| PRICE T ROWE ASSOCIATES INC /MD/ | $4718.9万 | 0.01% |
| JANUS HENDERSON GROUP PLC | $2906.6万 | 0.01% |
| Venrock Adviser, LLC | $2678.7万 | 1.00% |
| PERCEPTIVE ADVISORS LLC | $2315.0万 | 0.45% |
| Ikarian Capital, LLC | $1809.9万 | 1.47% |
| Stonepine Capital Management, LLC | $1559.3万 | 6.24% |
| Logos Global Management LP | $999.4万 | 0.50% |
| MORGAN STANLEY | $953.9万 | 0.00% |
| Velan Capital Investment Management LP | $932.7万 | 5.84% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $863.7万 | 0.01% |
| Point72 Asset Management, L.P. | $853.8万 | 0.01% |
| MILLENNIUM MANAGEMENT LLC | $853.7万 | 0.00% |
| ARMISTICE CAPITAL, LLC | $765.6万 | 0.14% |
| Siren, L.L.C. | $683.0万 | 0.19% |
| BOOTHBAY FUND MANAGEMENT, LLC | $639.4万 | 0.08% |
| TD Asset Management Inc | $638.3万 | 0.01% |
| UBS Group AG | $609.9万 | 0.00% |
| RTW INVESTMENTS, LP | $592.0万 | 0.06% |
| MARSHALL WACE, LLP | $563.8万 | 0.01% |
| BVF INC/IL | $542.9万 | 0.17% |
| GREAT POINT PARTNERS LLC | $523.4万 | 1.20% |
| Woodline Partners LP | $517.9万 | 0.02% |
| FMR LLC | $515.8万 | 0.00% |
| AMERIPRISE FINANCIAL INC | $447.0万 | 0.00% |
| VANGUARD CAPITAL MANAGEMENT LLC | $421.2万 | 0.00% |
| Avidity Partners Management LP | $345.3万 | 0.70% |
| ADAR1 Capital Management, LLC | $341.3万 | 0.20% |
| Vivo Capital, LLC | $333.1万 | 0.28% |
| BOONE CAPITAL MANAGEMENT LLC | $319.8万 | 0.98% |
| Balyasny Asset Management L.P. | $311.2万 | 0.00% |
| STEMPOINT CAPITAL LP | $301.7万 | 0.58% |
| DIADEMA PARTNERS LP | $287.4万 | 0.49% |
| Integral Health Asset Management, LLC | $267.0万 | 0.13% |
| RENAISSANCE TECHNOLOGIES LLC | $244.0万 | 0.00% |
| CITADEL ADVISORS LLC | $243.9万 | 0.00% |
| SPHERA FUNDS MANAGEMENT LTD. | $217.5万 | 0.35% |
| ExodusPoint Capital Management, LP | $192.7万 | 0.02% |
| Sofinnova Investments, Inc. | $166.9万 | 0.06% |
| Verdad Advisers, LP | $152.4万 | 1.72% |
| GEODE CAPITAL MANAGEMENT, LLC | $110.6万 | 0.00% |
| TWO SIGMA INVESTMENTS, LP | $109.7万 | 0.00% |
| DIMENSIONAL FUND ADVISORS LP | $100.1万 | 0.00% |
| Persistent Asset Partners Ltd | $93.0万 | 0.35% |
| Vestal Point Capital, LP | $85.4万 | 0.02% |
| Trexquant Investment LP | $81.1万 | 0.01% |
| XTX Topco Ltd | $76.5万 | 0.01% |
| Creek Drive Management Group LLC | $72.0万 | 0.16% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | $71.8万 | 0.01% |
| Artia Global Partners LP | $67.3万 | 0.13% |
| HRT FINANCIAL LP | $66.8万 | 0.00% |
| JANE STREET GROUP, LLC | $53.8万 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | $53.5万 | 0.00% |
| GOLDMAN SACHS GROUP INC | $50.9万 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $50.1万 | 0.00% |
| STATE STREET CORP | $46.4万 | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $46.3万 | 0.00% |
| Qube Research & Technologies Ltd | $45.2万 | 0.00% |
| BANK OF AMERICA CORP /DE/ | $29.7万 | 0.00% |
| BlackRock, Inc. | $27.1万 | 0.00% |
| BARCLAYS PLC | $26.7万 | 0.00% |
| Quadrature Capital Ltd | $24.7万 | 0.00% |
| Verition Fund Management LLC | $21.7万 | 0.00% |
| Corient Private Wealth LLC | $19.8万 | 0.00% |
| NORTHERN TRUST CORP | $19.3万 | 0.00% |
| LETKO, BROSSEAU & ASSOCIATES INC | $17.0万 | 0.00% |
| JPMORGAN CHASE & CO | $13.2万 | 0.00% |
| ACADIAN ASSET MANAGEMENT LLC | $7.1万 | 0.00% |
| Vanguard Global Advisers, LLC | $5.3万 | 0.00% |
| Rockefeller Capital Management L.P. | $4.0万 | 0.00% |
| Tower Research Capital LLC (TRC) | $1.8万 | 0.00% |
| BNP PARIBAS FINANCIAL MARKETS | $4900.5 | 0.00% |
| Caitong International Asset Management Co., Ltd | $911.0 | 0.00% |
| Allworth Financial LP | $16.0 | 0.00% |
| MAI Capital Management | $16.0 | 0.00% |
| CITIGROUP INC | $16.0 | 0.00% |
| Physician Wealth Advisors, Inc. | $16.0 | 0.00% |
| Titiun Yejiel | $16.0 | 0.00% |
| JONES FINANCIAL COMPANIES LLLP | $15.0 | 0.00% |
| Union Bancaire Privee, UBP SA | $11.0 | 0.00% |
| ROYAL BANK OF CANADA | $0.0 | 0.00% |