SB
Samsara BioCapital, LLC 13F Holdings & Recent Stock Buys (Q2 2026)
Samsara BioCapital, LLCCIK: 0001744967
ContrarianQuality / disciplined sizing
Total reported value
$1.2B
Reporting period: 2026-06-30 · Number of holdings: 24
Samsara BioCapital, LLC disclosed 24 holdings in its latest 13F filing for the period ending 2026-06-30, with total reported value of $1.2B and a quarterly turnover rate of 26.6%.
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Personality snowflake
- Concentration
- 61.37
- Portfolio Stability
- 26.63
- Momentum
- 0
- Sector conviction
- 0
- Diversification
- 48
- Sizing Uniformity
- 83.27
Sector classification currently covers about 0% of this portfolio's disclosed value; the remainder includes holdings (e.g. unmapped tickers, options, or other security types) not yet covered by our sector mapping.
Source and citation information
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Recent moves
View source Form 13F filing on SEC.govNew buy 010911105
Trim KLRS
-0.5% -$22.3M
Trim MLYS
0.0% -$645.8K
Trim SRRK
0.0% $40.3M
Trim SGP
0.0% -$7.7M
Add SEPN
0.0% $29.8M
Holdings Map
New buyAddUnchangedTrim
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Data Source Notice: AlphaSMO is the web's most authoritative 13F / Inside Trader database. Institutional holdings and insider trades presented here are precisely computed to deliver accurate portfolio reporting.
Top 10 holdings by weight
Full holdings list this quarter
| # | Ticker | Issuer | Asset Subclass | Weight | Weight Change | Shares Change | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | SRRK | Scholar Rock Holding CORP | Stock-Other | 31.16% | -1.79% | — | |
| 2 | ALMS | Alumis Inc | Stock-Other | 14.67% | +1.09% | — | |
| 3 | MLYS | Mineralys Therapeutics Inc | Stock-Other | 13.01% | -2.44% | — | |
| 4 | SEPN | Septerna Inc | Stock-Other | 8.66% | +1.31% | — | |
| 5 | ✓ | Stock-Other | 5.52% | +5.52% | NEW | ||
| 6 | NGNE | Neurogene Inc | Stock-Other | 4.44% | +1.08% | — | |
| 7 | KLRS | Kalaris Therapeutics Inc | Stock-Other | 4.31% | -2.95% | -0.52% | |
| 8 | SGP | Spyglass Pharma Inc | Stock-Other | 3.86% | -1.45% | — | |
| 9 | STRO | Sutro Biopharma Inc | Stock-Other | 2.90% | +0.33% | — | |
| 10 | IVA | Inventiva SA - Adr | Stock-Other | 1.96% | -0.84% | +21.56% | |
| 11 | JBIO | Jade Biosciences Inc | Stock-Other | 1.34% | +0.02% | -24.01% | |
| 12 | ✓ | Stock-Other | 1.25% | +1.25% | NEW | ||
| 13 | VTVT | Vtv Therapeutics Inc- Cl A | Stock-Other | 0.92% | -0.23% | — | |
| 14 | AQST | Aquestive Therapeutics Inc | Stock-Other | 0.85% | -0.16% | — | |
| 15 | NKTX | Nkarta Inc | Stock-Other | 0.82% | +0.10% | — | |
| 16 | ARTV | Artiva Biotherapeutics Inc | Stock-Other | 0.76% | +0.76% | NEW | |
| 17 | RANI | Rani Therapeutics Holdings-a | Stock-Other | 0.65% | +0.04% | +21.99% | |
| 18 | AGMB | Agomab Therapeutics NV | Stock-Other | 0.64% | +0.03% | — | |
| 19 | ABVX | Abivax Sa-adr | Stock-Other | 0.60% | -0.01% | -2.63% | |
| 20 | XFOR | X4 Pharmaceuticals Inc | Stock-Other | 0.54% | -0.20% | -23.85% | |
| 21 | ✓ | Stock-Other | 0.46% | +0.46% | NEW | ||
| 22 | CHRS | Coherus Oncology Inc | Stock-Other | 0.39% | -0.17% | — | |
| 23 | UPB | Upstream Bio Inc | Stock-Other | 0.20% | -0.44% | -51.94% | |
| 24 | GOSS | Gossamer Bio Inc | Stock-Other | 0.10% | -0.13% | — |
Portfolio Performance
Performance for Q3 2026
+5.3%
Performance Last 4 Quarters
+78.4%
- Stdev
- +43.2%
- Beta
- +0.49
- Alpha
- +36.3%
- Max Drawdown
- -26.7%
- Annualized Perf
- +44.6%
- Batting Avg vs S&P
- +48.1%
- Sortino
- +2.71
- Stutzer
- +0.33
- Treynor
- +0.93
- Sterling
- +1.54
- Calmar
- +1.67
- Information Ratio
- +0.62
- Tracking Error
- +43.2%
- Stdev Down
- +16.8%
- Winning Months %
- +63%
- Losing Months %
- +37%
- Best 12 Months
- +122.5%
- Worst 12 Months
- -1.4%
- Efficiency Ratio
- +0.53
- Sharpe
- +1.05
- Stdev Sectors
- —
- Skewness
- +1.21
- Kurtosis
- +1.26
- Upside Potential
- +4.61
Reported value over time
Sector allocation
Not enough sector-mapped data yet
Sector allocation over time
Quarterly history
| Period | Holdings | Total value | Stability | Top holdings | |
|---|---|---|---|---|---|
| 2026 Q2 | 24 | $1.2B | 27 | ||
| 2026 Q1 | 22 | $1.0B | 38 | ||
| 2025 Q4 | 21 | $969.3M | 42 | ||
| 2025 Q3 | 27 | $765.9M | 57 | ||
| 2025 Q2 | 29 | $488.9M | 0 | ||
| 2025 Q1 | 37 | $560.8M | 100 | ||
| 2024 Q4 | 43 | $728.6M | 0 | ||
| 2024 Q3 | 42 | $520.3M | 0 | ||
| 2024 Q2 | 40 | $477.8M | 0 | ||
| 2024 Q1 | 39 | $646.4M | 0 | ||
| 2023 Q4 | 41 | $642.8M | 0 | ||
| 2023 Q3 | 41 | $326.7M | 0 | ||
| 2023 Q2 | 47 | $569.7M | 0 | ||
| 2023 Q1 | 56 | $483.8M | 0 | ||
| 2022 Q4 | 54 | $461.5M | 0 | ||
| 2022 Q3 | 56 | $428.9M | 0 | ||
| 2022 Q2 | 57 | $375.1M | 0 | ||
| 2022 Q1 | 57 | $397.2M | 0 | ||
| 2021 Q4 | 51 | $515.5M | 0 | ||
| 2021 Q3 | 48 | $637.3M | 0 | ||
| 2021 Q2 | 50 | $810.1M | 68 | ||
| 2021 Q1 | 44 | $542.2M | 100 | ||
| 2020 Q4 | 43 | $994.4M | 100 | ||
| 2020 Q3 | 36 | $358.5M | 68 | ||
| 2020 Q2 | 32 | $310.9M | 76 | ||
| 2020 Q1 | 28 | $173.8M | 47 | ||
| 2019 Q4 | 19 | $208.7M | 51 | ||
| 2019 Q3 | 18 | $146.9M | 35 | ||
| 2019 Q2 | 21 | $151.4M | 32 | ||
| 2019 Q1 | 18 | $127.2M | 39 | ||
| 2018 Q4 | 17 | $104.2M | 0 |
Holding changes this quarter
Samsara BioCapital, LLC's most significant position changes for 2026-06-30: New buy: ; New buy: ; New buy: Artiva Biotherapeutics Inc (ARTV); Sold out: Arcellx Inc (ACLXGBX); New buy: .
| # | Ticker | Issuer | Weight Change | Shares Change | Action |
|---|---|---|---|---|---|
| 1 | ✓ | +5.5% | NEW | New buy | |
| 2 | SEPN | Septerna Inc | +1.3% | — | Unchanged |
| 3 | ✓ | +1.3% | NEW | New buy | |
| 4 | ALMS | Alumis Inc | +1.1% | — | Unchanged |
| 5 | NGNE | Neurogene Inc | +1.1% | — | Unchanged |
| 6 | ARTV | Artiva Biotherapeutics Inc | +0.8% | NEW | New buy |
| 7 | ✓ | +0.5% | NEW | New buy | |
| 8 | STRO | Sutro Biopharma Inc | +0.3% | — | Unchanged |
| 9 | NKTX | Nkarta Inc | +0.1% | — | Unchanged |
| 10 | RANI | Rani Therapeutics Holdings-a | 0% | +21.99% | Add |
| 11 | AGMB | Agomab Therapeutics NV | 0% | — | Unchanged |
| 12 | JBIO | Jade Biosciences Inc | 0% | -24.01% | Trim |
| 13 | ABVX | Abivax Sa-adr | 0% | -2.63% | Trim |
| 14 | GOSS | Gossamer Bio Inc | -0.1% | — | Unchanged |
| 15 | AQST | Aquestive Therapeutics Inc | -0.2% | — | Unchanged |
| 16 | CHRS | Coherus Oncology Inc | -0.2% | — | Unchanged |
| 17 | XFOR | X4 Pharmaceuticals Inc | -0.2% | -23.85% | Trim |
| 18 | VTVT | Vtv Therapeutics Inc- Cl A | -0.2% | — | Unchanged |
| 19 | UPB | Upstream Bio Inc | -0.4% | -51.94% | Trim |
| 20 | PVLA | Palvella Therapeutics Inc | -0.5% | EXIT | Sold out |
| 21 | ACLXGBX | Arcellx Inc | -0.7% | EXIT | Sold out |
| 22 | IVA | Inventiva SA - Adr | -0.8% | +21.56% | Add |
| 23 | SGP | Spyglass Pharma Inc | -1.5% | — | Unchanged |
| 24 | SRRK | Scholar Rock Holding CORP | -1.8% | — | Unchanged |
| 25 | MLYS | Mineralys Therapeutics Inc | -2.4% | — | Unchanged |
| 26 | KLRS | Kalaris Therapeutics Inc | -3% | -0.52% | Trim |
Filing History
FAQ
What is Samsara BioCapital, LLC and what type of investor is it?
Samsara BioCapital, LLC is an investment manager that files SEC Form 13F quarterly, disclosing its U.S. public equity holdings to regulators. As of the most recent reporting period (2026-06-30), the firm manages a tracked equity portfolio valued at approximately $1.2B, spread across 24 disclosed positions.
What are Samsara BioCapital, LLC's largest equity positions?
Based on the latest 13F filing, Samsara BioCapital, LLC's top holdings by market value are:
1. Scholar Rock Holding CORP (SRRK) — $379.4M (31.2%)
2. Alumis Inc (ALMS) — $178.6M (14.7%)
3. Mineralys Therapeutics Inc (MLYS) — $158.4M (13.0%)
4. Septerna Inc (SEPN) — $105.5M (8.7%)
5. — $67.2M (5.5%)
What changes did Samsara BioCapital, LLC make in its most recent portfolio filing?
In the latest reported quarter, Samsara BioCapital, LLC made 13 notable position adjustments: 4 new positions were initiated, 2 existing holdings were added to, 5 positions were partially reduced, and 2 were completely exited. The largest of these moves: New buy: ; New buy: ; New buy: Artiva Biotherapeutics Inc (ARTV); Sold out: Arcellx Inc (ACLXGBX); New buy:
What sectors does Samsara BioCapital, LLC focus on?
Sector breakdown data is not yet available for Samsara BioCapital, LLC. Check back after the next 13F processing cycle.
Investment Profile
Samsara BioCapital, LLC returned an annualized 44.6% over the trailing 27 months — outperforming the S&P 500 by 36.3 points — based on a reconstructed track record of its disclosed 13F positions, with a beta of 0.49 (less volatile than the market) and a 48% quarterly batting average against the index.
Its portfolio is moderately concentrated and moderately active.
Its turnover score has risen from 0 to 27 over the past 4 quarters — a shift toward more active trading.
It has added to its ALMS position over the past two quarters (+$122.4M, now $178.6M), while trimming KLRS over the same stretch (-$56.9M, still holding $52.4M).
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Developer Access
Access Samsara BioCapital, LLC's institutional profile programmatically:
REST API
curl https://alphasmo.com/api/v1/institutions/samsara-biocapital-llcCLI
npx alphasmo institutions get samsara-biocapital-llc