13F GuideFiling Basics
What is SEC Form 13F? Ultimate Guide to Institutional Equity Filings
Learn how SEC Form 13F filings work, the $100M threshold, 45-day reporting lag, and how to track top hedge fund holdings.
AlphaSMO Research GuideRead Guide
CIK: 0001482416
Total reported value
$604.3M
$604.3M
68 檔
36.4%
In Q4 2025, Sio Capital Management, LLC's U.S. equity holdings reached a combined market value of $604.3M, distributed across 68 disclosed stock positions.
In Q4 2025, Sio Capital Management, LLC displayed an active expansion posture, initiating 27 new positions and adding to 8 existing holdings, outstripping position reductions.
| # | Ticker | Issuer | Asset Subclass | Weight | Weight Change | Shares Change | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | CELC | Celcuity Inc | Stock-Other | 7.48% | -1.27% | -39.34% | |
| 2 | CI | THE Cigna Group | Stock-Healthcare | 7.46% | +2.63% | NEW | |
| 3 | SNY | Sanofi-adr | Stock-Healthcare | 7.41% | +0.91% | +72.68% | |
| 4 | MMS | Maximus Inc | Stock-Industrials | 6.79% | -0.71% | -10.28% | |
| 5 | ZBH | Zimmer Biomet Holdings Inc | Stock-Healthcare | 5.45% | +1.06% | — | |
| 6 | RYTM | Rhythm Pharmaceuticals Inc | Stock-Other | 4.47% | — | — | |
| 7 | KVUE | Kenvue Inc | Stock-Consumer Staples | 3.98% | — | +73.63% | |
| 8 | OGN | Organon & Co | Stock-Healthcare | 3.86% | -0.74% | EXIT | |
| 9 | ICLR | ICON Public Limited Company | Stock-Healthcare | 3.65% | -2.32% | — | |
| 10 | WAY | Waystar Holding CORP | Stock-Other | 3.16% | -2.53% | — | |
| 11 | LIVN | LivaNova PLC | Stock-Other | 3.12% | -3.84% | EXIT | |
| 12 | DNTH | Dianthus Therapeutics Inc | Stock-Other | 3.08% | -3.49% | -17.87% | |
| 13 | BHVN | Biohaven Ltd. | Stock-Other | 2.21% | -1.41% | EXIT | |
| 14 | GPCR | Structure Therapeutics Inc | Stock-Other | 2.20% | -1.45% | EXIT | |
| 15 | BMRN | Biomarin Pharmaceutical Inc | Stock-Healthcare | 2.18% | -1.57% | EXIT | |
| 16 | TYRA | Tyra Biosciences Inc | Stock-Other | 2.18% | +0.35% | +2.15% | |
| 17 | BTSG | Brightspring Health Services | Stock-Other | 1.81% | — | — | |
| 18 | CNC | Centene CORP | Stock-Healthcare | 1.78% | -0.47% | EXIT | |
| 19 | CRL | Charles River Laboratories | Stock-Healthcare | 1.73% | — | — | |
| 20 | TFX | Teleflex Inc | Stock-Healthcare | 1.67% | -1.63% | EXIT | |
| 21 | AVR | Anteris Technologies Global | Stock-Other | 1.47% | +4.76% | +5.76% | |
| 22 | TARA | Protara Therapeutic Inc | Stock-Other | 1.44% | -0.26% | — | |
| 23 | CCRN | Cross Country Healthcare Inc | Stock-Other | 1.36% | +0.92% | — | |
| 24 | HAE | Haemonetics Corp/mass | Stock-Other | 1.17% | -1.78% | EXIT | |
| 25 | ANIP | Ani Pharmaceuticals Inc | Stock-Other | 1.08% | -1.60% | +56.62% | |
| 26 | AQST | Aquestive Therapeutics Inc | Stock-Other | 1.01% | -0.12% | -33.71% | |
| 27 | DRUG | Bright Minds Biosciences Inc | Stock-Other | 1.01% | -0.04% | -57.08% | |
| 28 | EWTX | Edgewise Therapeutics Inc | Stock-Other | 0.93% | -1.22% | EXIT | |
| 29 | ABVX | Abivax Sa-adr | Stock-Other | 0.91% | -2.17% | EXIT | |
| 30 | CRNX | Crinetics Pharmaceuticals In | Stock-Other | 0.91% | -1.30% | EXIT | |
| 31 | RAPP | Rapport Therapeutics Inc | Stock-Other | 0.88% | +0.47% | — | |
| 32 | COR | Cencora Inc | Stock-Healthcare | 0.84% | +3.58% | — | |
| 33 | MCK | Mckesson CORP | Stock-Healthcare | 0.83% | — | — | |
| 34 | IRON | Disc Medicine Inc | Stock-Other | 0.72% | -0.60% | EXIT | |
| 35 | ✓ | Proqr Therapeutics N.v. | Stock-Other | 0.69% | -0.45% | EXIT | |
| 36 | FULC | Fulcrum Therapeutics Inc | Stock-Other | 0.68% | — | — | |
| 37 | SVRA | Savara Inc | Stock-Other | 0.58% | +0.15% | -15.54% | |
| 38 | ORKA | Oruka Therapeutics Inc | Stock-Other | 0.56% | +1.86% | — | |
| 39 | VTYXUSD | Ventyx Biosciences Inc | Stock-Other | 0.55% | — | -53.24% | |
| 40 | PMVP | Pmv Pharmaceuticals Inc | Stock-Other | 0.52% | +0.03% | — | |
| 41 | SI | Shoulder Innovations Inc | Stock-Other | 0.51% | -0.44% | EXIT | |
| 42 | ALGS | Aligos Therapeutics Inc | Stock-Other | 0.49% | -0.04% | — | |
| 43 | VIR | Vir Biotechnology Inc | Stock-Other | 0.45% | -0.12% | — | |
| 44 | ALKS | Alkermes plc | Stock-Healthcare | 0.42% | — | -85.87% | |
| 45 | IDYA | Ideaya Biosciences Inc | Stock-Other | 0.41% | +2.96% | NEW | |
| 46 | KYMR | Kymera Therapeutics Inc | Stock-Other | 0.39% | -0.38% | EXIT | |
| 47 | ELTX | Elicio Therapeutics Inc | Stock-Other | 0.37% | -0.02% | EXIT | |
| 48 | OVID | Ovid Therapeutics Inc | Stock-Other | 0.37% | +0.05% | — | |
| 49 | CNTX | Context Therapeutics Inc | Stock-Other | 0.31% | -0.34% | EXIT | |
| 50 | HYPR | Hyperfine Inc | Stock-Other | 0.31% | -0.15% | EXIT |
| # | Ticker | Issuer | Weight Change | Shares Change | Action |
|---|---|---|---|---|---|
| 1 | SNY | Sanofi-adr | +0.7% | +72.68% | Add |
| 2 | KVUE | Kenvue Inc | +0.5% | +73.63% | Add |
| 3 | TFX | Teleflex Inc | +0.4% | +116.88% | Add |
| 4 | TYRA | Tyra Biosciences Inc | +0.4% | +2.15% | Add |
| 5 | 430 | Terns Pharmaceuticals Inc | 0% | — | Unchanged |
| 6 | NXTC | Nextcure Inc | — | — | Unchanged |
| 7 | HUMAW | Humacyte Inc-cw27 | — | — | Unchanged |
| 8 | RCKTW | Rocket Pharmaceuticals In-27 | — | — | Unchanged |
| 9 | CNTX | Context Therapeutics Inc | 0% | — | Unchanged |
| 10 | AVTX | Avalo Therapeutics Inc | 0% | — | Unchanged |
| 11 | BOLD | Boundless Bio Inc | 0% | — | Unchanged |
| 12 | ✓ | Nyxoah S A | 0% | — | Unchanged |
| 13 | FHTX | Foghorn Therapeutics Inc | -0.1% | — | Unchanged |
| 14 | SVRA | Savara Inc | -0.1% | -15.54% | Trim |
| 15 | VTYXUSD | Ventyx Biosciences Inc | -0.1% | -53.24% | Trim |
| 16 | OVID | Ovid Therapeutics Inc | -0.1% | — | Unchanged |
| 17 | ✓ | Modular Med Inc | -0.1% | — | Unchanged |
| 18 | TELA | Tela Bio Inc | -0.1% | — | Unchanged |
| 19 | BBOT | Bridgebio Oncology Therapeut | -0.1% | — | Unchanged |
| 20 | ANIP | Ani Pharmaceuticals Inc | -0.2% | +56.62% | Add |
| 21 | VIR | Vir Biotechnology Inc | -0.2% | — | Unchanged |
| 22 | EWTX | Edgewise Therapeutics Inc | -0.3% | -22.69% | Trim |
| 23 | ALGS | Aligos Therapeutics Inc | -0.3% | — | Unchanged |
| 24 | ✓ | -0.4% | -51.71% | Trim | |
| 25 | PMVP | Pmv Pharmaceuticals Inc | -0.4% | — | Unchanged |
| 26 | ✓ | Proqr Therapeutics N.v. | -0.4% | +4.29% | Add |
| 27 | IDYA | Ideaya Biosciences Inc | -0.5% | -39.04% | Trim |
| 28 | RAPP | Rapport Therapeutics Inc | -0.5% | — | Unchanged |
| 29 | AVR | Anteris Technologies Global | -0.6% | +5.76% | Add |
| 30 | SI | Shoulder Innovations Inc | -0.6% | -34.87% | Trim |
| 31 | BMRN | Biomarin Pharmaceutical Inc | -0.9% | +3.36% | Add |
| 32 | CRNX | Crinetics Pharmaceuticals In | -0.9% | -28.60% | Trim |
| 33 | AQST | Aquestive Therapeutics Inc | -1.1% | -33.71% | Trim |
| 34 | HAE | Haemonetics Corp/mass | -1.3% | -53.22% | Trim |
| 35 | CNC | Centene CORP | -1.7% | -29.22% | Trim |
| 36 | DRUG | Bright Minds Biosciences Inc | -1.9% | -57.08% | Trim |
| 37 | CELC | Celcuity Inc | -2.4% | -39.34% | Trim |
| 38 | DNTH | Dianthus Therapeutics Inc | -2.7% | -17.87% | Trim |
| 39 | IRON | Disc Medicine Inc | -4% | -79.78% | Trim |
| 40 | ALKS | Alkermes plc | -4.7% | -85.87% | Trim |
| 41 | MMS | Maximus Inc | -6.1% | -10.28% | Trim |
| 42 | CI | THE Cigna Group | — | NEW | New buy |
| 43 | ZBH | Zimmer Biomet Holdings Inc | — | NEW | New buy |
| 44 | RYTM | Rhythm Pharmaceuticals Inc | — | NEW | New buy |
| 45 | OGN | Organon & Co | — | NEW | New buy |
| 46 | ICLR | ICON Public Limited Company | — | NEW | New buy |
| 47 | WAY | Waystar Holding CORP | — | NEW | New buy |
| 48 | LIVN | LivaNova PLC | — | NEW | New buy |
| 49 | MRK | Merck & Co. Inc. | — | EXIT | Sold out |
| 50 | HSIC | Henry Schein Inc | — | EXIT | Sold out |
According to official SEC Form 13F filings, Sio Capital Management, LLC reported a total U.S. public equity portfolio value of $604.3M across 68 disclosed positions in Q4 2025.
Expert Analysis & Guides for Tracking Wall Street Smart Money Movements
Learn how SEC Form 13F filings work, the $100M threshold, 45-day reporting lag, and how to track top hedge fund holdings.
In terms of portfolio concentration, the top 5 core holdings (including CELC, CI, SNY) accounted for 36.4% of total reported equity market value during Q4 2025.
Top New Position Initiated
CI
市值: $47.4M
Top Position Liquidated / Trimmed
MRK
前期市值: $14.9M
During Q4 2025, Sio Capital Management, LLC's top holdings by market value included CELC (7.5%)、CI (7.5%)、SNY (7.4%). The largest single position, CELC, represented 7.5% of total portfolio value.
In Q4 2025, Sio Capital Management, LLC made 61 total portfolio adjustments, initiating 27 new buys, adding to 8 positions, trimming 16 holdings, and fully liquidating 10 stocks.
All holding records on this page are fetched directly from the U.S. Securities and Exchange Commission (SEC) EDGAR system (Form 13F-HR). AlphaSMO parses CUSIP identifiers and formats data into Schema.org-compliant datasets.
Understand SEC Form 4 insider disclosures for corporate officers, directors, and 10% owners to track executive transactions.
Understand Rule 144 restricted stock sale notices to spot planned insider liquidations before market sell pressure arrives.
Explore the 5% beneficial ownership threshold, 13D vs 13G filing differences, and recent SEC accelerated deadline rules.
Best practices for analyzing 13F quarterly changes without getting misled by stock splits, options, or market valuation drift.
Learn how AlphaSMO's flagship signal detects high-conviction stocks where 13F hedge funds and corporate insiders buy at the same time.