| FMR LLC | $36.4億 | 0.19% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $24.6億 | 0.28% |
| JANUS HENDERSON GROUP PLC | $18.5億 | 0.88% |
| Capital World Investors | $16.5億 | 0.22% |
| Artisan Partners Limited Partnership | $10.7億 | 1.72% |
| WELLINGTON MANAGEMENT GROUP LLP | $7.5億 | 0.14% |
| Avoro Capital Advisors LLC | $7.3億 | 7.18% |
| BlackRock, Inc. | $5.9億 | 0.01% |
| RTW INVESTMENTS, LP | $5.2億 | 5.16% |
| Invesco Ltd. | $4.3億 | 0.07% |
| MORGAN STANLEY | $4.1億 | 0.02% |
| ALLIANCEBERNSTEIN L.P. | $3.6億 | 0.12% |
| BANK OF AMERICA CORP /DE/ | $2.9億 | 0.02% |
| SANDS CAPITAL MANAGEMENT, LLC | $2.5億 | 0.97% |
| Bellevue Group AG | $2.3億 | 5.44% |
| CITADEL ADVISORS LLC | $2.1億 | 0.03% |
| SEI INVESTMENTS CO | $2.1億 | 0.19% |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | $1.9億 | 0.64% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $1.7億 | 0.02% |
| JENNISON ASSOCIATES LLC | $1.7億 | 0.12% |
| FRANKLIN RESOURCES INC | $1.7億 | 0.04% |
| GOLDMAN SACHS GROUP INC | $1.7億 | 0.02% |
| Clearbridge Investments, LLC | $1.7億 | 0.15% |
| Fiera Capital Corp | $1.6億 | 0.54% |
| AMERIPRISE FINANCIAL INC | $1.6億 | 0.04% |
| Allspring Global Investments Holdings, LLC | $1.3億 | 0.22% |
| AMERICAN CENTURY COMPANIES INC | $1.3億 | 0.07% |
| Checkpoint Capital L.P. | $1.1億 | 40.10% |
| LORD, ABBETT & CO. LLC | $1.1億 | 0.36% |
| Legal & General Group Plc | $1.1億 | 0.03% |
| Pictet Asset Management Holding SA | $1.1億 | 0.11% |
| DEUTSCHE BANK AG\ | $1.0億 | 0.03% |
| BAMCO INC /NY/ | $1.0億 | 0.31% |
| ORBIMED ADVISORS LLC | $9997.1万 | 2.05% |
| D. E. Shaw & Co., Inc. | $9787.0万 | 0.06% |
| LAZARD ASSET MANAGEMENT LLC | $9737.7万 | 0.16% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $9431.0万 | 0.11% |
| EVENTIDE ASSET MANAGEMENT, LLC | $9173.6万 | 1.52% |
| AGF MANAGEMENT LTD | $9133.2万 | 0.41% |
| TWO SIGMA INVESTMENTS, LP | $7968.6万 | 0.06% |
| FIRST TRUST ADVISORS LP | $7827.9万 | 0.06% |
| PINEBRIDGE INVESTMENTS LLC | $7580.9万 | 0.64% |
| Rock Springs Capital Management LP | $7193.0万 | 4.24% |
| FEDERATED HERMES, INC. | $6955.9万 | 0.11% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $6572.3万 | 0.10% |
| BANK OF MONTREAL /CAN/ | $6231.4万 | 0.02% |
| BRAIDWELL LP | $6202.7万 | 2.07% |
| 1832 Asset Management L.P. | $6148.7万 | 0.06% |
| TimesSquare Capital Management, LLC | $6069.6万 | 1.03% |
| Aberdeen Group plc | $5995.8万 | 0.10% |
| TD Asset Management Inc | $5902.2万 | 0.05% |
| Eagle Health Investments LP | $5574.4万 | 9.75% |
| Public Sector Pension Investment Board | $5352.7万 | 0.17% |
| MILLENNIUM MANAGEMENT LLC | $5284.5万 | 0.02% |
| Ensign Peak Advisors, Inc | $5228.4万 | 0.10% |
| PGGM Investments | $5222.3万 | 0.92% |
| Nuveen, LLC | $4837.2万 | 0.01% |
| BESSEMER GROUP INC | $4692.0万 | 0.07% |
| Amundi | $4486.1万 | 0.01% |
| ENVESTNET ASSET MANAGEMENT INC | $4485.1万 | 0.01% |
| Life Cycle Investment Partners Ltd | $4298.8万 | 0.27% |
| NORTHERN TRUST CORP | $4287.0万 | 0.01% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | $4262.8万 | 0.07% |
| JANE STREET GROUP, LLC | $4121.4万 | 0.01% |
| Handelsbanken Fonder AB | $4011.0万 | 0.13% |
| Candriam S.C.A. | $3954.2万 | 0.21% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $3602.3万 | 0.03% |
| NOMURA ASSET MANAGEMENT CO LTD | $3600.6万 | 0.09% |
| LMR Partners LLP | $3058.9万 | 0.07% |
| VAN ECK ASSOCIATES CORP | $2950.0万 | 0.02% |
| NEW YORK STATE COMMON RETIREMENT FUND | $2879.9万 | 0.04% |
| DIMENSIONAL FUND ADVISORS LP | $2832.7万 | 0.01% |
| WELLS FARGO & COMPANY/MN | $2782.5万 | 0.01% |
| RAYMOND JAMES FINANCIAL INC | $2687.4万 | 0.01% |
| Patient Square Capital LP | $2681.3万 | 4.76% |
| Davern Capital Partners, LP | $2559.2万 | 7.02% |
| ROYAL BANK OF CANADA | $2403.6万 | 0.00% |
| VICTORY CAPITAL MANAGEMENT INC | $2355.4万 | 0.02% |
| UBS Group AG | $2311.0万 | 0.00% |
| Tri Locum Partners LP | $2310.1万 | 3.24% |
| Jefferies Financial Group Inc. | $2191.1万 | 0.15% |
| Hudson Bay Capital Management LP | $2190.8万 | 0.08% |
| Artia Global Partners LP | $2171.7万 | 4.35% |
| Perpetual Ltd | $2070.9万 | 0.32% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $2008.6万 | 0.00% |
| Jones Hill Capital LP | $1898.3万 | 4.07% |
| Qube Research & Technologies Ltd | $1864.8万 | 0.02% |
| BAKER BROS. ADVISORS LP | $1838.3万 | 0.11% |
| Squarepoint Ops LLC | $1831.4万 | 0.02% |
| ODDO BHF ASSET MANAGEMENT SAS | $1826.3万 | 0.72% |
| GEODE CAPITAL MANAGEMENT, LLC | $1721.1万 | 0.00% |
| LPL Financial LLC | $1697.7万 | 0.00% |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | $1654.1万 | 0.07% |
| BLAIR WILLIAM & CO/IL | $1636.2万 | 0.05% |
| Caption Management, LLC | $1606.6万 | 0.09% |
| NATIXIS ADVISORS, LLC | $1488.2万 | 0.02% |
| HSBC HOLDINGS PLC | $1488.2万 | 0.01% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | $1480.7万 | 0.01% |
| MIROVA | $1448.3万 | 0.59% |
| HRT FINANCIAL LP | $1369.5万 | 0.03% |
| Bank of New York Mellon Corp | $1254.8万 | 0.00% |
| JONES FINANCIAL COMPANIES LLLP | $1162.2万 | 0.01% |
| Assenagon Asset Management S.A. | $1079.7万 | 0.02% |
| DCF Advisers, LLC | $1069.8万 | 2.85% |
| Allianz Asset Management GmbH | $1051.6万 | 0.01% |
| CenterBook Partners LP | $1017.5万 | 0.55% |
| Ilmarinen Mutual Pension Insurance Co | $1007.7万 | 0.08% |
| Erste Asset Management GmbH | $1000.5万 | 0.09% |
| Balyasny Asset Management L.P. | $957.4万 | 0.01% |
| Thrivent Financial for Lutherans | $926.1万 | 0.02% |
| JPMORGAN CHASE & CO | $916.0万 | 0.00% |
| USS Investment Management Ltd | $887.2万 | 0.04% |
| Tower Research Capital LLC (TRC) | $884.5万 | 0.23% |
| CANADA LIFE ASSURANCE Co | $848.4万 | 0.02% |
| Quantinno Capital Management LP | $814.1万 | 0.01% |
| Optiver Holding B.V. | $738.3万 | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $686.7万 | 0.00% |
| Steward Partners Investment Advisory, LLC | $684.3万 | 0.03% |
| ASSETMARK, INC | $677.3万 | 0.01% |
| CITIGROUP INC | $663.2万 | 0.00% |
| Campbell & CO Investment Adviser LLC | $659.7万 | 0.38% |
| Crossmark Global Holdings, Inc. | $633.0万 | 0.09% |
| CVFG LLC | $622.0万 | 0.77% |
| Creative Planning | $601.7万 | 0.00% |
| STIFEL FINANCIAL CORP | $589.3万 | 0.01% |
| Cinctive Capital Management LP | $561.3万 | 0.37% |
| MACKENZIE FINANCIAL CORP | $543.0万 | 0.01% |
| Point72 Asset Management, L.P. | $518.5万 | 0.01% |
| EFG International AG | $517.5万 | 0.11% |
| NAVELLIER & ASSOCIATES INC | $512.9万 | 0.53% |
| Trexquant Investment LP | $511.8万 | 0.04% |
| Federation des caisses Desjardins du Quebec | $505.3万 | 0.02% |
| Maryland State Retirement & Pension System | $503.3万 | 0.10% |
| Cetera Investment Advisers | $491.6万 | 0.01% |
| MML INVESTORS SERVICES, LLC | $439.0万 | 0.01% |
| EAGLE GLOBAL ADVISORS LLC | $438.3万 | 0.16% |
| iA Global Asset Management Inc. | $438.2万 | 0.06% |
| Y-Intercept (Hong Kong) Ltd | $429.7万 | 0.08% |
| Mitsubishi UFJ Asset Management Co., Ltd. | $405.3万 | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | $404.9万 | 0.00% |
| BARCLAYS PLC | $401.6万 | 0.00% |
| SIH Partners, LLLP | $395.6万 | 0.05% |
| HighTower Advisors, LLC | $386.9万 | 0.00% |
| QVT Financial LP | $381.0万 | 0.28% |
| STATE STREET CORP | $373.4万 | 0.00% |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | $369.1万 | 0.02% |
| China Universal Asset Management Co., Ltd. | $367.7万 | 0.28% |
| M&T Bank Corp | $365.3万 | 0.01% |
| Varma Mutual Pension Insurance Co | $365.1万 | 0.02% |
| HighVista Strategies LLC | $359.1万 | 0.99% |