13F 申报指南13F 概念全攻略
什么是 SEC Form 13F 申报？美股机构大户持股全攻略
完整解读 Form 13F 申报规范、1 亿美元门槛与 45 天延迟申报机制，学会如何追踪顶级对冲基金与机构法人持仓动向。
AlphaSMO 权威研究指南阅读专题
CIK: 0001425738
申报总市值
US$14.9亿
US$14.9亿
56 檔
30.7%
在 Q1 2025 的 13F 官方备案中，Redmile Group, LLC 管理的美股投资组合规模来到 US$14.9亿，整体持股档数为 56 档。
在 Q1 2025，Redmile Group, LLC 展现出较为审慎的避险与获利了结姿态。本季共减仓 16 个仓位并完全清仓 62 档持股，调降曝光的仓位数量高于加仓动作。
在资产配置集中度方面，Redmile Group, LLC 的前 5 大核心持股（包含 SRRK, KRYS, AM6 等）合计占整体申报市值的 30.7%，反映机构在主要关键仓位上的权重分布。
本季最大新建仓标的
ZYME
市值: US$5703.6万
本季最大获利了结 / 清仓标的
ARGX
前期市值: US$2.4亿
| # | 代码 | 标的名称 | 资产子类别 | 占比 | 占比变动 | 持仓量变化 | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | SRRK | Scholar Rock Holding CORP | 股票-其他 | 13.37% | -13.59% | -3.33% | |
| 2 | KRYS | Krystal Biotech Inc | 股票-医疗保健 | 12.57% | +4.25% | -2.06% | |
| 3 | AM6 | Amicus Therapeutics Inc | 股票-其他 | 7.35% | — | +35.14% | |
| 4 | ZYME | Zymeworks Inc | 股票-其他 | 5.39% | +0.04% | -1.06% | |
| 5 | NRIX | Nurix Therapeutics Inc | 股票-其他 | 4.55% | -1.30% | -3.36% | |
| 6 | REPL | Replimune Group Inc | 股票-其他 | 4.51% | — | -0.14% | |
| 7 | LIVN | LivaNova PLC | 股票-其他 | 3.77% | +0.05% | -2.82% | |
| 8 | AKRO | Akero Therapeutics Inc | 股票-其他 | 3.59% | — | -23.96% | |
| 9 | IMNM | Immunome Inc | 股票-其他 | 3.41% | -1.06% | +11.04% | |
| 10 | RGNX | Regenxbio Inc | 股票-其他 | 3.24% | +1.09% | — | |
| 11 | BEAM | Beam Therapeutics Inc | 股票-其他 | 2.97% | +0.73% | +5.35% | |
| 12 | STOK | Stoke Therapeutics Inc | 股票-其他 | 2.82% | -0.31% | -2.34% | |
| 13 | KYMR | Kymera Therapeutics Inc | 股票-其他 | 2.54% | — | -10.63% | |
| 14 | ✓ | Adc Therapeutics SA | 股票-其他 | 2.09% | -3.01% | — | |
| 15 | BHVN | Biohaven Ltd. | 股票-其他 | 1.97% | — | -4.10% | |
| 16 | ABSI | Absci CORP | 股票-其他 | 1.96% | +3.60% | — | |
| 17 | BSX | Boston Scientific CORP | 股票-医疗保健 | 1.84% | — | -38.19% | |
| 18 | COGT | Cogent Biosciences Inc | 股票-其他 | 1.82% | -0.44% | -9.53% | |
| 19 | NGNE | Neurogene Inc | 股票-其他 | 1.45% | +1.03% | -0.89% | |
| 20 | ETNBGBP | 89bio Inc | 股票-其他 | 1.30% | — | -12.95% | |
| 21 | ✓ | Establishment Labs Holdings In | 股票-其他 | 1.29% | +0.12% | +4.75% | |
| 22 | ANNX | Annexon Inc | 股票-其他 | 1.15% | -0.79% | — | |
| 23 | CLDX | Celldex Therapeutics Inc | 股票-其他 | 1.01% | +0.53% | -4.16% | |
| 24 | FATE | Fate Therapeutics Inc | 股票-其他 | 0.96% | +1.31% | — | |
| 25 | IDYA | Ideaya Biosciences Inc | 股票-其他 | 0.83% | +0.45% | -13.68% | |
| 26 | IMVT | Immunovant Inc | 股票-其他 | 0.79% | — | -14.24% | |
| 27 | CBLL | Ceribell Inc | 股票-其他 | 0.79% | +0.04% | — | |
| 28 | ✓ | Rapt Therapeutics Inc | 股票-其他 | 0.75% | — | — | |
| 29 | SLDB | Solid Biosciences Inc | 股票-其他 | 0.71% | +0.35% | +228.19% | |
| 30 | PODD | Insulet CORP | 股票-医疗保健 | 0.67% | — | +183.60% | |
| 31 | BNTX | Biontech Se-adr | 股票-其他 | 0.63% | — | -12.46% | |
| 32 | SLN | Silence Therapeutics Plc-adr | 股票-其他 | 0.59% | +0.84% | -7.68% | |
| 33 | PEN | Penumbra Inc | 股票-医疗保健 | 0.58% | — | -11.27% | |
| 34 | IRTC | Irhythm Holdings Inc | 股票-医疗保健 | 0.56% | — | — | |
| 35 | KROS | Keros Therapeutics Inc | 股票-其他 | 0.53% | — | — | |
| 36 | ✓ | Verve Therapeutics Inc | 股票-其他 | 0.52% | — | -8.42% | |
| 37 | NUVB | Nuvation Bio Inc | 股票-其他 | 0.50% | +0.26% | — | |
| 38 | STTK | Shattuck Labs Inc | 股票-其他 | 0.50% | +0.85% | — | |
| 39 | MASI* | Masimo CORP | 股票-其他 | 0.41% | — | — | |
| 40 | PRME | Prime Medicine Inc | 股票-其他 | 0.39% | -0.03% | — | |
| 41 | ORKA | Oruka Therapeutics Inc | 股票-其他 | 0.38% | — | -6.01% | |
| 42 | 1K0 | Igm Biosciences Inc | 股票-其他 | 0.32% | — | — | |
| 43 | CYTK | Cytokinetics Inc | 股票-医疗保健 | 0.31% | — | -11.34% | |
| 44 | FDMT | 4d Molecular Therapeutics In | 股票-其他 | 0.30% | — | -16.68% | |
| 45 | PLRX | Pliant Therapeutics Inc | 股票-其他 | 0.26% | — | -29.08% | |
| 46 | ✓ | Lava Therapeutics NV | 股票-其他 | 0.25% | — | — | |
| 47 | ATRA | Atara Biotherapeutics Inc | 股票-其他 | 0.25% | +0.20% | — | |
| 48 | XERS | Xeris Biopharma Holdings Inc | 股票-其他 | 0.23% | — | — | |
| 49 | ALXO | Alx Oncology Holdings Inc | 股票-其他 | 0.21% | -0.03% | -1.32% | |
| 50 | RPTX | Repare Therapeutics Inc | 股票-其他 | 0.18% | — | -1.65% |
| # | 代码 | 标的名称 | 占比变动 | 持仓量变化 | 异动类型 |
|---|---|---|---|---|---|
| 1 | SRRK | Scholar Rock Holding CORP | +12.4% | -3.33% | 加仓 |
| 2 | KRYS | Krystal Biotech Inc | +10.5% | -2.06% | 减仓 |
| 3 | AM6 | Amicus Therapeutics Inc | +4.4% | +35.14% | 减仓 |
| 4 | NRIX | Nurix Therapeutics Inc | +3.3% | -3.36% | 加仓 |
| 5 | AKRO | Akero Therapeutics Inc | +2.6% | -23.96% | 减仓 |
| 6 | LIVN | LivaNova PLC | +2.4% | -2.82% | 减仓 |
| 7 | REPL | Replimune Group Inc | +2.1% | -0.14% | 加仓 |
| 8 | RGNX | Regenxbio Inc | +2% | — | 加仓 |
| 9 | STOK | Stoke Therapeutics Inc | +1.6% | -2.34% | 加仓 |
| 10 | KYMR | Kymera Therapeutics Inc | +0.7% | -10.63% | 减仓 |
| 11 | ANNX | Annexon Inc | 0% | — | 加仓 |
| 12 | NUVB | Nuvation Bio Inc | -0.1% | — | 减仓 |
| 13 | ✓ | Lava Therapeutics NV | -0.2% | — | 减仓 |
| 14 | CLDX | Celldex Therapeutics Inc | -0.5% | -4.16% | 减仓 |
| 15 | ALXO | Alx Oncology Holdings Inc | -0.5% | -1.32% | 加仓 |
| 16 | ✓ | Adc Therapeutics SA | -0.6% | — | 加仓 |
| 17 | BEAM | Beam Therapeutics Inc | -0.9% | +5.35% | 减仓 |
| 18 | RPTX | Repare Therapeutics Inc | -1% | -1.65% | 减仓 |
| 19 | PLRX | Pliant Therapeutics Inc | -1.1% | -29.08% | 减仓 |
| 20 | ✓ | Verve Therapeutics Inc | -1.2% | -8.42% | 减仓 |
| 21 | STTK | Shattuck Labs Inc | -1.9% | — | 减仓 |
| 22 | ALLKGUSD | Allakos Inc | -2.8% | -71.59% | 减仓 |
| 23 | 1K0 | Igm Biosciences Inc | -3.9% | — | 减仓 |
| 24 | FATE | Fate Therapeutics Inc | -15.7% | — | 减仓 |
| 25 | ARGX | Argenx Se - Adr | — | EXIT | 清仓 |
| 26 | NVTA1EUR | Invitae CORP | — | EXIT | 清仓 |
| 27 | DCPHEUR | Deciphera Pharmaceuticals In | — | EXIT | 清仓 |
| 28 | JAZZ | Jazz Pharmaceuticals plc | — | EXIT | 清仓 |
| 29 | MYOSUSD | Medavail Holdings Inc | — | EXIT | 清仓 |
| 30 | OSH3USD | Oak Street Health Inc | — | EXIT | 清仓 |
| 31 | SGENUSD | Seagen Inc | — | EXIT | 清仓 |
| 32 | SKIN | Skinhealth Systems Inc | — | EXIT | 清仓 |
| 33 | ATRAGBX | Atara Biotherapeutics Inc | — | EXIT | 清仓 |
| 34 | NVROEUR | Nevro CORP | — | EXIT | 清仓 |
| 35 | DXCM | Dexcom Inc | — | EXIT | 清仓 |
| 36 | EPZMEUR | Epizyme Inc | — | EXIT | 清仓 |
| 37 | PRTA | Prothena Corporation plc | — | EXIT | 清仓 |
| 38 | ZYUSD | Zymergen Inc | — | EXIT | 清仓 |
| 39 | IMGNEUR | Immunogen Inc | — | EXIT | 清仓 |
| 40 | ZYME | Zymeworks Inc | — | NEW | 新建仓 |
| 41 | ✓ | 1life Healthcare Inc | — | EXIT | 清仓 |
| 42 | NGMUSD | Ngm Biopharmaceuticals Inc | — | EXIT | 清仓 |
| 43 | TCRRUSD | Tcr2 Therapeutics Inc | — | EXIT | 清仓 |
| 44 | GMAB | Genmab A/s -sp Adr | — | EXIT | 清仓 |
| 45 | SLQT | Selectquote Inc | — | EXIT | 清仓 |
| 46 | ICUI | Icu Medical Inc | — | EXIT | 清仓 |
| 47 | ELV | Elevance Health Inc | — | EXIT | 清仓 |
| 48 | CRL | Charles River Laboratories | — | EXIT | 清仓 |
| 49 | CI | THE Cigna Group | — | EXIT | 清仓 |
| 50 | UNH | Unitedhealth Group Inc | — | EXIT | 清仓 |
根据 SEC 官方 Form 13F 申报备案，Redmile Group, LLC 在 Q1 2025 季度的美股持仓总市值约为 US$14.9亿，共申报了 56 个公开持股仓位。
在 Q1 2025 季度，Redmile Group, LLC 按市值排列的前三大核心持股分别为：SRRK (13.4%)、KRYS (12.6%)、AM6 (7.3%)。其中最大持股仓位 SRRK 占据整体投资组合约 13.4% 的权重。
在 Q1 2025 季度中，Redmile Group, LLC 共进行了 118 项持仓异动，包含新建仓 32 个仓位、加仓 8 个仓位、减仓 16 个仓位以及清仓 62 个仓位。 其中最大新建仓标的为 ZYME。 本季清仓仓位包含 ARGX。
本页面所有持股数据均直接同步自美国证券交易委员会（SEC）EDGAR 官方系统之 13F-HR / 13F-HR/A 季度申报文件。AlphaSMO 通过机器解析 CUSIP 与个股对照，提供 100% 精准对齐的历史时序数据集，并支持 Schema.org 结构化数据格式。
精选 AlphaSMO 大户持股与内部人交易深度分析，提升投资决策胜率
完整解读 Form 13F 申报规范、1 亿美元门槛与 45 天延迟申报机制，学会如何追踪顶级对冲基金与机构法人持仓动向。
深入剖析 5% 股权申报门槛、13D 与 13G 之差异，以及最新 SEC 申报时程规范，洞察机构法人的激进投资动向。