| EcoR1 Capital, LLC | $575.2M | 24.41% |
| Rubric Capital Management LP | $175.3M | 1.86% |
| BlackRock, Inc. | $114.0M | 0.00% |
| BVF INC/IL | $93.5M | 2.98% |
| PERCEPTIVE ADVISORS LLC | $87.9M | 1.72% |
| MORGAN STANLEY | $62.1M | 0.00% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $47.8M | 0.06% |
| VANGUARD CAPITAL MANAGEMENT LLC | $42.7M | 0.00% |
| CITADEL ADVISORS LLC | $31.3M | 0.01% |
| DIMENSIONAL FUND ADVISORS LP | $28.5M | 0.01% |
| Nextech Invest, Ltd. | $27.9M | 1.96% |
| STATE STREET CORP | $25.3M | 0.00% |
| Capricorn Fund Managers Ltd | $25.2M | 3.93% |
| DEUTSCHE BANK AG\ | $23.1M | 0.01% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | $18.6M | 0.01% |
| Assenagon Asset Management S.A. | $18.2M | 0.03% |
| FMR LLC | $16.7M | 0.00% |
| GEODE CAPITAL MANAGEMENT, LLC | $16.5M | 0.00% |
| Nuveen, LLC | $16.3M | 0.00% |
| GOLDMAN SACHS GROUP INC | $15.0M | 0.00% |
| MPM BIOIMPACT LLC | $14.2M | 1.09% |
| Prosight Management, LP | $13.5M | 2.21% |
| Qube Research & Technologies Ltd | $12.8M | 0.01% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $12.5M | 0.00% |
| Redmile Group, LLC | $12.3M | 0.82% |
| Hillsdale Investment Management Inc. | $8.7M | 0.24% |
| SummitTX Capital, L.P. | $8.0M | 0.25% |
| NORTHERN TRUST CORP | $8.0M | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $8.0M | 0.00% |
| ROYCE & ASSOCIATES LP | $7.5M | 0.07% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $6.9M | 0.00% |
| PICTON MAHONEY ASSET MANAGEMENT | $6.4M | 0.05% |
| Granahan Investment Management, LLC | $6.3M | 0.30% |
| HRT FINANCIAL LP | $6.0M | 0.01% |
| BANK OF AMERICA CORP /DE/ | $5.9M | 0.00% |
| D. E. Shaw & Co., Inc. | $5.9M | 0.00% |
| JANE STREET GROUP, LLC | $5.7M | 0.00% |
| PANAGORA ASSET MANAGEMENT INC | $5.2M | 0.02% |
| Man Group plc | $4.8M | 0.01% |
| WELLS FARGO & COMPANY/MN | $4.7M | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $4.6M | 0.00% |
| FEDERATED HERMES, INC. | $4.6M | 0.01% |
| RAYMOND JAMES FINANCIAL INC | $4.4M | 0.00% |
| UBS Group AG | $4.3M | 0.00% |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | $4.1M | 0.03% |
| KENNEDY CAPITAL MANAGEMENT LLC | $3.7M | 0.08% |
| XTX Topco Ltd | $3.6M | 0.06% |
| DIADEMA PARTNERS LP | $3.6M | 0.61% |
| WELLINGTON MANAGEMENT GROUP LLP | $3.5M | 0.00% |
| Invesco Ltd. | $3.1M | 0.00% |
| Bank of New York Mellon Corp | $3.1M | 0.00% |
| CITIGROUP INC | $2.9M | 0.00% |
| JPMORGAN CHASE & CO | $2.8M | 0.00% |
| PLATINUM INVESTMENT MANAGEMENT LTD | $2.6M | 0.66% |
| Tidal Investments LLC | $2.6M | 0.01% |
| Tema ETFs LLC | $2.6M | 0.18% |
| Fisher Asset Management, LLC | $2.5M | 0.00% |
| Susquehanna Portfolio Strategies, LLC | $2.5M | 0.04% |
| AQR CAPITAL MANAGEMENT LLC | $2.3M | 0.00% |
| KORNITZER CAPITAL MANAGEMENT INC /KS | $2.2M | 0.05% |
| VANGUARD FIDUCIARY TRUST CO | $2.1M | 0.00% |
| Squarepoint Ops LLC | $2.1M | 0.00% |
| MACKENZIE FINANCIAL CORP | $2.1M | 0.00% |
| Verdad Advisers, LP | $2.1M | 2.33% |
| PRINCIPAL FINANCIAL GROUP INC | $2.0M | 0.00% |
| FRANKLIN RESOURCES INC | $1.9M | 0.00% |
| STIFEL FINANCIAL CORP | $1.9M | 0.00% |
| RHUMBLINE ADVISERS | $1.9M | 0.00% |
| CREDIT AGRICOLE S A | $1.9M | 0.00% |
| AMERIPRISE FINANCIAL INC | $1.9M | 0.00% |
| Swiss National Bank | $1.9M | 0.00% |
| AMERICAN CENTURY COMPANIES INC | $1.8M | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | $1.7M | 0.00% |
| ALLIANCEBERNSTEIN L.P. | $1.5M | 0.00% |
| Dana Investment Advisors, Inc. | $1.4M | 0.04% |
| Campbell & CO Investment Adviser LLC | $1.4M | 0.08% |
| DLD Asset Management, LP | $1.3M | 0.12% |
| MILLENNIUM MANAGEMENT LLC | $1.3M | 0.00% |
| Russell Investments Group, Ltd. | $1.2M | 0.00% |
| ROYAL BANK OF CANADA | $1.2M | 0.00% |
| SEGALL BRYANT & HAMILL, LLC | $1.1M | 0.02% |
| North Growth Management Ltd. | $1.1M | 0.17% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | $1.1M | 0.00% |
| VICTORY CAPITAL MANAGEMENT INC | $1.1M | 0.00% |
| ENVESTNET ASSET MANAGEMENT INC | $1.0M | 0.00% |
| Manatuck Hill Partners, LLC | $1.0M | 0.27% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $995.3K | 0.00% |
| Quantinno Capital Management LP | $992.6K | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $985.4K | 0.00% |
| Connor, Clark & Lunn Investment Management Ltd. | $949.5K | 0.00% |
| HSBC HOLDINGS PLC | $940.1K | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $936.2K | 0.00% |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | $929.7K | 0.00% |
| TUDOR INVESTMENT CORP ET AL | $923.4K | 0.00% |
| HighTower Advisors, LLC | $908.0K | 0.00% |
| Persistent Asset Partners Ltd | $899.8K | 0.34% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $889.0K | 0.00% |
| HighVista Strategies LLC | $853.5K | 0.24% |
| Vinva Investment Management Ltd | $850.8K | 0.01% |
| MARTINGALE ASSET MANAGEMENT L P | $820.4K | 0.02% |
| Creative Planning | $811.1K | 0.00% |
| MARSHALL WACE, LLP | $806.9K | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $791.1K | 0.00% |
| Engineers Gate Manager LP | $790.0K | 0.01% |
| SBI Okasan Asset Management Co.Ltd. | $774.7K | 0.03% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $762.0K | 0.00% |
| STRS OHIO | $753.7K | 0.00% |
| MetLife Investment Management, LLC | $742.5K | 0.00% |
| JOURNEY STRATEGIC WEALTH LLC | $727.4K | 0.02% |
| OXFORD ASSET MANAGEMENT LLP | $696.4K | 0.30% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | $686.3K | 0.00% |
| ExodusPoint Capital Management, LP | $685.4K | 0.01% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | $684.9K | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | $658.0K | 0.00% |
| Legal & General Group Plc | $656.3K | 0.00% |
| COMMONWEALTH EQUITY SERVICES, LLC | $651.8K | 0.00% |
| Walleye Capital LLC | $615.4K | 0.00% |
| RITHOLTZ WEALTH MANAGEMENT | $607.0K | 0.01% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $585.3K | 0.00% |
| Walleye Trading LLC | $575.9K | 0.00% |
| Headlands Technologies LLC | $572.0K | 0.07% |
| Duncan Williams Asset Management, LLC | $553.3K | 0.15% |
| PRUDENTIAL FINANCIAL INC | $550.1K | 0.00% |
| GSA CAPITAL PARTNERS LLP | $514.0K | 0.03% |
| Jackson Creek Investment Advisors LLC | $468.0K | 0.14% |
| BARCLAYS PLC | $460.1K | 0.00% |
| JANUS HENDERSON GROUP PLC | $455.8K | 0.00% |
| BANK OF MONTREAL /CAN/ | $437.4K | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | $435.0K | 0.00% |
| State of Wyoming | $429.4K | 0.05% |
| Quadrature Capital Ltd | $419.0K | 0.00% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $384.1K | 0.00% |
| AGF MANAGEMENT LTD | $375.6K | 0.00% |
| Amundi | $352.7K | 0.00% |
| Police & Firemen's Retirement System of New Jersey | $343.1K | 0.00% |
| China Universal Asset Management Co., Ltd. | $332.5K | 0.03% |
| Freestone Grove Partners LP | $324.1K | 0.00% |
| State of New Jersey Common Pension Fund D | $320.2K | 0.00% |
| Northwest & Ethical Investments L.P. | $316.4K | 0.01% |
| INTECH INVESTMENT MANAGEMENT LLC | $314.0K | 0.00% |
| Abacus Wealth Partners, LLC | $292.2K | 0.03% |
| Janney Montgomery Scott LLC | $288.0K | 0.00% |
| JAMES INVESTMENT RESEARCH, INC. | $273.6K | 0.03% |
| Ewing Morris & Co. Investment Partners Ltd. | $271.7K | 0.12% |
| Virtus Investment Advisers, LLC | $268.0K | 0.07% |
| LAZARD ASSET MANAGEMENT LLC | $265.5K | 0.00% |
| ProShare Advisors LLC | $264.8K | 0.00% |
| SG Americas Securities, LLC | $261.0K | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | $257.3K | 0.00% |
| PSP Research LLC | $250.4K | 0.18% |