Septerna Inc (SEPN) 13F Positioning & Ownership Changes (Q2 2026)

SEPN ranks #3555 out of 37696 tracked stocks by institutional interest — one of the most closely watched names in our coverage.

SEPN is a top-conviction position for Trv Gp Vi, LLC — at 60.7% of their entire disclosed 13F portfolio, it's one of their largest single bets, not just a passing allocation.

The largest dollar stake in SEPN belongs to Ra Capital Management, L.p., but the position matters far more to Trv Gp Vi, LLC, who has 60.7% of their own portfolio riding on it — a reminder that the biggest holder by size and the holder with the biggest bet aren't always the same fund.

GAMMA Investing LLC has added to its SEPN position for two straight quarters, increasing it by $27.2K to reach $53.9K today.

SEPN is up 0.1% today, and institutions have been net buyers of $171.6M this quarter — today's price move and the underlying institutional flow are pointing the same direction.

SEPN reported a net loss of $24.2M over the trailing twelve months.

• Not yet profitable — net loss of $24.2M over the trailing twelve months
• Revenue grew 13520.1% year over year
• Net income improved year over year, from -$87.5M to -$24.2M
• Generated $110.2M in positive operating cash flow
• Current ratio of 4.73x — enough short-term assets to cover short-term liabilities
• Liabilities run 0.56x equity — within a conventional range