13F 申报指南13F 概念全攻略
什么是 SEC Form 13F 申报？美股机构大户持股全攻略
完整解读 Form 13F 申报规范、1 亿美元门槛与 45 天延迟申报机制，学会如何追踪顶级对冲基金与机构法人持仓动向。
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CIK: 0001335325
申报总市值
US$4.4亿
US$4.4亿
156 檔
15.2%
在 Q1 2026 的 13F 官方备案中，HighVista Strategies LLC 管理的美股投资组合规模来到 US$4.4亿，整体持股档数为 156 档。
HighVista Strategies LLC 在 Q1 2026 进行了结构性的板块轮动与仓位换股。在开立 35 个全新仓位及加仓 46 档持股的同时，亦同步清仓 24 档并减仓 71 档标的。
在资产配置集中度方面，HighVista Strategies LLC 的前 5 大核心持股（包含 DBC, ABVX, PRAX 等）合计占整体申报市值的 15.2%，反映机构在主要关键仓位上的权重分布。
| # | 代码 | 标的名称 | 资产子类别 | 占比 | 占比变动 | 持仓量变化 | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | DBC | Invesco Db Commodity Index T | ETF-避险与商品 | 8.45% | -2.02% | — | |
| 2 | ABVX | Abivax Sa-adr | 股票-其他 | 3.48% | -0.05% | +56.89% | |
| 3 | PRAX | Praxis Precision Medicines I | 股票-其他 | 2.34% | -0.03% | +1.87% | |
| 4 | COGT | Cogent Biosciences Inc | 股票-其他 | 2.09% | -0.42% | -41.47% | |
| 5 | SYRE | Spyre Therapeutics Inc | 股票-其他 | 2.04% | -0.47% | -22.29% | |
| 6 | PCVX | Vaxcyte Inc | 股票-其他 | 2.00% | -0.02% | +9.29% | |
| 7 | RVMD | Revolution Medicines Inc | 股票-医疗保健 | 1.86% | +1.00% | -42.36% | |
| 8 | 430 | Terns Pharmaceuticals Inc | 股票-其他 | 1.66% | -1.66% | EXIT | |
| 9 | GPCR | Structure Therapeutics Inc | 股票-其他 | 1.65% | -0.05% | -35.80% | |
| 10 | NUVL | Nuvalent Inc-a | 股票-其他 | 1.60% | -1.60% | EXIT | |
| 11 | IMVT | Immunovant Inc | 股票-其他 | 1.54% | +0.90% | +1.47% | |
| 12 | SLNOEUR | Soleno Therapeutics Inc | 股票-其他 | 1.53% | -1.53% | EXIT | |
| 13 | TYRA | Tyra Biosciences Inc | 股票-其他 | 1.39% | -0.04% | +274.23% | |
| 14 | AMLX | Amylyx Pharmaceuticals Inc | 股票-其他 | 1.35% | +0.23% | +47.43% | |
| 15 | AMZN | Amazon.com Inc | 股票-周期性消费 | 1.29% | -0.56% | +28.74% | |
| 16 | LBRX | Lb Pharmaceuticals Inc | 股票-其他 | 1.18% | +0.39% | +23.90% | |
| 17 | RLAY | Relay Therapeutics Inc | 股票-其他 | 1.16% | +1.00% | -22.60% | |
| 18 | INSM | Insmed Inc | 股票-医疗保健 | 1.10% | -0.34% | -38.28% | |
| 19 | NVDA | Nvidia CORP | 股票-科技 | 1.08% | -0.09% | +57.67% | |
| 20 | ORKA | Oruka Therapeutics Inc | 股票-其他 | 1.07% | -0.16% | — | |
| 21 | CYTK | Cytokinetics Inc | 股票-医疗保健 | 1.07% | +0.45% | -48.81% | |
| 22 | LQDA | Liquidia CORP | 股票-其他 | 1.04% | +0.74% | -36.06% | |
| 23 | OCUL | Ocular Therapeutix Inc | 股票-其他 | 1.03% | -0.12% | +28.34% | |
| 24 | TARS | Tarsus Pharmaceuticals Inc | 股票-其他 | 1.02% | +0.23% | -2.05% | |
| 25 | BBIO | Bridgebio Pharma Inc | 股票-医疗保健 | 1.02% | -0.80% | -38.21% | |
| 26 | MLTX | Moonlake Immunotherapeutics | 股票-其他 | 1.00% | -0.17% | — | |
| 27 | ARGX | Argenx Se - Adr | 股票-医疗保健 | 0.99% | -0.03% | +37.07% | |
| 28 | PTGX | Protagonist Therapeutics Inc | 股票-其他 | 0.99% | -0.31% | -53.97% | |
| 29 | PALI | Palisade Bio Inc | 股票-其他 | 0.98% | -0.01% | +55.33% | |
| 30 | DFTX | Definium Therapeutics Inc | 股票-其他 | 0.97% | +1.63% | — | |
| 31 | NRIX | Nurix Therapeutics Inc | 股票-其他 | 0.97% | +0.16% | — | |
| 32 | AXSM | Axsome Therapeutics Inc | 股票-医疗保健 | 0.95% | +0.18% | +83.60% | |
| 33 | IVA | Inventiva SA - Adr | 股票-其他 | 0.94% | -0.22% | — | |
| 34 | DYN | Dyne Therapeutics Inc | 股票-其他 | 0.92% | -0.05% | +206.71% | |
| 35 | APGE | Apogee Therapeutics Inc | 股票-其他 | 0.83% | -0.83% | EXIT | |
| 36 | GHRS | GH Research PLC | 股票-其他 | 0.83% | +0.14% | -11.36% | |
| 37 | DNTH | Dianthus Therapeutics Inc | 股票-其他 | 0.82% | +0.32% | -26.60% | |
| 38 | MAZE | Maze Therapeutics Inc | 股票-其他 | 0.82% | +0.11% | -41.39% | |
| 39 | ERAS | Erasca Inc | 股票-其他 | 0.81% | -0.14% | — | |
| 40 | EWTX | Edgewise Therapeutics Inc | 股票-其他 | 0.80% | +0.04% | -46.28% | |
| 41 | ELVN | Enliven Therapeutics Inc | 股票-其他 | 0.79% | +0.81% | -11.43% | |
| 42 | XENE | Xenon Pharmaceuticals Inc | 股票-其他 | 0.79% | -0.30% | — | |
| 43 | CLDX | Celldex Therapeutics Inc | 股票-其他 | 0.78% | -0.04% | +72.56% | |
| 44 | VERA | Vera Therapeutics Inc | 股票-其他 | 0.77% | +0.27% | — | |
| 45 | PHVS | Pharvaris N.V. | 股票-其他 | 0.76% | +0.51% | -39.73% | |
| 46 | VRDN | Viridian Therapeutics Inc | 股票-其他 | 0.72% | -0.05% | -63.96% | |
| 47 | ALKS | Alkermes plc | 股票-医疗保健 | 0.71% | +1.43% | +177.22% | |
| 48 | ALMS | Alumis Inc | 股票-其他 | 0.69% | +0.59% | — | |
| 49 | MSFT | Microsoft CORP | 股票-科技 | 0.66% | -0.45% | -1.22% | |
| 50 | EYPT | Eyepoint Inc | 股票-其他 | 0.65% | -0.14% | — |
| # | 代码 | 标的名称 | 占比变动 | 持仓量变化 | 异动类型 |
|---|---|---|---|---|---|
| 1 | DBC | Invesco Db Commodity Index T | +2.4% | — | 不变 |
| 2 | TYRA | Tyra Biosciences Inc | +1.2% | +274.23% | 加仓 |
| 3 | ABVX | Abivax Sa-adr | +1% | +56.89% | 加仓 |
| 4 | PCVX | Vaxcyte Inc | +0.6% | +9.29% | 加仓 |
| 5 | DYN | Dyne Therapeutics Inc | +0.6% | +206.71% | 加仓 |
| 6 | AMLX | Amylyx Pharmaceuticals Inc | +0.6% | +47.43% | 加仓 |
| 7 | ALKS | Alkermes plc | +0.5% | +177.22% | 加仓 |
| 8 | ELVN | Enliven Therapeutics Inc | +0.5% | -11.43% | 减仓 |
| 9 | SYRE | Spyre Therapeutics Inc | +0.5% | -22.29% | 减仓 |
| 10 | AXSM | Axsome Therapeutics Inc | +0.4% | +83.60% | 加仓 |
| 11 | CLDX | Celldex Therapeutics Inc | +0.4% | +72.56% | 加仓 |
| 12 | NVDA | Nvidia CORP | +0.4% | +57.67% | 加仓 |
| 13 | LBRX | Lb Pharmaceuticals Inc | +0.4% | +23.90% | 加仓 |
| 14 | PRAX | Praxis Precision Medicines I | +0.4% | +1.87% | 加仓 |
| 15 | DNTH | Dianthus Therapeutics Inc | +0.3% | -26.60% | 减仓 |
| 16 | CIEN | Ciena CORP | +0.3% | +1.93% | 加仓 |
| 17 | AMZN | Amazon.com Inc | +0.3% | +28.74% | 加仓 |
| 18 | ARGX | Argenx Se - Adr | +0.2% | +37.07% | 加仓 |
| 19 | IMCR | Immunocore Holdings Plc-adr | +0.2% | +77.88% | 加仓 |
| 20 | CORZ | Core Scientific Inc | +0.2% | +62.82% | 加仓 |
| 21 | LITE | Lumentum Holdings Inc | +0.2% | -27.80% | 减仓 |
| 22 | PALI | Palisade Bio Inc | +0.2% | +55.33% | 加仓 |
| 23 | ETR | Entergy CORP | +0.2% | +30.98% | 加仓 |
| 24 | ASND | Ascendis Pharma A/S | +0.2% | +57.95% | 加仓 |
| 25 | NKTR | Nektar Therapeutics | +0.2% | +23.88% | 加仓 |
| 26 | CTMX | Cytomx Therapeutics Inc | +0.2% | +48.53% | 加仓 |
| 27 | PBR-A | Petroleo Brasil-sp Pref Adr | +0.2% | +7.61% | 加仓 |
| 28 | AGX | Argan Inc | +0.1% | — | 不变 |
| 29 | XEL | Xcel Energy Inc | +0.1% | +55.85% | 加仓 |
| 30 | HPE | Hewlett Packard Enterprise | +0.1% | +18.11% | 加仓 |
| 31 | CPNG | Coupang Inc | +0.1% | +85.69% | 加仓 |
| 32 | APH | Amphenol Corp-cl A | +0.1% | +38.13% | 加仓 |
| 33 | MMM | 3m Co | +0.1% | +55.70% | 加仓 |
| 34 | KBR | Kbr Inc | +0.1% | +31.33% | 加仓 |
| 35 | RBC | RBC Bearings Inc | +0.1% | -1.48% | 减仓 |
| 36 | IMVT | Immunovant Inc | +0.1% | +1.47% | 加仓 |
| 37 | NOK | Nokia Corp-spon Adr | +0.1% | +18.98% | 加仓 |
| 38 | CGON | Cg Oncology Inc | +0.1% | -32.09% | 减仓 |
| 39 | CLH | Clean Harbors Inc | +0.1% | -11.21% | 减仓 |
| 40 | FLS | Flowserve CORP | +0.1% | — | 不变 |
| 41 | BBD | Banco Bradesco-adr | +0.1% | +9.46% | 加仓 |
| 42 | U | Unity Software Inc | +0.1% | +118.97% | 加仓 |
| 43 | INTU | Intuit Inc | +0.1% | +65.64% | 加仓 |
| 44 | JANX | Janux Therapeutics Inc | 0% | +19.16% | 加仓 |
| 45 | MTZ | Mastec Inc | 0% | -27.85% | 减仓 |
| 46 | GHRS | GH Research PLC | 0% | -11.36% | 减仓 |
| 47 | V | Visa Inc-class A Shares | 0% | +13.51% | 加仓 |
| 48 | XPO | Xpo Inc | 0% | -29.87% | 减仓 |
| 49 | EDU | New Oriental Educatio-sp Adr | 0% | -3.90% | 减仓 |
| 50 | APG | Api Group CORP | — | -13.89% | 减仓 |
根据 SEC 官方 Form 13F 申报备案，HighVista Strategies LLC 在 Q1 2026 季度的美股持仓总市值约为 US$4.4亿，共申报了 156 个公开持股仓位。
在 Q1 2026 季度，HighVista Strategies LLC 按市值排列的前三大核心持股分别为：DBC (8.4%)、ABVX (3.5%)、PRAX (2.3%)。其中最大持股仓位 DBC 占据整体投资组合约 8.4% 的权重。
精选 AlphaSMO 大户持股与内部人交易深度分析，提升投资决策胜率
完整解读 Form 13F 申报规范、1 亿美元门槛与 45 天延迟申报机制，学会如何追踪顶级对冲基金与机构法人持仓动向。
本季最大新建仓标的
ORKA
市值: US$387.1万
本季最大获利了结 / 清仓标的
CDTX
前期市值: US$506.5万
在 Q1 2026 季度中，HighVista Strategies LLC 共进行了 176 项持仓异动，包含新建仓 35 个仓位、加仓 46 个仓位、减仓 71 个仓位以及清仓 24 个仓位。 其中最大新建仓标的为 ORKA。 本季清仓仓位包含 CDTX。
本页面所有持股数据均直接同步自美国证券交易委员会（SEC）EDGAR 官方系统之 13F-HR / 13F-HR/A 季度申报文件。AlphaSMO 通过机器解析 CUSIP 与个股对照，提供 100% 精准对齐的历史时序数据集，并支持 Schema.org 结构化数据格式。
解析公司高管、董事与 10% 大股东之 Form 4 内部人交易申报，掌握高管自家股票买卖第一手信号。
深入剖析 5% 股权申报门槛、13D 与 13G 之差异，以及最新 SEC 申报时程规范，洞察机构法人的激进投资动向。