| Ikarian Capital, LLC | $14.3M | 1.16% |
| Commodore Capital LP | $10.9M | 0.63% |
| RA CAPITAL MANAGEMENT, L.P. | $10.7M | 0.11% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $10.1M | 0.02% |
| T. Rowe Price Investment Management, Inc. | $8.6M | 0.01% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $7.3M | 0.00% |
| Caption Management, LLC | $6.6M | 0.04% |
| GOLDMAN SACHS GROUP INC | $5.3M | 0.00% |
| Catalio Capital Management, LP | $5.0M | 1.04% |
| BOOTHBAY FUND MANAGEMENT, LLC | $4.2M | 0.05% |
| Squadron Capital Management LLC | $4.2M | 1.53% |
| VANGUARD CAPITAL MANAGEMENT LLC | $4.1M | 0.00% |
| JANE STREET GROUP, LLC | $3.3M | 0.00% |
| MILLENNIUM MANAGEMENT LLC | $2.8M | 0.00% |
| CITADEL ADVISORS LLC | $2.8M | 0.00% |
| Affinity Asset Advisors, LLC | $2.8M | 0.14% |
| Avidity Partners Management LP | $2.6M | 0.52% |
| Soleus Capital Management, L.P. | $2.5M | 0.10% |
| ADAR1 Capital Management, LLC | $1.9M | 0.11% |
| Boxer Capital Management, LLC | $1.7M | 0.22% |
| Davidson Kempner Capital Management LP | $1.7M | 0.02% |
| Eversept Partners, LP | $1.7M | 0.09% |
| ACORN CAPITAL ADVISORS, LLC | $1.6M | 0.46% |
| Jump Financial, LLC | $1.5M | 0.02% |
| Trexquant Investment LP | $1.4M | 0.01% |
| Ally Bridge Group (NY) LLC | $1.4M | 1.12% |
| ACADIAN ASSET MANAGEMENT LLC | $1.4M | 0.00% |
| BlackRock, Inc. | $1.4M | 0.00% |
| DIADEMA PARTNERS LP | $1.3M | 0.23% |
| Brevan Howard Capital Management LP | $1.2M | 0.01% |
| GEODE CAPITAL MANAGEMENT, LLC | $1.1M | 0.00% |
| UBS Group AG | $1.1M | 0.00% |
| GROUP ONE TRADING LLC | $1.1M | 0.00% |
| Balyasny Asset Management L.P. | $951.1K | 0.00% |
| SILVERBACK ASSET MANAGEMENT LLC | $919.1K | 0.13% |
| XTX Topco Ltd | $915.9K | 0.02% |
| TWO SIGMA INVESTMENTS, LP | $842.4K | 0.00% |
| MARSHALL WACE, LLP | $715.5K | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | $640.2K | 0.00% |
| Engineers Gate Manager LP | $626.2K | 0.01% |
| RENAISSANCE TECHNOLOGIES LLC | $587.2K | 0.00% |
| Tetragon Partners GP Ltd | $573.6K | 0.11% |
| C WorldWide Group Holding A/S | $557.0K | 0.01% |
| STATE STREET CORP | $449.7K | 0.00% |
| Connor, Clark & Lunn Investment Management Ltd. | $440.5K | 0.00% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | $400.3K | 0.01% |
| ROYAL BANK OF CANADA | $336.0K | 0.00% |
| DAFNA Capital Management LLC | $255.1K | 0.06% |
| NORTHERN TRUST CORP | $214.8K | 0.00% |
| Zimmer Partners, LP | $208.9K | 0.01% |
| Centiva Capital, LP | $188.3K | 0.00% |
| China Universal Asset Management Co., Ltd. | $167.1K | 0.01% |
| Point72 Asset Management, L.P. | $167.1K | 0.00% |
| Baird Financial Group, Inc. | $165.9K | 0.00% |
| Susquehanna Portfolio Strategies, LLC | $139.4K | 0.00% |
| BANK OF AMERICA CORP /DE/ | $108.5K | 0.00% |
| OMERS ADMINISTRATION Corp | $108.1K | 0.00% |
| MORGAN STANLEY | $103.4K | 0.00% |
| Invesco Ltd. | $93.2K | 0.00% |
| Velan Capital Investment Management LP | $83.6K | 0.05% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $74.8K | 0.00% |
| HSBC HOLDINGS PLC | $65.6K | 0.00% |
| Bank of New York Mellon Corp | $63.5K | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $61.0K | 0.00% |
| Vanguard Global Advisers, LLC | $45.7K | 0.00% |
| BARCLAYS PLC | $41.4K | 0.00% |
| CITIGROUP INC | $27.5K | 0.00% |
| TD Waterhouse Canada Inc. | $18.6K | 0.00% |
| Rockefeller Capital Management L.P. | $4.1K | 0.00% |
| FMR LLC | $3.7K | 0.00% |
| JPMORGAN CHASE & CO | $2.5K | 0.00% |
| OSAIC HOLDINGS, INC. | $2.2K | 0.00% |
| Persistent Asset Partners Ltd | $2.1K | 0.00% |
| HARBOUR INVESTMENTS, INC. | $1.6K | 0.00% |
| Quent Capital, LLC | $1.3K | 0.00% |
| MB, LEVIS & ASSOCIATES, LLC | $557.0 | 0.00% |
| SBI Securities Co., Ltd. | $373.0 | 0.00% |
| Activest Wealth Management | $368.0 | 0.00% |
| Allworth Financial LP | $145.0 | 0.00% |
| Advisory Services Network, LLC | $67.0 | 0.00% |
| West Branch Capital LLC | $17.0 | 0.00% |
| PlanVest Financial, Inc | $6.0 | 0.00% |
| BNP PARIBAS FINANCIAL MARKETS | $4.7 | 0.00% |