13F 申报指南13F 概念全攻略
什么是 SEC Form 13F 申报？美股机构大户持股全攻略
完整解读 Form 13F 申报规范、1 亿美元门槛与 45 天延迟申报机制，学会如何追踪顶级对冲基金与机构法人持仓动向。
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CIK: 0001055951
申报总市值
US$53.7亿
US$53.7亿
112 檔
24.5%
Q1 2024 季度申报显示，Orbimed Advisors LLC 披露的美股组合总市值为 US$53.7亿，涵盖 112 个不同之权益投资仓位。
Orbimed Advisors LLC 在 Q1 2024 进行了结构性的板块轮动与仓位换股。在开立 9 个全新仓位及加仓 12 档持股的同时，亦同步清仓 10 档并减仓 14 档标的。
在资产配置集中度方面，Orbimed Advisors LLC 的前 5 大核心持股（包含 SVA, LLY, EWTX 等）合计占整体申报市值的 24.5%，反映机构在主要关键仓位上的权重分布。
| # | 代码 | 标的名称 | 资产子类别 | 占比 | 占比变动 | 持仓量变化 | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | SVA | Sinovac Biotech Ltd. | 股票-其他 | 6.23% | +3.06% | — | |
| 2 | LLY | Eli Lilly & Co | 股票-医疗保健 | 5.14% | +1.30% | -1.26% | |
| 3 | EWTX | Edgewise Therapeutics Inc | 股票-其他 | 5.02% | +1.73% | +3.12% | |
| 4 | BSX | Boston Scientific CORP | 股票-医疗保健 | 4.11% | -1.88% | -1.02% | |
| 5 | ISRG | Intuitive Surgical Inc | 股票-医疗保健 | 3.60% | -0.80% | -1.18% | |
| 6 | BIIB | Biogen Inc | 股票-医疗保健 | 3.56% | +0.02% | +8.86% | |
| 7 | MRK | Merck & Co. Inc. | 股票-医疗保健 | 3.18% | -0.05% | +24.74% | |
| 8 | JANX | Janux Therapeutics Inc | 股票-其他 | 2.95% | -0.13% | +28.86% | |
| 9 | ELVN | Enliven Therapeutics Inc | 股票-其他 | 2.90% | +0.02% | — | |
| 10 | THC | Tenet Healthcare CORP | 股票-医疗保健 | 2.26% | — | -4.17% | |
| 11 | BMRN | Biomarin Pharmaceutical Inc | 股票-医疗保健 | 2.05% | — | -18.64% | |
| 12 | NVLSEUR | Alpine Immune Sciences Inc | 股票-其他 | 1.95% | — | +5.73% | |
| 13 | IRON | Disc Medicine Inc | 股票-其他 | 1.94% | -0.91% | — | |
| 14 | SYK | Stryker CORP | 股票-医疗保健 | 1.76% | -0.30% | — | |
| 15 | SPRY | Ars Pharmaceuticals Inc | 股票-其他 | 1.73% | -0.12% | — | |
| 16 | SRPT | Sarepta Therapeutics Inc | 股票-医疗保健 | 1.65% | — | — | |
| 17 | IONS | Ionis Pharmaceuticals Inc | 股票-医疗保健 | 1.60% | — | -2.51% | |
| 18 | ELV | Elevance Health Inc | 股票-医疗保健 | 1.60% | +0.21% | +18.80% | |
| 19 | XTNT | Xtant Medical Holdings Inc | 股票-其他 | 1.57% | — | — | |
| 20 | EVH | Evolent Health Inc - A | 股票-其他 | 1.56% | — | -5.13% | |
| 21 | APLSUSD | Apellis Pharmaceuticals Inc | 股票-其他 | 1.56% | — | +56.99% | |
| 22 | SWTXUSD | Springworks Therapeutics Inc | 股票-其他 | 1.54% | — | -46.97% | |
| 23 | KROS | Keros Therapeutics Inc | 股票-其他 | 1.54% | -0.02% | — | |
| 24 | NTRA | Natera Inc | 股票-医疗保健 | 1.51% | +0.26% | -5.77% | |
| 25 | TMO | Thermo Fisher Scientific Inc | 股票-医疗保健 | 1.41% | +0.38% | -8.21% | |
| 26 | PCVX | Vaxcyte Inc | 股票-其他 | 1.33% | — | -7.54% | |
| 27 | CRNX | Crinetics Pharmaceuticals In | 股票-其他 | 1.19% | -0.04% | -16.93% | |
| 28 | SRRK | Scholar Rock Holding CORP | 股票-其他 | 1.16% | — | -15.79% | |
| 29 | ARGX | Argenx Se - Adr | 股票-医疗保健 | 1.09% | -0.44% | +79.20% | |
| 30 | ICLR | ICON Public Limited Company | 股票-医疗保健 | 1.07% | — | +31.69% | |
| 31 | NBIX | Neurocrine Biosciences Inc | 股票-医疗保健 | 1.07% | — | -18.52% | |
| 32 | SIBN | Si-bone Inc | 股票-其他 | 1.03% | — | +49.38% | |
| 33 | VRNA | Verona Pharma PLC - Adr | 股票-其他 | 1.00% | — | -10.05% | |
| 34 | ✓ | Third Harmonic Bio Inc | 股票-其他 | 1.00% | — | — | |
| 35 | AVBP | Arrivent Biopharma Inc | 股票-其他 | 0.99% | +0.53% | — | |
| 36 | NPCE | Neuropace Inc | 股票-其他 | 0.97% | -0.11% | — | |
| 37 | PRLD | Prelude Therapeutics Inc | 股票-其他 | 0.95% | +0.60% | — | |
| 38 | VRTX | Vertex Pharmaceuticals Inc | 股票-医疗保健 | 0.94% | — | -29.97% | |
| 39 | 430 | Terns Pharmaceuticals Inc | 股票-其他 | 0.92% | — | — | |
| 40 | CYTK | Cytokinetics Inc | 股票-医疗保健 | 0.88% | +0.04% | NEW | |
| 41 | APGE | Apogee Therapeutics Inc | 股票-其他 | 0.87% | — | -43.74% | |
| 42 | CMPX | Compass Therapeutics Inc | 股票-其他 | 0.81% | -1.03% | — | |
| 43 | GERN | Geron CORP | 股票-其他 | 0.78% | — | +2558.48% | |
| 44 | SNDX | Syndax Pharmaceuticals Inc | 股票-其他 | 0.76% | +0.17% | — | |
| 45 | QTTB | Q32 Bio Inc | 股票-其他 | 0.70% | +0.68% | — | |
| 46 | ESPR | Esperion Therapeutics Inc | 股票-其他 | 0.67% | -0.59% | EXIT | |
| 47 | ✓ | Ikena Oncology Inc | 股票-其他 | 0.66% | -0.45% | EXIT | |
| 48 | UNH | Unitedhealth Group Inc | 股票-医疗保健 | 0.63% | +1.33% | NEW | |
| 49 | RYTM | Rhythm Pharmaceuticals Inc | 股票-其他 | 0.56% | +0.11% | +31.34% | |
| 50 | ALXO | Alx Oncology Holdings Inc | 股票-其他 | 0.56% | -0.01% | -12.18% |
| # | 代码 | 标的名称 | 占比变动 | 持仓量变化 | 异动类型 |
|---|---|---|---|---|---|
| 1 | JANX | Janux Therapeutics Inc | +2.2% | +28.86% | 加仓 |
| 2 | EWTX | Edgewise Therapeutics Inc | +1.8% | +3.12% | 加仓 |
| 3 | NVLSEUR | Alpine Immune Sciences Inc | +1% | +5.73% | 加仓 |
| 4 | AVBP | Arrivent Biopharma Inc | +1% | NEW | 新建仓 |
| 5 | LLY | Eli Lilly & Co | +0.9% | -1.26% | 减仓 |
| 6 | MRK | Merck & Co. Inc. | +0.9% | +24.74% | 加仓 |
| 7 | CYTK | Cytokinetics Inc | +0.9% | NEW | 新建仓 |
| 8 | GERN | Geron CORP | +0.8% | +2558.48% | 加仓 |
| 9 | SPRY | Ars Pharmaceuticals Inc | +0.7% | — | 不变 |
| 10 | QTTB | Q32 Bio Inc | +0.7% | NEW | 新建仓 |
| 11 | ESPR | Esperion Therapeutics Inc | +0.7% | NEW | 新建仓 |
| 12 | KROS | Keros Therapeutics Inc | +0.5% | — | 不变 |
| 13 | PRAX | Praxis Precision Medicines I | +0.5% | NEW | 新建仓 |
| 14 | MLYS | Mineralys Therapeutics Inc | +0.5% | NEW | 新建仓 |
| 15 | APLSUSD | Apellis Pharmaceuticals Inc | +0.5% | +56.99% | 加仓 |
| 16 | RNAGBP | Avidity Biosciences Inc | +0.5% | NEW | 新建仓 |
| 17 | ARGX | Argenx Se - Adr | +0.5% | +79.20% | 加仓 |
| 18 | ELVN | Enliven Therapeutics Inc | +0.4% | — | 不变 |
| 19 | THC | Tenet Healthcare CORP | +0.4% | -4.17% | 减仓 |
| 20 | DYN | Dyne Therapeutics Inc | +0.4% | NEW | 新建仓 |
| 21 | NTRA | Natera Inc | +0.3% | -5.77% | 减仓 |
| 22 | ICLR | ICON Public Limited Company | +0.3% | +31.69% | 加仓 |
| 23 | SRPT | Sarepta Therapeutics Inc | +0.3% | — | 不变 |
| 24 | HRTX | Heron Therapeutics Inc | +0.3% | +70.56% | 加仓 |
| 25 | BSX | Boston Scientific CORP | +0.3% | -1.02% | 减仓 |
| 26 | ELV | Elevance Health Inc | +0.3% | +18.80% | 加仓 |
| 27 | ISRG | Intuitive Surgical Inc | +0.2% | -1.18% | 减仓 |
| 28 | TYRA | Tyra Biosciences Inc | +0.2% | NEW | 新建仓 |
| 29 | MORFUSD | Morphic Holding Inc | +0.2% | +104.28% | 加仓 |
| 30 | APGE | Apogee Therapeutics Inc | +0.2% | -43.74% | 减仓 |
| 31 | SYK | Stryker CORP | +0.2% | — | 不变 |
| 32 | PFE | Pfizer Inc | -0.3% | EXIT | 清仓 |
| 33 | ALNY | Alnylam Pharmaceuticals Inc | -0.3% | EXIT | 清仓 |
| 34 | ALXO | Alx Oncology Holdings Inc | -0.4% | -12.18% | 减仓 |
| 35 | AMGN | Amgen Inc | -0.4% | -50.20% | 减仓 |
| 36 | SRRK | Scholar Rock Holding CORP | -0.4% | -15.79% | 减仓 |
| 37 | VRTX | Vertex Pharmaceuticals Inc | -0.5% | -29.97% | 减仓 |
| 38 | IONS | Ionis Pharmaceuticals Inc | -0.5% | -2.51% | 减仓 |
| 39 | VRNA | Verona Pharma PLC - Adr | -0.5% | -10.05% | 减仓 |
| 40 | ✓ | Fusion Pharmaceuticals Inc | -0.6% | EXIT | 清仓 |
| 41 | BIIB | Biogen Inc | -0.7% | +8.86% | 加仓 |
| 42 | IOVA | Iovance Biotherapeutics Inc | -0.8% | EXIT | 清仓 |
| 43 | SWTXUSD | Springworks Therapeutics Inc | -0.8% | -46.97% | 减仓 |
| 44 | BMRN | Biomarin Pharmaceutical Inc | -1% | -18.64% | 减仓 |
| 45 | HUM | Humana Inc | -1% | EXIT | 清仓 |
| 46 | RCM1USD | R1 Rcm Inc | -1% | EXIT | 清仓 |
| 47 | ✓ | Theseus Pharmaceuticals Inc | -1.4% | EXIT | 清仓 |
| 48 | UTHR | United Therapeutics CORP | -1.7% | EXIT | 清仓 |
| 49 | ✓ | Gracell Biotechnologies-adr | -1.9% | EXIT | 清仓 |
| 50 | ✓ | Rayzebio Inc | -2.9% | EXIT | 清仓 |
根据 SEC 官方 Form 13F 申报备案，Orbimed Advisors LLC 在 Q1 2024 季度的美股持仓总市值约为 US$53.7亿，共申报了 112 个公开持股仓位。
在 Q1 2024 季度，Orbimed Advisors LLC 按市值排列的前三大核心持股分别为：SVA (6.2%)、LLY (5.1%)、EWTX (5.0%)。其中最大持股仓位 SVA 占据整体投资组合约 6.2% 的权重。
精选 AlphaSMO 大户持股与内部人交易深度分析，提升投资决策胜率
完整解读 Form 13F 申报规范、1 亿美元门槛与 45 天延迟申报机制，学会如何追踪顶级对冲基金与机构法人持仓动向。
本季最大新建仓标的
AVBP
市值: US$5406.8万
本季最大获利了结 / 清仓标的
RAYZEBIO INC
前期市值: US$1.5亿
在 Q1 2024 季度中，Orbimed Advisors LLC 共进行了 45 项持仓异动，包含新建仓 9 个仓位、加仓 12 个仓位、减仓 14 个仓位以及清仓 10 个仓位。 其中最大新建仓标的为 AVBP。 本季清仓仓位包含 RAYZEBIO INC。
本页面所有持股数据均直接同步自美国证券交易委员会（SEC）EDGAR 官方系统之 13F-HR / 13F-HR/A 季度申报文件。AlphaSMO 通过机器解析 CUSIP 与个股对照，提供 100% 精准对齐的历史时序数据集，并支持 Schema.org 结构化数据格式。
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深入剖析 5% 股权申报门槛、13D 与 13G 之差异，以及最新 SEC 申报时程规范，洞察机构法人的激进投资动向。