PM
Prosight Management, LP SEC 13F Filing (Q2 2026) — Holdings & Portfolio
Prosight Management, LPCIK: 0001617201
Sector-focusedMomentum followerQuality / disciplined sizing
Total reported value
$580.4M
Reporting period: 2026-06-30 · Number of holdings: 36
Prosight Management, LP disclosed 36 holdings in its latest 13F filing for the period ending 2026-06-30, with total reported value of $580.4M and a quarterly turnover rate of 58.3%.
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Personality snowflake
- Concentration
- 25.04
- Portfolio Stability
- 58.27
- Momentum
- 100
- Sector conviction
- 100
- Diversification
- 72
- Sizing Uniformity
- 88.64
Prosight Management, LP's disclosed holdings carry a Herfindahl concentration index of 0.063 — mathematically equivalent to about 16 equally-sized positions, well below its 36 actual disclosed holdings. That gap points to a strategy built around a small core of high-conviction bets rather than broad diversification.
Position sizes are fairly uniform across the portfolio (a coefficient of variation of 1.14), suggesting a disciplined, rules-based approach to how much capital goes into each idea.
No strong tilt toward either adding to existing winners or initiating outsized new positions was observed in the latest reported quarter.
Sector classification currently covers about 35% of this portfolio's disclosed value; the remainder includes holdings (e.g. unmapped tickers, options, or other security types) not yet covered by our sector mapping.
Source and citation information
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Recent moves
View source Form 13F filing on SEC.govTrim PRCT
-86.2% -$42.6M
New buy INSM
Trim WGS
-83.7% -$27.7M
Trim H0036K147
-5.7% -$22.8M
Trim MGTX
-96.6% -$21.6M
Add IRTC
+1555.0% $18.5M
Holdings Map
New buyAddUnchangedTrim
Top 10 holdings by weight
Full holdings list this quarter
| # | Ticker | Issuer | Asset Subclass | Weight | Weight Change | Shares Change | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | LKFT | Lakefront Biotherapeutic-adr | Stock-Other | 10.56% | +2.93% | +31.83% | |
| 2 | JANX | Janux Therapeutics Inc | Stock-Other | 10.07% | +1.98% | +7.17% | |
| 3 | NKTR | Nektar Therapeutics | Stock-Other | 9.74% | +1.07% | +10.20% | |
| 4 | BSX | Boston Scientific CORP | Stock-Healthcare | 9.34% | +1.15% | +59.67% | |
| 5 | STTK | Shattuck Labs Inc | Stock-Other | 7.12% | +1.84% | +19.05% | |
| 6 | INSM | Insmed Inc | Stock-Healthcare | 6.90% | +6.90% | NEW | |
| 7 | ALNY | Alnylam Pharmaceuticals Inc | Stock-Healthcare | 5.09% | +0.97% | +29.05% | |
| 8 | SNDX | Syndax Pharmaceuticals Inc | Stock-Other | 4.52% | +1.57% | +55.84% | |
| 9 | KURA | Kura Oncology Inc | Stock-Other | 3.82% | -0.66% | -39.76% | |
| 10 | ALKS | Alkermes plc | Stock-Healthcare | 3.56% | +0.58% | -23.22% | |
| 11 | IRTC | Irhythm Holdings Inc | Stock-Healthcare | 3.39% | +3.20% | +1555.00% | |
| 12 | VEEV | Veeva Systems Inc-class A | Stock-Healthcare | 3.25% | +0.76% | +22.80% | |
| 13 | ZYME | Zymeworks Inc | Stock-Other | 3.04% | +0.83% | +25.12% | |
| 14 | ABVX | Abivax Sa-adr | Stock-Other | 2.47% | +0.55% | +2.28% | |
| 15 | CRNX | Crinetics Pharmaceuticals In | Stock-Other | 2.42% | +0.34% | +7.05% | |
| 16 | MLYS | Mineralys Therapeutics Inc | Stock-Other | 2.09% | +2.09% | NEW | |
| 17 | ✓ | Adc Therapeutics SA | Stock-Other | 1.44% | -3.66% | -5.73% | |
| 18 | ICUI | Icu Medical Inc | Stock-Other | 1.29% | +0.71% | +85.79% | |
| 19 | ISRG | Intuitive Surgical Inc | Stock-Healthcare | 1.16% | +0.86% | +325.00% | |
| 20 | CRBP | Corbus Pharmaceuticals Holdi | Stock-Other | 1.05% | -0.02% | -6.76% | |
| 21 | PRCT | Procept Biorobotics CORP | Stock-Other | 1.04% | -6.94% | -86.21% | |
| 22 | WGS | Genedx Holdings CORP | Stock-Other | 1.01% | -4.50% | -83.67% | |
| 23 | OPCH | Option Care Health Inc | Stock-Healthcare | 0.98% | +0.98% | NEW | |
| 24 | OKUR | Onkure Therapeutics Inc-a | Stock-Other | 0.77% | -0.69% | -54.56% | |
| 25 | EBS | Emergent Biosolutions Inc | Stock-Healthcare | 0.66% | -0.21% | -28.03% | |
| 26 | PFE | Pfizer Inc | Stock-Healthcare | 0.56% | +0.56% | NEW | |
| 27 | KIDS | Orthopediatrics CORP | Stock-Other | 0.52% | -0.27% | -47.92% | |
| 28 | RCKT | Rocket Pharmaceuticals Inc | Stock-Other | 0.41% | +0.01% | +2.36% | |
| 29 | ANTX | An2 Therapeutics Inc | Stock-Other | 0.40% | +0.11% | -7.97% | |
| 30 | PLRX | Pliant Therapeutics Inc | Stock-Other | 0.27% | -0.07% | -17.83% | |
| 31 | TECX | Tectonic Therapeutic Inc | Stock-Other | 0.24% | -0.16% | -50.26% | |
| 32 | MGTX | MeiraGTx Holdings plc | Stock-Other | 0.21% | -3.52% | -96.58% | |
| 33 | EFOR | Everforth Inc | Stock-Other | 0.21% | +0.21% | NEW | |
| 34 | RNTX | Rein Therapeutics Inc | Stock-Other | 0.20% | +0.11% | +167.25% | |
| 35 | COYA | Coya Therapeutics Inc | Stock-Other | 0.17% | -0.10% | -59.56% | |
| 36 | IMRX | Immuneering CORP - Class A | Stock-Other | 0.03% | -0.08% | -70.13% |
Portfolio Performance
Performance for Q3 2026
+15.5%
Performance Last 4 Quarters
+47.4%
- Stdev
- +23.1%
- Beta
- +0.6
- Alpha
- -1.3%
- Max Drawdown
- -31.5%
- Annualized Perf
- +8.4%
- Batting Avg vs S&P
- +38.9%
- Sortino
- +0.81
- Stutzer
- +0.14
- Treynor
- +0.18
- Sterling
- +0.34
- Calmar
- +0.27
- Information Ratio
- -0.42
- Tracking Error
- +22.3%
- Stdev Down
- +13.2%
- Winning Months %
- +50%
- Losing Months %
- +50%
- Best 12 Months
- +57%
- Worst 12 Months
- -25.5%
- Efficiency Ratio
- +0.14
- Sharpe
- +0.46
- Stdev Sectors
- 0%
- Skewness
- +0.42
- Kurtosis
- -0.15
- Upside Potential
- +2.8
Reported value over time
Sector allocation
Sector allocation over time
Quarterly history
| Period | Holdings | Total value | Stability | Top holdings | |
|---|---|---|---|---|---|
| 2026 Q2 | 36 | $580.4M | 58 | ||
| 2026 Q1 | 46 | $609.8M | 66 | ||
| 2025 Q4 | 38 | $483.9M | 71 | ||
| 2025 Q3 | 44 | $428.8M | 66 | ||
| 2025 Q2 | 39 | $410.1M | 0 | ||
| 2025 Q1 | 38 | $304.3M | 100 | ||
| 2024 Q4 | 36 | $361.8M | 0 | ||
| 2024 Q3 | 47 | $406.4M | 0 | ||
| 2024 Q2 | 46 | $334.6M | 0 | ||
| 2024 Q1 | 44 | $359.5M | 0 | ||
| 2023 Q4 | 35 | $249.1M | 0 | ||
| 2023 Q3 | 41 | $315.5M | 0 | ||
| 2023 Q2 | 37 | $341.6M | 0 | ||
| 2023 Q1 | 41 | $210.9M | 0 | ||
| 2022 Q4 | 40 | $183.4M | 0 | ||
| 2022 Q3 | 38 | $186.7M | 0 | ||
| 2022 Q2 | 24 | $126.9M | 0 | ||
| 2022 Q1 | 32 | $154.9M | 0 | ||
| 2021 Q4 | 36 | $167.0M | 0 | ||
| 2021 Q3 | 43 | $181.8M | 0 | ||
| 2021 Q2 | 46 | $159.9M | 87 | ||
| 2021 Q1 | 37 | $122.1M | 96 | ||
| 2020 Q4 | 42 | $216.4M | 68 | ||
| 2020 Q3 | 47 | $210.2M | 68 | ||
| 2020 Q2 | 52 | $233.0M | 67 | ||
| 2020 Q1 | 44 | $213.9M | 74 | ||
| 2019 Q4 | 38 | $227.7M | 71 | ||
| 2019 Q3 | 34 | $180.3M | 53 | ||
| 2019 Q2 | 39 | $198.3M | 67 | ||
| 2019 Q1 | 38 | $228.6M | 60 | ||
| 2018 Q4 | 35 | $193.7M | 66 | ||
| 2018 Q3 | 32 | $179.3M | 86 | ||
| 2018 Q2 | 31 | $136.4M | 80 | ||
| 2018 Q1 | 32 | $159.4M | 88 | ||
| 2017 Q4 | 29 | $136.0M | 0 |
Holding changes this quarter
Prosight Management, LP's most significant position changes for 2026-06-30: New buy: Insmed Inc (INSM); New buy: Mineralys Therapeutics Inc (MLYS); Sold out: Concentra Group Holdings Par (CON); Sold out: Terns Pharmaceuticals Inc (430); Sold out: Phreesia Inc (PHR).
| # | Ticker | Issuer | Weight Change | Shares Change | Action |
|---|---|---|---|---|---|
| 1 | INSM | Insmed Inc | +6.9% | NEW | New buy |
| 2 | IRTC | Irhythm Holdings Inc | +3.2% | +1555.00% | Add |
| 3 | LKFT | Lakefront Biotherapeutic-adr | +2.9% | +31.83% | Add |
| 4 | MLYS | Mineralys Therapeutics Inc | +2.1% | NEW | New buy |
| 5 | JANX | Janux Therapeutics Inc | +2% | +7.17% | Add |
| 6 | STTK | Shattuck Labs Inc | +1.8% | +19.05% | Add |
| 7 | SNDX | Syndax Pharmaceuticals Inc | +1.6% | +55.84% | Add |
| 8 | BSX | Boston Scientific CORP | +1.2% | +59.67% | Add |
| 9 | NKTR | Nektar Therapeutics | +1.1% | +10.20% | Add |
| 10 | OPCH | Option Care Health Inc | +1% | NEW | New buy |
| 11 | ALNY | Alnylam Pharmaceuticals Inc | +1% | +29.05% | Add |
| 12 | ISRG | Intuitive Surgical Inc | +0.9% | +325.00% | Add |
| 13 | ZYME | Zymeworks Inc | +0.8% | +25.12% | Add |
| 14 | VEEV | Veeva Systems Inc-class A | +0.8% | +22.80% | Add |
| 15 | ICUI | Icu Medical Inc | +0.7% | +85.79% | Add |
| 16 | ALKS | Alkermes plc | +0.6% | -23.22% | Trim |
| 17 | PFE | Pfizer Inc | +0.6% | NEW | New buy |
| 18 | ABVX | Abivax Sa-adr | +0.6% | +2.28% | Add |
| 19 | CRNX | Crinetics Pharmaceuticals In | +0.3% | +7.05% | Add |
| 20 | EFOR | Everforth Inc | +0.2% | NEW | New buy |
| 21 | RNTX | Rein Therapeutics Inc | +0.1% | +167.25% | Add |
| 22 | ANTX | An2 Therapeutics Inc | +0.1% | -7.97% | Trim |
| 23 | RCKT | Rocket Pharmaceuticals Inc | 0% | +2.36% | Add |
| 24 | CRBP | Corbus Pharmaceuticals Holdi | 0% | -6.76% | Trim |
| 25 | PLRX | Pliant Therapeutics Inc | -0.1% | -17.83% | Trim |
| 26 | TMDX | Transmedics Group Inc | -0.1% | EXIT | Sold out |
| 27 | IMRX | Immuneering CORP - Class A | -0.1% | -70.13% | Trim |
| 28 | NVCR | NovoCure Limited | -0.1% | EXIT | Sold out |
| 29 | COYA | Coya Therapeutics Inc | -0.1% | -59.56% | Trim |
| 30 | PVLA | Palvella Therapeutics Inc | -0.1% | EXIT | Sold out |
| 31 | TECX | Tectonic Therapeutic Inc | -0.2% | -50.26% | Trim |
| 32 | TBI | Trueblue Inc | -0.2% | EXIT | Sold out |
| 33 | EBS | Emergent Biosolutions Inc | -0.2% | -28.03% | Trim |
| 34 | VKTX | Viking Therapeutics Inc | -0.2% | EXIT | Sold out |
| 35 | KIDS | Orthopediatrics CORP | -0.3% | -47.92% | Trim |
| 36 | RGNX | Regenxbio Inc | -0.3% | EXIT | Sold out |
| 37 | ACET | Adicet Bio Inc | -0.3% | EXIT | Sold out |
| 38 | OMER | Omeros CORP | -0.3% | EXIT | Sold out |
| 39 | UPB | Upstream Bio Inc | -0.4% | EXIT | Sold out |
| 40 | KURA | Kura Oncology Inc | -0.7% | -39.76% | Trim |
| 41 | OKUR | Onkure Therapeutics Inc-a | -0.7% | -54.56% | Trim |
| 42 | IMVT | Immunovant Inc | -0.7% | EXIT | Sold out |
| 43 | ROIV | Roivant Sciences Ltd. | -0.8% | EXIT | Sold out |
| 44 | SDGR | Schrodinger Inc | -1% | EXIT | Sold out |
| 45 | PHR | Phreesia Inc | -1.5% | EXIT | Sold out |
| 46 | 430 | Terns Pharmaceuticals Inc | -1.8% | EXIT | Sold out |
| 47 | CON | Concentra Group Holdings Par | -1.8% | EXIT | Sold out |
| 48 | MGTX | MeiraGTx Holdings plc | -3.5% | -96.58% | Trim |
| 49 | ✓ | Adc Therapeutics SA | -3.7% | -5.73% | Trim |
| 50 | WGS | Genedx Holdings CORP | -4.5% | -83.67% | Trim |
1–50 of 51
Filing History
FAQ
What is Prosight Management, LP and what type of investor is it?
Prosight Management, LP is an investment manager that files SEC Form 13F quarterly, disclosing its U.S. public equity holdings to regulators. As of the most recent reporting period (2026-06-30), the firm manages a tracked equity portfolio valued at approximately $580.4M, spread across 36 disclosed positions.
What are Prosight Management, LP's largest equity positions?
Based on the latest 13F filing, Prosight Management, LP's top holdings by market value are:
1. Lakefront Biotherapeutic-adr (LKFT) — $61.3M (10.6%)
2. Janux Therapeutics Inc (JANX) — $58.4M (10.1%)
3. Nektar Therapeutics (NKTR) — $56.5M (9.7%)
4. Boston Scientific CORP (BSX) — $54.2M (9.3%)
5. Shattuck Labs Inc (STTK) — $41.3M (7.1%)
What changes did Prosight Management, LP make in its most recent portfolio filing?
In the latest reported quarter, Prosight Management, LP made 51 notable position adjustments: 5 new positions were initiated, 16 existing holdings were added to, 15 positions were partially reduced, and 15 were completely exited. The largest of these moves: New buy: Insmed Inc (INSM); New buy: Mineralys Therapeutics Inc (MLYS); Sold out: Concentra Group Holdings Par (CON); Sold out: Terns Pharmaceuticals Inc (430); Sold out: Phreesia Inc (PHR)
What sectors does Prosight Management, LP focus on?
Prosight Management, LP is concentrated in the following sectors based on its current disclosed equity portfolio:
• Health Care: 100.0%
Investment Profile
Prosight Management, LP returned an annualized 8.4% over the trailing 36 months — underperforming the S&P 500 by 1.3 points — based on a reconstructed track record of its disclosed 13F positions, with a beta of 0.60 (less volatile than the market) and a 39% quarterly batting average against the index.
Its portfolio is broadly diversified and fast-trading, with 100.0% of the portfolio concentrated in Health Care.
Its turnover score has risen from 0 to 58 over the past 4 quarters — a shift toward more active trading.
It has added to its BSX position over the past two quarters (+$34.2M, now $54.2M), while trimming MGTX over the same stretch (-$24.3M, still holding $1.2M).
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Developer Access
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