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Octagon Capital Advisors LP 13F Disclosure (Q2 2026) — Portfolio & Holdings
Octagon Capital Advisors LPCIK: 0001839435
Momentum followerQuality / disciplined sizing
Total reported value
$1.1B
Reporting period: 2026-06-30 · Number of holdings: 27
Octagon Capital Advisors LP disclosed 27 holdings in its latest 13F filing for the period ending 2026-06-30, with total reported value of $1.1B and a quarterly turnover rate of 49.3%.
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Personality snowflake
- Concentration
- 32.98
- Portfolio Stability
- 49.31
- Momentum
- 100
- Sector conviction
- 0
- Diversification
- 54
- Sizing Uniformity
- 88.72
Sector classification currently covers about 0% of this portfolio's disclosed value; the remainder includes holdings (e.g. unmapped tickers, options, or other security types) not yet covered by our sector mapping.
Source and citation information
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Recent moves
View source Form 13F filing on SEC.govAdd DFTX
+20.9% $92.7M
Add ABVX
+46.7% $56.9M
Sold out 260
Sold out 4XC1
Sold out 430
New buy 29479A908
Holdings Map
New buyAddUnchangedTrim
Top 10 holdings by weight
Full holdings list this quarter
| # | Ticker | Issuer | Asset Subclass | Weight | Weight Change | Shares Change | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | DNTH | Dianthus Therapeutics Inc | Stock-Other | 16.14% | -1.94% | -5.39% | |
| 2 | DFTX | Definium Therapeutics Inc | Stock-Other | 12.47% | +7.37% | +20.90% | |
| 3 | ABVX | Abivax Sa-adr | Stock-Other | 11.89% | +3.55% | +46.68% | |
| 4 | COGT | Cogent Biosciences Inc | Stock-Other | 8.17% | -1.84% | — | |
| 5 | ALMS | Alumis Inc | Stock-Other | 7.16% | +0.26% | — | |
| 6 | AVBP | Arrivent Biopharma Inc | Stock-Other | 6.15% | +1.12% | — | |
| 7 | TSHA | Taysha Gene Therapies Inc | Stock-Other | 5.93% | +1.55% | +9.41% | |
| 8 | BIOA | Bioage Labs Inc | Stock-Other | 3.85% | +0.47% | — | |
| 9 | MIRM | Mirum Pharmaceuticals Inc | Stock-Other | 3.57% | +0.11% | — | |
| 10 | KYMR | Kymera Therapeutics Inc | Stock-Other | 3.20% | -0.72% | -27.06% | |
| 11 | AKTS | Aktis Oncology Inc | Stock-Other | 2.78% | +0.88% | — | |
| 12 | XENE | Xenon Pharmaceuticals Inc | Stock-Other | 2.66% | -0.49% | — | |
| 13 | ✓ | Erasca Inc | Stock-Other | 2.07% | +2.07% | NEW | |
| 14 | PALI | Palisade Bio Inc | Stock-Other | 1.93% | -0.06% | — | |
| 15 | OCUL | Ocular Therapeutix Inc | Stock-Other | 1.83% | -1.14% | -34.47% | |
| 16 | IRON | Disc Medicine Inc | Stock-Other | 1.78% | -0.13% | — | |
| 17 | SMMT | Summit Therapeutics Inc | Stock-Other | 1.64% | +1.64% | NEW | |
| 18 | PHVS | Pharvaris N.V. | Stock-Other | 1.42% | +0.90% | +176.80% | |
| 19 | ANL | Adlai Nortye Ltd-adr | Stock-Other | 0.97% | +0.97% | NEW | |
| 20 | DTIL | Precision Biosciences Inc | Stock-Other | 0.95% | -0.41% | -39.64% | |
| 21 | DBVT | Dbv Technologies Sa-spon Adr | Stock-Other | 0.85% | -0.48% | — | |
| 22 | FTH | Faeth Therapeutics Inc | Stock-Other | 0.81% | +0.81% | NEW | |
| 23 | GYRE | Gyre Therapeutics Inc | Stock-Other | 0.57% | +0.57% | NEW | |
| 24 | TRVI | Trevi Therapeutics Inc | Stock-Other | 0.53% | -1.43% | -78.79% | |
| 25 | UNCY | Unicycive Therapeutics Inc | Stock-Other | 0.42% | -0.31% | — | |
| 26 | CNTX | Context Therapeutics Inc | Stock-Other | 0.15% | -1.37% | -41.90% | |
| 27 | GOSS | Gossamer Bio Inc | Stock-Other | 0.11% | -0.17% | — |
Portfolio Performance
Performance for Q3 2026
+6.1%
Performance Last 4 Quarters
+78.4%
- Stdev
- +41.6%
- Beta
- +0.63
- Alpha
- +31.1%
- Max Drawdown
- -40.2%
- Annualized Perf
- +41.8%
- Batting Avg vs S&P
- +44.4%
- Sortino
- +2.49
- Stutzer
- +0.32
- Treynor
- +0.68
- Sterling
- +1.33
- Calmar
- +1.04
- Information Ratio
- +0.59
- Tracking Error
- +41.2%
- Stdev Down
- +17.2%
- Winning Months %
- +63%
- Losing Months %
- +37%
- Best 12 Months
- +201.7%
- Worst 12 Months
- -23.6%
- Efficiency Ratio
- +0.52
- Sharpe
- +1.03
- Stdev Sectors
- —
- Skewness
- +1.17
- Kurtosis
- +1.93
- Upside Potential
- +4.22
Reported value over time
Sector allocation
Not enough sector-mapped data yet
Sector allocation over time
Quarterly history
| Period | Holdings | Total value | Stability | Top holdings | |
|---|---|---|---|---|---|
| 2026 Q2 | 27 | $1.1B | 49 | ||
| 2026 Q1 | 29 | $903.6M | 68 | ||
| 2025 Q4 | 27 | $823.7M | 49 | ||
| 2025 Q3 | 27 | $659.8M | 100 | ||
| 2025 Q2 | 30 | $455.6M | 0 | ||
| 2025 Q1 | 35 | $516.8M | 100 | ||
| 2024 Q4 | 33 | $607.7M | 0 | ||
| 2024 Q3 | 42 | $642.9M | 0 | ||
| 2024 Q2 | 47 | $636.3M | 0 | ||
| 2024 Q1 | 57 | $834.4M | 0 | ||
| 2023 Q4 | 33 | $625.0M | 0 | ||
| 2023 Q3 | 40 | $650.9M | 0 | ||
| 2023 Q2 | 41 | $718.7M | 0 | ||
| 2023 Q1 | 36 | $695.0M | 0 | ||
| 2022 Q4 | 32 | $642.2M | 0 | ||
| 2022 Q3 | 35 | $579.4M | 0 | ||
| 2022 Q2 | 20 | $374.7M | 0 | ||
| 2022 Q1 | 24 | $462.6M | 0 | ||
| 2021 Q4 | 28 | $513.9M | 0 | ||
| 2021 Q3 | 30 | $406.1M | 0 | ||
| 2021 Q2 | 34 | $482.8M | 72 | ||
| 2021 Q1 | 28 | $265.5M | 50 | ||
| 2020 Q4 | 31 | $288.5M | 0 |
Holding changes this quarter
Octagon Capital Advisors LP's most significant position changes for 2026-06-30: Sold out: Centessa Pharmaceuticals-adr (260); Sold out: Kalvista Pharmaceuticals Inc (4XC1); Sold out: Terns Pharmaceuticals Inc (430); New buy: Erasca Inc; New buy: Summit Therapeutics Inc (SMMT).
| # | Ticker | Issuer | Weight Change | Shares Change | Action |
|---|---|---|---|---|---|
| 1 | DFTX | Definium Therapeutics Inc | +7.4% | +20.90% | Add |
| 2 | ABVX | Abivax Sa-adr | +3.6% | +46.68% | Add |
| 3 | ✓ | Erasca Inc | +2.1% | NEW | New buy |
| 4 | SMMT | Summit Therapeutics Inc | +1.6% | NEW | New buy |
| 5 | TSHA | Taysha Gene Therapies Inc | +1.6% | +9.41% | Add |
| 6 | AVBP | Arrivent Biopharma Inc | +1.1% | — | Unchanged |
| 7 | ANL | Adlai Nortye Ltd-adr | +1% | NEW | New buy |
| 8 | PHVS | Pharvaris N.V. | +0.9% | +176.80% | Add |
| 9 | AKTS | Aktis Oncology Inc | +0.9% | — | Unchanged |
| 10 | FTH | Faeth Therapeutics Inc | +0.8% | NEW | New buy |
| 11 | GYRE | Gyre Therapeutics Inc | +0.6% | NEW | New buy |
| 12 | BIOA | Bioage Labs Inc | +0.5% | — | Unchanged |
| 13 | ALMS | Alumis Inc | +0.3% | — | Unchanged |
| 14 | MIRM | Mirum Pharmaceuticals Inc | +0.1% | — | Unchanged |
| 15 | PALI | Palisade Bio Inc | -0.1% | — | Unchanged |
| 16 | IRON | Disc Medicine Inc | -0.1% | — | Unchanged |
| 17 | GOSS | Gossamer Bio Inc | -0.2% | — | Unchanged |
| 18 | UNCY | Unicycive Therapeutics Inc | -0.3% | — | Unchanged |
| 19 | EVMN | Evommune Inc | -0.4% | EXIT | Sold out |
| 20 | CATX | Perspective Therapeutics Inc | -0.4% | EXIT | Sold out |
| 21 | DTIL | Precision Biosciences Inc | -0.4% | -39.64% | Trim |
| 22 | DBVT | Dbv Technologies Sa-spon Adr | -0.5% | — | Unchanged |
| 23 | XENE | Xenon Pharmaceuticals Inc | -0.5% | — | Unchanged |
| 24 | LXEO | Lexeo Therapeutics Inc | -0.7% | EXIT | Sold out |
| 25 | BBOT | Bridgebio Oncology Therapeut | -0.7% | EXIT | Sold out |
| 26 | KYMR | Kymera Therapeutics Inc | -0.7% | -27.06% | Trim |
| 27 | OCUL | Ocular Therapeutix Inc | -1.1% | -34.47% | Trim |
| 28 | CNTX | Context Therapeutics Inc | -1.4% | -41.90% | Trim |
| 29 | TRVI | Trevi Therapeutics Inc | -1.4% | -78.79% | Trim |
| 30 | COGT | Cogent Biosciences Inc | -1.8% | — | Unchanged |
| 31 | DNTH | Dianthus Therapeutics Inc | -1.9% | -5.39% | Trim |
| 32 | 430 | Terns Pharmaceuticals Inc | -3.1% | EXIT | Sold out |
| 33 | 4XC1 | Kalvista Pharmaceuticals Inc | -3.2% | EXIT | Sold out |
| 34 | 260 | Centessa Pharmaceuticals-adr | -3.3% | EXIT | Sold out |
Filing History
FAQ
What is Octagon Capital Advisors LP and what type of investor is it?
Octagon Capital Advisors LP is an investment manager that files SEC Form 13F quarterly, disclosing its U.S. public equity holdings to regulators. As of the most recent reporting period (2026-06-30), the firm manages a tracked equity portfolio valued at approximately $1.1B, spread across 27 disclosed positions.
What are Octagon Capital Advisors LP's largest equity positions?
Based on the latest 13F filing, Octagon Capital Advisors LP's top holdings by market value are:
1. Dianthus Therapeutics Inc (DNTH) — $179.5M (16.1%)
2. Definium Therapeutics Inc (DFTX) — $138.8M (12.5%)
3. Abivax Sa-adr (ABVX) — $132.3M (11.9%)
4. Cogent Biosciences Inc (COGT) — $90.9M (8.2%)
5. Alumis Inc (ALMS) — $79.7M (7.2%)
What changes did Octagon Capital Advisors LP make in its most recent portfolio filing?
In the latest reported quarter, Octagon Capital Advisors LP made 22 notable position adjustments: 5 new positions were initiated, 4 existing holdings were added to, 6 positions were partially reduced, and 7 were completely exited. The largest of these moves: Sold out: Centessa Pharmaceuticals-adr (260); Sold out: Kalvista Pharmaceuticals Inc (4XC1); Sold out: Terns Pharmaceuticals Inc (430); New buy: Erasca Inc; New buy: Summit Therapeutics Inc (SMMT)
What sectors does Octagon Capital Advisors LP focus on?
Sector breakdown data is not yet available for Octagon Capital Advisors LP. Check back after the next 13F processing cycle.
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Data Source Notice: AlphaSMO is the web's most authoritative 13F / Inside Trader database. Institutional holdings and insider trades presented here are precisely computed to deliver accurate portfolio reporting.
Investment Profile
Octagon Capital Advisors LP returned an annualized 41.8% over the trailing 27 months — outperforming the S&P 500 by 31.1 points — based on a reconstructed track record of its disclosed 13F positions, with a beta of 0.63 (less volatile than the market) and a 44% quarterly batting average against the index.
Its portfolio is broadly diversified and moderately active.
Its turnover score has risen from 0 to 49 over the past 4 quarters — a shift toward more active trading.
It has added to its DNTH position over the past two quarters (+$79.9M, now $179.5M), while trimming GOSS over the same stretch (-$41.9M, still holding $1.3M).
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Developer Access
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REST API
curl https://alphasmo.com/api/v1/institutions/octagon-capital-advisors-lpCLI
npx alphasmo institutions get octagon-capital-advisors-lp