CC
Commodore Capital LP 13F Holdings & Position Changes (Q2 2026)
Commodore Capital LPCIK: 0001831942
Sector-focusedMomentum followerQuality / disciplined sizing
Total reported value
$1.7B
Reporting period: 2026-06-30 · Number of holdings: 33
Commodore Capital LP disclosed 33 holdings in its latest 13F filing for the period ending 2026-06-30, with total reported value of $1.7B and a quarterly turnover rate of 49.8%.
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Personality snowflake
- Concentration
- 24.87
- Portfolio Stability
- 49.82
- Momentum
- 100
- Sector conviction
- 100
- Diversification
- 66
- Sizing Uniformity
- 89.58
Commodore Capital LP's disclosed holdings carry a Herfindahl concentration index of 0.062 — mathematically equivalent to about 16 equally-sized positions, well below its 33 actual disclosed holdings. That gap points to a strategy built around a small core of high-conviction bets rather than broad diversification.
Position sizes are fairly uniform across the portfolio (a coefficient of variation of 1.04), suggesting a disciplined, rules-based approach to how much capital goes into each idea.
No strong tilt toward either adding to existing winners or initiating outsized new positions was observed in the latest reported quarter.
Sector classification currently covers about 9% of this portfolio's disclosed value; the remainder includes holdings (e.g. unmapped tickers, options, or other security types) not yet covered by our sector mapping.
Source and citation information
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Recent moves
View source Form 13F filing on SEC.govTrim NUVL
-88.0% -$73.1M
New buy TNGX
Add RLAY
-29.4% $55.4M
Add DFTX
0.0% $56.3M
Sold out ERAS
Sold out XENE
Holdings Map
New buyAddUnchangedTrim
Top 10 holdings by weight
Full holdings list this quarter
| # | Ticker | Issuer | Asset Subclass | Weight | Weight Change | Shares Change | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | RLAY | Relay Therapeutics Inc | Stock-Other | 13.37% | +3.58% | -29.41% | |
| 2 | ELVN | Enliven Therapeutics Inc | Stock-Other | 9.90% | +2.47% | — | |
| 3 | ALKS | Alkermes plc | Stock-Healthcare | 9.36% | +0.77% | -28.57% | |
| 4 | COGT | Cogent Biosciences Inc | Stock-Other | 7.03% | +0.60% | +5.61% | |
| 5 | AMLX | Amylyx Pharmaceuticals Inc | Stock-Other | 6.04% | +1.50% | — | |
| 6 | DFTX | Definium Therapeutics Inc | Stock-Other | 5.60% | +3.41% | — | |
| 7 | SYRE | Spyre Therapeutics Inc | Stock-Other | 4.48% | -1.10% | -55.72% | |
| 8 | ANRO | Alto Neuroscience Inc | Stock-Other | 4.28% | +0.74% | — | |
| 9 | TNGX | Tango Therapeutics Inc | Stock-Other | 4.19% | +4.19% | NEW | |
| 10 | EYPT | Eyepoint Inc | Stock-Other | 3.92% | +1.81% | +62.83% | |
| 11 | TYRA | Tyra Biosciences Inc | Stock-Other | 3.57% | -1.91% | -24.24% | |
| 12 | DMRA | Damora Therapeutics Inc | Stock-Other | 3.00% | +0.09% | — | |
| 13 | CLDX | Celldex Therapeutics Inc | Stock-Other | 2.99% | -1.96% | -49.94% | |
| 14 | PHVS | Pharvaris N.V. | Stock-Other | 2.93% | -0.21% | -25.74% | |
| 15 | LBRX | Lb Pharmaceuticals Inc | Stock-Other | 2.90% | +0.76% | — | |
| 16 | ASMB | Assembly Biosciences Inc | Stock-Other | 2.32% | +0.71% | +41.50% | |
| 17 | EDIT | Editas Medicine Inc | Stock-Other | 1.72% | +1.72% | NEW | |
| 18 | KYMR | Kymera Therapeutics Inc | Stock-Other | 1.71% | -1.90% | -66.67% | |
| 19 | CATX | Perspective Therapeutics Inc | Stock-Other | 1.29% | -0.24% | — | |
| 20 | IPSC | Century Therapeutics Inc | Stock-Other | 1.27% | +0.13% | — | |
| 21 | ✓ | Zura Bio LTD | Stock-Other | 1.14% | +0.02% | — | |
| 22 | AVTX | Avalo Therapeutics Inc | Stock-Other | 1.12% | +0.70% | +110.83% | |
| 23 | IFRX | InflaRx N.V. | Stock-Other | 0.97% | +0.97% | NEW | |
| 24 | ANTX | An2 Therapeutics Inc | Stock-Other | 0.85% | +0.39% | +25.71% | |
| 25 | NUVL | Nuvalent Inc-a | Stock-Other | 0.74% | -4.20% | -88.00% | |
| 26 | SABS | Sab Biotherapeutics Inc | Stock-Other | 0.67% | -0.31% | -34.80% | |
| 27 | IKT | Inhibikase Therapeutics Inc | Stock-Other | 0.65% | +0.13% | — | |
| 28 | RLMD | Relmada Therapeutics Inc | Stock-Other | 0.59% | +0.33% | +124.80% | |
| 29 | PEPG | Pepgen Inc | Stock-Other | 0.48% | +0.02% | — | |
| 30 | ✓ | Stock-Other | 0.32% | +0.32% | NEW | ||
| 31 | ✓ | Helix Acquisition CORP Iii | Stock-Other | 0.32% | +0.03% | — | |
| 32 | LONA | Leonabio Inc | Stock-Other | 0.25% | -0.03% | — | |
| 33 | VTGN | Vistagen Therapeutics Inc | Stock-Other | 0.04% | +0.04% | NEW |
💡
Data Source Notice: AlphaSMO is the web's most authoritative 13F / Inside Trader database. Institutional holdings and insider trades presented here are precisely computed to deliver accurate portfolio reporting.
Portfolio Performance
Performance for Q3 2026
+27%
Performance Last 4 Quarters
+136.4%
- Stdev
- +33.8%
- Beta
- +1.09
- Alpha
- +10.8%
- Max Drawdown
- -48.7%
- Annualized Perf
- +30.9%
- Batting Avg vs S&P
- +47.2%
- Sortino
- +1.8
- Stutzer
- +0.28
- Treynor
- +0.3
- Sterling
- +0.97
- Calmar
- +0.63
- Information Ratio
- +0.41
- Tracking Error
- +30.7%
- Stdev Down
- +18.1%
- Winning Months %
- +52.8%
- Losing Months %
- +47.2%
- Best 12 Months
- +158.2%
- Worst 12 Months
- -42.4%
- Efficiency Ratio
- +0.42
- Sharpe
- +0.97
- Stdev Sectors
- 0%
- Skewness
- -0.01
- Kurtosis
- -0.76
- Upside Potential
- +3.59
Reported value over time
Sector allocation
Sector allocation over time
Quarterly history
| Period | Holdings | Total value | Stability | Top holdings | |
|---|---|---|---|---|---|
| 2026 Q2 | 33 | $1.7B | 50 | ||
| 2026 Q1 | 36 | $1.7B | 61 | ||
| 2025 Q4 | 33 | $1.5B | 72 | ||
| 2025 Q3 | 37 | $2.0B | 71 | ||
| 2025 Q2 | 33 | $1.4B | 0 | ||
| 2025 Q1 | 31 | $1.4B | 100 | ||
| 2024 Q4 | 31 | $1.4B | 0 | ||
| 2024 Q3 | 36 | $1.6B | 0 | ||
| 2024 Q2 | 35 | $1.5B | 0 | ||
| 2024 Q1 | 39 | $1.5B | 0 | ||
| 2023 Q4 | 32 | $1.1B | 0 | ||
| 2023 Q3 | 30 | $855.5M | 0 | ||
| 2023 Q2 | 26 | $889.8M | 0 | ||
| 2023 Q1 | 32 | $656.8M | 0 | ||
| 2022 Q4 | 35 | $663.5M | 0 | ||
| 2022 Q3 | 30 | $621.9M | 0 | ||
| 2022 Q2 | 24 | $473.0M | 0 | ||
| 2022 Q1 | 27 | $447.7M | 0 | ||
| 2021 Q4 | 25 | $431.8M | 0 | ||
| 2021 Q3 | 29 | $379.3M | 0 | ||
| 2021 Q2 | 29 | $287.0M | 0 | ||
| 2021 Q1 | 31 | $251.0M | 0 | ||
| 2020 Q4 | 28 | $183.9M | 0 |
Holding changes this quarter
Commodore Capital LP's most significant position changes for 2026-06-30: New buy: Tango Therapeutics Inc (TNGX); Sold out: Erasca Inc (ERAS); Sold out: Xenon Pharmaceuticals Inc (XENE); Sold out: Nurix Therapeutics Inc (NRIX); Sold out: Corvus Pharmaceuticals Inc (CRVS).
| # | Ticker | Issuer | Weight Change | Shares Change | Action |
|---|---|---|---|---|---|
| 1 | TNGX | Tango Therapeutics Inc | +4.2% | NEW | New buy |
| 2 | RLAY | Relay Therapeutics Inc | +3.6% | -29.41% | Trim |
| 3 | DFTX | Definium Therapeutics Inc | +3.4% | — | Unchanged |
| 4 | ELVN | Enliven Therapeutics Inc | +2.5% | — | Unchanged |
| 5 | EYPT | Eyepoint Inc | +1.8% | +62.83% | Add |
| 6 | EDIT | Editas Medicine Inc | +1.7% | NEW | New buy |
| 7 | AMLX | Amylyx Pharmaceuticals Inc | +1.5% | — | Unchanged |
| 8 | IFRX | InflaRx N.V. | +1% | NEW | New buy |
| 9 | ALKS | Alkermes plc | +0.8% | -28.57% | Trim |
| 10 | LBRX | Lb Pharmaceuticals Inc | +0.8% | — | Unchanged |
| 11 | ANRO | Alto Neuroscience Inc | +0.7% | — | Unchanged |
| 12 | ASMB | Assembly Biosciences Inc | +0.7% | +41.50% | Add |
| 13 | AVTX | Avalo Therapeutics Inc | +0.7% | +110.83% | Add |
| 14 | COGT | Cogent Biosciences Inc | +0.6% | +5.61% | Add |
| 15 | ANTX | An2 Therapeutics Inc | +0.4% | +25.71% | Add |
| 16 | RLMD | Relmada Therapeutics Inc | +0.3% | +124.80% | Add |
| 17 | ✓ | +0.3% | NEW | New buy | |
| 18 | IKT | Inhibikase Therapeutics Inc | +0.1% | — | Unchanged |
| 19 | IPSC | Century Therapeutics Inc | +0.1% | — | Unchanged |
| 20 | DMRA | Damora Therapeutics Inc | +0.1% | — | Unchanged |
| 21 | VTGN | Vistagen Therapeutics Inc | 0% | NEW | New buy |
| 22 | ✓ | Helix Acquisition CORP Iii | 0% | — | Unchanged |
| 23 | ✓ | Zura Bio LTD | 0% | — | Unchanged |
| 24 | PEPG | Pepgen Inc | 0% | — | Unchanged |
| 25 | LONA | Leonabio Inc | 0% | — | Unchanged |
| 26 | PHVS | Pharvaris N.V. | -0.2% | -25.74% | Trim |
| 27 | CATX | Perspective Therapeutics Inc | -0.2% | — | Unchanged |
| 28 | SABS | Sab Biotherapeutics Inc | -0.3% | -34.80% | Trim |
| 29 | KPTI | Karyopharm Therapeutics Inc | -0.6% | EXIT | Sold out |
| 30 | PALI | Palisade Bio Inc | -0.7% | EXIT | Sold out |
| 31 | SYRE | Spyre Therapeutics Inc | -1.1% | -55.72% | Trim |
| 32 | SLNOEUR | Soleno Therapeutics Inc | -1.3% | EXIT | Sold out |
| 33 | OCUL | Ocular Therapeutix Inc | -1.3% | EXIT | Sold out |
| 34 | KYMR | Kymera Therapeutics Inc | -1.9% | -66.67% | Trim |
| 35 | TYRA | Tyra Biosciences Inc | -1.9% | -24.24% | Trim |
| 36 | CRVS | Corvus Pharmaceuticals Inc | -1.9% | EXIT | Sold out |
| 37 | CLDX | Celldex Therapeutics Inc | -2% | -49.94% | Trim |
| 38 | NRIX | Nurix Therapeutics Inc | -2% | EXIT | Sold out |
| 39 | XENE | Xenon Pharmaceuticals Inc | -2.8% | EXIT | Sold out |
| 40 | ERAS | Erasca Inc | -3% | EXIT | Sold out |
| 41 | NUVL | Nuvalent Inc-a | -4.2% | -88.00% | Trim |
Filing History
FAQ
What is Commodore Capital LP and what type of investor is it?
Commodore Capital LP is an investment manager that files SEC Form 13F quarterly, disclosing its U.S. public equity holdings to regulators. As of the most recent reporting period (2026-06-30), the firm manages a tracked equity portfolio valued at approximately $1.7B, spread across 33 disclosed positions.
What are Commodore Capital LP's largest equity positions?
Based on the latest 13F filing, Commodore Capital LP's top holdings by market value are:
1. Relay Therapeutics Inc (RLAY) — $224.5M (13.4%)
2. Enliven Therapeutics Inc (ELVN) — $166.2M (9.9%)
3. Alkermes plc (ALKS) — $157.2M (9.4%)
4. Cogent Biosciences Inc (COGT) — $118.0M (7.0%)
5. Amylyx Pharmaceuticals Inc (AMLX) — $101.5M (6.0%)
What changes did Commodore Capital LP make in its most recent portfolio filing?
In the latest reported quarter, Commodore Capital LP made 28 notable position adjustments: 5 new positions were initiated, 6 existing holdings were added to, 9 positions were partially reduced, and 8 were completely exited. The largest of these moves: New buy: Tango Therapeutics Inc (TNGX); Sold out: Erasca Inc (ERAS); Sold out: Xenon Pharmaceuticals Inc (XENE); Sold out: Nurix Therapeutics Inc (NRIX); Sold out: Corvus Pharmaceuticals Inc (CRVS)
What sectors does Commodore Capital LP focus on?
Commodore Capital LP is concentrated in the following sectors based on its current disclosed equity portfolio:
• Health Care: 100.0%
Investment Profile
Commodore Capital LP returned an annualized 30.9% over the trailing 36 months — outperforming the S&P 500 by 10.8 points — based on a reconstructed track record of its disclosed 13F positions, with a beta of 1.09 (roughly in line with the market) and a 47% quarterly batting average against the index.
Its portfolio is broadly diversified and moderately active, with 100.0% of the portfolio concentrated in Health Care.
Its turnover score has risen from 0 to 50 over the past 4 quarters — a shift toward more active trading.
It has added to its ELVN position for two straight quarters, increasing it by $93.9M to reach $166.2M.
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Developer Access
Access Commodore Capital LP's institutional profile programmatically:
REST API
curl https://alphasmo.com/api/v1/institutions/commodore-capital-lpCLI
npx alphasmo institutions get commodore-capital-lp