| T. Rowe Price Investment Management, Inc. | $11.5億 | 0.80% |
| BlackRock, Inc. | $10.9億 | 0.02% |
| FMR LLC | $7.1億 | 0.04% |
| WELLINGTON MANAGEMENT GROUP LLP | $5.3億 | 0.10% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $3.9億 | 0.02% |
| STATE STREET CORP | $3.8億 | 0.01% |
| VANGUARD CAPITAL MANAGEMENT LLC | $3.6億 | 0.01% |
| Avoro Capital Advisors LLC | $2.2億 | 2.16% |
| GEODE CAPITAL MANAGEMENT, LLC | $2.1億 | 0.01% |
| BANK OF AMERICA CORP /DE/ | $2.1億 | 0.02% |
| RTW INVESTMENTS, LP | $1.8億 | 1.78% |
| ARMISTICE CAPITAL, LLC | $1.8億 | 3.12% |
| Integral Health Asset Management, LLC | $1.7億 | 8.20% |
| GOLDMAN SACHS GROUP INC | $1.6億 | 0.02% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $1.5億 | 0.02% |
| UBS Group AG | $1.4億 | 0.02% |
| Caption Management, LLC | $1.2億 | 0.71% |
| Polar Capital Holdings Plc | $1.1億 | 0.39% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $1.0億 | 0.01% |
| CITADEL ADVISORS LLC | $1.0億 | 0.02% |
| MORGAN STANLEY | $9920.0万 | 0.01% |
| Paradigm Biocapital Advisors LP | $9760.3万 | 1.99% |
| NORTHERN TRUST CORP | $9501.8万 | 0.01% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $9207.9万 | 0.01% |
| Deep Track Capital, LP | $9058.1万 | 1.48% |
| Capital International Investors | $8824.1万 | 0.02% |
| Ikarian Capital, LLC | $8189.1万 | 6.65% |
| Frazier Life Sciences Management, L.P. | $7644.8万 | 1.97% |
| Balyasny Asset Management L.P. | $7237.9万 | 0.09% |
| PRINCIPAL FINANCIAL GROUP INC | $7207.2万 | 0.04% |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | $7168.3万 | 0.24% |
| Bank of New York Mellon Corp | $6631.8万 | 0.01% |
| Woodline Partners LP | $6593.8万 | 0.25% |
| Royalty Pharma Sub-Manager, LLC | $6461.8万 | 37.40% |
| Logos Global Management LP | $5767.1万 | 2.88% |
| JPMORGAN CHASE & CO | $5691.3万 | 0.00% |
| Melqart Asset Management (UK) Ltd | $5562.5万 | 5.48% |
| VANGUARD FIDUCIARY TRUST CO | $5270.3万 | 0.01% |
| Qube Research & Technologies Ltd | $5137.3万 | 0.06% |
| Capital Research Global Investors | $5081.7万 | 0.01% |
| Fisher Asset Management, LLC | $5063.6万 | 0.02% |
| Pictet Asset Management Holding SA | $4929.7万 | 0.05% |
| D. E. Shaw & Co., Inc. | $4925.7万 | 0.03% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $4708.2万 | 0.05% |
| Affinity Asset Advisors, LLC | $4616.9万 | 2.38% |
| FEDERATED HERMES, INC. | $4610.1万 | 0.07% |
| Point72 Asset Management, L.P. | $4356.7万 | 0.06% |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | $4352.1万 | 3.69% |
| MARSHALL WACE, LLP | $4327.7万 | 0.04% |
| ADAR1 Capital Management, LLC | $4169.2万 | 2.45% |
| BROWN ADVISORY INC | $4051.2万 | 0.07% |
| Siren, L.L.C. | $4046.6万 | 1.12% |
| Foresite Capital Management IV, LLC | $3317.2万 | 13.99% |
| MPM BIOIMPACT LLC | $3295.5万 | 2.54% |
| GW&K Investment Management, LLC | $3260.0万 | 0.29% |
| Invesco Ltd. | $3196.5万 | 0.00% |
| AMERIPRISE FINANCIAL INC | $3193.4万 | 0.01% |
| Aberdeen Group plc | $3185.3万 | 0.05% |
| EVENTIDE ASSET MANAGEMENT, LLC | $3157.7万 | 0.52% |
| AMERICAN CENTURY COMPANIES INC | $2926.1万 | 0.02% |
| ALLIANCEBERNSTEIN L.P. | $2917.0万 | 0.01% |
| TD Asset Management Inc | $2773.8万 | 0.02% |
| BOOTHBAY FUND MANAGEMENT, LLC | $2744.1万 | 0.36% |
| FRANKLIN RESOURCES INC | $2700.9万 | 0.01% |
| RHUMBLINE ADVISERS | $2435.9万 | 0.02% |
| GROUP ONE TRADING LLC | $2399.1万 | 0.05% |
| Nuveen, LLC | $2318.8万 | 0.01% |
| GSK plc | $2243.8万 | 3.74% |
| Candriam S.C.A. | $2209.4万 | 0.11% |
| GILDER GAGNON HOWE & CO LLC | $2181.5万 | 0.26% |
| MILLENNIUM MANAGEMENT LLC | $2154.3万 | 0.01% |
| JANE STREET GROUP, LLC | $2121.0万 | 0.00% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | $2054.1万 | 0.01% |
| CITIGROUP INC | $2011.9万 | 0.01% |
| E. Ohman J:or Asset Management AB | $1982.3万 | 0.52% |
| Trails Edge Capital Partners, LP | $1977.3万 | 4.53% |
| Vestal Point Capital, LP | $1977.3万 | 0.55% |
| SPHERA FUNDS MANAGEMENT LTD. | $1971.5万 | 3.13% |
| NOMURA HOLDINGS INC | $1932.0万 | 0.05% |
| TWO SIGMA INVESTMENTS, LP | $1878.5万 | 0.02% |
| First Turn Management, LLC | $1869.9万 | 2.09% |
| JANUS HENDERSON GROUP PLC | $1859.3万 | 0.01% |
| Susquehanna Portfolio Strategies, LLC | $1835.1万 | 0.27% |
| BARCLAYS PLC | $1764.1万 | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | $1710.1万 | 0.02% |
| DIADEMA PARTNERS LP | $1647.8万 | 2.80% |
| Handelsbanken Fonder AB | $1630.0万 | 0.05% |
| Capital World Investors | $1595.3万 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $1586.0万 | 0.00% |
| Swiss National Bank | $1514.6万 | 0.01% |
| Sarissa Capital Management LP | $1506.9万 | 9.56% |
| HSBC HOLDINGS PLC | $1463.2万 | 0.01% |
| DAFNA Capital Management LLC | $1433.5万 | 3.26% |
| Freestone Grove Partners LP | $1428.7万 | 0.10% |
| Catalio Capital Management, LP | $1420.4万 | 2.97% |
| Mirador Capital Partners LP | $1335.8万 | 1.89% |
| Hudson Bay Capital Management LP | $1321.3万 | 0.05% |
| EMERALD ADVISERS, LLC | $1310.4万 | 0.41% |
| California Public Employees Retirement System | $1308.5万 | 0.01% |
| DEUTSCHE BANK AG\ | $1233.4万 | 0.00% |
| SEGALL BRYANT & HAMILL, LLC | $1187.7万 | 0.17% |
| Checkpoint Capital L.P. | $1186.4万 | 4.26% |
| PINNACLE ASSOCIATES LTD | $1167.0万 | 0.15% |
| Russell Investments Group, Ltd. | $1147.0万 | 0.01% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $1101.5万 | 0.01% |
| AQR CAPITAL MANAGEMENT LLC | $1031.8万 | 0.00% |
| Legal & General Group Plc | $995.4万 | 0.00% |
| Alyeska Investment Group, L.P. | $988.7万 | 0.03% |
| Retirement Systems of Alabama | $987.9万 | 0.03% |
| FIRST TRUST ADVISORS LP | $961.6万 | 0.01% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $900.3万 | 0.01% |
| EMERALD MUTUAL FUND ADVISERS TRUST | $892.8万 | 0.43% |
| STEMPOINT CAPITAL LP | $854.0万 | 1.64% |
| Impax Asset Management Group plc | $823.9万 | 0.06% |
| ROYCE & ASSOCIATES LP | $819.2万 | 0.08% |
| MetLife Investment Management, LLC | $812.9万 | 0.04% |
| ALGERT GLOBAL LLC | $771.9万 | 0.12% |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | $728.3万 | 0.01% |
| LMR Partners LLP | $710.5万 | 0.02% |
| Creative Planning | $710.2万 | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | $705.2万 | 0.01% |
| Exome Asset Management LLC | $683.6万 | 3.54% |
| PEREGRINE CAPITAL MANAGEMENT LLC | $683.0万 | 0.25% |
| Lombard Odier Asset Management (Europe) Ltd | $674.9万 | 0.37% |
| Schonfeld Strategic Advisors LLC | $669.4万 | 0.05% |
| Boxer Capital Management, LLC | $659.1万 | 0.87% |
| Monashee Investment Management LLC | $659.1万 | 3.59% |
| DIMENSIONAL FUND ADVISORS LP | $622.9万 | 0.00% |
| Sofinnova Investments, Inc. | $605.0万 | 0.23% |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | $599.0万 | 0.07% |
| THORNBURG INVESTMENT MANAGEMENT INC | $548.3万 | 0.06% |
| Walleye Trading LLC | $533.9万 | 0.01% |
| J. Goldman & Co LP | $524.0万 | 0.15% |
| NEUBERGER BERMAN GROUP LLC | $508.1万 | 0.00% |
| WELLS FARGO & COMPANY/MN | $490.0万 | 0.00% |
| Erste Asset Management GmbH | $484.6万 | 0.04% |
| Rafferty Asset Management, LLC | $478.6万 | 0.02% |
| Aquatic Capital Management LLC | $477.7万 | 0.14% |
| Granahan Investment Management, LLC | $477.6万 | 0.23% |
| STATE OF WISCONSIN INVESTMENT BOARD | $475.0万 | 0.01% |
| SILVERARC CAPITAL MANAGEMENT, LLC | $469.3万 | 0.48% |
| Nicholas Investment Partners, LP | $460.3万 | 0.33% |
| SEI INVESTMENTS CO | $460.1万 | 0.00% |
| Pier Capital, LLC | $458.6万 | 0.76% |
| CANADA LIFE ASSURANCE Co | $451.9万 | 0.01% |
| RAYMOND JAMES FINANCIAL INC | $451.5万 | 0.00% |
| Tyro Capital Management LLC | $426.2万 | 0.46% |
| ACT CAPITAL MANAGEMENT, LLC | $425.1万 | 3.34% |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | $413.8万 | 0.03% |
| Seven Fleet Capital Management LP | $403.8万 | 1.28% |