13F 申报指南13F 概念全攻略
什么是 SEC Form 13F 申报？美股机构大户持股全攻略
完整解读 Form 13F 申报规范、1 亿美元门槛与 45 天延迟申报机制，学会如何追踪顶级对冲基金与机构法人持仓动向。
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CIK: 0001631134
申报总市值
US$19.3亿
US$19.3亿
59 檔
34.5%
在 Q3 2025 的 13F 官方备案中，Sofinnova Investments, Inc. 管理的美股投资组合规模来到 US$19.3亿，整体持股档数为 59 档。
Sofinnova Investments, Inc. 在 Q3 2025 进行了结构性的板块轮动与仓位换股。在开立 23 个全新仓位及加仓 15 档持股的同时，亦同步清仓 26 档并减仓 18 档标的。
在资产配置集中度方面，Sofinnova Investments, Inc. 的前 5 大核心持股（包含 NTRA, GILD, UTHR 等）合计占整体申报市值的 34.5%，反映机构在主要关键仓位上的权重分布。
| # | 代码 | 标的名称 | 资产子类别 | 占比 | 占比变动 | 持仓量变化 | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | NTRA | Natera Inc | 股票-医疗保健 | 13.65% | +9.98% | — | |
| 2 | GILD | Gilead Sciences Inc | 股票-医疗保健 | 7.60% | +2.24% | NEW | |
| 3 | UTHR | United Therapeutics CORP | 股票-医疗保健 | 6.60% | -3.28% | +142.78% | |
| 4 | VERA | Vera Therapeutics Inc | 股票-其他 | 4.44% | +1.93% | — | |
| 5 | JAZZ | Jazz Pharmaceuticals plc | 股票-医疗保健 | 4.24% | +0.25% | -15.17% | |
| 6 | AZNN | Astrazeneca Plc-spons Adr | 股票-其他 | 3.46% | — | +180.57% | |
| 7 | RAPP | Rapport Therapeutics Inc | 股票-其他 | 3.16% | +1.84% | -2.41% | |
| 8 | BSX | Boston Scientific CORP | 股票-医疗保健 | 3.04% | — | +32.06% | |
| 9 | QURE | uniQure N.V. | 股票-其他 | 2.99% | — | -39.88% | |
| 10 | DXCM | Dexcom Inc | 股票-医疗保健 | 2.87% | -0.94% | EXIT | |
| 11 | ISRG | Intuitive Surgical Inc | 股票-医疗保健 | 2.71% | +0.82% | NEW | |
| 12 | AXSM | Axsome Therapeutics Inc | 股票-医疗保健 | 2.61% | -0.62% | +320.36% | |
| 13 | ROIV | Roivant Sciences Ltd. | 股票-医疗保健 | 2.61% | -0.50% | EXIT | |
| 14 | IBB | Ishares Biotechnology ETF | ETF-科技型 | 2.57% | -3.05% | EXIT | |
| 15 | VRTX | Vertex Pharmaceuticals Inc | 股票-医疗保健 | 2.52% | — | — | |
| 16 | BBIO | Bridgebio Pharma Inc | 股票-医疗保健 | 2.36% | -1.15% | EXIT | |
| 17 | XBI | Ss Spdr S&p Biotech ETF | ETF-科技型 | 2.19% | -5.10% | EXIT | |
| 18 | RNAGBP | Avidity Biosciences Inc | 股票-其他 | 2.09% | — | +49.78% | |
| 19 | ABBV | Abbvie Inc | 股票-医疗保健 | 1.91% | — | -43.21% | |
| 20 | AVBP | Arrivent Biopharma Inc | 股票-其他 | 1.71% | +1.56% | — | |
| 21 | COGT | Cogent Biosciences Inc | 股票-其他 | 1.67% | -1.02% | -29.43% | |
| 22 | GKOS | Glaukos CORP | 股票-医疗保健 | 1.40% | — | — | |
| 23 | IDYA | Ideaya Biosciences Inc | 股票-其他 | 1.37% | +0.35% | -57.04% | |
| 24 | RYTM | Rhythm Pharmaceuticals Inc | 股票-其他 | 1.36% | +0.85% | -69.55% | |
| 25 | AKRO | Akero Therapeutics Inc | 股票-其他 | 1.23% | — | -13.70% | |
| 26 | APGE | Apogee Therapeutics Inc | 股票-其他 | 1.23% | — | +642.21% | |
| 27 | EXK | Exact Sciences CORP | 股票-原材料 | 1.09% | — | +75.23% | |
| 28 | ✓ | Immatics NV | 股票-其他 | 1.04% | +0.56% | -0.57% | |
| 29 | SMMT | Summit Therapeutics Inc | 股票-其他 | 1.02% | — | +28.57% | |
| 30 | PHVS | Pharvaris N.V. | 股票-其他 | 1.01% | +0.70% | +26.36% | |
| 31 | SUPN | Supernus Pharmaceuticals Inc | 股票-医疗保健 | 0.99% | +0.62% | -52.82% | |
| 32 | RCUS | Arcus Biosciences Inc | 股票-其他 | 0.91% | +0.75% | +0.51% | |
| 33 | ✓ | Merus N V | 股票-其他 | 0.86% | — | -58.79% | |
| 34 | INSM | Insmed Inc | 股票-医疗保健 | 0.82% | -1.28% | -66.76% | |
| 35 | INBX | Inhibrx Biosciences Inc | 股票-其他 | 0.81% | +0.44% | -37.90% | |
| 36 | BIOA | Bioage Labs Inc | 股票-其他 | 0.74% | +1.39% | -0.48% | |
| 37 | CELC | Celcuity Inc | 股票-其他 | 0.68% | -2.89% | EXIT | |
| 38 | DYN | Dyne Therapeutics Inc | 股票-其他 | 0.68% | +0.77% | +60.33% | |
| 39 | PTCT | Ptc Therapeutics Inc | 股票-医疗保健 | 0.63% | — | -50.28% | |
| 40 | GEHC | GE Healthcare Technology | 股票-医疗保健 | 0.62% | — | — | |
| 41 | SLNOEUR | Soleno Therapeutics Inc | 股票-其他 | 0.61% | -0.02% | EXIT | |
| 42 | PRAX | Praxis Precision Medicines I | 股票-其他 | 0.50% | -0.67% | +999.66% | |
| 43 | SVRA | Savara Inc | 股票-其他 | 0.47% | +0.04% | -1.21% | |
| 44 | EWTX | Edgewise Therapeutics Inc | 股票-其他 | 0.46% | +0.34% | -27.43% | |
| 45 | ANAB | Anaptysbio Inc | 股票-其他 | 0.43% | +1.20% | -75.37% | |
| 46 | CMPX | Compass Therapeutics Inc | 股票-其他 | 0.39% | -0.51% | EXIT | |
| 47 | NKTR | Nektar Therapeutics | 股票-其他 | 0.37% | +0.31% | — | |
| 48 | LQDA | Liquidia CORP | 股票-其他 | 0.31% | -0.72% | EXIT | |
| 49 | CDTX | Cidara Therapeutics Inc | 股票-其他 | 0.28% | — | -84.56% | |
| 50 | IMNM | Immunome Inc | 股票-其他 | 0.28% | +0.47% | -43.99% |
| # | 代码 | 标的名称 | 占比变动 | 持仓量变化 | 异动类型 |
|---|---|---|---|---|---|
| 1 | GILD | Gilead Sciences Inc | +4.5% | +19.23% | 加仓 |
| 2 | QURE | uniQure N.V. | +2.6% | -39.88% | 加仓 |
| 3 | ISRG | Intuitive Surgical Inc | +2.3% | +56.98% | 加仓 |
| 4 | RAPP | Rapport Therapeutics Inc | +1.9% | -2.41% | 减仓 |
| 5 | ROIV | Roivant Sciences Ltd. | +1.8% | -22.98% | 加仓 |
| 6 | RNAGBP | Avidity Biosciences Inc | +1.4% | +49.78% | 加仓 |
| 7 | AXSM | Axsome Therapeutics Inc | +1.3% | +320.36% | 加仓 |
| 8 | DXCM | Dexcom Inc | +1.1% | +48.87% | 加仓 |
| 9 | COGT | Cogent Biosciences Inc | +0.8% | -29.43% | 减仓 |
| 10 | BBIO | Bridgebio Pharma Inc | +0.7% | -16.24% | 加仓 |
| 11 | ✓ | Immatics NV | +0.6% | -0.57% | 加仓 |
| 12 | PHVS | Pharvaris N.V. | +0.4% | +26.36% | 加仓 |
| 13 | RCUS | Arcus Biosciences Inc | +0.4% | +0.51% | 加仓 |
| 14 | DYN | Dyne Therapeutics Inc | +0.2% | +60.33% | 加仓 |
| 15 | INBX | Inhibrx Biosciences Inc | +0.2% | -37.90% | 减仓 |
| 16 | BIOA | Bioage Labs Inc | +0.2% | -0.48% | 减仓 |
| 17 | PRAX | Praxis Precision Medicines I | +0.1% | +999.66% | 加仓 |
| 18 | JAZZ | Jazz Pharmaceuticals plc | +0.1% | -15.17% | 加仓 |
| 19 | VERA | Vera Therapeutics Inc | +0.1% | — | 不变 |
| 20 | IRON | Disc Medicine Inc | 0% | +85.35% | 加仓 |
| 21 | ✓ | Establishment Labs Holdings In | -0.1% | -61.64% | 减仓 |
| 22 | IMNM | Immunome Inc | -0.1% | -43.99% | 减仓 |
| 23 | AKRO | Akero Therapeutics Inc | -0.1% | -13.70% | 减仓 |
| 24 | SUPN | Supernus Pharmaceuticals Inc | -0.1% | -52.82% | 减仓 |
| 25 | SRRK | Scholar Rock Holding CORP | -0.2% | +18.80% | 减仓 |
| 26 | RYTM | Rhythm Pharmaceuticals Inc | -0.2% | -69.55% | 减仓 |
| 27 | AVBP | Arrivent Biopharma Inc | -0.3% | — | 不变 |
| 28 | EWTX | Edgewise Therapeutics Inc | -0.5% | -27.43% | 减仓 |
| 29 | ACAD | Acadia Pharmaceuticals Inc | -0.5% | — | 减仓 |
| 30 | SVRA | Savara Inc | -0.5% | -1.21% | 减仓 |
| 31 | NTRA | Natera Inc | -0.7% | — | 不变 |
| 32 | INSM | Insmed Inc | -0.7% | -66.76% | 减仓 |
| 33 | ANAB | Anaptysbio Inc | -1% | -75.37% | 减仓 |
| 34 | PTCT | Ptc Therapeutics Inc | -1.3% | -50.28% | 减仓 |
| 35 | IDYA | Ideaya Biosciences Inc | -1.4% | -57.04% | 减仓 |
| 36 | SLNOEUR | Soleno Therapeutics Inc | -4.1% | -59.95% | 减仓 |
| 37 | UTHR | United Therapeutics CORP | — | NEW | 新建仓 |
| 38 | SYK | Stryker CORP | — | EXIT | 清仓 |
| 39 | QQQ | Invesco Qqq Trust Series 1 | — | EXIT | 清仓 |
| 40 | IWM | Ishares Russell 2000 ETF | — | EXIT | 清仓 |
| 41 | AZNN | Astrazeneca Plc-spons Adr | — | NEW | 新建仓 |
| 42 | BSX | Boston Scientific CORP | — | NEW | 新建仓 |
| 43 | MDT | Medtronic plc | — | EXIT | 清仓 |
| 44 | ALNY | Alnylam Pharmaceuticals Inc | — | EXIT | 清仓 |
| 45 | IBB | Ishares Biotechnology ETF | — | NEW | 新建仓 |
| 46 | VRTX | Vertex Pharmaceuticals Inc | — | NEW | 新建仓 |
| 47 | LLY | Eli Lilly & Co | — | EXIT | 清仓 |
| 48 | XBI | Ss Spdr S&p Biotech ETF | — | NEW | 新建仓 |
| 49 | ABBV | Abbvie Inc | — | NEW | 新建仓 |
| 50 | SNDX | Syndax Pharmaceuticals Inc | — | EXIT | 清仓 |
根据 SEC 官方 Form 13F 申报备案，Sofinnova Investments, Inc. 在 Q3 2025 季度的美股持仓总市值约为 US$19.3亿，共申报了 59 个公开持股仓位。
在 Q3 2025 季度，Sofinnova Investments, Inc. 按市值排列的前三大核心持股分别为：NTRA (13.7%)、GILD (7.6%)、UTHR (6.6%)。其中最大持股仓位 NTRA 占据整体投资组合约 13.7% 的权重。
精选 AlphaSMO 大户持股与内部人交易深度分析，提升投资决策胜率
完整解读 Form 13F 申报规范、1 亿美元门槛与 45 天延迟申报机制，学会如何追踪顶级对冲基金与机构法人持仓动向。
本季最大新建仓标的
UTHR
市值: US$1.2亿
本季最大获利了结 / 清仓标的
SYK
前期市值: US$1.1亿
在 Q3 2025 季度中，Sofinnova Investments, Inc. 共进行了 82 项持仓异动，包含新建仓 23 个仓位、加仓 15 个仓位、减仓 18 个仓位以及清仓 26 个仓位。 其中最大新建仓标的为 UTHR。 本季清仓仓位包含 SYK。
本页面所有持股数据均直接同步自美国证券交易委员会（SEC）EDGAR 官方系统之 13F-HR / 13F-HR/A 季度申报文件。AlphaSMO 通过机器解析 CUSIP 与个股对照，提供 100% 精准对齐的历史时序数据集，并支持 Schema.org 结构化数据格式。
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