13F 申报指南13F 概念全攻略
什么是 SEC Form 13F 申报？美股机构大户持股全攻略
完整解读 Form 13F 申报规范、1 亿美元门槛与 45 天延迟申报机制，学会如何追踪顶级对冲基金与机构法人持仓动向。
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CIK: 0001773195
申报总市值
US$22.1亿
US$22.1亿
92 檔
22.1%
根据最新整理的 13F 季度数据集，Affinity Asset Advisors, LLC 于 Q4 2025 结束时的管理资产规模为 US$22.1亿。该机构在本季度申报了 92 档美股持仓，呈现出该时期的主要投资地图。
Affinity Asset Advisors, LLC 在 Q4 2025 进行了结构性的板块轮动与仓位换股。在开立 27 个全新仓位及加仓 27 档持股的同时，亦同步清仓 28 档并减仓 19 档标的。
在资产配置集中度方面，Affinity Asset Advisors, LLC 的前 5 大核心持股（包含 XBI, APGE, INSM 等）合计占整体申报市值的 22.1%，反映机构在主要关键仓位上的权重分布。
| # | 代码 | 标的名称 | 资产子类别 | 占比 | 占比变动 | 持仓量变化 | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | XBI | Ss Spdr S&p Biotech ETF | ETF-科技型 | 10.42% | — | — | |
| 2 | APGE | Apogee Therapeutics Inc | 股票-其他 | 5.31% | +0.33% | +5.24% | |
| 3 | INSM | Insmed Inc | 股票-医疗保健 | 4.46% | -0.92% | -31.30% | |
| 4 | ABVX | Abivax Sa-adr | 股票-其他 | 3.88% | -0.34% | +40.28% | |
| 5 | IBB | Ishares Biotechnology ETF | ETF-科技型 | 3.85% | — | — | |
| 6 | VTYXUSD | Ventyx Biosciences Inc | 股票-其他 | 3.34% | — | +65.24% | |
| 7 | XENE | Xenon Pharmaceuticals Inc | 股票-其他 | 3.19% | -0.68% | -10.71% | |
| 8 | PRAX | Praxis Precision Medicines I | 股票-其他 | 3.11% | -0.03% | — | |
| 9 | CYTK | Cytokinetics Inc | 股票-医疗保健 | 2.90% | -0.26% | +128.57% | |
| 10 | AMGN | Amgen Inc | 股票-医疗保健 | 2.70% | — | — | |
| 11 | SYRE | Spyre Therapeutics Inc | 股票-其他 | 2.67% | +1.80% | +0.94% | |
| 12 | WVE | Wave Life Sciences Ltd. | 股票-其他 | 2.62% | -0.52% | EXIT | |
| 13 | TEVA | Teva Pharmaceutical-sp Adr | 股票-医疗保健 | 2.49% | -1.61% | — | |
| 14 | XLV | Ss Health Care Select Sector | ETF-其他 | 2.21% | — | — | |
| 15 | ROIV | Roivant Sciences Ltd. | 股票-医疗保健 | 2.10% | +1.99% | +112.50% | |
| 16 | ACLXGBX | Arcellx Inc | 股票-其他 | 1.95% | -2.15% | EXIT | |
| 17 | NUVL | Nuvalent Inc-a | 股票-其他 | 1.85% | -0.05% | -16.07% | |
| 18 | LXEO | Lexeo Therapeutics Inc | 股票-其他 | 1.81% | -0.28% | -17.32% | |
| 19 | ALKS | Alkermes plc | 股票-医疗保健 | 1.59% | +0.79% | -20.00% | |
| 20 | FBRX | Forte Biosciences Inc | 股票-其他 | 1.57% | -0.25% | — | |
| 21 | TRVI | Trevi Therapeutics Inc | 股票-其他 | 1.53% | +0.29% | -23.21% | |
| 22 | MLYS | Mineralys Therapeutics Inc | 股票-其他 | 1.51% | -0.14% | -2.67% | |
| 23 | BBIO | Bridgebio Pharma Inc | 股票-医疗保健 | 1.39% | -0.58% | EXIT | |
| 24 | ORKA | Oruka Therapeutics Inc | 股票-其他 | 1.39% | +1.27% | -16.35% | |
| 25 | 430 | Terns Pharmaceuticals Inc | 股票-其他 | 1.27% | -1.53% | EXIT | |
| 26 | ANAB | Anaptysbio Inc | 股票-其他 | 1.23% | -0.17% | — | |
| 27 | QURE | uniQure N.V. | 股票-其他 | 1.16% | +0.53% | +183.33% | |
| 28 | CGEM | Cullinan Therapeutics Inc | 股票-其他 | 1.14% | +0.15% | +632.37% | |
| 29 | OMER 9.5 06-15-29债券 | Omeros CORP | 债券 | 1.10% | -0.13% | +18.10% | |
| 30 | AVTX | Avalo Therapeutics Inc | 股票-其他 | 1.09% | +1.39% | +4.46% | |
| 31 | NRIX | Nurix Therapeutics Inc | 股票-其他 | 1.05% | +0.29% | — | |
| 32 | TSHA | Taysha Gene Therapies Inc | 股票-其他 | 1.03% | +0.31% | +10.00% | |
| 33 | MDGL | Madrigal Pharmaceuticals Inc | 股票-医疗保健 | 1.03% | -0.52% | -72.93% | |
| 34 | SVRA | Savara Inc | 股票-其他 | 0.96% | -0.01% | +86.48% | |
| 35 | PTGX | Protagonist Therapeutics Inc | 股票-其他 | 0.86% | +0.01% | — | |
| 36 | 260 | Centessa Pharmaceuticals-adr | 股票-其他 | 0.86% | -2.87% | EXIT | |
| 37 | ✓ | Establishment Labs Holdings In | 股票-其他 | 0.83% | +0.28% | -35.48% | |
| 38 | ERAS | Erasca Inc | 股票-其他 | 0.83% | -0.12% | -9.00% | |
| 39 | VERA | Vera Therapeutics Inc | 股票-其他 | 0.72% | -0.04% | -17.58% | |
| 40 | COGT | Cogent Biosciences Inc | 股票-其他 | 0.71% | -0.70% | — | |
| 41 | OVID | Ovid Therapeutics Inc | 股票-其他 | 0.66% | +0.01% | +169.81% | |
| 42 | TVTX | Travere Therapeutics Inc | 股票-其他 | 0.65% | +0.31% | -40.00% | |
| 43 | JBIO | Jade Biosciences Inc | 股票-其他 | 0.63% | +0.38% | +994.59% | |
| 44 | TVTX 2.25 03-01-29债券 | Travere Therapeutics Inc | 债券 | 0.57% | — | — | |
| 45 | NAMS | NewAmsterdam Pharma Company N.V. | 股票-其他 | 0.55% | -0.03% | — | |
| 46 | CLDX | Celldex Therapeutics Inc | 股票-其他 | 0.54% | +0.36% | +16.67% | |
| 47 | ✓ | Zura Bio LTD | 股票-其他 | 0.54% | -0.40% | +42.32% | |
| 48 | TNGX | Tango Therapeutics Inc | 股票-其他 | 0.50% | — | — | |
| 49 | STRO | Sutro Biopharma Inc | 股票-其他 | 0.49% | +0.38% | — | |
| 50 | RVMD | Revolution Medicines Inc | 股票-医疗保健 | 0.45% | +1.12% | — |
| # | 代码 | 标的名称 | 占比变动 | 持仓量变化 | 异动类型 |
|---|---|---|---|---|---|
| 1 | VTYXUSD | Ventyx Biosciences Inc | +2.3% | +65.24% | 加仓 |
| 2 | WVE | Wave Life Sciences Ltd. | +1.3% | +28.57% | 加仓 |
| 3 | APGE | Apogee Therapeutics Inc | +1.3% | +5.24% | 加仓 |
| 4 | ABVX | Abivax Sa-adr | +1.2% | +40.28% | 加仓 |
| 5 | CYTK | Cytokinetics Inc | +1.2% | +128.57% | 加仓 |
| 6 | BBIO | Bridgebio Pharma Inc | +1.1% | +392.31% | 加仓 |
| 7 | ROIV | Roivant Sciences Ltd. | +1.1% | +112.50% | 加仓 |
| 8 | CGEM | Cullinan Therapeutics Inc | +1% | +632.37% | 加仓 |
| 9 | OMER 9.5 06-15-29债券 | Omeros CORP | +0.7% | +18.10% | 加仓 |
| 10 | SYRE | Spyre Therapeutics Inc | +0.6% | +0.94% | 加仓 |
| 11 | JBIO | Jade Biosciences Inc | +0.6% | +994.59% | 加仓 |
| 12 | SVRA | Savara Inc | +0.5% | +86.48% | 加仓 |
| 13 | OVID | Ovid Therapeutics Inc | +0.4% | +169.81% | 加仓 |
| 14 | KPTI | Karyopharm Therapeutics Inc | +0.3% | +464.45% | 加仓 |
| 15 | ✓ | Engene Holdings Inc | +0.3% | +735.55% | 加仓 |
| 16 | NRIX | Nurix Therapeutics Inc | +0.3% | — | 不变 |
| 17 | MBX | Mbx Biosciences Inc | +0.2% | +51.52% | 加仓 |
| 18 | TSHA | Taysha Gene Therapies Inc | +0.2% | +10.00% | 加仓 |
| 19 | SGMT | Sagimet Biosciences Inc-a | +0.2% | +228.07% | 加仓 |
| 20 | NXTC | Nextcure Inc | +0.1% | +28.88% | 加仓 |
| 21 | CLYM | Climb Bio Inc | +0.1% | — | 不变 |
| 22 | ✓ | Zura Bio LTD | +0.1% | +42.32% | 加仓 |
| 23 | ABUS | Arbutus Biopharma CORP | +0.1% | +146.76% | 加仓 |
| 24 | RVMD | Revolution Medicines Inc | 0% | — | 不变 |
| 25 | TEVA | Teva Pharmaceutical-sp Adr | 0% | — | 不变 |
| 26 | ERAS | Erasca Inc | 0% | -9.00% | 减仓 |
| 27 | CELC 2.75 08-01-31债券 | Celcuity Inc | 0% | — | 不变 |
| 28 | QTTB | Q32 Bio Inc | 0% | — | 不变 |
| 29 | RCKTW | Rocket Pharmaceuticals In-27 | — | — | 不变 |
| 30 | ADGM | Adagio Medical Holdings Inc | 0% | — | 不变 |
| 31 | AVTX | Avalo Therapeutics Inc | 0% | +4.46% | 加仓 |
| 32 | OBIO | Orchestra Biomed Holdings In | 0% | -21.24% | 减仓 |
| 33 | EPRX | Eupraxia Pharmaceuticals Inc | 0% | — | 不变 |
| 34 | CMPS | Compass Pathways PLC | 0% | — | 不变 |
| 35 | VRDN | Viridian Therapeutics Inc | 0% | — | 不变 |
| 36 | AVR | Anteris Technologies Global | 0% | +8.15% | 加仓 |
| 37 | CATX | Perspective Therapeutics Inc | 0% | — | 不变 |
| 38 | VERA | Vera Therapeutics Inc | -0.1% | -17.58% | 减仓 |
| 39 | ✓ | Newamsterdam Pharma Company | -0.1% | — | 不变 |
| 40 | CRNX | Crinetics Pharmaceuticals In | -0.1% | — | 不变 |
| 41 | GERN | Geron CORP | -0.1% | — | 不变 |
| 42 | ✓ | -0.1% | — | 不变 | |
| 43 | TVTX 2.25 03-01-29债券 | Travere Therapeutics Inc | -0.1% | — | 不变 |
| 44 | NAMS | NewAmsterdam Pharma Company N.V. | -0.1% | — | 不变 |
| 45 | IMVT | Immunovant Inc | -0.1% | -33.33% | 减仓 |
| 46 | CLDX | Celldex Therapeutics Inc | -0.1% | +16.67% | 加仓 |
| 47 | ORKA | Oruka Therapeutics Inc | -0.2% | -16.35% | 减仓 |
| 48 | ✓ | Establishment Labs Holdings In | -0.3% | -35.48% | 减仓 |
| 49 | SMMT | Summit Therapeutics Inc | -0.3% | — | 不变 |
| 50 | ✓ | -0.3% | -85.71% | 减仓 |
根据 SEC 官方 Form 13F 申报备案，Affinity Asset Advisors, LLC 在 Q4 2025 季度的美股持仓总市值约为 US$22.1亿，共申报了 92 个公开持股仓位。
在 Q4 2025 季度，Affinity Asset Advisors, LLC 按市值排列的前三大核心持股分别为：XBI (10.4%)、APGE (5.3%)、INSM (4.5%)。其中最大持股仓位 XBI 占据整体投资组合约 10.4% 的权重。
精选 AlphaSMO 大户持股与内部人交易深度分析，提升投资决策胜率
完整解读 Form 13F 申报规范、1 亿美元门槛与 45 天延迟申报机制，学会如何追踪顶级对冲基金与机构法人持仓动向。
本季最大新建仓标的
XBI
市值: US$1.8亿
本季最大获利了结 / 清仓标的
VRNA
前期市值: US$6669.4万
在 Q4 2025 季度中，Affinity Asset Advisors, LLC 共进行了 101 项持仓异动，包含新建仓 27 个仓位、加仓 27 个仓位、减仓 19 个仓位以及清仓 28 个仓位。 其中最大新建仓标的为 XBI。 本季清仓仓位包含 VRNA。
本页面所有持股数据均直接同步自美国证券交易委员会（SEC）EDGAR 官方系统之 13F-HR / 13F-HR/A 季度申报文件。AlphaSMO 通过机器解析 CUSIP 与个股对照，提供 100% 精准对齐的历史时序数据集，并支持 Schema.org 结构化数据格式。
解析公司高管、董事与 10% 大股东之 Form 4 内部人交易申报，掌握高管自家股票买卖第一手信号。
深入剖析 5% 股权申报门槛、13D 与 13G 之差异，以及最新 SEC 申报时程规范，洞察机构法人的激进投资动向。