13F 申报指南13F 概念全攻略
什么是 SEC Form 13F 申报？美股机构大户持股全攻略
完整解读 Form 13F 申报规范、1 亿美元门槛与 45 天延迟申报机制，学会如何追踪顶级对冲基金与机构法人持仓动向。
AlphaSMO 权威研究指南阅读专题
CIK: 0001389933
申报总市值
US$5.2亿
US$5.2亿
77 檔
32.0%
Q4 2025 季度申报显示，DAFNA Capital Management LLC 披露的美股组合总市值为 US$5.2亿，涵盖 77 个不同之权益投资仓位。
DAFNA Capital Management LLC 在 Q4 2025 进行了结构性的板块轮动与仓位换股。在开立 12 个全新仓位及加仓 16 档持股的同时，亦同步清仓 10 档并减仓 29 档标的。
在资产配置集中度方面，DAFNA Capital Management LLC 的前 5 大核心持股（包含 RVMD, XBI, STXS 等）合计占整体申报市值的 32.0%，反映机构在主要关键仓位上的权重分布。
| # | 代码 | 标的名称 | 资产子类别 | 占比 | 占比变动 | 持仓量变化 | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | RVMD | Revolution Medicines Inc | 股票-医疗保健 | 11.18% | +7.24% | -8.01% | |
| 2 | XBI | Ss Spdr S&p Biotech ETF | ETF-科技型 | 9.53% | -3.32% | -16.19% | |
| 3 | STXS | Stereotaxis Inc | 股票-其他 | 7.31% | -1.24% | — | |
| 4 | ATRC | Atricure Inc | 股票-其他 | 5.49% | -0.69% | +0.87% | |
| 5 | CYTK | Cytokinetics Inc | 股票-医疗保健 | 5.48% | -0.47% | -6.06% | |
| 6 | IDYA | Ideaya Biosciences Inc | 股票-其他 | 4.07% | -0.08% | -6.15% | |
| 7 | AXGN | Axogen Inc | 股票-其他 | 3.63% | -0.04% | -35.76% | |
| 8 | XENE | Xenon Pharmaceuticals Inc | 股票-其他 | 3.00% | -0.43% | — | |
| 9 | IBB | Ishares Biotechnology ETF | ETF-科技型 | 2.67% | -0.85% | -33.57% | |
| 10 | BHVN | Biohaven Ltd. | 股票-其他 | 2.51% | -1.24% | +306.08% | |
| 11 | RCUS | Arcus Biosciences Inc | 股票-其他 | 2.39% | +0.42% | -31.28% | |
| 12 | NBIX | Neurocrine Biosciences Inc | 股票-医疗保健 | 2.33% | -0.26% | — | |
| 13 | DAWNGBX | Day One Biopharmaceuticals I | 股票-其他 | 2.16% | -4.77% | EXIT | |
| 14 | TNDM | Tandem Diabetes Care Inc | 股票-其他 | 1.81% | -0.53% | — | |
| 15 | ASND | Ascendis Pharma A/S | 股票-其他 | 1.40% | -1.21% | EXIT | |
| 16 | DXCM | Dexcom Inc | 股票-医疗保健 | 1.36% | -0.12% | +34.67% | |
| 17 | SNDX | Syndax Pharmaceuticals Inc | 股票-其他 | 1.36% | +0.24% | -44.51% | |
| 18 | 4XC1 | Kalvista Pharmaceuticals Inc | 股票-其他 | 1.34% | -1.22% | EXIT | |
| 19 | CMPS | Compass Pathways PLC | 股票-其他 | 1.30% | +2.39% | — | |
| 20 | INGN | Inogen Inc | 股票-其他 | 1.29% | -0.15% | +36.56% | |
| 21 | ASND 2.25 04-01-28债券 | Ascendis Pharma A/s | 债券 | 1.27% | -1.35% | EXIT | |
| 22 | DNLI | Denali Therapeutics Inc | 股票-其他 | 1.22% | +2.23% | +89.02% | |
| 23 | MBX | Mbx Biosciences Inc | 股票-其他 | 1.21% | -1.07% | +94.43% | |
| 24 | BCAX | Bicara Therapeutics Inc | 股票-其他 | 1.02% | -0.30% | -17.48% | |
| 25 | LKFT | Lakefront Biotherapeutic-adr | 股票-其他 | 0.99% | -0.15% | — | |
| 26 | CATBUSD | Astria Therapeutics Inc | 股票-其他 | 0.93% | — | -4.69% | |
| 27 | EWTX | Edgewise Therapeutics Inc | 股票-其他 | 0.92% | +0.96% | -25.26% | |
| 28 | IMVT | Immunovant Inc | 股票-其他 | 0.89% | +0.25% | -21.39% | |
| 29 | PRCT | Procept Biorobotics CORP | 股票-其他 | 0.88% | -0.16% | — | |
| 30 | HELP | Cybin Inc | 股票-其他 | 0.86% | +0.11% | — | |
| 31 | ALKS | Alkermes plc | 股票-医疗保健 | 0.85% | -0.11% | -3.34% | |
| 32 | LRMR | Larimar Therapeutics Inc | 股票-其他 | 0.83% | -0.91% | -8.62% | |
| 33 | STOK | Stoke Therapeutics Inc | 股票-其他 | 0.80% | -0.15% | -35.88% | |
| 34 | LXEO | Lexeo Therapeutics Inc | 股票-其他 | 0.79% | -0.16% | -4.81% | |
| 35 | BCRX | Biocryst Pharmaceuticals Inc | 股票-其他 | 0.76% | -0.17% | +91.64% | |
| 36 | NKTR | Nektar Therapeutics | 股票-其他 | 0.74% | +1.54% | +36.37% | |
| 37 | ✓ | Proqr Therapeutics N.v. | 股票-其他 | 0.74% | -0.04% | — | |
| 38 | IPSC | Century Therapeutics Inc | 股票-其他 | 0.65% | -0.13% | +63.92% | |
| 39 | ✓ | Immatics NV | 股票-其他 | 0.64% | -0.28% | +11.12% | |
| 40 | GPCR | Structure Therapeutics Inc | 股票-其他 | 0.60% | -0.03% | -37.29% | |
| 41 | MPLT | Maplight Therapeutics Inc | 股票-其他 | 0.59% | +0.38% | — | |
| 42 | ALGN | Align Technology Inc | 股票-医疗保健 | 0.58% | -0.13% | +45.45% | |
| 43 | KURA | Kura Oncology Inc | 股票-其他 | 0.57% | -0.19% | -49.10% | |
| 44 | AQST | Aquestive Therapeutics Inc | 股票-其他 | 0.56% | +0.16% | -26.66% | |
| 45 | RAPP | Rapport Therapeutics Inc | 股票-其他 | 0.53% | +0.07% | — | |
| 46 | PROF | Profound Medical CORP | 股票-其他 | 0.52% | -0.06% | — | |
| 47 | SPRY | Ars Pharmaceuticals Inc | 股票-其他 | 0.51% | — | +35.28% | |
| 48 | ✓ | Mediwound LTD | 股票-其他 | 0.49% | -0.09% | — | |
| 49 | VKTX | Viking Therapeutics Inc | 股票-医疗保健 | 0.49% | — | -7.75% | |
| 50 | PODD | Insulet CORP | 股票-医疗保健 | 0.45% | +1.28% | — |
| # | 代码 | 标的名称 | 占比变动 | 持仓量变化 | 异动类型 |
|---|---|---|---|---|---|
| 1 | RVMD | Revolution Medicines Inc | +3.6% | -8.01% | 减仓 |
| 2 | BHVN | Biohaven Ltd. | +1.6% | +306.08% | 加仓 |
| 3 | MBX | Mbx Biosciences Inc | +0.8% | +94.43% | 加仓 |
| 4 | TNDM | Tandem Diabetes Care Inc | +0.7% | — | 不变 |
| 5 | DNLI | Denali Therapeutics Inc | +0.6% | +89.02% | 加仓 |
| 6 | IDYA | Ideaya Biosciences Inc | +0.4% | -6.15% | 减仓 |
| 7 | IPSC | Century Therapeutics Inc | +0.4% | +63.92% | 加仓 |
| 8 | DAWNGBX | Day One Biopharmaceuticals I | +0.4% | — | 不变 |
| 9 | AXGN | Axogen Inc | +0.4% | -35.76% | 减仓 |
| 10 | CATBUSD | Astria Therapeutics Inc | +0.4% | -4.69% | 减仓 |
| 11 | BCRX | Biocryst Pharmaceuticals Inc | +0.4% | +91.64% | 加仓 |
| 12 | ATRC | Atricure Inc | +0.3% | +0.87% | 加仓 |
| 13 | RCUS | Arcus Biosciences Inc | +0.3% | -31.28% | 减仓 |
| 14 | DXCM | Dexcom Inc | +0.3% | +34.67% | 加仓 |
| 15 | CLDX | Celldex Therapeutics Inc | +0.3% | +179.46% | 加仓 |
| 16 | ALGN | Align Technology Inc | +0.2% | +45.45% | 加仓 |
| 17 | LXEO | Lexeo Therapeutics Inc | +0.2% | -4.81% | 减仓 |
| 18 | GPCR | Structure Therapeutics Inc | +0.2% | -37.29% | 减仓 |
| 19 | SPRY | Ars Pharmaceuticals Inc | +0.2% | +35.28% | 加仓 |
| 20 | CMPS | Compass Pathways PLC | +0.2% | — | 不变 |
| 21 | ✓ | Immatics NV | +0.2% | +11.12% | 加仓 |
| 22 | XENE | Xenon Pharmaceuticals Inc | +0.1% | — | 不变 |
| 23 | IMVT | Immunovant Inc | +0.1% | -21.39% | 减仓 |
| 24 | CYTK | Cytokinetics Inc | +0.1% | -6.06% | 减仓 |
| 25 | 4XC1 | Kalvista Pharmaceuticals Inc | +0.1% | -15.60% | 减仓 |
| 26 | INGN | Inogen Inc | +0.1% | +36.56% | 加仓 |
| 27 | VKTX | Viking Therapeutics Inc | +0.1% | -7.75% | 减仓 |
| 28 | EWTX | Edgewise Therapeutics Inc | +0.1% | -25.26% | 减仓 |
| 29 | ✓ | Polypid LTD | 0% | — | 不变 |
| 30 | ERAS | Erasca Inc | 0% | -27.30% | 减仓 |
| 31 | ALLO | Allogene Therapeutics Inc | 0% | — | 不变 |
| 32 | LRMR | Larimar Therapeutics Inc | 0% | -8.62% | 减仓 |
| 33 | FHTX | Foghorn Therapeutics Inc | 0% | — | 不变 |
| 34 | AUTL | Autolus Therapeutics PLC | 0% | — | 不变 |
| 35 | NGNE | Neurogene Inc | — | -7.90% | 减仓 |
| 36 | ✓ | Compugen LTD | — | — | 不变 |
| 37 | BCYC | Bicycle Therapeutics Plc-adr | 0% | — | 不变 |
| 38 | ✓ | Mediwound LTD | 0% | — | 不变 |
| 39 | RAPP | Rapport Therapeutics Inc | 0% | — | 不变 |
| 40 | BNTX | Biontech Se-adr | 0% | — | 不变 |
| 41 | NKTR | Nektar Therapeutics | 0% | +36.37% | 加仓 |
| 42 | ORIC | Oric Pharmaceuticals Inc | 0% | +34.75% | 加仓 |
| 43 | ✓ | Adc Therapeutics SA | -0.1% | -36.86% | 减仓 |
| 44 | PODD | Insulet CORP | -0.1% | — | 不变 |
| 45 | ASND 2.25 04-01-28债券 | Ascendis Pharma A/s | -0.1% | — | 不变 |
| 46 | ✓ | Proqr Therapeutics N.v. | -0.1% | — | 不变 |
| 47 | OBIO | Orchestra Biomed Holdings In | -0.1% | -65.12% | 减仓 |
| 48 | LKFT | Lakefront Biotherapeutic-adr | -0.1% | — | 不变 |
| 49 | NBIX | Neurocrine Biosciences Inc | -0.1% | — | 不变 |
| 50 | TELA | Tela Bio Inc | -0.1% | — | 不变 |
根据 SEC 官方 Form 13F 申报备案，DAFNA Capital Management LLC 在 Q4 2025 季度的美股持仓总市值约为 US$5.2亿，共申报了 77 个公开持股仓位。
在 Q4 2025 季度，DAFNA Capital Management LLC 按市值排列的前三大核心持股分别为：RVMD (11.2%)、XBI (9.5%)、STXS (7.3%)。其中最大持股仓位 RVMD 占据整体投资组合约 11.2% 的权重。
精选 AlphaSMO 大户持股与内部人交易深度分析，提升投资决策胜率
完整解读 Form 13F 申报规范、1 亿美元门槛与 45 天延迟申报机制，学会如何追踪顶级对冲基金与机构法人持仓动向。
本季最大新建仓标的
PRCT
市值: US$377.5万
本季最大获利了结 / 清仓标的
MERUS N V
前期市值: US$2075.5万
在 Q4 2025 季度中，DAFNA Capital Management LLC 共进行了 67 项持仓异动，包含新建仓 12 个仓位、加仓 16 个仓位、减仓 29 个仓位以及清仓 10 个仓位。 其中最大新建仓标的为 PRCT。 本季清仓仓位包含 MERUS N V。
本页面所有持股数据均直接同步自美国证券交易委员会（SEC）EDGAR 官方系统之 13F-HR / 13F-HR/A 季度申报文件。AlphaSMO 通过机器解析 CUSIP 与个股对照，提供 100% 精准对齐的历史时序数据集，并支持 Schema.org 结构化数据格式。
解析公司高管、董事与 10% 大股东之 Form 4 内部人交易申报，掌握高管自家股票买卖第一手信号。
深入剖析 5% 股权申报门槛、13D 与 13G 之差异，以及最新 SEC 申报时程规范，洞察机构法人的激进投资动向。