| Frazier Life Sciences Management, L.P. | US$4.0亿 | 10.27% |
| T. Rowe Price Investment Management, Inc. | US$3.4亿 | 0.24% |
| BlackRock, Inc. | US$3.3亿 | 0.01% |
| Venrock Adviser, LLC | US$2.7亿 | 9.89% |
| RTW INVESTMENTS, LP | US$2.6亿 | 2.60% |
| Vivo Capital, LLC | US$2.0亿 | 16.34% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$1.8亿 | 0.00% |
| Siren, L.L.C. | US$1.8亿 | 5.04% |
| Logos Global Management LP | US$1.8亿 | 9.01% |
| Paradigm Biocapital Advisors LP | US$1.7亿 | 3.44% |
| STATE STREET CORP | US$1.5亿 | 0.01% |
| ARCH Venture Management, LLC | US$1.1亿 | 16.95% |
| GEODE CAPITAL MANAGEMENT, LLC | US$9703.7万 | 0.01% |
| Cormorant Asset Management, LP | US$9384.4万 | 4.71% |
| Affinity Asset Advisors, LLC | US$8656.3万 | 4.47% |
| Balyasny Asset Management L.P. | US$8323.0万 | 0.11% |
| GOLDMAN SACHS GROUP INC | US$7888.1万 | 0.01% |
| JANUS HENDERSON GROUP PLC | US$5998.8万 | 0.03% |
| 5AM Venture Management, LLC | US$5640.3万 | 15.66% |
| SUVRETTA CAPITAL MANAGEMENT, LLC | US$5557.8万 | 1.42% |
| Commodore Capital LP | US$5137.2万 | 2.97% |
| BANK OF AMERICA CORP /DE/ | US$4944.4万 | 0.00% |
| a16z Capital Management, L.L.C. | US$4631.5万 | 3.59% |
| Woodline Partners LP | US$4581.4万 | 0.17% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$3397.8万 | 0.05% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$3071.3万 | 0.00% |
| SILVERARC CAPITAL MANAGEMENT, LLC | US$2996.2万 | 3.06% |
| UBS Group AG | US$2991.0万 | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$2937.4万 | 0.00% |
| DIMENSIONAL FUND ADVISORS LP | US$2887.3万 | 0.01% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$2869.9万 | 0.00% |
| NORTHERN TRUST CORP | US$2753.2万 | 0.00% |
| VICTORY CAPITAL MANAGEMENT INC | US$2677.0万 | 0.02% |
| VANGUARD FIDUCIARY TRUST CO | US$2488.3万 | 0.01% |
| FMR LLC | US$2410.9万 | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$2392.3万 | 0.00% |
| RENAISSANCE TECHNOLOGIES LLC | US$2263.4万 | 0.04% |
| D. E. Shaw & Co., Inc. | US$1973.2万 | 0.01% |
| Rock Springs Capital Management LP | US$1785.4万 | 1.05% |
| MORGAN STANLEY | US$1600.5万 | 0.00% |
| EcoR1 Capital, LLC | US$1456.2万 | 0.62% |
| First Turn Management, LLC | US$1403.8万 | 1.57% |
| JPMORGAN CHASE & CO | US$1381.1万 | 0.00% |
| CITADEL ADVISORS LLC | US$1233.2万 | 0.00% |
| Holocene Advisors, LP | US$1230.8万 | 0.03% |
| Invesco Ltd. | US$1229.6万 | 0.00% |
| Integral Health Asset Management, LLC | US$1132.6万 | 0.54% |
| Point72 Asset Management, L.P. | US$1121.8万 | 0.01% |
| AQR CAPITAL MANAGEMENT LLC | US$1118.4万 | 0.01% |
| AMERIPRISE FINANCIAL INC | US$1085.0万 | 0.00% |
| JANE STREET GROUP, LLC | US$999.3万 | 0.00% |
| Caption Management, LLC | US$991.0万 | 0.06% |
| ALLIANCEBERNSTEIN L.P. | US$983.9万 | 0.00% |
| WELLINGTON MANAGEMENT GROUP LLP | US$963.3万 | 0.00% |
| MILLENNIUM MANAGEMENT LLC | US$932.0万 | 0.00% |
| ExodusPoint Capital Management, LP | US$931.5万 | 0.08% |
| Bank of New York Mellon Corp | US$905.5万 | 0.00% |
| Nuveen, LLC | US$878.6万 | 0.00% |
| Ensign Peak Advisors, Inc | US$810.2万 | 0.02% |
| MARSHALL WACE, LLP | US$690.1万 | 0.01% |
| Spruce Street Capital LP | US$683.7万 | 1.64% |
| Creative Planning | US$677.7万 | 0.00% |
| PRUDENTIAL FINANCIAL INC | US$674.2万 | 0.01% |
| Parkman Healthcare Partners LLC | US$658.0万 | 0.68% |
| TD Asset Management Inc | US$637.9万 | 0.01% |
| AMERICAN CENTURY COMPANIES INC | US$616.4万 | 0.00% |
| Polymer Capital Management (HK) LTD | US$578.7万 | 0.50% |
| ACUTA CAPITAL PARTNERS, LLC | US$573.7万 | 4.08% |
| Atom Investors LP | US$559.2万 | 0.40% |
| KVP Capital Advisors, LP | US$550.1万 | 4.11% |
| Swiss National Bank | US$544.9万 | 0.00% |
| Trexquant Investment LP | US$487.1万 | 0.04% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$419.1万 | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | US$410.3万 | 0.00% |
| SIMPLEX TRADING, LLC | US$408.9万 | 0.00% |
| Rafferty Asset Management, LLC | US$407.7万 | 0.02% |
| RHUMBLINE ADVISERS | US$392.6万 | 0.00% |
| STEMPOINT CAPITAL LP | US$388.1万 | 0.74% |
| FRED ALGER MANAGEMENT, LLC | US$383.2万 | 0.02% |
| Tidal Investments LLC | US$367.1万 | 0.01% |
| Tema ETFs LLC | US$367.1万 | 0.25% |
| Seven Fleet Capital Management LP | US$360.0万 | 1.14% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$350.5万 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$330.8万 | 0.00% |
| TANG CAPITAL MANAGEMENT LLC | US$323.6万 | 0.16% |
| Pictet Asset Management Holding SA | US$314.5万 | 0.00% |
| HighVista Strategies LLC | US$293.0万 | 0.81% |
| Cinctive Capital Management LP | US$278.2万 | 0.18% |
| Longaeva Partners L.P. | US$277.1万 | 0.10% |
| DEUTSCHE BANK AG\ | US$264.3万 | 0.00% |
| NATIXIS | US$264.0万 | 0.01% |
| XTX Topco Ltd | US$238.8万 | 0.04% |
| NOMURA HOLDINGS INC | US$224.9万 | 0.01% |
| Informed Momentum Co LLC | US$223.2万 | 0.26% |
| Legal & General Group Plc | US$215.7万 | 0.00% |
| Vanguard Global Advisers, LLC | US$183.9万 | 0.00% |
| PROFUND ADVISORS LLC | US$183.2万 | 0.07% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$180.8万 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$173.4万 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$170.6万 | 0.00% |
| MetLife Investment Management, LLC | US$167.7万 | 0.01% |
| FRANKLIN RESOURCES INC | US$164.8万 | 0.00% |
| Burkehill Global Management, LP | US$161.8万 | 0.08% |
| SEVEN GRAND MANAGERS, LLC | US$161.8万 | 0.11% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$159.5万 | 0.00% |
| J. Goldman & Co LP | US$158.6万 | 0.05% |
| Squarepoint Ops LLC | US$153.2万 | 0.00% |
| ALGERT GLOBAL LLC | US$142.4万 | 0.02% |
| RAYMOND JAMES FINANCIAL INC | US$133.8万 | 0.00% |
| Cresset Asset Management, LLC | US$129.4万 | 0.01% |
| ArrowMark Colorado Holdings LLC | US$127.9万 | 0.03% |
| Virtus Investment Advisers, LLC | US$122.6万 | 0.34% |
| Harvest Investment Services, LLC | US$119.3万 | 0.22% |
| Schonfeld Strategic Advisors LLC | US$110.1万 | 0.01% |
| Hudson Bay Capital Management LP | US$105.7万 | 0.00% |
| Susquehanna Portfolio Strategies, LLC | US$95.6万 | 0.01% |
| State of New Jersey Common Pension Fund D | US$94.1万 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | US$93.1万 | 0.01% |
| GILDER GAGNON HOWE & CO LLC | US$91.6万 | 0.01% |
| Cerity Partners LLC | US$90.2万 | 0.00% |
| Brevan Howard Capital Management LP | US$89.2万 | 0.01% |
| China Universal Asset Management Co., Ltd. | US$88.9万 | 0.07% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$88.6万 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | US$83.3万 | 0.01% |
| CITIGROUP INC | US$79.5万 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$77.5万 | 0.00% |
| Vanguard Personalized Indexing Management, LLC | US$75.9万 | 0.01% |
| ARIZONA STATE RETIREMENT SYSTEM | US$75.7万 | 0.00% |
| Connor, Clark & Lunn Investment Management Ltd. | US$73.4万 | 0.00% |
| BARCLAYS PLC | US$72.9万 | 0.00% |
| SG Americas Securities, LLC | US$72.3万 | 0.00% |
| Vanguard Investments Australia, Ltd. | US$71.7万 | 0.00% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | US$68.5万 | 0.00% |
| ProShare Advisors LLC | US$66.9万 | 0.00% |
| KLP KAPITALFORVALTNING AS | US$60.7万 | 0.00% |
| Verdad Advisers, LP | US$53.5万 | 0.60% |
| STRS OHIO | US$53.4万 | 0.00% |
| CWM, LLC | US$53.0万 | 0.00% |
| E Fund Management Co., Ltd. | US$52.8万 | 0.02% |
| Tower Research Capital LLC (TRC) | US$52.3万 | 0.01% |
| SEI INVESTMENTS CO | US$51.4万 | 0.00% |
| Marks Group Wealth Management, Inc | US$48.3万 | 0.05% |
| Persistent Asset Partners Ltd | US$45.7万 | 0.17% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$44.9万 | 0.00% |
| FORA Capital, LLC | US$43.3万 | 0.03% |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | US$41.7万 | 0.00% |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | US$40.2万 | 0.36% |
| Quantbot Technologies LP | US$37.6万 | 0.02% |
| TEACHER RETIREMENT SYSTEM OF TEXAS | US$35.7万 | 0.00% |
| Quadrature Capital Ltd | US$35.1万 | 0.00% |