MB
MPM BioImpact LLC — 13F Filing & Top Stock Positions (Q2 2026)
MPM BioImpact LLCCIK: 0001687078
Sector-focusedMomentum followerQuality / disciplined sizing
Total reported value
$1.6B
Reporting period: 2026-06-30 · Number of holdings: 37
MPM BioImpact LLC disclosed 37 holdings in its latest 13F filing for the period ending 2026-06-30, with total reported value of $1.6B and a quarterly turnover rate of 70.4%.
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Personality snowflake
- Concentration
- 18.54
- Portfolio Stability
- 70.38
- Momentum
- 100
- Sector conviction
- 100
- Diversification
- 74
- Sizing Uniformity
- 91.43
MPM BioImpact LLC's disclosed holdings carry a Herfindahl concentration index of 0.046 — mathematically equivalent to about 22 equally-sized positions, well below its 37 actual disclosed holdings. That gap points to a strategy built around a small core of high-conviction bets rather than broad diversification.
Position sizes are fairly uniform across the portfolio (a coefficient of variation of 0.86), suggesting a disciplined, rules-based approach to how much capital goes into each idea.
No strong tilt toward either adding to existing winners or initiating outsized new positions was observed in the latest reported quarter.
Sector classification currently covers about 11% of this portfolio's disclosed value; the remainder includes holdings (e.g. unmapped tickers, options, or other security types) not yet covered by our sector mapping.
Source and citation information
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Recent moves
View source Form 13F filing on SEC.govTrim DBVT
-29.7% -$48.8M
Sold out AGIO
New buy RARE
Add AKTS
0.0% $69.3M
Add LQDA
-1.4% $57.5M
Sold out XENE
Holdings Map
New buyAddUnchangedTrim
Top 10 holdings by weight
Full holdings list this quarter
| # | Ticker | Issuer | Asset Subclass | Weight | Weight Change | Shares Change | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | CGEM | Cullinan Therapeutics Inc | Stock-Other | 10.81% | +2.42% | +27.24% | |
| 2 | AKTS | Aktis Oncology Inc | Stock-Other | 9.50% | +2.82% | — | |
| 3 | LQDA | Liquidia CORP | Stock-Other | 6.74% | +2.64% | -1.35% | |
| 4 | RVMD | Revolution Medicines Inc | Stock-Healthcare | 5.62% | +1.81% | -2.82% | |
| 5 | CORT | Corcept Therapeutics Inc | Stock-Healthcare | 4.09% | +1.02% | -21.78% | |
| 6 | EWTX | Edgewise Therapeutics Inc | Stock-Other | 4.02% | -0.02% | -2.40% | |
| 7 | TVTX | Travere Therapeutics Inc | Stock-Other | 3.89% | +1.29% | -0.94% | |
| 8 | DBVT | Dbv Technologies Sa-spon Adr | Stock-Other | 3.67% | -4.74% | -29.68% | |
| 9 | TRVI | Trevi Therapeutics Inc | Stock-Other | 3.50% | +0.46% | -6.82% | |
| 10 | ALMS | Alumis Inc | Stock-Other | 3.46% | -0.60% | -15.40% | |
| 11 | QURE | uniQure N.V. | Stock-Other | 3.44% | +1.71% | -10.47% | |
| 12 | RARE | Ultragenyx Pharmaceutical In | Stock-Other | 2.89% | +2.89% | NEW | |
| 13 | RLAY | Relay Therapeutics Inc | Stock-Other | 2.76% | +0.95% | +2.38% | |
| 14 | ABVX | Abivax Sa-adr | Stock-Other | 2.73% | +1.81% | +213.56% | |
| 15 | DYN | Dyne Therapeutics Inc | Stock-Other | 2.60% | +0.63% | +36.50% | |
| 16 | DNTH | Dianthus Therapeutics Inc | Stock-Other | 2.50% | -0.25% | -0.94% | |
| 17 | BIOA | Bioage Labs Inc | Stock-Other | 2.49% | +2.49% | NEW | |
| 18 | URGN | UroGen Pharma Ltd. | Stock-Other | 2.09% | +0.78% | -1.10% | |
| 19 | MLTX | Moonlake Immunotherapeutics | Stock-Other | 1.91% | -0.70% | -11.27% | |
| 20 | PVLA | Palvella Therapeutics Inc | Stock-Other | 1.90% | -0.09% | -1.15% | |
| 21 | TSHA | Taysha Gene Therapies Inc | Stock-Other | 1.87% | +1.87% | NEW | |
| 22 | SNDX | Syndax Pharmaceuticals Inc | Stock-Other | 1.78% | -0.64% | -0.54% | |
| 23 | GLUE | Monte Rosa Therapeutics Inc | Stock-Other | 1.71% | +0.21% | -1.35% | |
| 24 | ✓ | Zura Bio LTD | Stock-Other | 1.61% | +1.61% | NEW | |
| 25 | NTRA | Natera Inc | Stock-Healthcare | 1.53% | +0.09% | -0.47% | |
| 26 | STOK | Stoke Therapeutics Inc | Stock-Other | 1.44% | -0.49% | -5.70% | |
| 27 | ANL | Adlai Nortye Ltd-adr | Stock-Other | 1.36% | +1.36% | NEW | |
| 28 | BLTE | Belite Bio Inc - Adr | Stock-Other | 1.29% | +0.21% | +55.84% | |
| 29 | FBRX | Forte Biosciences Inc | Stock-Other | 1.28% | -0.72% | -1.32% | |
| 30 | ORIC | Oric Pharmaceuticals Inc | Stock-Other | 1.24% | -0.53% | +4.34% | |
| 31 | TARS | Tarsus Pharmaceuticals Inc | Stock-Other | 1.24% | -0.55% | -2.35% | |
| 32 | ANNX | Annexon Inc | Stock-Other | 1.23% | +1.23% | NEW | |
| 33 | DRUG | Bright Minds Biosciences Inc | Stock-Other | 0.87% | -0.33% | -4.74% | |
| 34 | TRDA | Entrada Therapeutics Inc | Stock-Other | 0.56% | +0.56% | NEW | |
| 35 | ACRS | Aclaris Therapeutics Inc | Stock-Other | 0.34% | +0.23% | +165.99% | |
| 36 | CNTX | Context Therapeutics Inc | Stock-Other | 0.04% | -2.12% | -87.84% | |
| 37 | HOWL | Werewolf Therapeutics Inc | Stock-Other | — | -0.08% | -93.37% |
Portfolio Performance
Performance for Q3 2026
+19.3%
Performance Last 4 Quarters
+106.6%
- Stdev
- +35.9%
- Beta
- +0.62
- Alpha
- +17.2%
- Max Drawdown
- -44.4%
- Annualized Perf
- +26.3%
- Batting Avg vs S&P
- +50%
- Sortino
- +1.52
- Stutzer
- +0.24
- Treynor
- +0.48
- Sterling
- +0.88
- Calmar
- +0.59
- Information Ratio
- +0.27
- Tracking Error
- +35.3%
- Stdev Down
- +19.5%
- Winning Months %
- +63.9%
- Losing Months %
- +36.1%
- Best 12 Months
- +119.4%
- Worst 12 Months
- -39.5%
- Efficiency Ratio
- +0.34
- Sharpe
- +0.83
- Stdev Sectors
- 0%
- Skewness
- +0.27
- Kurtosis
- -0.38
- Upside Potential
- +3.3
Reported value over time
Sector allocation
Sector allocation over time
Quarterly history
| Period | Holdings | Total value | Stability | Top holdings | |
|---|---|---|---|---|---|
| 2026 Q2 | 37 | $1.6B | 70 | ||
| 2026 Q1 | 41 | $1.3B | 72 | ||
| 2025 Q4 | 38 | $874.0M | 97 | ||
| 2025 Q3 | 40 | $610.9M | 75 | ||
| 2025 Q2 | 44 | $577.2M | 0 | ||
| 2025 Q1 | 43 | $581.7M | 100 | ||
| 2024 Q4 | 47 | $704.4M | 0 | ||
| 2024 Q3 | 43 | $666.6M | 0 | ||
| 2024 Q2 | 44 | $643.5M | 0 | ||
| 2024 Q1 | 38 | $622.0M | 0 | ||
| 2023 Q4 | 32 | $427.4M | 0 | ||
| 2023 Q3 | 32 | $374.6M | 0 | ||
| 2023 Q2 | 34 | $496.6M | 0 | ||
| 2023 Q1 | 31 | $384.9M | 0 | ||
| 2022 Q4 | 33 | $385.5M | 0 | ||
| 2022 Q3 | 38 | $422.2M | 0 | ||
| 2022 Q2 | 37 | $360.0M | 0 | ||
| 2022 Q1 | 37 | $372.6M | 0 | ||
| 2021 Q4 | 33 | $548.5M | 0 | ||
| 2021 Q3 | 33 | $644.7M | 0 | ||
| 2021 Q2 | 14 | $608.7M | 100 | ||
| 2021 Q1 | 13 | $795.9M | 72 | ||
| 2020 Q4 | 13 | $569.4M | 38 | ||
| 2020 Q3 | 12 | $415.1M | 32 | ||
| 2020 Q2 | 11 | $376.1M | 84 | ||
| 2020 Q1 | 10 | $163.7M | 66 | ||
| 2019 Q4 | 12 | $282.2M | 0 |
Holding changes this quarter
MPM BioImpact LLC's most significant position changes for 2026-06-30: New buy: Ultragenyx Pharmaceutical In (RARE); Sold out: Agios Pharmaceuticals Inc (AGIO); New buy: Bioage Labs Inc (BIOA); Sold out: Xenon Pharmaceuticals Inc (XENE); Sold out: Evommune Inc (EVMN).
| # | Ticker | Issuer | Weight Change | Shares Change | Action |
|---|---|---|---|---|---|
| 1 | RARE | Ultragenyx Pharmaceutical In | +2.9% | NEW | New buy |
| 2 | AKTS | Aktis Oncology Inc | +2.8% | — | Unchanged |
| 3 | LQDA | Liquidia CORP | +2.6% | -1.35% | Trim |
| 4 | BIOA | Bioage Labs Inc | +2.5% | NEW | New buy |
| 5 | CGEM | Cullinan Therapeutics Inc | +2.4% | +27.24% | Add |
| 6 | TSHA | Taysha Gene Therapies Inc | +1.9% | NEW | New buy |
| 7 | RVMD | Revolution Medicines Inc | +1.8% | -2.82% | Trim |
| 8 | ABVX | Abivax Sa-adr | +1.8% | +213.56% | Add |
| 9 | QURE | uniQure N.V. | +1.7% | -10.47% | Trim |
| 10 | ✓ | Zura Bio LTD | +1.6% | NEW | New buy |
| 11 | ANL | Adlai Nortye Ltd-adr | +1.4% | NEW | New buy |
| 12 | TVTX | Travere Therapeutics Inc | +1.3% | -0.94% | Trim |
| 13 | ANNX | Annexon Inc | +1.2% | NEW | New buy |
| 14 | CORT | Corcept Therapeutics Inc | +1% | -21.78% | Trim |
| 15 | RLAY | Relay Therapeutics Inc | +1% | +2.38% | Add |
| 16 | URGN | UroGen Pharma Ltd. | +0.8% | -1.10% | Trim |
| 17 | DYN | Dyne Therapeutics Inc | +0.6% | +36.50% | Add |
| 18 | TRDA | Entrada Therapeutics Inc | +0.6% | NEW | New buy |
| 19 | TRVI | Trevi Therapeutics Inc | +0.5% | -6.82% | Trim |
| 20 | ACRS | Aclaris Therapeutics Inc | +0.2% | +165.99% | Add |
| 21 | GLUE | Monte Rosa Therapeutics Inc | +0.2% | -1.35% | Trim |
| 22 | BLTE | Belite Bio Inc - Adr | +0.2% | +55.84% | Add |
| 23 | NTRA | Natera Inc | +0.1% | -0.47% | Trim |
| 24 | EWTX | Edgewise Therapeutics Inc | 0% | -2.40% | Trim |
| 25 | HOWL | Werewolf Therapeutics Inc | -0.1% | -93.37% | Trim |
| 26 | PVLA | Palvella Therapeutics Inc | -0.1% | -1.15% | Trim |
| 27 | DNTH | Dianthus Therapeutics Inc | -0.3% | -0.94% | Trim |
| 28 | DRUG | Bright Minds Biosciences Inc | -0.3% | -4.74% | Trim |
| 29 | ALLO | Allogene Therapeutics Inc | -0.4% | EXIT | Sold out |
| 30 | STOK | Stoke Therapeutics Inc | -0.5% | -5.70% | Trim |
| 31 | ORIC | Oric Pharmaceuticals Inc | -0.5% | +4.34% | Add |
| 32 | TARS | Tarsus Pharmaceuticals Inc | -0.6% | -2.35% | Trim |
| 33 | ALMS | Alumis Inc | -0.6% | -15.40% | Trim |
| 34 | SNDX | Syndax Pharmaceuticals Inc | -0.6% | -0.54% | Trim |
| 35 | MLTX | Moonlake Immunotherapeutics | -0.7% | -11.27% | Trim |
| 36 | FBRX | Forte Biosciences Inc | -0.7% | -1.32% | Trim |
| 37 | ✓ | Engene Holdings Inc | -1% | EXIT | Sold out |
| 38 | VRDN | Viridian Therapeutics Inc | -1% | EXIT | Sold out |
| 39 | ZYME | Zymeworks Inc | -1.1% | EXIT | Sold out |
| 40 | ARQT | Arcutis Biotherapeutics Inc | -1.3% | EXIT | Sold out |
| 41 | CLYM | Climb Bio Inc | -1.4% | EXIT | Sold out |
| 42 | CRVS | Corvus Pharmaceuticals Inc | -1.9% | EXIT | Sold out |
| 43 | CNTX | Context Therapeutics Inc | -2.1% | -87.84% | Trim |
| 44 | CYTK | Cytokinetics Inc | -2.5% | EXIT | Sold out |
| 45 | EVMN | Evommune Inc | -2.6% | EXIT | Sold out |
| 46 | XENE | Xenon Pharmaceuticals Inc | -2.6% | EXIT | Sold out |
| 47 | AGIO | Agios Pharmaceuticals Inc | -3.4% | EXIT | Sold out |
| 48 | DBVT | Dbv Technologies Sa-spon Adr | -4.7% | -29.68% | Trim |
Filing History
FAQ
What is MPM BioImpact LLC and what type of investor is it?
MPM BioImpact LLC is an investment manager that files SEC Form 13F quarterly, disclosing its U.S. public equity holdings to regulators. As of the most recent reporting period (2026-06-30), the firm manages a tracked equity portfolio valued at approximately $1.6B, spread across 37 disclosed positions.
What are MPM BioImpact LLC's largest equity positions?
Based on the latest 13F filing, MPM BioImpact LLC's top holdings by market value are:
1. Cullinan Therapeutics Inc (CGEM) — $177.2M (10.8%)
2. Aktis Oncology Inc (AKTS) — $155.9M (9.5%)
3. Liquidia CORP (LQDA) — $110.5M (6.7%)
4. Revolution Medicines Inc (RVMD) — $92.2M (5.6%)
5. Corcept Therapeutics Inc (CORT) — $67.0M (4.1%)
What changes did MPM BioImpact LLC make in its most recent portfolio filing?
In the latest reported quarter, MPM BioImpact LLC made 47 notable position adjustments: 7 new positions were initiated, 7 existing holdings were added to, 22 positions were partially reduced, and 11 were completely exited. The largest of these moves: New buy: Ultragenyx Pharmaceutical In (RARE); Sold out: Agios Pharmaceuticals Inc (AGIO); New buy: Bioage Labs Inc (BIOA); Sold out: Xenon Pharmaceuticals Inc (XENE); Sold out: Evommune Inc (EVMN)
What sectors does MPM BioImpact LLC focus on?
MPM BioImpact LLC is concentrated in the following sectors based on its current disclosed equity portfolio:
• Health Care: 100.0%
Investment Profile
MPM BioImpact LLC returned an annualized 26.3% over the trailing 36 months — outperforming the S&P 500 by 17.2 points — based on a reconstructed track record of its disclosed 13F positions, with a beta of 0.62 (less volatile than the market) and a 50% quarterly batting average against the index.
Its portfolio is broadly diversified and fast-trading, with 100.0% of the portfolio concentrated in Health Care.
Its turnover score has risen from 0 to 70 over the past 4 quarters — a shift toward more active trading.
It has added to its CGEM position over the past two quarters (+$98.0M, now $177.2M), while trimming TARS over the same stretch (-$6.7M, still holding $20.3M).
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Developer Access
Access MPM BioImpact LLC's institutional profile programmatically:
REST API
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