AP
Avidity Partners Management LP 13F Holdings (45 Positions, Q2 2026)
Avidity Partners Management LPCIK: 0001791827
Sector-focusedMomentum followerQuality / disciplined sizing
Total reported value
$624.4M
Reporting period: 2026-06-30 · Number of holdings: 45
Avidity Partners Management LP disclosed 45 holdings in its latest 13F filing for the period ending 2026-06-30, with total reported value of $624.4M and a quarterly turnover rate of 43.1%.
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Personality snowflake
- Concentration
- 62.64
- Portfolio Stability
- 43.11
- Momentum
- 100
- Sector conviction
- 100
- Diversification
- 90
- Sizing Uniformity
- 75.13
Avidity Partners Management LP's disclosed holdings carry a Herfindahl concentration index of 0.157 — mathematically equivalent to about 6 equally-sized positions, well below its 45 actual disclosed holdings. That gap points to a strategy built around a small core of high-conviction bets rather than broad diversification.
Position sizes vary widely across the portfolio (a coefficient of variation of 2.49), with a handful of outsized bets alongside many smaller positions.
Recent activity leans toward adding more aggressively to already-large existing positions than to newly initiated ones (a 2.7 percentage-point tilt) — a pattern consistent with a momentum-following approach.
Sector classification currently covers about 9% of this portfolio's disclosed value; the remainder includes holdings (e.g. unmapped tickers, options, or other security types) not yet covered by our sector mapping.
Source and citation information
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Recent moves
View source Form 13F filing on SEC.govAdd ORKA
0.0% $35.1M
Trim DNTH
0.0% $28.5M
Trim CNTX
0.0% -$10.3M
Add JBIO
+21.4% $18.1M
Trim CGON
+8.5% $12.2M
New buy 60705V103
Holdings Map
New buyAddUnchangedTrim
Top 10 holdings by weight
Full holdings list this quarter
| # | Ticker | Issuer | Asset Subclass | Weight | Weight Change | Shares Change | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | DNTH | Dianthus Therapeutics Inc | Stock-Other | 32.85% | -2.91% | — | |
| 2 | CGON | Cg Oncology Inc | Stock-Other | 15.92% | -1.75% | +8.53% | |
| 3 | ORKA | Oruka Therapeutics Inc | Stock-Other | 11.59% | +4.04% | — | |
| 4 | JBIO | Jade Biosciences Inc | Stock-Other | 6.05% | +2.06% | +21.42% | |
| 5 | ELVN | Enliven Therapeutics Inc | Stock-Other | 4.47% | +1.29% | +37.50% | |
| 6 | CATX | Perspective Therapeutics Inc | Stock-Other | 3.44% | -1.67% | +4.13% | |
| 7 | AKTS | Aktis Oncology Inc | Stock-Other | 2.50% | +0.80% | +3.34% | |
| 8 | PVLA | Palvella Therapeutics Inc | Stock-Other | 1.71% | -0.06% | — | |
| 9 | ✓ | Stock-Other | 1.71% | +1.71% | NEW | ||
| 10 | RGEN | Repligen CORP | Stock-Healthcare | 1.70% | -0.16% | — | |
| 11 | IMUX | Immunic Inc | Stock-Other | 1.65% | +1.65% | NEW | |
| 12 | SENS | Senseonics Holdings Inc | Stock-Other | 1.46% | +1.46% | NEW | |
| 13 | KPTI | Karyopharm Therapeutics Inc | Stock-Other | 1.45% | +0.93% | +99.35% | |
| 14 | TEVA | Teva Pharmaceutical-sp Adr | Stock-Healthcare | 1.09% | -1.66% | -55.57% | |
| 15 | DXCM | Dexcom Inc | Stock-Healthcare | 1.08% | -0.06% | +11.11% | |
| 16 | TEM | Tempus Ai Inc-cl A | Stock-Healthcare | 0.97% | +0.74% | +320.00% | |
| 17 | MDT | Medtronic plc | Stock-Healthcare | 0.88% | -0.87% | -30.00% | |
| 18 | VIR | Vir Biotechnology Inc | Stock-Other | 0.85% | -0.87% | -45.34% | |
| 19 | GPCR | Structure Therapeutics Inc | Stock-Other | 0.84% | +0.55% | +226.67% | |
| 20 | EHC | Encompass Health CORP | Stock-Healthcare | 0.68% | -0.14% | — | |
| 21 | TENX | Tenax Therapeutics Inc | Stock-Other | 0.62% | -0.08% | +23.16% | |
| 22 | NVCT | Nuvectis Pharma Inc | Stock-Other | 0.59% | +0.59% | NEW | |
| 23 | PODD | Insulet CORP | Stock-Healthcare | 0.59% | +0.59% | NEW | |
| 24 | BSX | Boston Scientific CORP | Stock-Healthcare | 0.55% | -0.21% | +33.33% | |
| 25 | MSLE | Satellos Bioscience Inc | Stock-Other | 0.48% | +0.04% | — | |
| 26 | ✓ | Stock-Other | 0.48% | +0.48% | NEW | ||
| 27 | CNTX | Context Therapeutics Inc | Stock-Other | 0.44% | -2.21% | — | |
| 28 | GILD | Gilead Sciences Inc | Stock-Healthcare | 0.40% | -0.16% | — | |
| 29 | CRL | Charles River Laboratories | Stock-Healthcare | 0.36% | +0.36% | NEW | |
| 30 | PHAT | Phathom Pharmaceuticals Inc | Stock-Other | 0.35% | -0.21% | -19.80% | |
| 31 | ✓ | Stock-Other | 0.32% | +0.32% | NEW | ||
| 32 | ✓ | Stock-Other | 0.28% | +0.28% | NEW | ||
| 33 | GMAB | Genmab A/s -sp Adr | Stock-Other | 0.22% | -0.05% | — | |
| 34 | NTLA | Intellia Therapeutics Inc | Stock-Other | 0.20% | +0.01% | — | |
| 35 | CRVS | Corvus Pharmaceuticals Inc | Stock-Other | 0.19% | -0.15% | -30.43% | |
| 36 | ODD | Oddity Tech Ltd. | Stock-Other | 0.17% | -0.02% | — | |
| 37 | ✓ | Stock-Other | 0.17% | +0.17% | NEW | ||
| 38 | EVMN | Evommune Inc | Stock-Other | 0.16% | +0.16% | NEW | |
| 39 | ABT | Abbott Laboratories | Stock-Healthcare | 0.15% | +0.15% | NEW | |
| 40 | BBIO | Bridgebio Pharma Inc | Stock-Healthcare | 0.12% | +0.12% | NEW | |
| 41 | PTON | Peloton Interactive Inc-a | Stock-Consumer Disc | 0.09% | -0.08% | -50.00% | |
| 42 | LEGN | Legend Biotech Corp-adr | Stock-Other | 0.07% | +0.07% | NEW | |
| 43 | BBOT | Bridgebio Oncology Therapeut | Stock-Other | 0.05% | -0.03% | — | |
| 44 | SVRA | Savara Inc | Stock-Other | 0.05% | +0.05% | NEW | |
| 45 | TRVI | Trevi Therapeutics Inc | Stock-Other | 0.02% | — | — |
Portfolio Performance
Performance for Q3 2026
+13.7%
Performance Last 4 Quarters
+117.4%
- Stdev
- +24.8%
- Beta
- +0.63
- Alpha
- +13.8%
- Max Drawdown
- -28.9%
- Annualized Perf
- +26.3%
- Batting Avg vs S&P
- +41.7%
- Sortino
- +2.06
- Stutzer
- +0.32
- Treynor
- +0.42
- Sterling
- +1.16
- Calmar
- +0.91
- Information Ratio
- +0.27
- Tracking Error
- +23.9%
- Stdev Down
- +12.8%
- Winning Months %
- +61.1%
- Losing Months %
- +38.9%
- Best 12 Months
- +134.1%
- Worst 12 Months
- -24.8%
- Efficiency Ratio
- +0.47
- Sharpe
- +1.07
- Stdev Sectors
- +48.9%
- Skewness
- +0.13
- Kurtosis
- -0.55
- Upside Potential
- +3.81
Reported value over time
Sector allocation
Sector allocation over time
Quarterly history
| Period | Holdings | Total value | Stability | Top holdings | |
|---|---|---|---|---|---|
| 2026 Q2 | 45 | $624.4M | 43 | ||
| 2026 Q1 | 45 | $493.8M | 75 | ||
| 2025 Q4 | 39 | $346.7M | 60 | ||
| 2025 Q3 | 43 | $439.4M | 100 | ||
| 2025 Q2 | 56 | $502.0M | 0 | ||
| 2025 Q1 | 67 | $524.7M | 100 | ||
| 2024 Q4 | 63 | $1.0B | 0 | ||
| 2024 Q3 | 81 | $2.0B | 0 | ||
| 2024 Q2 | 85 | $2.4B | 0 | ||
| 2024 Q1 | 90 | $3.1B | 0 | ||
| 2023 Q4 | 74 | $2.7B | 0 | ||
| 2023 Q3 | 83 | $2.5B | 0 | ||
| 2023 Q2 | 93 | $2.9B | 0 | ||
| 2023 Q1 | 83 | $3.0B | 0 | ||
| 2022 Q4 | 85 | $4.6B | 0 | ||
| 2022 Q3 | 98 | $4.9B | 0 | ||
| 2022 Q2 | 82 | $4.4B | 0 | ||
| 2022 Q1 | 92 | $4.8B | 0 | ||
| 2021 Q4 | 97 | $4.7B | 0 | ||
| 2021 Q3 | 105 | $4.5B | 0 | ||
| 2021 Q2 | 112 | $3.7B | 99 | ||
| 2021 Q1 | 94 | $3.6B | 80 | ||
| 2020 Q4 | 96 | $3.1B | 100 | ||
| 2020 Q3 | 68 | $2.2B | 100 | ||
| 2020 Q2 | 57 | $1.6B | 100 | ||
| 2020 Q1 | 52 | $723.6M | 100 | ||
| 2019 Q4 | 33 | $158.7M | 0 |
Holding changes this quarter
Avidity Partners Management LP's most significant position changes for 2026-06-30: New buy: ; New buy: Immunic Inc (IMUX); New buy: Senseonics Holdings Inc (SENS); Sold out: Immunic Inc (VTLUSD); New buy: Nuvectis Pharma Inc (NVCT).
| # | Ticker | Issuer | Weight Change | Shares Change | Action |
|---|---|---|---|---|---|
| 1 | ORKA | Oruka Therapeutics Inc | +4% | — | Unchanged |
| 2 | JBIO | Jade Biosciences Inc | +2.1% | +21.42% | Add |
| 3 | ✓ | +1.7% | NEW | New buy | |
| 4 | IMUX | Immunic Inc | +1.7% | NEW | New buy |
| 5 | SENS | Senseonics Holdings Inc | +1.5% | NEW | New buy |
| 6 | ELVN | Enliven Therapeutics Inc | +1.3% | +37.50% | Add |
| 7 | KPTI | Karyopharm Therapeutics Inc | +0.9% | +99.35% | Add |
| 8 | AKTS | Aktis Oncology Inc | +0.8% | +3.34% | Add |
| 9 | TEM | Tempus Ai Inc-cl A | +0.7% | +320.00% | Add |
| 10 | NVCT | Nuvectis Pharma Inc | +0.6% | NEW | New buy |
| 11 | PODD | Insulet CORP | +0.6% | NEW | New buy |
| 12 | GPCR | Structure Therapeutics Inc | +0.6% | +226.67% | Add |
| 13 | ✓ | +0.5% | NEW | New buy | |
| 14 | CRL | Charles River Laboratories | +0.4% | NEW | New buy |
| 15 | ✓ | +0.3% | NEW | New buy | |
| 16 | ✓ | +0.3% | NEW | New buy | |
| 17 | ✓ | +0.2% | NEW | New buy | |
| 18 | EVMN | Evommune Inc | +0.2% | NEW | New buy |
| 19 | ABT | Abbott Laboratories | +0.2% | NEW | New buy |
| 20 | BBIO | Bridgebio Pharma Inc | +0.1% | NEW | New buy |
| 21 | LEGN | Legend Biotech Corp-adr | +0.1% | NEW | New buy |
| 22 | SVRA | Savara Inc | +0.1% | NEW | New buy |
| 23 | MSLE | Satellos Bioscience Inc | 0% | — | Unchanged |
| 24 | NTLA | Intellia Therapeutics Inc | 0% | — | Unchanged |
| 25 | TRVI | Trevi Therapeutics Inc | — | — | Unchanged |
| 26 | ODD | Oddity Tech Ltd. | 0% | — | Unchanged |
| 27 | BBOT | Bridgebio Oncology Therapeut | 0% | — | Unchanged |
| 28 | GMAB | Genmab A/s -sp Adr | -0.1% | — | Unchanged |
| 29 | PVLA | Palvella Therapeutics Inc | -0.1% | — | Unchanged |
| 30 | DXCM | Dexcom Inc | -0.1% | +11.11% | Add |
| 31 | ACAD | Acadia Pharmaceuticals Inc | -0.1% | EXIT | Sold out |
| 32 | TENX | Tenax Therapeutics Inc | -0.1% | +23.16% | Add |
| 33 | PTON | Peloton Interactive Inc-a | -0.1% | -50.00% | Trim |
| 34 | ABUS | Arbutus Biopharma CORP | -0.1% | EXIT | Sold out |
| 35 | EHC | Encompass Health CORP | -0.1% | — | Unchanged |
| 36 | CRVS | Corvus Pharmaceuticals Inc | -0.2% | -30.43% | Trim |
| 37 | RGEN | Repligen CORP | -0.2% | — | Unchanged |
| 38 | GILD | Gilead Sciences Inc | -0.2% | — | Unchanged |
| 39 | AVR | Anteris Technologies Global | -0.2% | EXIT | Sold out |
| 40 | MLTX | Moonlake Immunotherapeutics | -0.2% | EXIT | Sold out |
| 41 | UNH | Unitedhealth Group Inc | -0.2% | EXIT | Sold out |
| 42 | PHAT | Phathom Pharmaceuticals Inc | -0.2% | -19.80% | Trim |
| 43 | BSX | Boston Scientific CORP | -0.2% | +33.33% | Add |
| 44 | ABVX | Abivax Sa-adr | -0.2% | EXIT | Sold out |
| 45 | CORT | Corcept Therapeutics Inc | -0.2% | EXIT | Sold out |
| 46 | RVMD | Revolution Medicines Inc | -0.3% | EXIT | Sold out |
| 47 | HIMS | Hims & Hers Health Inc | -0.3% | EXIT | Sold out |
| 48 | KVUE | Kenvue Inc | -0.4% | EXIT | Sold out |
| 49 | NTRA | Natera Inc | -0.4% | EXIT | Sold out |
| 50 | ICLR | ICON Public Limited Company | -0.4% | EXIT | Sold out |
1–50 of 60
Filing History
FAQ
What is Avidity Partners Management LP and what type of investor is it?
Avidity Partners Management LP is an investment manager that files SEC Form 13F quarterly, disclosing its U.S. public equity holdings to regulators. As of the most recent reporting period (2026-06-30), the firm manages a tracked equity portfolio valued at approximately $624.4M, spread across 45 disclosed positions.
What are Avidity Partners Management LP's largest equity positions?
Based on the latest 13F filing, Avidity Partners Management LP's top holdings by market value are:
1. Dianthus Therapeutics Inc (DNTH) — $205.1M (32.9%)
2. Cg Oncology Inc (CGON) — $99.4M (15.9%)
3. Oruka Therapeutics Inc (ORKA) — $72.4M (11.6%)
4. Jade Biosciences Inc (JBIO) — $37.8M (6.0%)
5. Enliven Therapeutics Inc (ELVN) — $27.9M (4.5%)
What changes did Avidity Partners Management LP make in its most recent portfolio filing?
In the latest reported quarter, Avidity Partners Management LP made 47 notable position adjustments: 15 new positions were initiated, 11 existing holdings were added to, 6 positions were partially reduced, and 15 were completely exited. The largest of these moves: New buy: ; New buy: Immunic Inc (IMUX); New buy: Senseonics Holdings Inc (SENS); Sold out: Immunic Inc (VTLUSD); New buy: Nuvectis Pharma Inc (NVCT)
What sectors does Avidity Partners Management LP focus on?
Avidity Partners Management LP is concentrated in the following sectors based on its current disclosed equity portfolio:
• Health Care: 98.9%
• Consumer Discretionary: 1.1%
💡
Data Source Notice: AlphaSMO is the web's most authoritative 13F / Inside Trader database. Institutional holdings and insider trades presented here are precisely computed to deliver accurate portfolio reporting.
Investment Profile
Avidity Partners Management LP returned an annualized 26.3% over the trailing 36 months — outperforming the S&P 500 by 13.8 points — based on a reconstructed track record of its disclosed 13F positions, with a beta of 0.63 (less volatile than the market) and a 42% quarterly batting average against the index.
Its portfolio is moderately concentrated and moderately active, with 98.9% of the portfolio concentrated in Health Care.
Its concentration score has risen from 14 to 63 over the past 4 quarters — a shift toward higher-conviction positions.
It has added to its DNTH position over the past two quarters (+$118.4M, now $205.1M), while trimming BSX over the same stretch (-$7.5M, still holding $3.4M).
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Developer Access
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