13F 申报指南13F 概念全攻略
什么是 SEC Form 13F 申报？美股机构大户持股全攻略
完整解读 Form 13F 申报规范、1 亿美元门槛与 45 天延迟申报机制，学会如何追踪顶级对冲基金与机构法人持仓动向。
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CIK: 0001389933
申报总市值
US$5.2亿
US$5.2亿
75 檔
29.8%
在 Q3 2025 申报期间，DAFNA Capital Management LLC（CIK: 0001389933）向美国 SEC 提交的 Form 13F 报告显示，其追踪之股票投资组合总市值达 US$5.2亿，共持有 75 个公开申报仓位。
在 Q3 2025，DAFNA Capital Management LLC 展现出较为审慎的避险与获利了结姿态。本季共减仓 26 个仓位并完全清仓 16 档持股，调降曝光的仓位数量高于加仓动作。
在资产配置集中度方面，DAFNA Capital Management LLC 的前 5 大核心持股（包含 STXS, XBI, RVMD 等）合计占整体申报市值的 29.8%，反映机构在主要关键仓位上的权重分布。
| # | 代码 | 标的名称 | 资产子类别 | 占比 | 占比变动 | 持仓量变化 | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | STXS | Stereotaxis Inc | 股票-其他 | 10.51% | -1.24% | — | |
| 2 | XBI | Ss Spdr S&p Biotech ETF | ETF-科技型 | 9.94% | -3.32% | -3.37% | |
| 3 | RVMD | Revolution Medicines Inc | 股票-医疗保健 | 7.58% | +7.24% | -2.95% | |
| 4 | CYTK | Cytokinetics Inc | 股票-医疗保健 | 5.36% | -0.47% | -0.79% | |
| 5 | ATRC | Atricure Inc | 股票-其他 | 5.16% | -0.69% | — | |
| 6 | ✓ | Merus N V | 股票-其他 | 5.13% | — | -44.72% | |
| 7 | IBB | Ishares Biotechnology ETF | ETF-科技型 | 3.66% | -0.85% | — | |
| 8 | IDYA | Ideaya Biosciences Inc | 股票-其他 | 3.63% | -0.08% | -12.79% | |
| 9 | AXGN | Axogen Inc | 股票-其他 | 3.27% | -0.04% | +0.07% | |
| 10 | XENE | Xenon Pharmaceuticals Inc | 股票-其他 | 2.86% | -0.43% | — | |
| 11 | NBIX | Neurocrine Biosciences Inc | 股票-医疗保健 | 2.45% | -0.26% | — | |
| 12 | RCUS | Arcus Biosciences Inc | 股票-其他 | 2.11% | +0.42% | — | |
| 13 | SNDX | Syndax Pharmaceuticals Inc | 股票-其他 | 1.90% | +0.24% | -7.89% | |
| 14 | DAWNGBX | Day One Biopharmaceuticals I | 股票-其他 | 1.74% | -4.77% | EXIT | |
| 15 | ASND | Ascendis Pharma A/S | 股票-其他 | 1.63% | -1.21% | EXIT | |
| 16 | ASND 2.25 04-01-28债券 | Ascendis Pharma A/s | 债券 | 1.34% | -1.35% | EXIT | |
| 17 | 4XC1 | Kalvista Pharmaceuticals Inc | 股票-其他 | 1.27% | -1.22% | EXIT | |
| 18 | BCAX | Bicara Therapeutics Inc | 股票-其他 | 1.24% | -0.30% | — | |
| 19 | INGN | Inogen Inc | 股票-其他 | 1.22% | -0.15% | — | |
| 20 | CMPS | Compass Pathways PLC | 股票-其他 | 1.15% | +2.39% | — | |
| 21 | LKFT | Lakefront Biotherapeutic-adr | 股票-其他 | 1.11% | -0.15% | — | |
| 22 | DXCM | Dexcom Inc | 股票-医疗保健 | 1.09% | -0.12% | — | |
| 23 | TNDM | Tandem Diabetes Care Inc | 股票-其他 | 1.07% | -0.53% | +20.73% | |
| 24 | KURA | Kura Oncology Inc | 股票-其他 | 1.01% | -0.19% | — | |
| 25 | ALKS | Alkermes plc | 股票-医疗保健 | 1.00% | -0.11% | +29.88% | |
| 26 | STOK | Stoke Therapeutics Inc | 股票-其他 | 0.99% | -0.15% | -66.18% | |
| 27 | SLNOEUR | Soleno Therapeutics Inc | 股票-其他 | 0.89% | — | — | |
| 28 | BHVN | Biohaven Ltd. | 股票-其他 | 0.87% | -1.24% | — | |
| 29 | EWTX | Edgewise Therapeutics Inc | 股票-其他 | 0.86% | +0.96% | -10.25% | |
| 30 | ✓ | Proqr Therapeutics N.v. | 股票-其他 | 0.82% | -0.04% | — | |
| 31 | LRMR | Larimar Therapeutics Inc | 股票-其他 | 0.82% | -0.91% | +176.70% | |
| 32 | CMPX | Compass Therapeutics Inc | 股票-其他 | 0.82% | — | +79.75% | |
| 33 | MLYS | Mineralys Therapeutics Inc | 股票-其他 | 0.78% | -0.01% | -77.53% | |
| 34 | NKTR | Nektar Therapeutics | 股票-其他 | 0.77% | +1.54% | +449.98% | |
| 35 | IMVT | Immunovant Inc | 股票-其他 | 0.76% | +0.25% | — | |
| 36 | KRRO | Korro Bio Inc | 股票-其他 | 0.72% | — | +5.40% | |
| 37 | AQST | Aquestive Therapeutics Inc | 股票-其他 | 0.71% | +0.16% | +260.98% | |
| 38 | DNLI | Denali Therapeutics Inc | 股票-其他 | 0.60% | +2.23% | — | |
| 39 | LXEO | Lexeo Therapeutics Inc | 股票-其他 | 0.59% | -0.16% | -5.29% | |
| 40 | ALEC | Alector Inc | 股票-其他 | 0.58% | -0.09% | -12.55% | |
| 41 | CATBUSD | Astria Therapeutics Inc | 股票-其他 | 0.58% | — | -1.54% | |
| 42 | RAPP | Rapport Therapeutics Inc | 股票-其他 | 0.55% | +0.07% | — | |
| 43 | TELA | Tela Bio Inc | 股票-其他 | 0.53% | +0.01% | — | |
| 44 | PODD | Insulet CORP | 股票-医疗保健 | 0.52% | +1.28% | -30.61% | |
| 45 | ✓ | Mediwound LTD | 股票-其他 | 0.51% | -0.09% | +76.20% | |
| 46 | ARAY | Accuray Inc | 股票-其他 | 0.50% | -0.07% | — | |
| 47 | ✓ | Immatics NV | 股票-其他 | 0.49% | -0.28% | -4.08% | |
| 48 | ALLO | Allogene Therapeutics Inc | 股票-其他 | 0.42% | +0.03% | — | |
| 49 | VKTX | Viking Therapeutics Inc | 股票-医疗保健 | 0.42% | — | — | |
| 50 | BCRX | Biocryst Pharmaceuticals Inc | 股票-其他 | 0.41% | -0.17% | — |
| # | 代码 | 标的名称 | 占比变动 | 持仓量变化 | 异动类型 |
|---|---|---|---|---|---|
| 1 | STXS | Stereotaxis Inc | +3.7% | — | 不变 |
| 2 | RVMD | Revolution Medicines Inc | +1% | -2.95% | 加仓 |
| 3 | IDYA | Ideaya Biosciences Inc | +0.9% | -12.79% | 减仓 |
| 4 | CYTK | Cytokinetics Inc | +0.8% | -0.79% | 减仓 |
| 5 | RCUS | Arcus Biosciences Inc | +0.7% | — | 加仓 |
| 6 | XBI | Ss Spdr S&p Biotech ETF | +0.6% | -3.37% | 减仓 |
| 7 | LRMR | Larimar Therapeutics Inc | +0.6% | +176.70% | 加仓 |
| 8 | AQST | Aquestive Therapeutics Inc | +0.6% | +260.98% | 加仓 |
| 9 | CMPS | Compass Pathways PLC | +0.6% | — | 加仓 |
| 10 | KRRO | Korro Bio Inc | +0.5% | +5.40% | 加仓 |
| 11 | BCAX | Bicara Therapeutics Inc | +0.5% | — | 加仓 |
| 12 | INGN | Inogen Inc | +0.3% | — | 加仓 |
| 13 | XENE | Xenon Pharmaceuticals Inc | +0.3% | — | 加仓 |
| 14 | ALEC | Alector Inc | +0.3% | -12.55% | 减仓 |
| 15 | ✓ | Proqr Therapeutics N.v. | +0.2% | — | 不变 |
| 16 | ✓ | Mediwound LTD | +0.2% | +76.20% | 加仓 |
| 17 | BDTX | Black Diamond Therapeutics I | +0.2% | -34.80% | 加仓 |
| 18 | LXEO | Lexeo Therapeutics Inc | +0.2% | -5.29% | 减仓 |
| 19 | NBIX | Neurocrine Biosciences Inc | +0.2% | — | 减仓 |
| 20 | LKFT | Lakefront Biotherapeutic-adr | +0.2% | — | 不变 |
| 21 | ✓ | Immatics NV | +0.2% | -4.08% | 减仓 |
| 22 | STOK | Stoke Therapeutics Inc | +0.2% | -66.18% | 减仓 |
| 23 | KURA | Kura Oncology Inc | +0.1% | — | 不变 |
| 24 | ALKS | Alkermes plc | +0.1% | +29.88% | 加仓 |
| 25 | GPCR | Structure Therapeutics Inc | +0.1% | — | 不变 |
| 26 | DNLI | Denali Therapeutics Inc | +0.1% | — | 加仓 |
| 27 | DAWNGBX | Day One Biopharmaceuticals I | +0.1% | +13.65% | 加仓 |
| 28 | CATBUSD | Astria Therapeutics Inc | +0.1% | -1.54% | 加仓 |
| 29 | ERAS | Erasca Inc | +0.1% | — | 加仓 |
| 30 | TELA | Tela Bio Inc | 0% | — | 不变 |
| 31 | ✓ | Adc Therapeutics SA | 0% | — | 减仓 |
| 32 | SPRY | Ars Pharmaceuticals Inc | 0% | — | 加仓 |
| 33 | STRO | Sutro Biopharma, Inc. | 0% | — | 不变 |
| 34 | SNDX | Syndax Pharmaceuticals Inc | — | -7.89% | 减仓 |
| 35 | ASND 2.25 04-01-28债券 | Ascendis Pharma A/s | — | — | 不变 |
| 36 | ✓ | 0% | — | 不变 | |
| 37 | ✓ | Compugen LTD | 0% | — | 不变 |
| 38 | VKTX | Viking Therapeutics Inc | 0% | — | 不变 |
| 39 | IPSC | Century Therapeutics Inc | 0% | — | 不变 |
| 40 | APRE | Aprea Therapeutics Inc | 0% | — | 不变 |
| 41 | NGNE | Neurogene Inc | 0% | -40.55% | 减仓 |
| 42 | ✓ | Polypid LTD | -0.1% | — | 减仓 |
| 43 | IBB | Ishares Biotechnology ETF | -0.1% | — | 不变 |
| 44 | IMVT | Immunovant Inc | -0.1% | — | 加仓 |
| 45 | KROS | Keros Therapeutics Inc | -0.1% | -38.06% | 减仓 |
| 46 | BCYC | Bicycle Therapeutics Plc-adr | -0.1% | — | 减仓 |
| 47 | ORIC | Oric Pharmaceuticals Inc | -0.1% | -22.62% | 减仓 |
| 48 | BNTX | Biontech Se-adr | -0.1% | — | 减仓 |
| 49 | ARAY | Accuray Inc | -0.1% | — | 不变 |
| 50 | ALLO | Allogene Therapeutics Inc | -0.2% | — | 不变 |
根据 SEC 官方 Form 13F 申报备案，DAFNA Capital Management LLC 在 Q3 2025 季度的美股持仓总市值约为 US$5.2亿，共申报了 75 个公开持股仓位。
在 Q3 2025 季度，DAFNA Capital Management LLC 按市值排列的前三大核心持股分别为：STXS (10.5%)、XBI (9.9%)、RVMD (7.6%)。其中最大持股仓位 STXS 占据整体投资组合约 10.5% 的权重。
精选 AlphaSMO 大户持股与内部人交易深度分析，提升投资决策胜率
完整解读 Form 13F 申报规范、1 亿美元门槛与 45 天延迟申报机制，学会如何追踪顶级对冲基金与机构法人持仓动向。
本季最大新建仓标的
SLNOEUR
市值: US$358.3万
本季最大获利了结 / 清仓标的
2655787D
前期市值: US$1347.7万
在 Q3 2025 季度中，DAFNA Capital Management LLC 共进行了 72 项持仓异动，包含新建仓 8 个仓位、加仓 22 个仓位、减仓 26 个仓位以及清仓 16 个仓位。 其中最大新建仓标的为 SLNOEUR。 本季清仓仓位包含 2655787D。
本页面所有持股数据均直接同步自美国证券交易委员会（SEC）EDGAR 官方系统之 13F-HR / 13F-HR/A 季度申报文件。AlphaSMO 通过机器解析 CUSIP 与个股对照，提供 100% 精准对齐的历史时序数据集，并支持 Schema.org 结构化数据格式。
解析公司高管、董事与 10% 大股东之 Form 4 内部人交易申报，掌握高管自家股票买卖第一手信号。
深入剖析 5% 股权申报门槛、13D 与 13G 之差异，以及最新 SEC 申报时程规范，洞察机构法人的激进投资动向。