RG
Redmile Group, LLC Quarterly 13F Portfolio Update (Q2 2026)
Redmile Group, LLCCIK: 0001425738
Sector-focusedMomentum followerDiversified strategy
Total reported value
$1.5B
Reporting period: 2026-06-30 · Number of holdings: 39
Redmile Group, LLC disclosed 39 holdings in its latest 13F filing for the period ending 2026-06-30, with total reported value of $1.5B and a quarterly turnover rate of 42.6%.
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Personality snowflake
- Concentration
- 31.49
- Portfolio Stability
- 42.62
- Momentum
- 100
- Sector conviction
- 100
- Diversification
- 78
- Sizing Uniformity
- 85.42
Redmile Group, LLC's disclosed holdings carry a Herfindahl concentration index of 0.079 — mathematically equivalent to about 13 equally-sized positions, well below its 39 actual disclosed holdings. That gap points to a strategy built around a small core of high-conviction bets rather than broad diversification.
Position sizes vary widely across the portfolio (a coefficient of variation of 1.46), with a handful of outsized bets alongside many smaller positions.
No strong tilt toward either adding to existing winners or initiating outsized new positions was observed in the latest reported quarter.
Sector classification currently covers about 17% of this portfolio's disclosed value; the remainder includes holdings (e.g. unmapped tickers, options, or other security types) not yet covered by our sector mapping.
Source and citation information
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Recent moves
View source Form 13F filing on SEC.govTrim SRRK
-52.5% -$208.6M
Add KRYS
-6.2% $60.9M
Add ABSI
-18.3% $53.4M
Trim H0036K147
-25.5% -$45.7M
Add AGMB
+1649.7% $33.8M
Add FATE
0.0% $19.3M
Holdings Map
New buyAddUnchangedTrim
Top 10 holdings by weight
Full holdings list this quarter
| # | Ticker | Issuer | Asset Subclass | Weight | Weight Change | Shares Change | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | SRRK | Scholar Rock Holding CORP | Stock-Other | 15.92% | -13.59% | -52.45% | |
| 2 | KRYS | Krystal Biotech Inc | Stock-Healthcare | 15.77% | +4.25% | -6.16% | |
| 3 | STOK | Stoke Therapeutics Inc | Stock-Other | 8.67% | -0.31% | -5.24% | |
| 4 | IMNM | Immunome Inc | Stock-Other | 6.99% | -1.06% | -11.64% | |
| 5 | NRIX | Nurix Therapeutics Inc | Stock-Other | 6.64% | -1.30% | -47.32% | |
| 6 | ABSI | Absci CORP | Stock-Other | 5.24% | +3.60% | -18.34% | |
| 7 | ANNX | Annexon Inc | Stock-Other | 4.55% | -0.79% | -18.42% | |
| 8 | RGNX | Regenxbio Inc | Stock-Other | 3.51% | +1.09% | — | |
| 9 | STTK | Shattuck Labs Inc | Stock-Other | 3.21% | +0.85% | +24.41% | |
| 10 | NGNE | Neurogene Inc | Stock-Other | 2.98% | +1.03% | -3.25% | |
| 11 | BEAM | Beam Therapeutics Inc | Stock-Other | 2.68% | +0.73% | -5.93% | |
| 12 | AGMB | Agomab Therapeutics NV | Stock-Other | 2.38% | +2.27% | +1649.71% | |
| 13 | FATE | Fate Therapeutics Inc | Stock-Other | 2.33% | +1.31% | — | |
| 14 | IDYA | Ideaya Biosciences Inc | Stock-Other | 1.60% | +0.45% | +22.85% | |
| 15 | SLN | Silence Therapeutics Plc-adr | Stock-Other | 1.60% | +0.84% | — | |
| 16 | COGT | Cogent Biosciences Inc | Stock-Other | 1.31% | -0.44% | -26.85% | |
| 17 | SLDB | Solid Biosciences Inc | Stock-Other | 1.31% | +0.35% | -3.14% | |
| 18 | NUVB | Nuvation Bio Inc | Stock-Other | 1.16% | +0.26% | -3.88% | |
| 19 | CLDX | Celldex Therapeutics Inc | Stock-Other | 1.08% | +0.53% | +65.93% | |
| 20 | CLYM | Climb Bio Inc | Stock-Other | 1.07% | +1.07% | NEW | |
| 21 | ALXO | Alx Oncology Holdings Inc | Stock-Other | 1.03% | -0.03% | -7.18% | |
| 22 | BMRN | Biomarin Pharmaceutical Inc | Stock-Healthcare | 1.02% | +0.37% | +52.52% | |
| 23 | XENE | Xenon Pharmaceuticals Inc | Stock-Other | 0.93% | -0.08% | -12.68% | |
| 24 | ZYME | Zymeworks Inc | Stock-Other | 0.86% | +0.04% | — | |
| 25 | ✓ | Adc Therapeutics SA | Stock-Other | 0.83% | -3.01% | -25.49% | |
| 26 | AURA | Aura Biosciences Inc | Stock-Other | 0.79% | +0.79% | NEW | |
| 27 | ✓ | Stock-Other | 0.53% | +0.53% | NEW | ||
| 28 | LIVN | LivaNova PLC | Stock-Other | 0.51% | +0.05% | -14.03% | |
| 29 | ✓ | Establishment Labs Holdings In | Stock-Other | 0.51% | +0.12% | -14.01% | |
| 30 | CBLL | Ceribell Inc | Stock-Other | 0.51% | +0.04% | — | |
| 31 | DBVT | Dbv Technologies Sa-spon Adr | Stock-Other | 0.45% | -0.23% | -16.47% | |
| 32 | INSM | Insmed Inc | Stock-Healthcare | 0.37% | +0.37% | NEW | |
| 33 | PRME | Prime Medicine Inc | Stock-Other | 0.34% | -0.03% | -12.65% | |
| 34 | ATRA | Atara Biotherapeutics Inc | Stock-Other | 0.34% | +0.20% | — | |
| 35 | EPRX | Eupraxia Pharmaceuticals Inc | Stock-Other | 0.27% | -0.07% | -12.66% | |
| 36 | ORIC | Oric Pharmaceuticals Inc | Stock-Other | 0.26% | -0.09% | -12.92% | |
| 37 | ARDX | Ardelyx Inc | Stock-Other | 0.22% | -0.07% | -12.49% | |
| 38 | IVVD | Invivyd Inc | Stock-Other | 0.15% | -0.08% | -1.92% | |
| 39 | PLRX | Pliant Therapeutics Inc | Stock-Other | 0.06% | — | — |
Portfolio Performance
Performance for Q3 2026
+17.5%
Performance Last 4 Quarters
+102.4%
- Stdev
- +34%
- Beta
- +1.11
- Alpha
- +5.7%
- Max Drawdown
- -41.2%
- Annualized Perf
- +24.8%
- Batting Avg vs S&P
- +47.2%
- Sortino
- +1.47
- Stutzer
- +0.24
- Treynor
- +0.25
- Sterling
- +0.77
- Calmar
- +0.6
- Information Ratio
- +0.26
- Tracking Error
- +30.8%
- Stdev Down
- +18.9%
- Winning Months %
- +55.6%
- Losing Months %
- +44.4%
- Best 12 Months
- +114.1%
- Worst 12 Months
- -40%
- Efficiency Ratio
- +0.33
- Sharpe
- +0.82
- Stdev Sectors
- 0%
- Skewness
- +0.03
- Kurtosis
- -0.63
- Upside Potential
- +3.29
Reported value over time
Sector allocation
Sector allocation over time
Quarterly history
| Period | Holdings | Total value | Stability | Top holdings | |
|---|---|---|---|---|---|
| 2026 Q2 | 39 | $1.5B | 43 | ||
| 2026 Q1 | 35 | $1.5B | 36 | ||
| 2025 Q4 | 34 | $1.4B | 60 | ||
| 2025 Q3 | 40 | $1.0B | 59 | ||
| 2025 Q2 | 48 | $939.6M | 0 | ||
| 2025 Q1 | 56 | $1.1B | 100 | ||
| 2024 Q4 | 62 | $1.4B | 0 | ||
| 2024 Q3 | 63 | $1.7B | 0 | ||
| 2024 Q2 | 63 | $1.7B | 0 | ||
| 2024 Q1 | 77 | $2.7B | 0 | ||
| 2023 Q4 | 70 | $2.8B | 0 | ||
| 2023 Q3 | 68 | $2.1B | 0 | ||
| 2023 Q2 | 72 | $2.6B | 0 | ||
| 2023 Q1 | 76 | $2.3B | 0 | ||
| 2022 Q4 | 69 | $2.4B | 0 | ||
| 2022 Q3 | 70 | $2.6B | 0 | ||
| 2022 Q2 | 71 | $2.6B | 0 | ||
| 2022 Q1 | 70 | $3.2B | 0 | ||
| 2021 Q4 | 71 | $4.4B | 0 | ||
| 2021 Q3 | 75 | $5.7B | 0 | ||
| 2021 Q2 | 86 | $6.8B | 27 | ||
| 2021 Q1 | 86 | $7.1B | 47 | ||
| 2020 Q4 | 87 | $8.3B | 62 | ||
| 2020 Q3 | 81 | $5.4B | 51 | ||
| 2020 Q2 | 80 | $5.4B | 66 | ||
| 2020 Q1 | 69 | $3.6B | 54 | ||
| 2019 Q4 | 64 | $4.2B | 77 | ||
| 2019 Q3 | 74 | $3.0B | 67 | ||
| 2019 Q2 | 81 | $3.5B | 45 | ||
| 2019 Q1 | 82 | $3.4B | 47 | ||
| 2018 Q4 | 78 | $2.5B | 52 | ||
| 2018 Q3 | 83 | $3.3B | 47 | ||
| 2018 Q2 | 81 | $2.9B | 48 | ||
| 2018 Q1 | 64 | $2.6B | 100 | ||
| 2017 Q4 | 69 | $2.3B | 0 | ||
| 2017 Q3 | 65 | $2.0B | 70 | ||
| 2017 Q2 | 64 | $1.6B | 52 | ||
| 2017 Q1 | 60 | $1.5B | 60 | ||
| 2016 Q4 | 50 | $1.2B | 46 | ||
| 2016 Q3 | 51 | $1.3B | 75 | ||
| 2016 Q2 | 54 | $1.0B | 57 | ||
| 2016 Q1 | 47 | $977.1M | 65 | ||
| 2015 Q4 | 57 | $1.3B | 61 | ||
| 2015 Q3 | 58 | $1.3B | 100 | ||
| 2015 Q2 | 55 | $1.2B | 67 | ||
| 2015 Q1 | 54 | $1.1B | 82 | ||
| 2014 Q4 | 54 | $918.4M | 67 | ||
| 2014 Q3 | 54 | $865.8M | 81 | ||
| 2014 Q2 | 48 | $824.5M | 82 | ||
| 2014 Q1 | 55 | $837.6M | 92 | ||
| 2013 Q4 | 56 | $810.4M | 100 | ||
| 2013 Q3 | 50 | $664.0M | 99 | ||
| 2013 Q2 | 49 | $567.5M | 99 |
💡
Data Source Notice: AlphaSMO is the web's most authoritative 13F / Inside Trader database. Institutional holdings and insider trades presented here are precisely computed to deliver accurate portfolio reporting.
Holding changes this quarter
Redmile Group, LLC's most significant position changes for 2026-06-30: New buy: Climb Bio Inc (CLYM); New buy: Aura Biosciences Inc (AURA); New buy: ; New buy: Insmed Inc (INSM); Trim: Scholar Rock Holding CORP (SRRK) — shares -52.45%.
| # | Ticker | Issuer | Weight Change | Shares Change | Action |
|---|---|---|---|---|---|
| 1 | KRYS | Krystal Biotech Inc | +4.3% | -6.16% | Trim |
| 2 | ABSI | Absci CORP | +3.6% | -18.34% | Trim |
| 3 | AGMB | Agomab Therapeutics NV | +2.3% | +1649.71% | Add |
| 4 | FATE | Fate Therapeutics Inc | +1.3% | — | Unchanged |
| 5 | RGNX | Regenxbio Inc | +1.1% | — | Unchanged |
| 6 | CLYM | Climb Bio Inc | +1.1% | NEW | New buy |
| 7 | NGNE | Neurogene Inc | +1% | -3.25% | Trim |
| 8 | STTK | Shattuck Labs Inc | +0.9% | +24.41% | Add |
| 9 | SLN | Silence Therapeutics Plc-adr | +0.8% | — | Unchanged |
| 10 | AURA | Aura Biosciences Inc | +0.8% | NEW | New buy |
| 11 | BEAM | Beam Therapeutics Inc | +0.7% | -5.93% | Trim |
| 12 | ✓ | +0.5% | NEW | New buy | |
| 13 | CLDX | Celldex Therapeutics Inc | +0.5% | +65.93% | Add |
| 14 | IDYA | Ideaya Biosciences Inc | +0.5% | +22.85% | Add |
| 15 | INSM | Insmed Inc | +0.4% | NEW | New buy |
| 16 | BMRN | Biomarin Pharmaceutical Inc | +0.4% | +52.52% | Add |
| 17 | SLDB | Solid Biosciences Inc | +0.4% | -3.14% | Trim |
| 18 | NUVB | Nuvation Bio Inc | +0.3% | -3.88% | Trim |
| 19 | ATRA | Atara Biotherapeutics Inc | +0.2% | — | Unchanged |
| 20 | ✓ | Establishment Labs Holdings In | +0.1% | -14.01% | Trim |
| 21 | LIVN | LivaNova PLC | +0.1% | -14.03% | Trim |
| 22 | ZYME | Zymeworks Inc | 0% | — | Unchanged |
| 23 | CBLL | Ceribell Inc | 0% | — | Unchanged |
| 24 | PLRX | Pliant Therapeutics Inc | — | — | Unchanged |
| 25 | ALXO | Alx Oncology Holdings Inc | 0% | -7.18% | Trim |
| 26 | PRME | Prime Medicine Inc | 0% | -12.65% | Trim |
| 27 | ARDX | Ardelyx Inc | -0.1% | -12.49% | Trim |
| 28 | EPRX | Eupraxia Pharmaceuticals Inc | -0.1% | -12.66% | Trim |
| 29 | XENE | Xenon Pharmaceuticals Inc | -0.1% | -12.68% | Trim |
| 30 | IVVD | Invivyd Inc | -0.1% | -1.92% | Trim |
| 31 | ORIC | Oric Pharmaceuticals Inc | -0.1% | -12.92% | Trim |
| 32 | DBVT | Dbv Technologies Sa-spon Adr | -0.2% | -16.47% | Trim |
| 33 | STOK | Stoke Therapeutics Inc | -0.3% | -5.24% | Trim |
| 34 | COGT | Cogent Biosciences Inc | -0.4% | -26.85% | Trim |
| 35 | ANNX | Annexon Inc | -0.8% | -18.42% | Trim |
| 36 | IMNM | Immunome Inc | -1.1% | -11.64% | Trim |
| 37 | NRIX | Nurix Therapeutics Inc | -1.3% | -47.32% | Trim |
| 38 | ✓ | Adc Therapeutics SA | -3% | -25.49% | Trim |
| 39 | SRRK | Scholar Rock Holding CORP | -13.6% | -52.45% | Trim |
Filing History
FAQ
What is Redmile Group, LLC and what type of investor is it?
Redmile Group, LLC is an investment manager that files SEC Form 13F quarterly, disclosing its U.S. public equity holdings to regulators. As of the most recent reporting period (2026-06-30), the firm manages a tracked equity portfolio valued at approximately $1.5B, spread across 39 disclosed positions.
What are Redmile Group, LLC's largest equity positions?
Based on the latest 13F filing, Redmile Group, LLC's top holdings by market value are:
1. Scholar Rock Holding CORP (SRRK) — $237.1M (15.9%)
2. Krystal Biotech Inc (KRYS) — $234.9M (15.8%)
3. Stoke Therapeutics Inc (STOK) — $129.1M (8.7%)
4. Immunome Inc (IMNM) — $104.1M (7.0%)
5. Nurix Therapeutics Inc (NRIX) — $98.8M (6.6%)
What changes did Redmile Group, LLC make in its most recent portfolio filing?
In the latest reported quarter, Redmile Group, LLC made 32 notable position adjustments: 4 new positions were initiated, 5 existing holdings were added to, 23 positions were partially reduced, and 0 were completely exited. The largest of these moves: New buy: Climb Bio Inc (CLYM); New buy: Aura Biosciences Inc (AURA); New buy: ; New buy: Insmed Inc (INSM); Trim: Scholar Rock Holding CORP (SRRK) — shares -52.45%
What sectors does Redmile Group, LLC focus on?
Redmile Group, LLC is concentrated in the following sectors based on its current disclosed equity portfolio:
• Health Care: 100.0%
Investment Profile
Redmile Group, LLC returned an annualized 24.8% over the trailing 36 months — outperforming the S&P 500 by 5.7 points — based on a reconstructed track record of its disclosed 13F positions, with a beta of 1.11 (more volatile than the market) and a 47% quarterly batting average against the index.
Its portfolio is broadly diversified and moderately active, with 100.0% of the portfolio concentrated in Health Care.
Its turnover score has risen from 0 to 43 over the past 4 quarters — a shift toward more active trading.
It has added to its KRYS position over the past two quarters (+$67.8M, now $234.9M), while trimming NRIX over the same stretch (-$54.7M, still holding $98.8M).
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Developer Access
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