13F 申报指南13F 概念全攻略
什么是 SEC Form 13F 申报？美股机构大户持股全攻略
完整解读 Form 13F 申报规范、1 亿美元门槛与 45 天延迟申报机制，学会如何追踪顶级对冲基金与机构法人持仓动向。
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CIK: 0001631134
申报总市值
US$19.3亿
US$19.3亿
60 檔
46.1%
根据最新整理的 13F 季度数据集，Sofinnova Investments, Inc. 于 Q4 2025 结束时的管理资产规模为 US$19.3亿。该机构在本季度申报了 60 档美股持仓，呈现出该时期的主要投资地图。
Sofinnova Investments, Inc. 在 Q4 2025 进行了结构性的板块轮动与仓位换股。在开立 11 个全新仓位及加仓 22 档持股的同时，亦同步清仓 10 档并减仓 19 档标的。
在资产配置集中度方面，Sofinnova Investments, Inc. 的前 5 大核心持股（包含 NTRA, JAZZ, AZNN 等）合计占整体申报市值的 46.1%，反映机构在主要关键仓位上的权重分布。
| # | 代码 | 标的名称 | 资产子类别 | 占比 | 占比变动 | 持仓量变化 | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | NTRA | Natera Inc | 股票-医疗保健 | 15.31% | +9.98% | — | |
| 2 | JAZZ | Jazz Pharmaceuticals plc | 股票-医疗保健 | 7.04% | +0.25% | +63.01% | |
| 3 | AZNN | Astrazeneca Plc-spons Adr | 股票-其他 | 6.47% | — | +98.11% | |
| 4 | VERA | Vera Therapeutics Inc | 股票-其他 | 6.10% | +1.93% | — | |
| 5 | BMY | Bristol-myers Squibb Co | 股票-医疗保健 | 3.52% | -1.97% | — | |
| 6 | UTHR | United Therapeutics CORP | 股票-医疗保健 | 3.31% | -3.28% | -45.21% | |
| 7 | VRTX | Vertex Pharmaceuticals Inc | 股票-医疗保健 | 3.22% | — | +39.63% | |
| 8 | ABBV | Abbvie Inc | 股票-医疗保健 | 3.13% | — | +110.50% | |
| 9 | ISRG | Intuitive Surgical Inc | 股票-医疗保健 | 3.10% | +0.82% | NEW | |
| 10 | COGT | Cogent Biosciences Inc | 股票-其他 | 3.02% | -1.02% | -7.25% | |
| 11 | LLY | Eli Lilly & Co | 股票-医疗保健 | 2.86% | — | — | |
| 12 | RAPP | Rapport Therapeutics Inc | 股票-其他 | 2.49% | +1.84% | -2.22% | |
| 13 | BBIO | Bridgebio Pharma Inc | 股票-医疗保健 | 2.38% | -1.15% | EXIT | |
| 14 | RNAGBP | Avidity Biosciences Inc | 股票-其他 | 2.32% | — | -14.93% | |
| 15 | DYN | Dyne Therapeutics Inc | 股票-其他 | 1.90% | +0.77% | +128.66% | |
| 16 | BMRN | Biomarin Pharmaceutical Inc | 股票-医疗保健 | 1.79% | -0.62% | — | |
| 17 | APGE | Apogee Therapeutics Inc | 股票-其他 | 1.74% | — | -5.41% | |
| 18 | CDTX | Cidara Therapeutics Inc | 股票-其他 | 1.72% | — | +232.61% | |
| 19 | PRAX | Praxis Precision Medicines I | 股票-其他 | 1.60% | -0.67% | -27.26% | |
| 20 | ✓ | Immatics NV | 股票-其他 | 1.56% | +0.56% | +54.21% | |
| 21 | INBX | Inhibrx Biosciences Inc | 股票-其他 | 1.55% | +0.44% | +3.31% | |
| 22 | IMNM | Immunome Inc | 股票-其他 | 1.50% | +0.47% | +271.17% | |
| 23 | AVBP | Arrivent Biopharma Inc | 股票-其他 | 1.47% | +1.56% | — | |
| 24 | GKOS | Glaukos CORP | 股票-医疗保健 | 1.40% | — | -7.94% | |
| 25 | IDYA | Ideaya Biosciences Inc | 股票-其他 | 1.32% | +0.35% | -4.07% | |
| 26 | BIOA | Bioage Labs Inc | 股票-其他 | 1.31% | +1.39% | — | |
| 27 | CELC | Celcuity Inc | 股票-其他 | 1.29% | -2.89% | EXIT | |
| 28 | RYTM | Rhythm Pharmaceuticals Inc | 股票-其他 | 1.25% | +0.85% | +9.89% | |
| 29 | 260 | Centessa Pharmaceuticals-adr | 股票-其他 | 1.19% | — | — | |
| 30 | SUPN | Supernus Pharmaceuticals Inc | 股票-医疗保健 | 1.19% | +0.62% | +46.68% | |
| 31 | INSM | Insmed Inc | 股票-医疗保健 | 1.18% | -1.28% | +50.28% | |
| 32 | ALC | Alcon Inc. | 股票-医疗保健 | 1.13% | -1.20% | — | |
| 33 | RCUS | Arcus Biosciences Inc | 股票-其他 | 1.13% | +0.75% | -10.27% | |
| 34 | DXCM | Dexcom Inc | 股票-医疗保健 | 1.08% | -0.94% | EXIT | |
| 35 | PHVS | Pharvaris N.V. | 股票-其他 | 0.89% | +0.70% | +0.72% | |
| 36 | NKTR | Nektar Therapeutics | 股票-其他 | 0.80% | +0.31% | +270.41% | |
| 37 | CMPX | Compass Therapeutics Inc | 股票-其他 | 0.78% | -0.51% | EXIT | |
| 38 | ROIV | Roivant Sciences Ltd. | 股票-医疗保健 | 0.69% | -0.50% | EXIT | |
| 39 | ANAB | Anaptysbio Inc | 股票-其他 | 0.60% | +1.20% | +13.14% | |
| 40 | GEHC | GE Healthcare Technology | 股票-医疗保健 | 0.57% | — | +6.48% | |
| 41 | EWTX | Edgewise Therapeutics Inc | 股票-其他 | 0.47% | +0.34% | -15.84% | |
| 42 | EXK | Exact Sciences CORP | 股票-原材料 | 0.44% | — | -72.21% | |
| 43 | IRON | Disc Medicine Inc | 股票-其他 | 0.38% | +0.36% | +719.08% | |
| 44 | AMLX | Amylyx Pharmaceuticals Inc | 股票-其他 | 0.27% | — | — | |
| 45 | MASI* | Masimo CORP | 股票-其他 | 0.26% | — | — | |
| 46 | QURE | uniQure N.V. | 股票-其他 | 0.18% | — | -81.16% | |
| 47 | NXTC | Nextcure Inc | 股票-其他 | 0.14% | -0.07% | — | |
| 48 | WVE | Wave Life Sciences Ltd. | 股票-其他 | 0.12% | +0.01% | -7.47% | |
| 49 | XENE | Xenon Pharmaceuticals Inc | 股票-其他 | 0.12% | -0.67% | EXIT | |
| 50 | EVMN | Evommune Inc | 股票-其他 | 0.11% | — | — |
| # | 代码 | 标的名称 | 占比变动 | 持仓量变化 | 异动类型 |
|---|---|---|---|---|---|
| 1 | AZNN | Astrazeneca Plc-spons Adr | +3% | +98.11% | 加仓 |
| 2 | JAZZ | Jazz Pharmaceuticals plc | +2.8% | +63.01% | 加仓 |
| 3 | NTRA | Natera Inc | +1.7% | — | 不变 |
| 4 | VERA | Vera Therapeutics Inc | +1.7% | — | 不变 |
| 5 | CDTX | Cidara Therapeutics Inc | +1.4% | +232.61% | 加仓 |
| 6 | COGT | Cogent Biosciences Inc | +1.4% | -7.25% | 减仓 |
| 7 | ABBV | Abbvie Inc | +1.2% | +110.50% | 加仓 |
| 8 | DYN | Dyne Therapeutics Inc | +1.2% | +128.66% | 加仓 |
| 9 | IMNM | Immunome Inc | +1.2% | +271.17% | 加仓 |
| 10 | PRAX | Praxis Precision Medicines I | +1.1% | -27.26% | 减仓 |
| 11 | INBX | Inhibrx Biosciences Inc | +0.7% | +3.31% | 加仓 |
| 12 | VRTX | Vertex Pharmaceuticals Inc | +0.7% | +39.63% | 加仓 |
| 13 | CELC | Celcuity Inc | +0.6% | +18.17% | 加仓 |
| 14 | BIOA | Bioage Labs Inc | +0.6% | — | 不变 |
| 15 | ✓ | Immatics NV | +0.5% | +54.21% | 加仓 |
| 16 | APGE | Apogee Therapeutics Inc | +0.5% | -5.41% | 减仓 |
| 17 | NKTR | Nektar Therapeutics | +0.4% | +270.41% | 加仓 |
| 18 | ISRG | Intuitive Surgical Inc | +0.4% | +14.49% | 加仓 |
| 19 | CMPX | Compass Therapeutics Inc | +0.4% | +65.88% | 加仓 |
| 20 | INSM | Insmed Inc | +0.4% | +50.28% | 加仓 |
| 21 | IRON | Disc Medicine Inc | +0.3% | +719.08% | 加仓 |
| 22 | RNAGBP | Avidity Biosciences Inc | +0.2% | -14.93% | 减仓 |
| 23 | RCUS | Arcus Biosciences Inc | +0.2% | -10.27% | 减仓 |
| 24 | SUPN | Supernus Pharmaceuticals Inc | +0.2% | +46.68% | 加仓 |
| 25 | ANAB | Anaptysbio Inc | +0.2% | +13.14% | 加仓 |
| 26 | NXTC | Nextcure Inc | +0.1% | — | 不变 |
| 27 | ✓ | Establishment Labs Holdings In | +0.1% | +162.96% | 加仓 |
| 28 | WVE | Wave Life Sciences Ltd. | +0.1% | -7.47% | 减仓 |
| 29 | ACAD | Acadia Pharmaceuticals Inc | +0.1% | +144.65% | 加仓 |
| 30 | BBIO | Bridgebio Pharma Inc | 0% | -13.39% | 减仓 |
| 31 | JBIO | Jade Biosciences Inc | 0% | — | 不变 |
| 32 | EWTX | Edgewise Therapeutics Inc | 0% | -15.84% | 减仓 |
| 33 | GKOS | Glaukos CORP | — | -7.94% | 减仓 |
| 34 | IMA | Imagenebio Inc | — | — | 不变 |
| 35 | BOLT | Bolt Biotherapeutics Inc | 0% | — | 不变 |
| 36 | IDYA | Ideaya Biosciences Inc | -0.1% | -4.07% | 减仓 |
| 37 | GEHC | GE Healthcare Technology | -0.1% | +6.48% | 加仓 |
| 38 | RYTM | Rhythm Pharmaceuticals Inc | -0.1% | +9.89% | 加仓 |
| 39 | PHVS | Pharvaris N.V. | -0.1% | +0.72% | 加仓 |
| 40 | AVBP | Arrivent Biopharma Inc | -0.2% | — | 不变 |
| 41 | SVRA | Savara Inc | -0.4% | -87.45% | 减仓 |
| 42 | SLNOEUR | Soleno Therapeutics Inc | -0.6% | -92.53% | 减仓 |
| 43 | EXK | Exact Sciences CORP | -0.7% | -72.21% | 减仓 |
| 44 | RAPP | Rapport Therapeutics Inc | -0.7% | -2.22% | 减仓 |
| 45 | DXCM | Dexcom Inc | -1.8% | -51.49% | 减仓 |
| 46 | ROIV | Roivant Sciences Ltd. | -1.9% | -76.67% | 减仓 |
| 47 | AXSM | Axsome Therapeutics Inc | -2.5% | -96.88% | 减仓 |
| 48 | QURE | uniQure N.V. | -2.8% | -81.16% | 减仓 |
| 49 | UTHR | United Therapeutics CORP | -3.3% | -45.21% | 减仓 |
| 50 | GILD | Gilead Sciences Inc | — | EXIT | 清仓 |
根据 SEC 官方 Form 13F 申报备案，Sofinnova Investments, Inc. 在 Q4 2025 季度的美股持仓总市值约为 US$19.3亿，共申报了 60 个公开持股仓位。
在 Q4 2025 季度，Sofinnova Investments, Inc. 按市值排列的前三大核心持股分别为：NTRA (15.3%)、JAZZ (7.0%)、AZNN (6.5%)。其中最大持股仓位 NTRA 占据整体投资组合约 15.3% 的权重。
精选 AlphaSMO 大户持股与内部人交易深度分析，提升投资决策胜率
完整解读 Form 13F 申报规范、1 亿美元门槛与 45 天延迟申报机制，学会如何追踪顶级对冲基金与机构法人持仓动向。
本季最大新建仓标的
BMY
市值: US$8161.1万
本季最大获利了结 / 清仓标的
GILD
前期市值: US$1.4亿
在 Q4 2025 季度中，Sofinnova Investments, Inc. 共进行了 62 项持仓异动，包含新建仓 11 个仓位、加仓 22 个仓位、减仓 19 个仓位以及清仓 10 个仓位。 其中最大新建仓标的为 BMY。 本季清仓仓位包含 GILD。
本页面所有持股数据均直接同步自美国证券交易委员会（SEC）EDGAR 官方系统之 13F-HR / 13F-HR/A 季度申报文件。AlphaSMO 通过机器解析 CUSIP 与个股对照，提供 100% 精准对齐的历史时序数据集，并支持 Schema.org 结构化数据格式。
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