13F 申报指南13F 概念全攻略
什么是 SEC Form 13F 申报？美股机构大户持股全攻略
完整解读 Form 13F 申报规范、1 亿美元门槛与 45 天延迟申报机制，学会如何追踪顶级对冲基金与机构法人持仓动向。
AlphaSMO 权威研究指南阅读专题
CIK: 0001224962
申报总市值
US$66.6亿
US$66.6亿
116 檔
23.8%
Q4 2025 季度申报显示，Perceptive Advisors LLC 披露的美股组合总市值为 US$66.6亿，涵盖 116 个不同之权益投资仓位。
在 Q4 2025，Perceptive Advisors LLC 操作展现出积极扩展与加仓意向。本季共新建仓 39 个新仓位，并对 32 个既有持股进行加仓（合计增持 71 档），相较减仓与清仓仓位显著占优。
在资产配置集中度方面，Perceptive Advisors LLC 的前 5 大核心持股（包含 PRAX, CELC, RYTM 等）合计占整体申报市值的 23.8%，反映机构在主要关键仓位上的权重分布。
| # | 代码 | 标的名称 | 资产子类别 | 占比 | 占比变动 | 持仓量变化 | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | PRAX | Praxis Precision Medicines I | 股票-其他 | 10.49% | -2.59% | +27.58% | |
| 2 | CELC | Celcuity Inc | 股票-其他 | 5.62% | -1.95% | +6.90% | |
| 3 | RYTM | Rhythm Pharmaceuticals Inc | 股票-其他 | 4.86% | +0.28% | -99.39% | |
| 4 | ASND | Ascendis Pharma A/S | 股票-其他 | 4.11% | -6.84% | EXIT | |
| 5 | APGE | Apogee Therapeutics Inc | 股票-其他 | 3.14% | +0.08% | +72.39% | |
| 6 | ROIV | Roivant Sciences Ltd. | 股票-医疗保健 | 3.09% | -0.18% | +8.37% | |
| 7 | NUVL | Nuvalent Inc-a | 股票-其他 | 2.99% | -0.23% | +6.58% | |
| 8 | TVTX | Travere Therapeutics Inc | 股票-其他 | 2.91% | +0.80% | +12.74% | |
| 9 | XBI | Ss Spdr S&p Biotech ETF | ETF-科技型 | 2.39% | +0.71% | NEW | |
| 10 | EXK | Exact Sciences CORP | 股票-原材料 | 2.17% | — | +157.90% | |
| 11 | PTGX | Protagonist Therapeutics Inc | 股票-其他 | 2.10% | -0.73% | +31.09% | |
| 12 | INBX | Inhibrx Biosciences Inc | 股票-其他 | 2.05% | -0.05% | +9.41% | |
| 13 | EWTX | Edgewise Therapeutics Inc | 股票-其他 | 1.97% | -0.05% | +17.44% | |
| 14 | ✓ | Immatics NV | 股票-其他 | 1.94% | -0.42% | +10.66% | |
| 15 | SYRE | Spyre Therapeutics Inc | 股票-其他 | 1.79% | +2.03% | +149.64% | |
| 16 | AMLX | Amylyx Pharmaceuticals Inc | 股票-其他 | 1.78% | — | -7.46% | |
| 17 | ACLXGBX | Arcellx Inc | 股票-其他 | 1.70% | — | -40.61% | |
| 18 | VRDN | Viridian Therapeutics Inc | 股票-其他 | 1.69% | -0.29% | +108.06% | |
| 19 | BSX | Boston Scientific CORP | 股票-医疗保健 | 1.66% | +0.16% | NEW | |
| 20 | AM6 | Amicus Therapeutics Inc | 股票-其他 | 1.62% | — | — | |
| 21 | ZYME | Zymeworks Inc | 股票-其他 | 1.53% | -0.08% | +56.02% | |
| 22 | CATBUSD | Astria Therapeutics Inc | 股票-其他 | 1.51% | — | — | |
| 23 | MGTX | MeiraGTx Holdings plc | 股票-其他 | 1.46% | +0.44% | -18.22% | |
| 24 | AORT | Artivion Inc | 股票-其他 | 1.40% | -0.58% | -14.74% | |
| 25 | 260 | Centessa Pharmaceuticals-adr | 股票-其他 | 1.30% | -4.08% | EXIT | |
| 26 | DYN | Dyne Therapeutics Inc | 股票-其他 | 1.21% | -0.75% | +543.72% | |
| 27 | NRIX | Nurix Therapeutics Inc | 股票-其他 | 1.20% | +0.45% | +151.09% | |
| 28 | SLDB | Solid Biosciences Inc | 股票-其他 | 1.19% | +0.11% | — | |
| 29 | BLTE | Belite Bio Inc - Adr | 股票-其他 | 1.18% | -0.47% | EXIT | |
| 30 | ABVX | Abivax Sa-adr | 股票-其他 | 1.10% | -0.57% | +17.94% | |
| 31 | IVVD | Invivyd Inc | 股票-其他 | 0.96% | -0.29% | — | |
| 32 | ✓ | Engene Holdings Inc | 股票-其他 | 0.94% | -0.78% | EXIT | |
| 33 | RGEN | Repligen CORP | 股票-医疗保健 | 0.92% | -0.14% | +16.68% | |
| 34 | IMVT | Immunovant Inc | 股票-其他 | 0.90% | +0.01% | +25.63% | |
| 35 | ISRG | Intuitive Surgical Inc | 股票-医疗保健 | 0.89% | -0.46% | +68.69% | |
| 36 | SION | Sionna Therapeutics Inc | 股票-其他 | 0.86% | +0.08% | — | |
| 37 | NBIX | Neurocrine Biosciences Inc | 股票-医疗保健 | 0.84% | -0.17% | EXIT | |
| 38 | DHR | Danaher CORP | 股票-医疗保健 | 0.82% | +0.37% | NEW | |
| 39 | ORKA | Oruka Therapeutics Inc | 股票-其他 | 0.80% | +0.58% | +16.44% | |
| 40 | CTMX | Cytomx Therapeutics Inc | 股票-其他 | 0.74% | -0.34% | — | |
| 41 | OMDA | Omada Health Inc | 股票-其他 | 0.67% | +0.07% | — | |
| 42 | CDTX | Cidara Therapeutics Inc | 股票-其他 | 0.65% | — | — | |
| 43 | IRON | Disc Medicine Inc | 股票-其他 | 0.64% | — | — | |
| 44 | DRUG | Bright Minds Biosciences Inc | 股票-其他 | 0.62% | -0.54% | EXIT | |
| 45 | PEN | Penumbra Inc | 股票-医疗保健 | 0.61% | — | -49.88% | |
| 46 | ANRO | Alto Neuroscience Inc | 股票-其他 | 0.57% | -0.24% | +1048.51% | |
| 47 | CAI | Caris Life Sciences Inc | 股票-其他 | 0.55% | — | +3.46% | |
| 48 | JAZZ | Jazz Pharmaceuticals plc | 股票-医疗保健 | 0.52% | -0.02% | — | |
| 49 | PALI | Palisade Bio Inc | 股票-其他 | 0.50% | -0.05% | — | |
| 50 | RAPT | Rapt Therapeutics Inc | 股票-其他 | 0.50% | — | +349.12% |
| # | 代码 | 标的名称 | 占比变动 | 持仓量变化 | 异动类型 |
|---|---|---|---|---|---|
| 1 | PRAX | Praxis Precision Medicines I | +8.1% | +27.58% | 加仓 |
| 2 | APGE | Apogee Therapeutics Inc | +1.6% | +72.39% | 加仓 |
| 3 | EXK | Exact Sciences CORP | +1.4% | +157.90% | 加仓 |
| 4 | CELC | Celcuity Inc | +1.4% | +6.90% | 加仓 |
| 5 | SYRE | Spyre Therapeutics Inc | +1.2% | +149.64% | 加仓 |
| 6 | BLTE | Belite Bio Inc - Adr | +1.1% | +732.01% | 加仓 |
| 7 | DYN | Dyne Therapeutics Inc | +1% | +543.72% | 加仓 |
| 8 | NRIX | Nurix Therapeutics Inc | +0.8% | +151.09% | 加仓 |
| 9 | BSX | Boston Scientific CORP | +0.8% | +215.81% | 加仓 |
| 10 | VRDN | Viridian Therapeutics Inc | +0.8% | +108.06% | 加仓 |
| 11 | INBX | Inhibrx Biosciences Inc | +0.8% | +9.41% | 加仓 |
| 12 | ANRO | Alto Neuroscience Inc | +0.6% | +1048.51% | 加仓 |
| 13 | ✓ | Engene Holdings Inc | +0.5% | +179.85% | 加仓 |
| 14 | ZYME | Zymeworks Inc | +0.5% | +56.02% | 加仓 |
| 15 | RAPT | Rapt Therapeutics Inc | +0.4% | +349.12% | 加仓 |
| 16 | TVTX | Travere Therapeutics Inc | +0.3% | +12.74% | 加仓 |
| 17 | ISRG | Intuitive Surgical Inc | +0.2% | +68.69% | 加仓 |
| 18 | EWTX | Edgewise Therapeutics Inc | +0.2% | +17.44% | 加仓 |
| 19 | LONA | Leonabio Inc | +0.2% | +244.13% | 加仓 |
| 20 | AM6 | Amicus Therapeutics Inc | +0.2% | — | 不变 |
| 21 | BBNX | Beta Bionics Inc | +0.2% | +116.93% | 加仓 |
| 22 | IMVT | Immunovant Inc | +0.2% | +25.63% | 加仓 |
| 23 | CATBUSD | Astria Therapeutics Inc | +0.2% | — | 不变 |
| 24 | ABVX | Abivax Sa-adr | +0.2% | +17.94% | 加仓 |
| 25 | NAUT | Nautilus Biotechnology Inc | +0.1% | — | 不变 |
| 26 | PTGX | Protagonist Therapeutics Inc | +0.1% | +31.09% | 加仓 |
| 27 | KOD | Kodiak Sciences Inc | +0.1% | +33.77% | 加仓 |
| 28 | ORKA | Oruka Therapeutics Inc | +0.1% | +16.44% | 加仓 |
| 29 | CTNM | Contineum Therapeutics Inc-a | +0.1% | +104.95% | 加仓 |
| 30 | RAPP | Rapport Therapeutics Inc | 0% | +66.84% | 加仓 |
| 31 | OBIO | Orchestra Biomed Holdings In | — | -3.12% | 减仓 |
| 32 | CELC 2.75 08-01-31债券 | Celcuity Inc | — | — | 不变 |
| 33 | AVTX | Avalo Therapeutics Inc | — | — | 不变 |
| 34 | RVMDW | Revolution Medicines Inc-28 | — | — | 不变 |
| 35 | SRZNW | Surrozen Inc-cw25 | — | — | 不变 |
| 36 | PEPG | Pepgen Inc | 0% | — | 不变 |
| 37 | LXEO | Lexeo Therapeutics Inc | 0% | — | 不变 |
| 38 | ENSC | Ensysce Biosciences Inc | 0% | — | 不变 |
| 39 | BDSX | Biodesix Inc | 0% | — | 不变 |
| 40 | AXSM | Axsome Therapeutics Inc | 0% | — | 不变 |
| 41 | ✓ | Envveno Medical CORP | 0% | — | 不变 |
| 42 | IKT | Inhibikase Therapeutics Inc | -0.1% | — | 不变 |
| 43 | IRD | Opus Genetics Inc | -0.1% | — | 不变 |
| 44 | ✓ | Crescent Biopharma Inc. | -0.1% | — | 不变 |
| 45 | SEPN | Septerna Inc | -0.1% | -20.00% | 减仓 |
| 46 | XENE | Xenon Pharmaceuticals Inc | -0.1% | — | 不变 |
| 47 | AVR | Anteris Technologies Global | -0.1% | -1.74% | 减仓 |
| 48 | KRYS | Krystal Biotech Inc | -0.1% | -50.00% | 减仓 |
| 49 | RGEN | Repligen CORP | -0.1% | +16.68% | 加仓 |
| 50 | GOSS | Gossamer Bio Inc | -0.1% | -17.65% | 减仓 |
根据 SEC 官方 Form 13F 申报备案，Perceptive Advisors LLC 在 Q4 2025 季度的美股持仓总市值约为 US$66.6亿，共申报了 116 个公开持股仓位。
在 Q4 2025 季度，Perceptive Advisors LLC 按市值排列的前三大核心持股分别为：PRAX (10.5%)、CELC (5.6%)、RYTM (4.9%)。其中最大持股仓位 PRAX 占据整体投资组合约 10.5% 的权重。
精选 AlphaSMO 大户持股与内部人交易深度分析，提升投资决策胜率
完整解读 Form 13F 申报规范、1 亿美元门槛与 45 天延迟申报机制，学会如何追踪顶级对冲基金与机构法人持仓动向。
本季最大新建仓标的
XBI
市值: US$1.3亿
本季最大获利了结 / 清仓标的
MERUS N V
前期市值: US$1.3亿
在 Q4 2025 季度中，Perceptive Advisors LLC 共进行了 107 项持仓异动，包含新建仓 39 个仓位、加仓 32 个仓位、减仓 21 个仓位以及清仓 15 个仓位。 其中最大新建仓标的为 XBI。 本季清仓仓位包含 MERUS N V。
本页面所有持股数据均直接同步自美国证券交易委员会（SEC）EDGAR 官方系统之 13F-HR / 13F-HR/A 季度申报文件。AlphaSMO 通过机器解析 CUSIP 与个股对照，提供 100% 精准对齐的历史时序数据集，并支持 Schema.org 结构化数据格式。
解析公司高管、董事与 10% 大股东之 Form 4 内部人交易申报，掌握高管自家股票买卖第一手信号。
深入剖析 5% 股权申报门槛、13D 与 13G 之差异，以及最新 SEC 申报时程规范，洞察机构法人的激进投资动向。