13F 申报指南13F 概念全攻略
什么是 SEC Form 13F 申报？美股机构大户持股全攻略
完整解读 Form 13F 申报规范、1 亿美元门槛与 45 天延迟申报机制，学会如何追踪顶级对冲基金与机构法人持仓动向。
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CIK: 0001631134
申报总市值
US$19.3亿
US$19.3亿
69 檔
44.3%
在 Q1 2026 的 13F 官方备案中，Sofinnova Investments, Inc. 管理的美股投资组合规模来到 US$19.3亿，整体持股档数为 69 档。
在 Q1 2026，Sofinnova Investments, Inc. 操作展现出积极扩展与加仓意向。本季共新建仓 25 个新仓位，并对 24 个既有持股进行加仓（合计增持 49 档），相较减仓与清仓仓位显著占优。
在资产配置集中度方面，Sofinnova Investments, Inc. 的前 5 大核心持股（包含 NTRA, IWM, UTHR 等）合计占整体申报市值的 44.3%，反映机构在主要关键仓位上的权重分布。
| # | 代码 | 标的名称 | 资产子类别 | 占比 | 占比变动 | 持仓量变化 | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | NTRA | Natera Inc | 股票-医疗保健 | 11.78% | +9.98% | — | |
| 2 | IWM | Ishares Russell 2000 ETF | ETF-中小型股 | 5.66% | -5.66% | EXIT | |
| 3 | UTHR | United Therapeutics CORP | 股票-医疗保健 | 5.42% | -3.28% | +52.48% | |
| 4 | XBI | Ss Spdr S&p Biotech ETF | ETF-科技型 | 5.10% | -5.10% | EXIT | |
| 5 | BMY | Bristol-myers Squibb Co | 股票-医疗保健 | 4.58% | -1.97% | +31.44% | |
| 6 | JAZZ | Jazz Pharmaceuticals plc | 股票-医疗保健 | 4.30% | +0.25% | -37.67% | |
| 7 | VERA | Vera Therapeutics Inc | 股票-其他 | 4.27% | +1.93% | — | |
| 8 | AZN | AstraZeneca PLC | 股票-医疗保健 | 3.42% | -3.42% | EXIT | |
| 9 | QQQ | Invesco Qqq Trust Series 1 | ETF-科技型 | 3.29% | -3.29% | EXIT | |
| 10 | COGT | Cogent Biosciences Inc | 股票-其他 | 3.09% | -1.02% | +7.09% | |
| 11 | IBB | Ishares Biotechnology ETF | ETF-科技型 | 3.05% | -3.05% | EXIT | |
| 12 | CELC | Celcuity Inc | 股票-其他 | 2.89% | -2.89% | EXIT | |
| 13 | RARE | Ultragenyx Pharmaceutical In | 股票-其他 | 2.78% | +1.05% | +4096.74% | |
| 14 | AXSM | Axsome Therapeutics Inc | 股票-医疗保健 | 2.65% | -0.62% | +3264.97% | |
| 15 | RAPP | Rapport Therapeutics Inc | 股票-其他 | 2.26% | +1.84% | — | |
| 16 | INSM | Insmed Inc | 股票-医疗保健 | 2.15% | -1.28% | +120.71% | |
| 17 | ALC | Alcon Inc. | 股票-医疗保健 | 2.09% | -1.20% | +119.53% | |
| 18 | SUPN | Supernus Pharmaceuticals Inc | 股票-医疗保健 | 1.87% | +0.62% | +72.54% | |
| 19 | BMRN | Biomarin Pharmaceutical Inc | 股票-医疗保健 | 1.68% | -0.62% | +12.17% | |
| 20 | BIIB | Biogen Inc | 股票-医疗保健 | 1.60% | -1.60% | EXIT | |
| 21 | BIOA | Bioage Labs Inc | 股票-其他 | 1.52% | +1.39% | — | |
| 22 | RYTM | Rhythm Pharmaceuticals Inc | 股票-其他 | 1.49% | +0.85% | +65.85% | |
| 23 | AVBP | Arrivent Biopharma Inc | 股票-其他 | 1.49% | +1.56% | — | |
| 24 | IDYA | Ideaya Biosciences Inc | 股票-其他 | 1.43% | +0.35% | +27.87% | |
| 25 | IMNM | Immunome Inc | 股票-其他 | 1.41% | +0.47% | +5.15% | |
| 26 | NKTR | Nektar Therapeutics | 股票-其他 | 1.39% | +0.31% | +16.17% | |
| 27 | ✓ | Immatics NV | 股票-其他 | 1.36% | +0.56% | +5.67% | |
| 28 | BBIO | Bridgebio Pharma Inc | 股票-医疗保健 | 1.15% | -1.15% | EXIT | |
| 29 | DYN | Dyne Therapeutics Inc | 股票-其他 | 1.13% | +0.77% | -27.52% | |
| 30 | INBX | Inhibrx Biosciences Inc | 股票-其他 | 1.04% | +0.44% | -10.70% | |
| 31 | DXCM | Dexcom Inc | 股票-医疗保健 | 0.94% | -0.94% | EXIT | |
| 32 | PHVS | Pharvaris N.V. | 股票-其他 | 0.88% | +0.70% | +9.82% | |
| 33 | PFE | Pfizer Inc | 股票-医疗保健 | 0.85% | -0.85% | EXIT | |
| 34 | PRAX | Praxis Precision Medicines I | 股票-其他 | 0.78% | -0.67% | -49.35% | |
| 35 | GMAB | Genmab A/s -sp Adr | 股票-其他 | 0.77% | +4.97% | — | |
| 36 | RCUS | Arcus Biosciences Inc | 股票-其他 | 0.76% | +0.75% | -15.83% | |
| 37 | LQDA | Liquidia CORP | 股票-其他 | 0.72% | -0.72% | EXIT | |
| 38 | XENE | Xenon Pharmaceuticals Inc | 股票-其他 | 0.67% | -0.67% | EXIT | |
| 39 | SYK | Stryker CORP | 股票-医疗保健 | 0.56% | -0.56% | EXIT | |
| 40 | ANAB | Anaptysbio Inc | 股票-其他 | 0.52% | +1.20% | -13.71% | |
| 41 | CMPX | Compass Therapeutics Inc | 股票-其他 | 0.51% | -0.51% | EXIT | |
| 42 | ROIV | Roivant Sciences Ltd. | 股票-医疗保健 | 0.50% | -0.50% | EXIT | |
| 43 | EWTX | Edgewise Therapeutics Inc | 股票-其他 | 0.46% | +0.34% | -11.72% | |
| 44 | EXEL | Exelixis Inc | 股票-医疗保健 | 0.41% | +0.31% | — | |
| 45 | ORIC | Oric Pharmaceuticals Inc | 股票-其他 | 0.33% | -0.33% | EXIT | |
| 46 | TNGX | Tango Therapeutics Inc | 股票-其他 | 0.31% | -0.31% | EXIT | |
| 47 | TYRA | Tyra Biosciences Inc | 股票-其他 | 0.30% | -0.25% | — | |
| 48 | REPL | Replimune Group Inc | 股票-其他 | 0.30% | -0.30% | EXIT | |
| 49 | AXGN | Axogen Inc | 股票-其他 | 0.27% | -0.27% | EXIT | |
| 50 | DFTX | Definium Therapeutics Inc | 股票-其他 | 0.25% | +0.37% | — |
| # | 代码 | 标的名称 | 占比变动 | 持仓量变化 | 异动类型 |
|---|---|---|---|---|---|
| 1 | RARE | Ultragenyx Pharmaceutical In | +2.7% | +4096.74% | 加仓 |
| 2 | AXSM | Axsome Therapeutics Inc | +2.6% | +3264.97% | 加仓 |
| 3 | UTHR | United Therapeutics CORP | +2.1% | +52.48% | 加仓 |
| 4 | CELC | Celcuity Inc | +1.6% | +122.49% | 加仓 |
| 5 | BMY | Bristol-myers Squibb Co | +1.1% | +31.44% | 加仓 |
| 6 | INSM | Insmed Inc | +1% | +120.71% | 加仓 |
| 7 | ALC | Alcon Inc. | +1% | +119.53% | 加仓 |
| 8 | SUPN | Supernus Pharmaceuticals Inc | +0.7% | +72.54% | 加仓 |
| 9 | NKTR | Nektar Therapeutics | +0.6% | +16.17% | 加仓 |
| 10 | XENE | Xenon Pharmaceuticals Inc | +0.6% | +409.54% | 加仓 |
| 11 | RYTM | Rhythm Pharmaceuticals Inc | +0.2% | +65.85% | 加仓 |
| 12 | BIOA | Bioage Labs Inc | +0.2% | — | 不变 |
| 13 | IDYA | Ideaya Biosciences Inc | +0.1% | +27.87% | 加仓 |
| 14 | COGT | Cogent Biosciences Inc | +0.1% | +7.09% | 加仓 |
| 15 | AVBP | Arrivent Biopharma Inc | 0% | — | 不变 |
| 16 | MIRM | Mirum Pharmaceuticals Inc | 0% | +19.44% | 加仓 |
| 17 | SVRA | Savara Inc | — | +19.68% | 加仓 |
| 18 | SLNOEUR | Soleno Therapeutics Inc | — | +18.33% | 加仓 |
| 19 | IMA | Imagenebio Inc | — | — | 不变 |
| 20 | PHVS | Pharvaris N.V. | 0% | +9.82% | 加仓 |
| 21 | EWTX | Edgewise Therapeutics Inc | 0% | -11.72% | 减仓 |
| 22 | BOLT | Bolt Biotherapeutics Inc | 0% | — | 不变 |
| 23 | JBIO | Jade Biosciences Inc | 0% | — | 不变 |
| 24 | ACAD | Acadia Pharmaceuticals Inc | 0% | +19.80% | 加仓 |
| 25 | ✓ | Establishment Labs Holdings In | 0% | +19.61% | 加仓 |
| 26 | NXTC | Nextcure Inc | -0.1% | — | 不变 |
| 27 | WVE | Wave Life Sciences Ltd. | -0.1% | +19.64% | 加仓 |
| 28 | ANAB | Anaptysbio Inc | -0.1% | -13.71% | 减仓 |
| 29 | IMNM | Immunome Inc | -0.1% | +5.15% | 加仓 |
| 30 | BMRN | Biomarin Pharmaceutical Inc | -0.1% | +12.17% | 加仓 |
| 31 | DXCM | Dexcom Inc | -0.1% | +4.06% | 加仓 |
| 32 | IRON | Disc Medicine Inc | -0.2% | -29.45% | 减仓 |
| 33 | ROIV | Roivant Sciences Ltd. | -0.2% | -34.93% | 减仓 |
| 34 | ✓ | Immatics NV | -0.2% | +5.67% | 加仓 |
| 35 | RAPP | Rapport Therapeutics Inc | -0.2% | — | 不变 |
| 36 | CMPX | Compass Therapeutics Inc | -0.3% | -24.05% | 减仓 |
| 37 | RCUS | Arcus Biosciences Inc | -0.4% | -15.83% | 减仓 |
| 38 | INBX | Inhibrx Biosciences Inc | -0.5% | -10.70% | 减仓 |
| 39 | DYN | Dyne Therapeutics Inc | -0.8% | -27.52% | 减仓 |
| 40 | PRAX | Praxis Precision Medicines I | -0.8% | -49.35% | 减仓 |
| 41 | BBIO | Bridgebio Pharma Inc | -1.2% | -43.20% | 减仓 |
| 42 | VERA | Vera Therapeutics Inc | -1.8% | — | 不变 |
| 43 | JAZZ | Jazz Pharmaceuticals plc | -2.7% | -37.67% | 减仓 |
| 44 | NTRA | Natera Inc | -3.5% | — | 不变 |
| 45 | AZNN | Astrazeneca Plc-spons Adr | — | EXIT | 清仓 |
| 46 | IWM | Ishares Russell 2000 ETF | — | NEW | 新建仓 |
| 47 | XBI | Ss Spdr S&p Biotech ETF | — | NEW | 新建仓 |
| 48 | AZN | AstraZeneca PLC | — | NEW | 新建仓 |
| 49 | QQQ | Invesco Qqq Trust Series 1 | — | NEW | 新建仓 |
| 50 | IBB | Ishares Biotechnology ETF | — | NEW | 新建仓 |
根据 SEC 官方 Form 13F 申报备案，Sofinnova Investments, Inc. 在 Q1 2026 季度的美股持仓总市值约为 US$19.3亿，共申报了 69 个公开持股仓位。
在 Q1 2026 季度，Sofinnova Investments, Inc. 按市值排列的前三大核心持股分别为：NTRA (11.8%)、IWM (5.7%)、UTHR (5.4%)。其中最大持股仓位 NTRA 占据整体投资组合约 11.8% 的权重。
精选 AlphaSMO 大户持股与内部人交易深度分析，提升投资决策胜率
完整解读 Form 13F 申报规范、1 亿美元门槛与 45 天延迟申报机制，学会如何追踪顶级对冲基金与机构法人持仓动向。
本季最大新建仓标的
IWM
市值: US$1.5亿
本季最大获利了结 / 清仓标的
AZNN
前期市值: US$1.5亿
在 Q1 2026 季度中，Sofinnova Investments, Inc. 共进行了 76 项持仓异动，包含新建仓 25 个仓位、加仓 24 个仓位、减仓 11 个仓位以及清仓 16 个仓位。 其中最大新建仓标的为 IWM。 本季清仓仓位包含 AZNN。
本页面所有持股数据均直接同步自美国证券交易委员会（SEC）EDGAR 官方系统之 13F-HR / 13F-HR/A 季度申报文件。AlphaSMO 通过机器解析 CUSIP 与个股对照，提供 100% 精准对齐的历史时序数据集，并支持 Schema.org 结构化数据格式。
解析公司高管、董事与 10% 大股东之 Form 4 内部人交易申报，掌握高管自家股票买卖第一手信号。
深入剖析 5% 股权申报门槛、13D 与 13G 之差异，以及最新 SEC 申报时程规范，洞察机构法人的激进投资动向。