| RA CAPITAL MANAGEMENT, L.P. | US$1655.3万 | 0.18% |
| ACORN CAPITAL ADVISORS, LLC | US$1175.6万 | 3.34% |
| StepStone Group LP | US$1101.5万 | 5.31% |
| ADAR1 Capital Management, LLC | US$1008.1万 | 0.59% |
| Prosight Management, LP | US$891.9万 | 1.46% |
| BVF INC/IL | US$819.3万 | 0.26% |
| Vivo Capital, LLC | US$798.1万 | 0.66% |
| Vestal Point Capital, LP | US$761.7万 | 0.21% |
| Foresite Capital Management VI LLC | US$598.6万 | 1.30% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$498.8万 | 0.01% |
| Sio Capital Management, LLC | US$446.7万 | 0.64% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$241.1万 | 0.00% |
| NEA Management Company, LLC | US$198.1万 | 0.11% |
| Rosalind Advisors, Inc. | US$183.7万 | 0.74% |
| RENAISSANCE TECHNOLOGIES LLC | US$156.2万 | 0.00% |
| Carlyle Group Inc. | US$111.7万 | 0.01% |
| Affinity Asset Advisors, LLC | US$99.8万 | 0.05% |
| Sofinnova Investments, Inc. | US$58.7万 | 0.02% |
| Stonepine Capital Management, LLC | US$54.9万 | 0.22% |
| Shay Capital LLC | US$54.7万 | 0.05% |
| CANTOR FITZGERALD, L. P. | US$41.4万 | 0.01% |
| GEODE CAPITAL MANAGEMENT, LLC | US$40.9万 | 0.00% |
| Rangeley Capital, LLC | US$39.3万 | 0.38% |
| Aisling Capital Management LP | US$36.7万 | 0.08% |
| BlackRock, Inc. | US$20.5万 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | US$18.0万 | 0.00% |
| Aldebaran Capital, LLC | US$16.7万 | 0.13% |
| CITADEL ADVISORS LLC | US$15.6万 | 0.00% |
| HRT FINANCIAL LP | US$15.3万 | 0.00% |
| MARSHALL WACE, LLP | US$15.1万 | 0.00% |
| XTX Topco Ltd | US$14.1万 | 0.00% |
| MILLENNIUM MANAGEMENT LLC | US$12.6万 | 0.00% |
| JANE STREET GROUP, LLC | US$11.1万 | 0.00% |
| BARCLAYS PLC | US$10.4万 | 0.00% |
| TWO SIGMA INVESTMENTS, LP | US$10.0万 | 0.00% |
| GSA CAPITAL PARTNERS LLP | US$9.2万 | 0.01% |
| NORTHERN TRUST CORP | US$8.2万 | 0.00% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | US$6.7万 | 0.00% |
| MORGAN STANLEY | US$5.9万 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$5.6万 | 0.00% |
| STATE STREET CORP | US$5.6万 | 0.00% |
| NewEdge Advisors, LLC | US$4.5万 | 0.00% |
| UBS Group AG | US$1.4万 | 0.00% |
| Vanguard Global Advisers, LLC | US$3084.0 | 0.00% |
| ROYAL BANK OF CANADA | US$1000.0 | 0.00% |
| TRUST CO OF TOLEDO NA /OH/ | US$563.0 | 0.00% |
| OSAIC HOLDINGS, INC. | US$372.0 | 0.00% |
| JPMORGAN CHASE & CO | US$171.0 | 0.00% |
| BNP PARIBAS FINANCIAL MARKETS | US$11.6 | 0.00% |
| CITIGROUP INC | US$4.0 | 0.00% |