| FMR LLC | $4299.1万 | 0.00% |
| T. Rowe Price Investment Management, Inc. | $3228.9万 | 0.02% |
| Caligan Partners LP | $2441.1万 | 1.62% |
| BVF INC/IL | $2437.8万 | 0.78% |
| Avoro Capital Advisors LLC | $2105.1万 | 0.21% |
| Affinity Asset Advisors, LLC | $2001.9万 | 1.03% |
| Logos Global Management LP | $1940.9万 | 0.97% |
| Nantahala Capital Management, LLC | $1843.9万 | 0.68% |
| UBS Group AG | $1705.0万 | 0.00% |
| Caption Management, LLC | $1622.4万 | 0.09% |
| Point72 Asset Management, L.P. | $1367.8万 | 0.02% |
| FARALLON CAPITAL MANAGEMENT LLC | $1367.6万 | 0.08% |
| RTW INVESTMENTS, LP | $1279.4万 | 0.13% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $1275.0万 | 0.02% |
| MILLENNIUM MANAGEMENT LLC | $1247.4万 | 0.01% |
| TCG Crossover Management, LLC | $1102.4万 | 0.32% |
| Balyasny Asset Management L.P. | $1092.3万 | 0.01% |
| VANGUARD CAPITAL MANAGEMENT LLC | $1074.5万 | 0.00% |
| RA CAPITAL MANAGEMENT, L.P. | $989.8万 | 0.10% |
| BANK OF AMERICA CORP /DE/ | $960.0万 | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $951.3万 | 0.00% |
| Ikarian Capital, LLC | $836.1万 | 0.68% |
| BOOTHBAY FUND MANAGEMENT, LLC | $725.2万 | 0.09% |
| Commodore Capital LP | $721.1万 | 0.42% |
| ORBIMED ADVISORS LLC | $709.4万 | 0.15% |
| JENNISON ASSOCIATES LLC | $702.9万 | 0.00% |
| Soleus Capital Management, L.P. | $659.9万 | 0.27% |
| KENNEDY CAPITAL MANAGEMENT LLC | $579.3万 | 0.12% |
| DV Trading LLC | $537.6万 | 0.13% |
| BlackRock, Inc. | $488.3万 | 0.00% |
| Boxer Capital Management, LLC | $447.9万 | 0.59% |
| Pivotal bioVenture Partners Investment Advisor LLC | $441.8万 | 1.58% |
| CITADEL ADVISORS LLC | $389.0万 | 0.00% |
| Seven Fleet Capital Management LP | $319.2万 | 1.01% |
| JANE STREET GROUP, LLC | $288.9万 | 0.00% |
| NAN FUNG TRINITY (HK) LTD | $282.2万 | 0.31% |
| Velan Capital Investment Management LP | $276.4万 | 1.73% |
| JPMORGAN CHASE & CO | $270.8万 | 0.00% |
| Qube Research & Technologies Ltd | $260.5万 | 0.00% |
| AMERIPRISE FINANCIAL INC | $257.0万 | 0.00% |
| Aberdeen Group plc | $256.3万 | 0.00% |
| GEODE CAPITAL MANAGEMENT, LLC | $253.8万 | 0.00% |
| MORGAN STANLEY | $241.0万 | 0.00% |
| Hudson Bay Capital Management LP | $240.5万 | 0.01% |
| Exome Asset Management LLC | $237.9万 | 1.23% |
| MOODY ALDRICH PARTNERS LLC | $237.9万 | 0.43% |
| DEUTSCHE BANK AG\ | $224.0万 | 0.00% |
| PERCEPTIVE ADVISORS LLC | $208.5万 | 0.04% |
| STEMPOINT CAPITAL LP | $201.2万 | 0.39% |
| MARSHALL WACE, LLP | $192.8万 | 0.00% |
| XTX Topco Ltd | $189.2万 | 0.03% |
| Quadrature Capital Ltd | $186.9万 | 0.02% |
| GREAT POINT PARTNERS LLC | $186.1万 | 0.43% |
| RENAISSANCE TECHNOLOGIES LLC | $179.3万 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | $129.0万 | 0.00% |
| Squarepoint Ops LLC | $121.4万 | 0.00% |
| Rosalind Advisors, Inc. | $112.0万 | 0.45% |
| STATE STREET CORP | $107.0万 | 0.00% |
| TWO SIGMA INVESTMENTS, LP | $96.2万 | 0.00% |
| ACUTA CAPITAL PARTNERS, LLC | $90.8万 | 0.65% |
| GOLDMAN SACHS GROUP INC | $89.7万 | 0.00% |
| HighVista Strategies LLC | $87.5万 | 0.24% |
| SEI INVESTMENTS CO | $84.9万 | 0.00% |
| 683 Capital Management, LLC | $84.9万 | 0.04% |
| WELLS FARGO & COMPANY/MN | $77.8万 | 0.00% |
| TD Asset Management Inc | $76.8万 | 0.00% |
| DLD Asset Management, LP | $74.3万 | 0.07% |
| HRT FINANCIAL LP | $71.8万 | 0.00% |
| Man Group plc | $69.5万 | 0.00% |
| DIMENSIONAL FUND ADVISORS LP | $60.7万 | 0.00% |
| PRELUDE CAPITAL MANAGEMENT, LLC | $52.4万 | 0.04% |
| NORTHERN TRUST CORP | $45.6万 | 0.00% |
| EntryPoint Capital, LLC | $44.9万 | 0.13% |
| Aquatic Capital Management LLC | $44.4万 | 0.01% |
| Artia Global Partners LP | $43.3万 | 0.09% |
| GLENMEDE TRUST CO NA | $38.4万 | 0.00% |
| ENVESTNET ASSET MANAGEMENT INC | $29.9万 | 0.00% |
| Brevan Howard Capital Management LP | $28.8万 | 0.00% |
| ExodusPoint Capital Management, LP | $26.5万 | 0.00% |
| Susquehanna Portfolio Strategies, LLC | $25.7万 | 0.00% |
| WESTFIELD CAPITAL MANAGEMENT CO LP | $23.3万 | 0.00% |
| BARCLAYS PLC | $21.9万 | 0.00% |
| Jump Financial, LLC | $19.1万 | 0.00% |
| OMERS ADMINISTRATION Corp | $17.6万 | 0.00% |
| AlphaCentric Advisors LLC | $17.4万 | 0.17% |
| Shay Capital LLC | $15.2万 | 0.01% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $14.9万 | 0.00% |
| Persistent Asset Partners Ltd | $11.8万 | 0.04% |
| Vanguard Global Advisers, LLC | $8.4万 | 0.00% |
| BNP PARIBAS FINANCIAL MARKETS | $6.3万 | 0.00% |
| US BANCORP \DE\ | $5.1万 | 0.00% |
| PFS Partners, LLC | $3.0万 | 0.01% |
| ROYAL BANK OF CANADA | $2000.0 | 0.00% |
| Farther Finance Advisors, LLC | $1253.0 | 0.00% |
| Fortitude Family Office, LLC | $941.0 | 0.00% |
| EverSource Wealth Advisors, LLC | $523.0 | 0.00% |
| Activest Wealth Management | $15.0 | 0.00% |
| Silver Grove Financial Group, Inc. | $15.0 | 0.00% |
| Key Financial Inc | $15.0 | 0.00% |
| Parallel Advisors, LLC | $15.0 | 0.00% |
| OSAIC HOLDINGS, INC. | $14.0 | 0.00% |