Sio Capital Management, LLC 13F Holdings Overview (76 Positions)

CIK: 0001482416

Diversified strategyHigh-turnover traderSector-focused

Total reported value

$697.3M

Reporting period: 2026-03-31 · Number of holdings: 76

Sio Capital Management, LLC disclosed 76 holdings in its latest 13F filing for the period ending 2026-03-31, with total reported value of $697.3M and a quarterly turnover rate of 94.1%.

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Personality snowflake

Concentration: 12.02
Portfolio Stability: 94.14
Momentum/Contrarian: 100
Sector conviction: 100
Diversification: 100
Sizing Uniformity: 88.59

Sio Capital Management, LLC's disclosed holdings carry a Herfindahl concentration index of 0.030 — mathematically equivalent to about 33 equally-sized positions, well below its 76 actual disclosed holdings. That gap points to a strategy built around a small core of high-conviction bets rather than broad diversification.

Position sizes are fairly uniform across the portfolio (a coefficient of variation of 1.14), suggesting a disciplined, rules-based approach to how much capital goes into each idea.

No strong tilt toward either adding to existing winners or initiating outsized new positions was observed in the latest reported quarter.

Sector classification currently covers about 35% of this portfolio's disclosed value; the remainder includes holdings (e.g. unmapped tickers, options, or other security types) not yet covered by our sector mapping.

Recent moves

Trim SNY
-75.3%　-$35.5M
Trim ZBH
-83.8%　-$29.0M
Trim CELC
-59.4%　-$25.5M
Add COR
+534.6%　$26.3M
Trim OGN
-74.7%　-$19.3M
Add AVR
+187.1%　$20.5M

Holdings Map

New buyAddUnchangedTrim

Top 10 holdings by weight

Full holdings list this quarter

#	Ticker	Issuer	Asset Subclass	Weight	Weight Change	Shares Change
1	MMS	Maximus INC	Stock-Industrials	7.07%	+0.28%	+53.67%
2	WAY	Waystar Holding CORP	Stock-Other	5.68%	+2.52%	+167.59%
3	ICLR	ICON Public Limited Company	Stock-Healthcare	4.86%	+1.21%	+140.84%
4	COR	Cencora INC	Stock-Healthcare	4.55%	+3.71%	+534.55%
5	DNTH	Dianthus Therapeutics INC	Stock-Other	4.45%	+1.37%	-22.01%
6	AVR	Anteris Technologies Global	Stock-Other	4.28%	+2.81%	+187.15%
7	CORT	Corcept Therapeutics INC	Stock-Healthcare	3.90%	+3.90%	NEW
8	LIVN	LivaNova PLC	Stock-Other	3.84%	+0.72%	+30.78%
9	TYRA	Tyra Biosciences INC	Stock-Other	3.33%	+1.15%	+15.10%
10	CELC	Celcuity INC	Stock-Other	3.17%	-4.31%	-59.37%
11	GSK	Gsk Plc-spon Adr	Stock-Healthcare	3.05%	+3.05%	NEW
12	ANIP	Ani Pharmaceuticals INC	Stock-Other	2.93%	+1.85%	+204.27%
13	ABT	Abbott Laboratories	Stock-Healthcare	2.75%	+2.75%	NEW
14	EMBC	Embecta CORP	Stock-Healthcare	2.34%	+2.34%	NEW
15	ABVX	Abivax Sa-adr	Stock-Other	2.17%	+1.26%	+214.91%
16	VIR	Vir Biotechnology INC	Stock-Other	1.93%	+1.48%	+213.29%
17	HAE	Haemonetics Corp/mass	Stock-Other	1.78%	+0.61%	+138.23%
18	SION	Sionna Therapeutics INC	Stock-Other	1.69%	+1.69%	NEW
19	SNY	Sanofi-adr	Stock-Healthcare	1.66%	-5.75%	-75.33%
20	RAPP	Rapport Therapeutics INC	Stock-Other	1.65%	+0.77%	+97.99%
21	TFX	Teleflex INC	Stock-Healthcare	1.63%	—	+9.12%
22	BMRN	Biomarin Pharmaceutical INC	Stock-Healthcare	1.57%	-0.61%	-16.53%
23	CCRN	Cross Country Healthcare INC	Stock-Other	1.48%	—	+2.77%
24	TARA	Protara Therapeutic INC	Stock-Other	1.47%	—	+14.83%
25	GPCR	Structure Therapeutics INC	Stock-Other	1.45%	-0.75%	+3.77%
26	BHVN	Biohaven Ltd.	Stock-Other	1.41%	-0.80%	-6.49%
27	MNPR	Monopar Therapeutics INC	Stock-Other	1.36%	+1.36%	NEW
28	EYPT	Eyepoint INC	Stock-Other	1.33%	+1.33%	NEW
29	CRNX	Crinetics Pharmaceuticals In	Stock-Other	1.30%	+0.39%	+100.16%
30	EWTX	Edgewise Therapeutics INC	Stock-Other	1.22%	+0.29%	+13.27%
31	CMPS	Compass Pathways PLC	Stock-Other	1.19%	+1.19%	NEW
32	OCUL	Ocular Therapeutix INC	Stock-Other	1.18%	+1.18%	NEW
33	AQST	Aquestive Therapeutics INC	Stock-Other	1.14%	—	+93.63%
34	RLMD	Relmada Therapeutics INC	Stock-Other	0.96%	+0.96%	NEW
35	ORKA	Oruka Therapeutics INC	Stock-Other	0.93%	+0.37%	+12.16%
36	ZBIO	Zenas Biopharma INC	Stock-Other	0.93%	+0.93%	NEW
37	DRUG	Bright Minds Biosciences INC	Stock-Other	0.90%	—	+5.13%
38	QDEL	Quidelortho CORP	Stock-Other	0.85%	+0.85%	NEW
39	ZBH	Zimmer Biomet Holdings INC	Stock-Healthcare	0.81%	-4.64%	-83.76%
40	REPL	Replimune Group INC	Stock-Other	0.79%	+0.79%	NEW
41	OGN	Organon & Co	Stock-Healthcare	0.74%	-3.12%	-74.69%
42	OKUR	Onkure Therapeutics Inc-a	Stock-Other	0.64%	+0.64%	NEW
43	IRON	Disc Medicine INC	Stock-Other	0.60%	—	+13.23%
44	PMVP	Pmv Pharmaceuticals INC	Stock-Other	0.55%	—	+16.69%
45	IMNM	Immunome INC	Stock-Other	0.52%	+0.52%	NEW
46	IART	Integra Lifesciences Holding	Stock-Other	0.52%	+0.52%	NEW
47	SVRA	Savara INC	Stock-Other	0.48%	—	—
48	CNC	Centene CORP	Stock-Healthcare	0.47%	-1.31%	-63.55%
49	✓	Proqr Thrapeutics N V	Stock-Other	0.45%	—	-9.68%
50	SI	Shoulder Innovations INC	Stock-Other	0.44%	—	-7.60%

1–50 of 76

Portfolio Performance

Performance for Q3 2026

+13.6%

Performance Last 4 Quarters

+86.5%

Based on 76% of reported portfolio value with available pricing

Stdev: +27.7%
Beta: +0.95
Alpha: +17.9%
Max Drawdown: -22.4%
Annualized Perf: +37.4%
Batting Avg vs S&P: +51.5%
Sortino: +3.4
Stutzer: +0.41
Treynor: +0.37
Sterling: +1.66
Calmar: +1.67
Information Ratio: +0.69
Tracking Error: +24.7%
Stdev Down: +10.5%
Winning Months %: +66.7%
Losing Months %: +33.3%
Best 12 Months: +90.4%
Worst 12 Months: -15.3%
Efficiency Ratio: +0.68
Sharpe: +1.29
Stdev Sectors: +30%
Skewness: +1.11
Kurtosis: +1.58
Upside Potential: +5.27

Reported value over time

Sector allocation

Sector allocation over time

Quarterly history

Period	Holdings	Total value	Stability	Top holdings
2026-03-31	76	$697.3M	94	1MMS 2WAY 3ICLR Top holdings2026-03-31 1.MMS 2.WAY 3.ICLR 4.COR 5.DNTH 6.AVR 7.CORT 8.LIVN 9.TYRA 10.CELC
2025-12-31	68	$635.7M	96	1CELC 2CI 3SNY Top holdings2025-12-31 1.CELC 2.CI 3.SNY 4.MMS 5.ZBH 6.RYTM 7.KVUE 8.OGN 9.ICLR 10.WAY
2025-09-30	51	$395.2M	100	1MMS 2CELC 3SNY Top holdings2025-09-30 1.MMS 2.CELC 3.SNY 4.DNTH 5.ALKS 6.IRON 7.MRK 8.HSIC 9.CNC 10.KVUE
2025-06-30	52	$261.8M	0	1MMS 2IRON 3GMED Top holdings2025-06-30 1.MMS 2.IRON 3.GMED 4.CNC 5.MRK 6.DRUG 7.NBIX 8.BMRN 9.ANNX 10.IDXX
2025-03-31	54	$335.8M	100	1ICLR 2MMS 3MRK Top holdings2025-03-31 1.ICLR 2.MMS 3.MRK 4.ZBH 5.NBIX 6.LH 7.DRUG 8.GMED 9.TFX 10.EMBC
2024-12-31	51	$355.4M	0	1ICLR 2MMS 3CI Top holdings2024-12-31 1.ICLR 2.MMS 3.CI 4.LH 5.SNY 6.ZBH 7.DRUG 8.AVR 9.ANNX 10.TFX
2024-09-30	39	$252.2M	0	1LH 2ISRG 3TEVA Top holdings2024-09-30 1.LH 2.ISRG 3.TEVA 4.MMS 5.ZBH 6.VXRT 7.KVUE 8.TFX 9.TYRA 10.IRON
2024-06-30	48	$369.5M	0	1INSM 2LH 3TFX Top holdings2024-06-30 1.INSM 2.LH 3.TFX 4.ZBH 5.SNN 6.PCRX 7.OGN 8.GSK 9.CRBP 10.VXRT
2024-03-31	51	$335.8M	0	150540R2INSM 3CI Top holdings2024-03-31 1.50540R 2.INSM 3.CI 4.GMED 5.MDGL 6.GSK 7.ZBH 8.IRWD 9.MDT 10.OGN
2023-12-31	43	$439.2M	0	1MRTXEUR238406L350540R Top holdings2023-12-31 1.MRTXEUR 2.38406L 3.50540R 4.CI 5.GMED 6.INSM 7.GSK 8.IMGNEUR 9.UTHR 10.EMBC
2023-09-30	52	$323.1M	0	150540R2GMED 3GSK Top holdings2023-09-30 1.50540R 2.GMED 3.GSK 4.UTHR 5.CI 6.GEHC 7.BCYC 8.PFE 9.OGN 10.TFX
2023-06-30	47	$393.2M	0	1GEHC 2SWAVUSD350540R Top holdings2023-06-30 1.GEHC 2.SWAVUSD 3.50540R 4.CI 5.BCYC 6.SYK 7.UTHR 8.MED 9.GSK 10.GMED
2023-03-31	44	$202.3M	0	1CNC 2CI 3BCYC Top holdings2023-03-31 1.CNC 2.CI 3.BCYC 4.COR 5.UTHR 6.GEHC 7.OGN 8.MDT 9.AVTR 10.H0036K
2022-12-31	47	$270.4M	0	174349U2G5960S3BCYC Top holdings2022-12-31 1.74349U 2.G5960S 3.BCYC 4.CI 5.OGN 6.UTHR 7.DGX 8.COR 9.MDT 10.STAA
2022-09-30	49	$314.7M	0	1COR 2APLSUSD 3GSK Top holdings2022-09-30 1.COR 2.APLSUSD 3.GSK 4.G5960S 5.RLMD 6.74349U 7.BCYC 8.OGN 9.CI 10.SNY
2022-06-30	62	$266.2M	0	1COR2G5960S3OGN Top holdings2022-06-30 1.COR 2.G5960S 3.OGN 4.CI 5.INGN 6.BCYC 7.CNC 8.HCA 9.UTHR 10.BHC
2022-03-31	66	$302.3M	0	1VRTX2G5960S3CI Top holdings2022-03-31 1.VRTX 2.G5960S 3.CI 4.MRK 5.SNY 6.50540R 7.INGN 8.COR 9.MCK 10.UTHR
2021-12-31	70	$331.7M	0	1CI2G5960S3CRISEUR Top holdings2021-12-31 1.CI 2.G5960S 3.CRISEUR 4.MRK 5.CAH 6.GLD 7.LKFT 8.MCK 9.COR 10.UTHR
2021-09-30	61	$313.7M	0	1CI 2CRISEUR 3GLD Top holdings2021-09-30 1.CI 2.CRISEUR 3.GLD 4.SOLY 5.UHS 6.HCA 7.LKFT 8.AVAH 9.CNC 10.UTHR
2021-06-30	74	$402.3M	70	1ASND 2CRISEUR 3CI Top holdings2021-06-30 1.ASND 2.CRISEUR 3.CI 4.SOLY 5.GLD 6.AVAH 7.HCA 8.CNC 9.UHS 10.MCK
2021-03-31	89	$492.7M	71	1CRISEUR 2CI 3CAH Top holdings2021-03-31 1.CRISEUR 2.CI 3.CAH 4.GLD 5.SOLY 6.CNC 7.HCA 8.SPRU 9.CHRS 10.HRC
2020-12-31	89	$488.5M	79	1CRISEUR 2CVM1EUR 3GLD Top holdings2020-12-31 1.CRISEUR 2.CVM1EUR 3.GLD 4.SPRU 5.CHRS 6.BDQM 7.HCA 8.AZNN 9.CI 10.COR
2020-09-30	89	$505.0M	86	15907172GLD 3CHRS Top holdings2020-09-30 1.590717 2.GLD 3.CHRS 4.MCK 5.JNJ 6.HRC 7.BDQM 8.AMN 9.COR 10.CVM1EUR
2020-06-30	78	$342.7M	94	1CHRS 2GLD 3MCK Top holdings2020-06-30 1.CHRS 2.GLD 3.MCK 4.TEVA 5.GWPH 6.COR 7.MOH 8.HRC 9.MRK 10.59045L
2020-03-31	69	$298.4M	100	1AMGN 2MCK 3CHRS Top holdings2020-03-31 1.AMGN 2.MCK 3.CHRS 4.CVM1EUR 5.GWPH 6.BIIB 7.ELV 8.BSX 9.NVST 10.G0177J
2019-12-31	69	$419.8M	93	1ITCIEUR 2GWPH3G0177J Top holdings2019-12-31 1.ITCIEUR 2.GWPH 3.G0177J 4.CHRS 5.MDT 6.HCA 7.MRK 8.PFE 9.WCGEUR 10.CVM1EUR
2019-09-30	63	$310.5M	100	1GWPH 2JNJ3G0177J Top holdings2019-09-30 1.GWPH 2.JNJ 3.G0177J 4.HCA 5.WCGEUR 6.CHRS 7.PFE 8.ALNY 9.MDT 10.MCK
2019-06-30	71	$414.8M	100	1ACAD 2GWPH 3HCA Top holdings2019-06-30 1.ACAD 2.GWPH 3.HCA 4.WCGEUR 5.GSK 6.MRTXEUR 7.MEDP 8.LJPC 9.ALNY 10.MDT
2019-03-31	70	$370.4M	98	1CVS 2GWPH 3BIIB Top holdings2019-03-31 1.CVS 2.GWPH 3.BIIB 4.GILD 5.HCA 6.MDT 7.DRNAUSD 8.GSK 9.MEDP 10.ASND
2018-12-31	69	$274.5M	100	1AMGN 2MDT 3SNY Top holdings2018-12-31 1.AMGN 2.MDT 3.SNY 4.ALNY 5.COR 6.CI 7.CVS 8.CAH 9.HCA 10.GWPH
2018-09-30	64	$291.5M	100	1GSK 2AMGN 3CI Top holdings2018-09-30 1.GSK 2.AMGN 3.CI 4.PCRX 5.KURA 6.00817Y 7.SNY 8.HCA 9.MEIPUSD 10.ALNY
2018-06-30	49	$180.9M	100	1KURA 2ELV 3HCA Top holdings2018-06-30 1.KURA 2.ELV 3.HCA 4.MEIPUSD 5.ICLR 6.00817Y 7.DB 8.CI 9.CAH 10.SNY
2018-03-31	31	$166.4M	100	114888D2SNY 3KURA Top holdings2018-03-31 1.14888D 2.SNY 3.KURA 4.ELV 5.BIIB 6.UNH 7.LLY 8.MRK 9.BSX 10.VKTX
2017-12-31	45	$177.3M	100	1SG7 2GSK300817Y Top holdings2017-12-31 1.SG7 2.GSK 3.00817Y 4.ELV 5.G73268 6.ISRG 7.UNH 8.KURA 9.VKTX 10.682159
2017-09-30	54	$192.7M	100	1G0750W2SG73G73268 Top holdings2017-09-30 1.G0750W 2.SG7 3.G73268 4.GSK 5.00547W 6.INSM 7.00817Y 8.AGIO 9.SGENEUR 10.BIIB
2017-06-30	58	$210.4M	92	1G732682JNJ 3SNY Top holdings2017-06-30 1.G73268 2.JNJ 3.SNY 4.ISRG 5.00817Y 6.HCA 7.00484M 8.PHG 9.G0177J 10.PBYI
2017-03-31	46	$178.8M	100	100484M2G732683SNY Top holdings2017-03-31 1.00484M 2.G73268 3.SNY 4.GSK 5.PHG 6.BIIB 7.SG7 8.RIGLUSD 9.PBYI 10.TRHCEUR
2016-12-31	43	$171.4M	93	1ACAD 2GSK3G73268 Top holdings2016-12-31 1.ACAD 2.GSK 3.G73268 4.CAH 5.AMGN 6.PHG 7.SNY 8.CERNCHF 9.HRC 10.TRHCEUR
2016-09-30	32	$145.0M	91	1G732682AMGN 3PHG Top holdings2016-09-30 1.G73268 2.AMGN 3.PHG 4.CAH 5.SNY 6.TRHCEUR 7.04685W 8.MDCOUSD 9.SRPT 10.HRC
2016-06-30	43	$195.8M	100	1G732682BIIB 3CERNCHF Top holdings2016-06-30 1.G73268 2.BIIB 3.CERNCHF 4.CAH 5.AMGN 6.04685W 7.PHG 8.SNY 9.NEOS 10.03674U
2016-03-31	42	$273.2M	100	1JAZZ2G732683NEOS Top holdings2016-03-31 1.JAZZ 2.G73268 3.NEOS 4.MCK 5.AMGN 6.03674U 7.CAH 8.82481R 9.JNJ 10.LLY
2015-12-31	42	$225.8M	100	1G73268226746E3SNY Top holdings2015-12-31 1.G73268 2.26746E 3.SNY 4.NEOS 5.MCK 6.AAAPGBP 7.451731 8.VSIUSD 9.CI 10.00547W
2015-09-30	35	$145.9M	100	1G732682NEOS 3JNJ Top holdings2015-09-30 1.G73268 2.NEOS 3.JNJ 4.MDT 5.CAH 6.UNH 7.SNY 8.CI 9.451731 10.AMGN
2015-06-30	39	$202.4M	100	1GILD2G732683GSK Top holdings2015-06-30 1.GILD 2.G73268 3.GSK 4.JNJ 5.451731 6.338488 7.PFNXEUR 8.MDT 9.PETXEUR 10.CAH
2015-03-31	30	$175.7M	100	1CELG2G732683PFNXEUR Top holdings2015-03-31 1.CELG 2.G73268 3.PFNXEUR 4.JNJ 5.MRK 6.LLY 7.AZNN 8.UTHR 9.CAH 10.00547W
2014-12-31	30	$127.3M	0	1G732682SNY 3GSK Top holdings2014-12-31 1.G73268 2.SNY 3.GSK 4.G2554F 5.00547W 6.PETXEUR 7.020409 8.14170T 9.CAH 10.AGRXUSD

Holding changes this quarter

Sio Capital Management, LLC's most significant position changes for 2026-03-31: Sold out: THE Cigna Group (CI); Sold out: Rhythm Pharmaceuticals INC (RYTM); New buy: Corcept Therapeutics INC (CORT); Sold out: Kenvue INC (KVUE); New buy: Gsk Plc-spon Adr (GSK).

Position changes disclosed by Sio Capital Management, LLC for the quarter ending 2026-03-31, including ticker, issuer, weight change, shares change, and action
#	Ticker	Issuer	Weight Change	Shares Change	Action
1	COR	Cencora INC	+3.7%	+534.55%	Add
2	AVR	Anteris Technologies Global	+2.8%	+187.15%	Add
3	WAY	Waystar Holding CORP	+2.5%	+167.59%	Add
4	ANIP	Ani Pharmaceuticals INC	+1.9%	+204.27%	Add
5	VIR	Vir Biotechnology INC	+1.5%	+213.29%	Add
6	DNTH	Dianthus Therapeutics INC	+1.4%	-22.01%	Trim
7	ABVX	Abivax Sa-adr	+1.3%	+214.91%	Add
8	ICLR	ICON Public Limited Company	+1.2%	+140.84%	Add
9	TYRA	Tyra Biosciences INC	+1.2%	+15.10%	Add
10	RAPP	Rapport Therapeutics INC	+0.8%	+97.99%	Add
11	LIVN	LivaNova PLC	+0.7%	+30.78%	Add
12	HAE	Haemonetics Corp/mass	+0.6%	+138.23%	Add
13	CRNX	Crinetics Pharmaceuticals In	+0.4%	+100.16%	Add
14	ORKA	Oruka Therapeutics INC	+0.4%	+12.16%	Add
15	EWTX	Edgewise Therapeutics INC	+0.3%	+13.27%	Add
16	MMS	Maximus INC	+0.3%	+53.67%	Add
17	BMRN	Biomarin Pharmaceutical INC	-0.6%	-16.53%	Trim
18	GPCR	Structure Therapeutics INC	-0.8%	+3.77%	Add
19	BHVN	Biohaven Ltd.	-0.8%	-6.49%	Trim
20	CNC	Centene CORP	-1.3%	-63.55%	Trim
21	OGN	Organon & Co	-3.1%	-74.69%	Trim
22	CELC	Celcuity INC	-4.3%	-59.37%	Trim
23	ZBH	Zimmer Biomet Holdings INC	-4.6%	-83.76%	Trim
24	SNY	Sanofi-adr	-5.8%	-75.33%	Trim
25	CI	THE Cigna Group	—	EXIT	Sold out
26	RYTM	Rhythm Pharmaceuticals INC	—	EXIT	Sold out
27	CORT	Corcept Therapeutics INC	—	NEW	New buy
28	KVUE	Kenvue INC	—	EXIT	Sold out
29	GSK	Gsk Plc-spon Adr	—	NEW	New buy
30	ABT	Abbott Laboratories	—	NEW	New buy
31	EMBC	Embecta CORP	—	NEW	New buy
32	SION	Sionna Therapeutics INC	—	NEW	New buy
33	BTSG	Brightspring Health Services	—	EXIT	Sold out
34	CRL	Charles River Laboratories	—	EXIT	Sold out
35	MNPR	Monopar Therapeutics INC	—	NEW	New buy
36	EYPT	Eyepoint INC	—	NEW	New buy
37	CMPS	Compass Pathways PLC	—	NEW	New buy
38	OCUL	Ocular Therapeutix INC	—	NEW	New buy
39	RLMD	Relmada Therapeutics INC	—	NEW	New buy
40	ZBIO	Zenas Biopharma INC	—	NEW	New buy
41	QDEL	Quidelortho CORP	—	NEW	New buy
42	REPL	Replimune Group INC	—	NEW	New buy
43	MCK	Mckesson CORP	—	EXIT	Sold out
44	OKUR	Onkure Therapeutics Inc-a	—	NEW	New buy
45	FULC	Fulcrum Therapeutics INC	—	EXIT	Sold out
46	IMNM	Immunome INC	—	NEW	New buy
47	IART	Integra Lifesciences Holding	—	NEW	New buy
48	VTYXUSD	Ventyx Biosciences INC	—	EXIT	Sold out
49	ALKS	Alkermes plc	—	EXIT	Sold out
50	IDYA	Ideaya Biosciences INC	—	EXIT	Sold out

Filing History

Period	Filed	Type	EDGAR
2026-03-31	2026-05-14	13F-HR	View on EDGAR
2025-12-31	2026-02-17	13F-HR	View on EDGAR
2025-09-30	2025-11-13	13F-HR	View on EDGAR
2025-06-30	2025-08-13	13F-HR	View on EDGAR
2025-03-31	2025-05-15	13F-HR	View on EDGAR
2024-12-31	2025-02-14	13F-HR	View on EDGAR
2024-09-30	2024-11-14	13F-HR	View on EDGAR
2024-06-30	2024-08-14	13F-HR	View on EDGAR
2024-03-31	2024-05-15	13F-HR	View on EDGAR
2023-12-31	2024-02-13	13F-HR	View on EDGAR
2023-09-30	2023-11-14	13F-HR	View on EDGAR
2023-06-30	2023-08-14	13F-HR	View on EDGAR
2023-03-31	2023-05-12	13F-HR	View on EDGAR
2022-12-31	2023-02-13	13F-HR	View on EDGAR
2022-09-30	2022-11-14	13F-HR	View on EDGAR
2022-06-30	2022-08-15	13F-HR	View on EDGAR
2022-03-31	2022-05-16	13F-HR	View on EDGAR
2021-12-31	2022-02-14	13F-HR	View on EDGAR
2021-09-30	2021-11-15	13F-HR	View on EDGAR
2021-06-30	2021-08-16	13F-HR	View on EDGAR
2021-03-31	2021-05-14	13F-HR	View on EDGAR
2020-12-31	2021-02-16	13F-HR	View on EDGAR
2020-09-30	2020-11-16	13F-HR	View on EDGAR
2020-06-30	2020-08-14	13F-HR	View on EDGAR
2020-03-31	2020-05-15	13F-HR	View on EDGAR
2019-12-31	2020-02-14	13F-HR	View on EDGAR
2019-09-30	2019-11-14	13F-HR	View on EDGAR
2019-06-30	2019-08-14	13F-HR	View on EDGAR
2019-03-31	2019-05-15	13F-HR	View on EDGAR
2018-12-31	2019-02-14	13F-HR	View on EDGAR
2018-09-30	2018-11-14	13F-HR	View on EDGAR
2018-06-30	2018-08-14	13F-HR	View on EDGAR
2018-03-31	2018-05-15	13F-HR	View on EDGAR
2017-12-31	2018-02-14	13F-HR	View on EDGAR
2017-09-30	2017-11-14	13F-HR	View on EDGAR
2017-06-30	2017-08-14	13F-HR	View on EDGAR
2017-03-31	2017-05-15	13F-HR	View on EDGAR
2016-12-31	2017-02-14	13F-HR	View on EDGAR
2016-09-30	2016-11-15	13F-HR	View on EDGAR
2016-06-30	2016-08-15	13F-HR	View on EDGAR
2016-03-31	2016-05-16	13F-HR	View on EDGAR
2015-12-31	2016-02-16	13F-HR	View on EDGAR
2015-09-30	2015-11-13	13F-HR	View on EDGAR
2015-06-30	2015-08-14	13F-HR	View on EDGAR
2015-03-31	2015-05-15	13F-HR	View on EDGAR
2014-12-31	2015-02-17	13F-HR	View on EDGAR

FAQ

What is Sio Capital Management, LLC and what type of investor is it?

Sio Capital Management, LLC is a investment manager that files SEC Form 13F quarterly, disclosing its U.S. public equity holdings to regulators. As of the most recent reporting period (2026-03-31), the firm manages a tracked equity portfolio valued at approximately $697.3M, spread across 76 disclosed positions.

What are Sio Capital Management, LLC's largest equity positions?

Based on the latest 13F filing, Sio Capital Management, LLC's top holdings by market value are: 1. Maximus INC (MMS) — $49.3M (7.1%) 2. Waystar Holding CORP (WAY) — $39.6M (5.7%) 3. ICON Public Limited Company (ICLR) — $33.9M (4.9%) 4. Cencora INC (COR) — $31.7M (4.5%) 5. Dianthus Therapeutics INC (DNTH) — $31.1M (4.5%)

What changes did Sio Capital Management, LLC make in its most recent portfolio filing?

In the latest reported quarter, Sio Capital Management, LLC made 50 notable position adjustments: 16 new positions were initiated, 16 existing holdings were added to, 8 positions were partially reduced, and 10 were completely exited. The largest of these moves: Sold out: THE Cigna Group (CI); Sold out: Rhythm Pharmaceuticals INC (RYTM); New buy: Corcept Therapeutics INC (CORT); Sold out: Kenvue INC (KVUE); New buy: Gsk Plc-spon Adr (GSK)

What sectors does Sio Capital Management, LLC focus on?

Sio Capital Management, LLC is concentrated in the following sectors based on its current disclosed equity portfolio: • Health Care: 80.0% • Industrials: 20.0%

Peer Institutions

Institutions with a similar AUM

Abundance Wealth Counselors

CIK 0001767080

Total reported value

$697.2M

246 stks

2026-03-31

Concentration24.2

Portfolio Stability20.9

Sector conviction65.0

AUM within 0.0% of this institution

View detail

Allied Investment Advisors, LLC

CIK 0001729869

Total reported value

$697.4M

100 stks

2026-03-31

Concentration11.7

Portfolio Stability15.1

Sector conviction51.0

AUM within 0.0% of this institution

View detail

Mraz, Amerine & Associates, Inc.

CIK 0001542324

Total reported value

$697.1M

199 stks

2026-06-30

Concentration16.4

Portfolio Stability11.2

Sector conviction100.0

AUM within 0.0% of this institution

View detail

Similar Holdings Style

Institutions with overlapping top holdings

Hudson Edge Investment Partners INC.

CIK 0000740272

Total reported value

$684.3M

101 stks

2026-03-31

Concentration17.2

Portfolio Stability18.5

Sector conviction88.8

1 of the top 5 holdings overlap, including ICON Public Limited Company

View detail

Eagle Asset Management INC

CIK 0000790502

Total reported value

$19.6B

547 stks

2024-09-30

Stale — no recent filing

Concentration2.7

Portfolio Stability0.0

Sector conviction44.6

1 of the top 5 holdings overlap, including Cencora INC

View detail

William Harris Investors INC

CIK 0000928204

Total reported value

$347.5M

129 stks

2016-12-31

Stale — no recent filing

Concentration14.0

Portfolio Stability72.1

Sector conviction100.0

1 of the top 5 holdings overlap, including Cencora INC

View detail

Sio Capital Management, LLC 13F Holdings Overview (76 Positions)

CIK: 0001482416

Diversified strategyHigh-turnover traderSector-focused

Total reported value

$697.3M

Reporting period: 2026-03-31 · Number of holdings: 76

Sio Capital Management, LLC disclosed 76 holdings in its latest 13F filing for the period ending 2026-03-31, with total reported value of $697.3M and a quarterly turnover rate of 94.1%.

Browse other institutions with $100M to $1B AUM Browse other institutions starting with "S"

Personality snowflake

Concentration: 12.02
Portfolio Stability: 94.14
Momentum/Contrarian: 100
Sector conviction: 100
Diversification: 100
Sizing Uniformity: 88.59

Position sizes are fairly uniform across the portfolio (a coefficient of variation of 1.14), suggesting a disciplined, rules-based approach to how much capital goes into each idea.

No strong tilt toward either adding to existing winners or initiating outsized new positions was observed in the latest reported quarter.

Recent moves

Trim SNY
-75.3%　-$35.5M
Trim ZBH
-83.8%　-$29.0M
Trim CELC
-59.4%　-$25.5M
Add COR
+534.6%　$26.3M
Trim OGN
-74.7%　-$19.3M
Add AVR
+187.1%　$20.5M

Holdings Map

New buyAddUnchangedTrim

Top 10 holdings by weight

Full holdings list this quarter

#	Ticker	Issuer	Asset Subclass	Weight	Weight Change	Shares Change
1	MMS	Maximus INC	Stock-Industrials	7.07%	+0.28%	+53.67%
2	WAY	Waystar Holding CORP	Stock-Other	5.68%	+2.52%	+167.59%
3	ICLR	ICON Public Limited Company	Stock-Healthcare	4.86%	+1.21%	+140.84%
4	COR	Cencora INC	Stock-Healthcare	4.55%	+3.71%	+534.55%
5	DNTH	Dianthus Therapeutics INC	Stock-Other	4.45%	+1.37%	-22.01%
6	AVR	Anteris Technologies Global	Stock-Other	4.28%	+2.81%	+187.15%
7	CORT	Corcept Therapeutics INC	Stock-Healthcare	3.90%	+3.90%	NEW
8	LIVN	LivaNova PLC	Stock-Other	3.84%	+0.72%	+30.78%
9	TYRA	Tyra Biosciences INC	Stock-Other	3.33%	+1.15%	+15.10%
10	CELC	Celcuity INC	Stock-Other	3.17%	-4.31%	-59.37%
11	GSK	Gsk Plc-spon Adr	Stock-Healthcare	3.05%	+3.05%	NEW
12	ANIP	Ani Pharmaceuticals INC	Stock-Other	2.93%	+1.85%	+204.27%
13	ABT	Abbott Laboratories	Stock-Healthcare	2.75%	+2.75%	NEW
14	EMBC	Embecta CORP	Stock-Healthcare	2.34%	+2.34%	NEW
15	ABVX	Abivax Sa-adr	Stock-Other	2.17%	+1.26%	+214.91%
16	VIR	Vir Biotechnology INC	Stock-Other	1.93%	+1.48%	+213.29%
17	HAE	Haemonetics Corp/mass	Stock-Other	1.78%	+0.61%	+138.23%
18	SION	Sionna Therapeutics INC	Stock-Other	1.69%	+1.69%	NEW
19	SNY	Sanofi-adr	Stock-Healthcare	1.66%	-5.75%	-75.33%
20	RAPP	Rapport Therapeutics INC	Stock-Other	1.65%	+0.77%	+97.99%
21	TFX	Teleflex INC	Stock-Healthcare	1.63%	—	+9.12%
22	BMRN	Biomarin Pharmaceutical INC	Stock-Healthcare	1.57%	-0.61%	-16.53%
23	CCRN	Cross Country Healthcare INC	Stock-Other	1.48%	—	+2.77%
24	TARA	Protara Therapeutic INC	Stock-Other	1.47%	—	+14.83%
25	GPCR	Structure Therapeutics INC	Stock-Other	1.45%	-0.75%	+3.77%
26	BHVN	Biohaven Ltd.	Stock-Other	1.41%	-0.80%	-6.49%
27	MNPR	Monopar Therapeutics INC	Stock-Other	1.36%	+1.36%	NEW
28	EYPT	Eyepoint INC	Stock-Other	1.33%	+1.33%	NEW
29	CRNX	Crinetics Pharmaceuticals In	Stock-Other	1.30%	+0.39%	+100.16%
30	EWTX	Edgewise Therapeutics INC	Stock-Other	1.22%	+0.29%	+13.27%
31	CMPS	Compass Pathways PLC	Stock-Other	1.19%	+1.19%	NEW
32	OCUL	Ocular Therapeutix INC	Stock-Other	1.18%	+1.18%	NEW
33	AQST	Aquestive Therapeutics INC	Stock-Other	1.14%	—	+93.63%
34	RLMD	Relmada Therapeutics INC	Stock-Other	0.96%	+0.96%	NEW
35	ORKA	Oruka Therapeutics INC	Stock-Other	0.93%	+0.37%	+12.16%
36	ZBIO	Zenas Biopharma INC	Stock-Other	0.93%	+0.93%	NEW
37	DRUG	Bright Minds Biosciences INC	Stock-Other	0.90%	—	+5.13%
38	QDEL	Quidelortho CORP	Stock-Other	0.85%	+0.85%	NEW
39	ZBH	Zimmer Biomet Holdings INC	Stock-Healthcare	0.81%	-4.64%	-83.76%
40	REPL	Replimune Group INC	Stock-Other	0.79%	+0.79%	NEW
41	OGN	Organon & Co	Stock-Healthcare	0.74%	-3.12%	-74.69%
42	OKUR	Onkure Therapeutics Inc-a	Stock-Other	0.64%	+0.64%	NEW
43	IRON	Disc Medicine INC	Stock-Other	0.60%	—	+13.23%
44	PMVP	Pmv Pharmaceuticals INC	Stock-Other	0.55%	—	+16.69%
45	IMNM	Immunome INC	Stock-Other	0.52%	+0.52%	NEW
46	IART	Integra Lifesciences Holding	Stock-Other	0.52%	+0.52%	NEW
47	SVRA	Savara INC	Stock-Other	0.48%	—	—
48	CNC	Centene CORP	Stock-Healthcare	0.47%	-1.31%	-63.55%
49	✓	Proqr Thrapeutics N V	Stock-Other	0.45%	—	-9.68%
50	SI	Shoulder Innovations INC	Stock-Other	0.44%	—	-7.60%

1–50 of 76

Portfolio Performance

Performance for Q3 2026

+13.6%

Performance Last 4 Quarters

+86.5%

Based on 76% of reported portfolio value with available pricing

Stdev: +27.7%
Beta: +0.95
Alpha: +17.9%
Max Drawdown: -22.4%
Annualized Perf: +37.4%
Batting Avg vs S&P: +51.5%
Sortino: +3.4
Stutzer: +0.41
Treynor: +0.37
Sterling: +1.66
Calmar: +1.67
Information Ratio: +0.69
Tracking Error: +24.7%
Stdev Down: +10.5%
Winning Months %: +66.7%
Losing Months %: +33.3%
Best 12 Months: +90.4%
Worst 12 Months: -15.3%
Efficiency Ratio: +0.68
Sharpe: +1.29
Stdev Sectors: +30%
Skewness: +1.11
Kurtosis: +1.58
Upside Potential: +5.27

Reported value over time

Sector allocation

Sector allocation over time

Quarterly history

Period	Holdings	Total value	Stability	Top holdings
2026-03-31	76	$697.3M	94	1MMS 2WAY 3ICLR Top holdings2026-03-31 1.MMS 2.WAY 3.ICLR 4.COR 5.DNTH 6.AVR 7.CORT 8.LIVN 9.TYRA 10.CELC
2025-12-31	68	$635.7M	96	1CELC 2CI 3SNY Top holdings2025-12-31 1.CELC 2.CI 3.SNY 4.MMS 5.ZBH 6.RYTM 7.KVUE 8.OGN 9.ICLR 10.WAY
2025-09-30	51	$395.2M	100	1MMS 2CELC 3SNY Top holdings2025-09-30 1.MMS 2.CELC 3.SNY 4.DNTH 5.ALKS 6.IRON 7.MRK 8.HSIC 9.CNC 10.KVUE
2025-06-30	52	$261.8M	0	1MMS 2IRON 3GMED Top holdings2025-06-30 1.MMS 2.IRON 3.GMED 4.CNC 5.MRK 6.DRUG 7.NBIX 8.BMRN 9.ANNX 10.IDXX
2025-03-31	54	$335.8M	100	1ICLR 2MMS 3MRK Top holdings2025-03-31 1.ICLR 2.MMS 3.MRK 4.ZBH 5.NBIX 6.LH 7.DRUG 8.GMED 9.TFX 10.EMBC
2024-12-31	51	$355.4M	0	1ICLR 2MMS 3CI Top holdings2024-12-31 1.ICLR 2.MMS 3.CI 4.LH 5.SNY 6.ZBH 7.DRUG 8.AVR 9.ANNX 10.TFX
2024-09-30	39	$252.2M	0	1LH 2ISRG 3TEVA Top holdings2024-09-30 1.LH 2.ISRG 3.TEVA 4.MMS 5.ZBH 6.VXRT 7.KVUE 8.TFX 9.TYRA 10.IRON
2024-06-30	48	$369.5M	0	1INSM 2LH 3TFX Top holdings2024-06-30 1.INSM 2.LH 3.TFX 4.ZBH 5.SNN 6.PCRX 7.OGN 8.GSK 9.CRBP 10.VXRT
2024-03-31	51	$335.8M	0	150540R2INSM 3CI Top holdings2024-03-31 1.50540R 2.INSM 3.CI 4.GMED 5.MDGL 6.GSK 7.ZBH 8.IRWD 9.MDT 10.OGN
2023-12-31	43	$439.2M	0	1MRTXEUR238406L350540R Top holdings2023-12-31 1.MRTXEUR 2.38406L 3.50540R 4.CI 5.GMED 6.INSM 7.GSK 8.IMGNEUR 9.UTHR 10.EMBC
2023-09-30	52	$323.1M	0	150540R2GMED 3GSK Top holdings2023-09-30 1.50540R 2.GMED 3.GSK 4.UTHR 5.CI 6.GEHC 7.BCYC 8.PFE 9.OGN 10.TFX
2023-06-30	47	$393.2M	0	1GEHC 2SWAVUSD350540R Top holdings2023-06-30 1.GEHC 2.SWAVUSD 3.50540R 4.CI 5.BCYC 6.SYK 7.UTHR 8.MED 9.GSK 10.GMED
2023-03-31	44	$202.3M	0	1CNC 2CI 3BCYC Top holdings2023-03-31 1.CNC 2.CI 3.BCYC 4.COR 5.UTHR 6.GEHC 7.OGN 8.MDT 9.AVTR 10.H0036K
2022-12-31	47	$270.4M	0	174349U2G5960S3BCYC Top holdings2022-12-31 1.74349U 2.G5960S 3.BCYC 4.CI 5.OGN 6.UTHR 7.DGX 8.COR 9.MDT 10.STAA
2022-09-30	49	$314.7M	0	1COR 2APLSUSD 3GSK Top holdings2022-09-30 1.COR 2.APLSUSD 3.GSK 4.G5960S 5.RLMD 6.74349U 7.BCYC 8.OGN 9.CI 10.SNY
2022-06-30	62	$266.2M	0	1COR2G5960S3OGN Top holdings2022-06-30 1.COR 2.G5960S 3.OGN 4.CI 5.INGN 6.BCYC 7.CNC 8.HCA 9.UTHR 10.BHC
2022-03-31	66	$302.3M	0	1VRTX2G5960S3CI Top holdings2022-03-31 1.VRTX 2.G5960S 3.CI 4.MRK 5.SNY 6.50540R 7.INGN 8.COR 9.MCK 10.UTHR
2021-12-31	70	$331.7M	0	1CI2G5960S3CRISEUR Top holdings2021-12-31 1.CI 2.G5960S 3.CRISEUR 4.MRK 5.CAH 6.GLD 7.LKFT 8.MCK 9.COR 10.UTHR
2021-09-30	61	$313.7M	0	1CI 2CRISEUR 3GLD Top holdings2021-09-30 1.CI 2.CRISEUR 3.GLD 4.SOLY 5.UHS 6.HCA 7.LKFT 8.AVAH 9.CNC 10.UTHR
2021-06-30	74	$402.3M	70	1ASND 2CRISEUR 3CI Top holdings2021-06-30 1.ASND 2.CRISEUR 3.CI 4.SOLY 5.GLD 6.AVAH 7.HCA 8.CNC 9.UHS 10.MCK
2021-03-31	89	$492.7M	71	1CRISEUR 2CI 3CAH Top holdings2021-03-31 1.CRISEUR 2.CI 3.CAH 4.GLD 5.SOLY 6.CNC 7.HCA 8.SPRU 9.CHRS 10.HRC
2020-12-31	89	$488.5M	79	1CRISEUR 2CVM1EUR 3GLD Top holdings2020-12-31 1.CRISEUR 2.CVM1EUR 3.GLD 4.SPRU 5.CHRS 6.BDQM 7.HCA 8.AZNN 9.CI 10.COR
2020-09-30	89	$505.0M	86	15907172GLD 3CHRS Top holdings2020-09-30 1.590717 2.GLD 3.CHRS 4.MCK 5.JNJ 6.HRC 7.BDQM 8.AMN 9.COR 10.CVM1EUR
2020-06-30	78	$342.7M	94	1CHRS 2GLD 3MCK Top holdings2020-06-30 1.CHRS 2.GLD 3.MCK 4.TEVA 5.GWPH 6.COR 7.MOH 8.HRC 9.MRK 10.59045L
2020-03-31	69	$298.4M	100	1AMGN 2MCK 3CHRS Top holdings2020-03-31 1.AMGN 2.MCK 3.CHRS 4.CVM1EUR 5.GWPH 6.BIIB 7.ELV 8.BSX 9.NVST 10.G0177J
2019-12-31	69	$419.8M	93	1ITCIEUR 2GWPH3G0177J Top holdings2019-12-31 1.ITCIEUR 2.GWPH 3.G0177J 4.CHRS 5.MDT 6.HCA 7.MRK 8.PFE 9.WCGEUR 10.CVM1EUR
2019-09-30	63	$310.5M	100	1GWPH 2JNJ3G0177J Top holdings2019-09-30 1.GWPH 2.JNJ 3.G0177J 4.HCA 5.WCGEUR 6.CHRS 7.PFE 8.ALNY 9.MDT 10.MCK
2019-06-30	71	$414.8M	100	1ACAD 2GWPH 3HCA Top holdings2019-06-30 1.ACAD 2.GWPH 3.HCA 4.WCGEUR 5.GSK 6.MRTXEUR 7.MEDP 8.LJPC 9.ALNY 10.MDT
2019-03-31	70	$370.4M	98	1CVS 2GWPH 3BIIB Top holdings2019-03-31 1.CVS 2.GWPH 3.BIIB 4.GILD 5.HCA 6.MDT 7.DRNAUSD 8.GSK 9.MEDP 10.ASND
2018-12-31	69	$274.5M	100	1AMGN 2MDT 3SNY Top holdings2018-12-31 1.AMGN 2.MDT 3.SNY 4.ALNY 5.COR 6.CI 7.CVS 8.CAH 9.HCA 10.GWPH
2018-09-30	64	$291.5M	100	1GSK 2AMGN 3CI Top holdings2018-09-30 1.GSK 2.AMGN 3.CI 4.PCRX 5.KURA 6.00817Y 7.SNY 8.HCA 9.MEIPUSD 10.ALNY
2018-06-30	49	$180.9M	100	1KURA 2ELV 3HCA Top holdings2018-06-30 1.KURA 2.ELV 3.HCA 4.MEIPUSD 5.ICLR 6.00817Y 7.DB 8.CI 9.CAH 10.SNY
2018-03-31	31	$166.4M	100	114888D2SNY 3KURA Top holdings2018-03-31 1.14888D 2.SNY 3.KURA 4.ELV 5.BIIB 6.UNH 7.LLY 8.MRK 9.BSX 10.VKTX
2017-12-31	45	$177.3M	100	1SG7 2GSK300817Y Top holdings2017-12-31 1.SG7 2.GSK 3.00817Y 4.ELV 5.G73268 6.ISRG 7.UNH 8.KURA 9.VKTX 10.682159
2017-09-30	54	$192.7M	100	1G0750W2SG73G73268 Top holdings2017-09-30 1.G0750W 2.SG7 3.G73268 4.GSK 5.00547W 6.INSM 7.00817Y 8.AGIO 9.SGENEUR 10.BIIB
2017-06-30	58	$210.4M	92	1G732682JNJ 3SNY Top holdings2017-06-30 1.G73268 2.JNJ 3.SNY 4.ISRG 5.00817Y 6.HCA 7.00484M 8.PHG 9.G0177J 10.PBYI
2017-03-31	46	$178.8M	100	100484M2G732683SNY Top holdings2017-03-31 1.00484M 2.G73268 3.SNY 4.GSK 5.PHG 6.BIIB 7.SG7 8.RIGLUSD 9.PBYI 10.TRHCEUR
2016-12-31	43	$171.4M	93	1ACAD 2GSK3G73268 Top holdings2016-12-31 1.ACAD 2.GSK 3.G73268 4.CAH 5.AMGN 6.PHG 7.SNY 8.CERNCHF 9.HRC 10.TRHCEUR
2016-09-30	32	$145.0M	91	1G732682AMGN 3PHG Top holdings2016-09-30 1.G73268 2.AMGN 3.PHG 4.CAH 5.SNY 6.TRHCEUR 7.04685W 8.MDCOUSD 9.SRPT 10.HRC
2016-06-30	43	$195.8M	100	1G732682BIIB 3CERNCHF Top holdings2016-06-30 1.G73268 2.BIIB 3.CERNCHF 4.CAH 5.AMGN 6.04685W 7.PHG 8.SNY 9.NEOS 10.03674U
2016-03-31	42	$273.2M	100	1JAZZ2G732683NEOS Top holdings2016-03-31 1.JAZZ 2.G73268 3.NEOS 4.MCK 5.AMGN 6.03674U 7.CAH 8.82481R 9.JNJ 10.LLY
2015-12-31	42	$225.8M	100	1G73268226746E3SNY Top holdings2015-12-31 1.G73268 2.26746E 3.SNY 4.NEOS 5.MCK 6.AAAPGBP 7.451731 8.VSIUSD 9.CI 10.00547W
2015-09-30	35	$145.9M	100	1G732682NEOS 3JNJ Top holdings2015-09-30 1.G73268 2.NEOS 3.JNJ 4.MDT 5.CAH 6.UNH 7.SNY 8.CI 9.451731 10.AMGN
2015-06-30	39	$202.4M	100	1GILD2G732683GSK Top holdings2015-06-30 1.GILD 2.G73268 3.GSK 4.JNJ 5.451731 6.338488 7.PFNXEUR 8.MDT 9.PETXEUR 10.CAH
2015-03-31	30	$175.7M	100	1CELG2G732683PFNXEUR Top holdings2015-03-31 1.CELG 2.G73268 3.PFNXEUR 4.JNJ 5.MRK 6.LLY 7.AZNN 8.UTHR 9.CAH 10.00547W
2014-12-31	30	$127.3M	0	1G732682SNY 3GSK Top holdings2014-12-31 1.G73268 2.SNY 3.GSK 4.G2554F 5.00547W 6.PETXEUR 7.020409 8.14170T 9.CAH 10.AGRXUSD

Holding changes this quarter

Position changes disclosed by Sio Capital Management, LLC for the quarter ending 2026-03-31, including ticker, issuer, weight change, shares change, and action
#	Ticker	Issuer	Weight Change	Shares Change	Action
1	COR	Cencora INC	+3.7%	+534.55%	Add
2	AVR	Anteris Technologies Global	+2.8%	+187.15%	Add
3	WAY	Waystar Holding CORP	+2.5%	+167.59%	Add
4	ANIP	Ani Pharmaceuticals INC	+1.9%	+204.27%	Add
5	VIR	Vir Biotechnology INC	+1.5%	+213.29%	Add
6	DNTH	Dianthus Therapeutics INC	+1.4%	-22.01%	Trim
7	ABVX	Abivax Sa-adr	+1.3%	+214.91%	Add
8	ICLR	ICON Public Limited Company	+1.2%	+140.84%	Add
9	TYRA	Tyra Biosciences INC	+1.2%	+15.10%	Add
10	RAPP	Rapport Therapeutics INC	+0.8%	+97.99%	Add
11	LIVN	LivaNova PLC	+0.7%	+30.78%	Add
12	HAE	Haemonetics Corp/mass	+0.6%	+138.23%	Add
13	CRNX	Crinetics Pharmaceuticals In	+0.4%	+100.16%	Add
14	ORKA	Oruka Therapeutics INC	+0.4%	+12.16%	Add
15	EWTX	Edgewise Therapeutics INC	+0.3%	+13.27%	Add
16	MMS	Maximus INC	+0.3%	+53.67%	Add
17	BMRN	Biomarin Pharmaceutical INC	-0.6%	-16.53%	Trim
18	GPCR	Structure Therapeutics INC	-0.8%	+3.77%	Add
19	BHVN	Biohaven Ltd.	-0.8%	-6.49%	Trim
20	CNC	Centene CORP	-1.3%	-63.55%	Trim
21	OGN	Organon & Co	-3.1%	-74.69%	Trim
22	CELC	Celcuity INC	-4.3%	-59.37%	Trim
23	ZBH	Zimmer Biomet Holdings INC	-4.6%	-83.76%	Trim
24	SNY	Sanofi-adr	-5.8%	-75.33%	Trim
25	CI	THE Cigna Group	—	EXIT	Sold out
26	RYTM	Rhythm Pharmaceuticals INC	—	EXIT	Sold out
27	CORT	Corcept Therapeutics INC	—	NEW	New buy
28	KVUE	Kenvue INC	—	EXIT	Sold out
29	GSK	Gsk Plc-spon Adr	—	NEW	New buy
30	ABT	Abbott Laboratories	—	NEW	New buy
31	EMBC	Embecta CORP	—	NEW	New buy
32	SION	Sionna Therapeutics INC	—	NEW	New buy
33	BTSG	Brightspring Health Services	—	EXIT	Sold out
34	CRL	Charles River Laboratories	—	EXIT	Sold out
35	MNPR	Monopar Therapeutics INC	—	NEW	New buy
36	EYPT	Eyepoint INC	—	NEW	New buy
37	CMPS	Compass Pathways PLC	—	NEW	New buy
38	OCUL	Ocular Therapeutix INC	—	NEW	New buy
39	RLMD	Relmada Therapeutics INC	—	NEW	New buy
40	ZBIO	Zenas Biopharma INC	—	NEW	New buy
41	QDEL	Quidelortho CORP	—	NEW	New buy
42	REPL	Replimune Group INC	—	NEW	New buy
43	MCK	Mckesson CORP	—	EXIT	Sold out
44	OKUR	Onkure Therapeutics Inc-a	—	NEW	New buy
45	FULC	Fulcrum Therapeutics INC	—	EXIT	Sold out
46	IMNM	Immunome INC	—	NEW	New buy
47	IART	Integra Lifesciences Holding	—	NEW	New buy
48	VTYXUSD	Ventyx Biosciences INC	—	EXIT	Sold out
49	ALKS	Alkermes plc	—	EXIT	Sold out
50	IDYA	Ideaya Biosciences INC	—	EXIT	Sold out

Filing History

Period	Filed	Type	EDGAR
2026-03-31	2026-05-14	13F-HR	View on EDGAR
2025-12-31	2026-02-17	13F-HR	View on EDGAR
2025-09-30	2025-11-13	13F-HR	View on EDGAR
2025-06-30	2025-08-13	13F-HR	View on EDGAR
2025-03-31	2025-05-15	13F-HR	View on EDGAR
2024-12-31	2025-02-14	13F-HR	View on EDGAR
2024-09-30	2024-11-14	13F-HR	View on EDGAR
2024-06-30	2024-08-14	13F-HR	View on EDGAR
2024-03-31	2024-05-15	13F-HR	View on EDGAR
2023-12-31	2024-02-13	13F-HR	View on EDGAR
2023-09-30	2023-11-14	13F-HR	View on EDGAR
2023-06-30	2023-08-14	13F-HR	View on EDGAR
2023-03-31	2023-05-12	13F-HR	View on EDGAR
2022-12-31	2023-02-13	13F-HR	View on EDGAR
2022-09-30	2022-11-14	13F-HR	View on EDGAR
2022-06-30	2022-08-15	13F-HR	View on EDGAR
2022-03-31	2022-05-16	13F-HR	View on EDGAR
2021-12-31	2022-02-14	13F-HR	View on EDGAR
2021-09-30	2021-11-15	13F-HR	View on EDGAR
2021-06-30	2021-08-16	13F-HR	View on EDGAR
2021-03-31	2021-05-14	13F-HR	View on EDGAR
2020-12-31	2021-02-16	13F-HR	View on EDGAR
2020-09-30	2020-11-16	13F-HR	View on EDGAR
2020-06-30	2020-08-14	13F-HR	View on EDGAR
2020-03-31	2020-05-15	13F-HR	View on EDGAR
2019-12-31	2020-02-14	13F-HR	View on EDGAR
2019-09-30	2019-11-14	13F-HR	View on EDGAR
2019-06-30	2019-08-14	13F-HR	View on EDGAR
2019-03-31	2019-05-15	13F-HR	View on EDGAR
2018-12-31	2019-02-14	13F-HR	View on EDGAR
2018-09-30	2018-11-14	13F-HR	View on EDGAR
2018-06-30	2018-08-14	13F-HR	View on EDGAR
2018-03-31	2018-05-15	13F-HR	View on EDGAR
2017-12-31	2018-02-14	13F-HR	View on EDGAR
2017-09-30	2017-11-14	13F-HR	View on EDGAR
2017-06-30	2017-08-14	13F-HR	View on EDGAR
2017-03-31	2017-05-15	13F-HR	View on EDGAR
2016-12-31	2017-02-14	13F-HR	View on EDGAR
2016-09-30	2016-11-15	13F-HR	View on EDGAR
2016-06-30	2016-08-15	13F-HR	View on EDGAR
2016-03-31	2016-05-16	13F-HR	View on EDGAR
2015-12-31	2016-02-16	13F-HR	View on EDGAR
2015-09-30	2015-11-13	13F-HR	View on EDGAR
2015-06-30	2015-08-14	13F-HR	View on EDGAR
2015-03-31	2015-05-15	13F-HR	View on EDGAR
2014-12-31	2015-02-17	13F-HR	View on EDGAR

FAQ

What is Sio Capital Management, LLC and what type of investor is it?

What are Sio Capital Management, LLC's largest equity positions?

What changes did Sio Capital Management, LLC make in its most recent portfolio filing?

What sectors does Sio Capital Management, LLC focus on?

Sio Capital Management, LLC is concentrated in the following sectors based on its current disclosed equity portfolio: • Health Care: 80.0% • Industrials: 20.0%