Septerna Inc (SEPN) 13F Positioning & Ownership Changes (Q2 2026)

SEPN ranks #3545 out of 37503 tracked stocks by institutional interest — one of the most closely watched names in our coverage.

SEPN is a top-conviction position for Trv Gp Vi, LLC — at 60.7% of their entire disclosed 13F portfolio, it's one of their largest single bets, not just a passing allocation.

The largest dollar stake in SEPN belongs to Ra Capital Management, L.p., but the position matters far more to Trv Gp Vi, LLC, who has 60.7% of their own portfolio riding on it — a reminder that the biggest holder by size and the holder with the biggest bet aren't always the same fund.

Primecap Management Co/ca/ has added to its SEPN position for two straight quarters, increasing it by $23.9M to reach $39.1M today.

Invesco Ltd. has trimmed its SEPN position for two straight quarters, cutting it by $3.7M while still holding $806.9K.

SEPN is down 2.5% today, but institutions show net buying of $171.6M this quarter — a divergence between today's price move and the underlying institutional flow.

SEPN reported a net loss of $24.2M over the trailing twelve months.

• Not yet profitable — net loss of $24.2M over the trailing twelve months
• Revenue grew 13520.1% year over year
• Net income improved year over year, from -$87.5M to -$24.2M
• Generated $110.2M in positive operating cash flow
• Current ratio of 4.73x — enough short-term assets to cover short-term liabilities
• Liabilities run 0.56x equity — within a conventional range