | JNJ | Johnson & Johnson | +6.6% | NEW | New buy |
| 3 | ✓ | +4.2% | NEW | New buy | |
| 4 | PTGX | Protagonist Therapeutics Inc | +2.5% | NEW | New buy |
| 5 | AXSM | Axsome Therapeutics Inc | +2% | NEW | New buy |
| 6 | ✓ | +1.9% | NEW | New buy | |
| 7 | SEPN | Septerna Inc | +1.9% | +82.14% | Add |
| 8 | GILD | Gilead Sciences Inc | +1.6% | +64.31% | Add |
| 9 | ✓ | +1.6% | NEW | New buy | |
| 10 | ✓ | Ascendis Pharma A/s | +1.6% | NEW | New buy |
| 11 | ✓ | +1.4% | NEW | New buy | |
| 12 | NTRA | Natera Inc | +1.2% | +15.90% | Add |
| 13 | FDMT | 4d Molecular Therapeutics In | +1.2% | NEW | New buy |
| 14 | HTFL | Heartflow Inc | +1.2% | +44.47% | Add |
| 15 | DFTX | Definium Therapeutics Inc | +0.9% | -45.79% | Trim |
| 16 | MLYS | Mineralys Therapeutics Inc | +0.8% | +47.76% | Add |
| 17 | KPTI | Karyopharm Therapeutics Inc | +0.7% | +4.81% | Add |
| 18 | IRON | Disc Medicine Inc | +0.6% | +29.60% | Add |
| 19 | INCY | Incyte CORP | +0.5% | +5.23% | Add |
| 20 | BBOT | Bridgebio Oncology Therapeut | +0.5% | NEW | New buy |
| 21 | GUTS | Fractyl Health Inc | +0.4% | +12.33% | Add |
| 22 | IMCR | Immunocore Holdings Plc-adr | +0.4% | +75.51% | Add |
| 23 | CRVS | Corvus Pharmaceuticals Inc | +0.3% | +21.18% | Add |
| 24 | GPCR | Structure Therapeutics Inc | +0.2% | +8.29% | Add |
| 25 | ELDN | Eledon Pharmaceuticals Inc | +0.2% | +3.37% | Add |
| 26 | ATAI | Ataibeckley Inc | +0.1% | — | Unchanged |
| 27 | HYPR | Hyperfine Inc | 0% | — | Unchanged |
| 28 | OM | Outset Medical Inc | 0% | — | Unchanged |
| 29 | FTH | Faeth Therapeutics Inc | 0% | — | Unchanged |
| 30 | MGX | Metagenomi Therapeutics Inc | 0% | — | Unchanged |
| 31 | DYN | Dyne Therapeutics Inc | -0.1% | -13.44% | Trim |
| 32 | SNDX | Syndax Pharmaceuticals Inc | -0.1% | +16.48% | Add |
| 33 | TARA | Protara Therapeutic Inc | -0.3% | -10.32% | Trim |
| 34 | EW | Edwards Lifesciences CORP | -0.3% | -13.71% | Trim |
| 35 | BBIO | Bridgebio Pharma Inc | -0.3% | +5.33% | Add |
| 36 | TYRA | Tyra Biosciences Inc | -0.5% | EXIT | Sold out |
| 37 | NAMS | NewAmsterdam Pharma Company N.V. | -0.6% | EXIT | Sold out |
| 38 | PHAT | Phathom Pharmaceuticals Inc | -0.6% | EXIT | Sold out |
| 39 | SUPN | Supernus Pharmaceuticals Inc | -0.7% | EXIT | Sold out |
| 40 | BMY | Bristol-myers Squibb Co | -0.9% | -1.85% | Trim |
| 41 | ABVX | Abivax Sa-adr | -1.1% | EXIT | Sold out |
| 42 | MANE | Veradermics Inc | -1.2% | -73.58% | Trim |
| 43 | QURE | uniQure N.V. | -1.7% | EXIT | Sold out |
| 44 | RARE | Ultragenyx Pharmaceutical In | -1.7% | -62.83% | Trim |
| 45 | 4XC1 | Kalvista Pharmaceuticals Inc | -1.8% | EXIT | Sold out |
| 46 | ADPT | Adaptive Biotechnologies | -2.1% | EXIT | Sold out |
| 47 | CYTK | Cytokinetics Inc | -3% | EXIT | Sold out |
| 48 | BSX | Boston Scientific CORP | -3.9% | EXIT | Sold out |
| 49 | SLNOEUR | Soleno Therapeutics Inc | -4% | EXIT | Sold out |
| 50 | 430 | Terns Pharmaceuticals Inc | -4.5% | EXIT | Sold out |
1–50 of 52
Filing History
FAQ
What is Catalio Capital Management, LP and what type of investor is it?
Catalio Capital Management, LP is an investment manager that files SEC Form 13F quarterly, disclosing its U.S. public equity holdings to regulators. As of the most recent reporting period (2026-06-30), the firm manages a tracked equity portfolio valued at approximately $532.1M, spread across 39 disclosed positions.
What are Catalio Capital Management, LP's largest equity positions?
Based on the latest 13F filing, Catalio Capital Management, LP's top holdings by market value are:
1. — $55.2M (10.4%)
2. Johnson & Johnson (JNJ) — $35.3M (6.6%)
3. Gilead Sciences Inc (GILD) — $34.0M (6.4%)
4. Bridgebio Pharma Inc (BBIO) — $33.9M (6.4%)
5. Syndax Pharmaceuticals Inc (SNDX) — $26.6M (5.0%)
What changes did Catalio Capital Management, LP make in its most recent portfolio filing?
In the latest reported quarter, Catalio Capital Management, LP made 47 notable position adjustments: 11 new positions were initiated, 15 existing holdings were added to, 8 positions were partially reduced, and 13 were completely exited. The largest of these moves: New buy: ; New buy: Johnson & Johnson (JNJ); Sold out: Ascendis Pharma A/S (ASND); New buy: ; Sold out: Terns Pharmaceuticals Inc (430)
What sectors does Catalio Capital Management, LP focus on?
Catalio Capital Management, LP is concentrated in the following sectors based on its current disclosed equity portfolio:
• Health Care: 100.0%
Investment Profile
Catalio Capital Management, LP returned an annualized 36.2% over the trailing 19 months — outperforming the S&P 500 by 31.3 points — based on a reconstructed track record of its disclosed 13F positions, with a beta of 0.12 (less volatile than the market) and a 53% quarterly batting average against the index.
Its portfolio is broadly diversified and fast-trading, with 100.0% of the portfolio concentrated in Health Care.
Its turnover score has risen from 0 to 92 over the past 4 quarters — a shift toward more active trading.
It has added to its HTFL position over the past two quarters (+$13.8M, now $17.1M), while trimming BMY over the same stretch (-$11.2M, still holding $23.8M).
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Developer Access
Access Catalio Capital Management, LP's institutional profile programmatically:
REST API
curl https://alphasmo.com/api/v1/institutions/catalio-capital-management-lpCLI
npx alphasmo institutions get catalio-capital-management-lp