SA
Sectoral Asset Management Inc 13F Holdings & Position Changes (Q2 2026)
Sectoral Asset Management IncCIK: 0001274413
Diversified strategySector-focusedQuality / disciplined sizing
Total reported value
$143.3M
Reporting period: 2026-06-30 · Number of holdings: 82
SECTORAL ASSET MANAGEMENT INC disclosed 82 holdings in its latest 13F filing for the period ending 2026-06-30, with total reported value of $143.3M and a quarterly turnover rate of 60.0%.
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Personality snowflake
- Concentration
- 10.95
- Portfolio Stability
- 60.02
- Momentum
- 66.79
- Sector conviction
- 100
- Diversification
- 100
- Sizing Uniformity
- 88.78
Sectoral Asset Management Inc's disclosed holdings carry a Herfindahl concentration index of 0.027 — mathematically equivalent to about 37 equally-sized positions, well below its 82 actual disclosed holdings. That gap points to a strategy built around a small core of high-conviction bets rather than broad diversification.
Position sizes are fairly uniform across the portfolio (a coefficient of variation of 1.12), suggesting a disciplined, rules-based approach to how much capital goes into each idea.
No strong tilt toward either adding to existing winners or initiating outsized new positions was observed in the latest reported quarter.
Sector classification currently covers about 54% of this portfolio's disclosed value; the remainder includes holdings (e.g. unmapped tickers, options, or other security types) not yet covered by our sector mapping.
Source and citation information
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Recent moves
View source Form 13F filing on SEC.govSold out EVMN
New buy ORKA
New buy DFTX
New buy IRTC
Trim GILD
-25.0% -$1.5M
New buy AVTX
Holdings Map
New buyAddUnchangedTrim
Top 10 holdings by weight
Full holdings list this quarter
| # | Ticker | Issuer | Asset Subclass | Weight | Weight Change | Shares Change | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | CTNM | Contineum Therapeutics Inc-a | Stock-Other | 8.32% | +0.45% | — | |
| 2 | SI | Shoulder Innovations Inc | Stock-Other | 6.09% | +0.91% | — | |
| 3 | LLY | Eli Lilly & Co | Stock-Healthcare | 5.32% | +0.48% | — | |
| 4 | UNH | Unitedhealth Group Inc | Stock-Healthcare | 3.84% | +0.49% | -11.51% | |
| 5 | JNJ | Johnson & Johnson | Stock-Healthcare | 3.23% | -0.46% | — | |
| 6 | ORKA | Oruka Therapeutics Inc | Stock-Other | 2.79% | +2.79% | NEW | |
| 7 | BNTX | Biontech Se-adr | Stock-Other | 2.72% | +1.03% | +88.91% | |
| 8 | DFTX | Definium Therapeutics Inc | Stock-Other | 2.57% | +2.57% | NEW | |
| 9 | DXCM | Dexcom Inc | Stock-Healthcare | 2.39% | +1.18% | +118.48% | |
| 10 | RCUS | Arcus Biosciences Inc | Stock-Other | 2.39% | +1.53% | +146.00% | |
| 11 | AMGN | Amgen Inc | Stock-Healthcare | 2.33% | -0.58% | — | |
| 12 | SMMT | Summit Therapeutics Inc | Stock-Other | 2.24% | +1.08% | +216.28% | |
| 13 | IRTC | Irhythm Holdings Inc | Stock-Healthcare | 2.16% | +2.16% | NEW | |
| 14 | ABBV | Abbvie Inc | Stock-Healthcare | 2.14% | -0.06% | — | |
| 15 | MRK | Merck & Co. Inc. | Stock-Healthcare | 1.94% | -0.20% | — | |
| 16 | AVBP | Arrivent Biopharma Inc | Stock-Other | 1.92% | +1.32% | +163.36% | |
| 17 | VRTX | Vertex Pharmaceuticals Inc | Stock-Healthcare | 1.88% | -0.98% | -22.48% | |
| 18 | ARGX | Argenx Se - Adr | Stock-Healthcare | 1.83% | -0.44% | -20.57% | |
| 19 | GILD | Gilead Sciences Inc | Stock-Healthcare | 1.82% | -1.60% | -24.99% | |
| 20 | INSM | Insmed Inc | Stock-Healthcare | 1.73% | -1.07% | +18.04% | |
| 21 | TECX | Tectonic Therapeutic Inc | Stock-Other | 1.70% | +1.18% | +272.57% | |
| 22 | ISRG | Intuitive Surgical Inc | Stock-Healthcare | 1.62% | -0.38% | +11.43% | |
| 23 | ✓ | Immatics NV | Stock-Other | 1.59% | +1.02% | +236.57% | |
| 24 | SYK | Stryker CORP | Stock-Healthcare | 1.57% | -0.03% | +21.37% | |
| 25 | AVTX | Avalo Therapeutics Inc | Stock-Other | 1.55% | +1.55% | NEW | |
| 26 | ✓ | Crescent Biopharma Inc. | Stock-Other | 1.52% | +1.52% | NEW | |
| 27 | ROIV | Roivant Sciences Ltd. | Stock-Healthcare | 1.51% | +0.67% | +88.00% | |
| 28 | IQV | Iqvia Holdings Inc | Stock-Healthcare | 1.46% | +0.29% | +30.59% | |
| 29 | PLSE | Pulse Biosciences Inc | Stock-Other | 1.31% | +1.31% | NEW | |
| 30 | DHR | Danaher CORP | Stock-Healthcare | 1.28% | -0.23% | — | |
| 31 | TMO | Thermo Fisher Scientific Inc | Stock-Healthcare | 1.23% | -0.20% | — | |
| 32 | ABT | Abbott Laboratories | Stock-Healthcare | 1.14% | -1.04% | -29.31% | |
| 33 | ATEC | Alphatec Holdings Inc | Stock-Other | 1.12% | +1.12% | NEW | |
| 34 | BSX | Boston Scientific CORP | Stock-Healthcare | 1.08% | -0.73% | +4.46% | |
| 35 | TMDX | Transmedics Group Inc | Stock-Healthcare | 1.02% | +1.02% | NEW | |
| 36 | CYTK | Cytokinetics Inc | Stock-Healthcare | 0.97% | +0.52% | +123.70% | |
| 37 | REGN | Regeneron Pharmaceuticals | Stock-Healthcare | 0.94% | -1.12% | -25.69% | |
| 38 | CVS | Cvs Health CORP | Stock-Healthcare | 0.94% | +0.94% | NEW | |
| 39 | EW | Edwards Lifesciences CORP | Stock-Healthcare | 0.94% | -0.21% | -14.49% | |
| 40 | TRVI | Trevi Therapeutics Inc | Stock-Other | 0.85% | +0.07% | -11.89% | |
| 41 | BMY | Bristol-myers Squibb Co | Stock-Healthcare | 0.85% | -0.21% | — | |
| 42 | VERA | Vera Therapeutics Inc | Stock-Other | 0.77% | -0.13% | — | |
| 43 | COGT | Cogent Biosciences Inc | Stock-Other | 0.72% | -0.03% | +20.78% | |
| 44 | MDT | Medtronic plc | Stock-Healthcare | 0.61% | -0.19% | — | |
| 45 | TARS | Tarsus Pharmaceuticals Inc | Stock-Other | 0.58% | -0.13% | +17.86% | |
| 46 | KURA | Kura Oncology Inc | Stock-Other | 0.55% | +0.05% | — | |
| 47 | CNC | Centene CORP | Stock-Healthcare | 0.54% | +0.54% | NEW | |
| 48 | UTHR | United Therapeutics CORP | Stock-Healthcare | 0.52% | -0.43% | -19.88% | |
| 49 | HNGE | Hinge Health Inc-a | Stock-Other | 0.51% | +0.12% | -28.59% | |
| 50 | NKTR | Nektar Therapeutics | Stock-Other | 0.49% | -0.19% | -6.82% |
1–50 of 82
💡
Data Source Notice: AlphaSMO is the web's most authoritative 13F / Inside Trader database. Institutional holdings and insider trades presented here are precisely computed to deliver accurate portfolio reporting.
Portfolio Performance
Performance for Q3 2026
+10.2%
Performance Last 4 Quarters
+34.5%
- Stdev
- +22.2%
- Beta
- +0.83
- Alpha
- -1.3%
- Max Drawdown
- -18.9%
- Annualized Perf
- +13.8%
- Batting Avg vs S&P
- +36.1%
- Sortino
- +1.23
- Stutzer
- +0.2
- Treynor
- +0.18
- Sterling
- +0.62
- Calmar
- +0.73
- Information Ratio
- -0.24
- Tracking Error
- +19.5%
- Stdev Down
- +12.5%
- Winning Months %
- +58.3%
- Losing Months %
- +41.7%
- Best 12 Months
- +48.7%
- Worst 12 Months
- -12.6%
- Efficiency Ratio
- +0.27
- Sharpe
- +0.69
- Stdev Sectors
- 0%
- Skewness
- +0.33
- Kurtosis
- +0.27
- Upside Potential
- +2.94
Reported value over time
Sector allocation
Sector allocation over time
Quarterly history
| Period | Holdings | Total value | Stability | Top holdings | |
|---|---|---|---|---|---|
| 2026 Q2 | 82 | $143.3M | 60 | ||
| 2026 Q1 | 77 | $120.7M | 30 | ||
| 2025 Q4 | 74 | $124.8M | 65 | ||
| 2025 Q3 | 82 | $162.0M | 91 | ||
| 2025 Q2 | 94 | $151.5M | 0 | ||
| 2025 Q1 | 84 | $128.5M | 100 | ||
| 2024 Q4 | 86 | $149.8M | 0 | ||
| 2024 Q3 | 90 | $169.3M | 0 | ||
| 2024 Q2 | 97 | $246.1M | 0 | ||
| 2024 Q1 | 92 | $254.4M | 0 | ||
| 2023 Q4 | 104 | $232.2M | 0 | ||
| 2023 Q3 | 123 | $513.5M | 0 | ||
| 2023 Q2 | 121 | $599.8M | 0 | ||
| 2023 Q1 | 118 | $520.3M | 0 | ||
| 2022 Q4 | 120 | $516.8M | 0 | ||
| 2022 Q3 | 109 | $507.6M | 0 | ||
| 2022 Q2 | 112 | $496.3M | 0 | ||
| 2022 Q1 | 106 | $563.3M | 0 | ||
| 2021 Q4 | 108 | $664.4M | 0 | ||
| 2021 Q3 | 127 | $1.2B | 0 | ||
| 2021 Q2 | 127 | $1.2B | 100 | ||
| 2021 Q1 | 113 | $1.3B | 77 | ||
| 2020 Q4 | 97 | $1.4B | 65 | ||
| 2020 Q3 | 88 | $1.2B | 71 | ||
| 2020 Q2 | 191 | $1.1B | 91 | ||
| 2020 Q1 | 65 | $520.9M | 53 | ||
| 2019 Q4 | 65 | $670.2M | 73 | ||
| 2019 Q3 | 63 | $579.6M | 53 | ||
| 2019 Q2 | 92 | $836.3M | 32 | ||
| 2019 Q1 | 106 | $831.4M | 38 | ||
| 2018 Q4 | 104 | $735.6M | 46 | ||
| 2018 Q3 | 168 | $941.9M | 40 | ||
| 2018 Q2 | 67 | $894.4M | 45 | ||
| 2018 Q1 | 68 | $912.1M | 48 | ||
| 2017 Q4 | 67 | $800.3M | 48 | ||
| 2017 Q3 | 62 | $776.3M | 56 | ||
| 2017 Q2 | 61 | $914.4M | 45 | ||
| 2017 Q1 | 65 | $856.3M | 61 | ||
| 2016 Q4 | 55 | $902.7M | 50 | ||
| 2016 Q3 | 56 | $1.0B | 38 | ||
| 2016 Q2 | 64 | $968.4M | 94 | ||
| 2016 Q1 | 81 | $2.1B | 45 | ||
| 2015 Q4 | 75 | $2.3B | 35 | ||
| 2015 Q3 | 77 | $2.2B | 31 | ||
| 2015 Q2 | 91 | $2.4B | 51 | ||
| 2015 Q1 | 77 | $2.6B | 47 | ||
| 2014 Q4 | 64 | $2.2B | 34 | ||
| 2014 Q3 | 66 | $2.4B | 30 | ||
| 2014 Q2 | 64 | $2.4B | 34 | ||
| 2014 Q1 | 64 | $2.4B | 32 | ||
| 2013 Q4 | 59 | $2.3B | 41 | ||
| 2013 Q3 | 55 | $2.1B | 77 | ||
| 2013 Q2 | 56 | $3.4B | 0 |
Holding changes this quarter
Sectoral Asset Management Inc's most significant position changes for 2026-06-30: Sold out: Evommune Inc (EVMN); New buy: Oruka Therapeutics Inc (ORKA); New buy: Definium Therapeutics Inc (DFTX); New buy: Irhythm Holdings Inc (IRTC); New buy: Avalo Therapeutics Inc (AVTX).
| # | Ticker | Issuer | Weight Change | Shares Change | Action |
|---|---|---|---|---|---|
| 1 | ORKA | Oruka Therapeutics Inc | +2.8% | NEW | New buy |
| 2 | DFTX | Definium Therapeutics Inc | +2.6% | NEW | New buy |
| 3 | IRTC | Irhythm Holdings Inc | +2.2% | NEW | New buy |
| 4 | AVTX | Avalo Therapeutics Inc | +1.6% | NEW | New buy |
| 5 | RCUS | Arcus Biosciences Inc | +1.5% | +146.00% | Add |
| 6 | ✓ | Crescent Biopharma Inc. | +1.5% | NEW | New buy |
| 7 | AVBP | Arrivent Biopharma Inc | +1.3% | +163.36% | Add |
| 8 | PLSE | Pulse Biosciences Inc | +1.3% | NEW | New buy |
| 9 | DXCM | Dexcom Inc | +1.2% | +118.48% | Add |
| 10 | TECX | Tectonic Therapeutic Inc | +1.2% | +272.57% | Add |
| 11 | ATEC | Alphatec Holdings Inc | +1.1% | NEW | New buy |
| 12 | SMMT | Summit Therapeutics Inc | +1.1% | +216.28% | Add |
| 13 | BNTX | Biontech Se-adr | +1% | +88.91% | Add |
| 14 | ✓ | Immatics NV | +1% | +236.57% | Add |
| 15 | TMDX | Transmedics Group Inc | +1% | NEW | New buy |
| 16 | CVS | Cvs Health CORP | +0.9% | NEW | New buy |
| 17 | SI | Shoulder Innovations Inc | +0.9% | — | Unchanged |
| 18 | ROIV | Roivant Sciences Ltd. | +0.7% | +88.00% | Add |
| 19 | CNC | Centene CORP | +0.5% | NEW | New buy |
| 20 | CYTK | Cytokinetics Inc | +0.5% | +123.70% | Add |
| 21 | UNH | Unitedhealth Group Inc | +0.5% | -11.51% | Trim |
| 22 | LLY | Eli Lilly & Co | +0.5% | — | Unchanged |
| 23 | ✓ | Ascendis Pharma A/s | +0.5% | NEW | New buy |
| 24 | CTNM | Contineum Therapeutics Inc-a | +0.5% | — | Unchanged |
| 25 | HUM | Humana Inc | +0.4% | NEW | New buy |
| 26 | IQV | Iqvia Holdings Inc | +0.3% | +30.59% | Add |
| 27 | TEM | Tempus Ai Inc-cl A | +0.2% | NEW | New buy |
| 28 | CRBP | Corbus Pharmaceuticals Holdi | +0.1% | NEW | New buy |
| 29 | HNGE | Hinge Health Inc-a | +0.1% | -28.59% | Trim |
| 30 | TRVI | Trevi Therapeutics Inc | +0.1% | -11.89% | Trim |
| 31 | RVMD | Revolution Medicines Inc | +0.1% | — | Unchanged |
| 32 | KURA | Kura Oncology Inc | +0.1% | — | Unchanged |
| 33 | GH | Guardant Health Inc | 0% | — | Unchanged |
| 34 | ENGN | Engene Therapeutics Inc | 0% | NEW | New buy |
| 35 | AXSM | Axsome Therapeutics Inc | 0% | — | Unchanged |
| 36 | ILMN | Illumina Inc | 0% | — | Unchanged |
| 37 | PTCT | Ptc Therapeutics Inc | — | +12.33% | Add |
| 38 | MRNA | Moderna Inc | — | — | Unchanged |
| 39 | AGMB | Agomab Therapeutics NV | 0% | — | Unchanged |
| 40 | PALI | Palisade Bio Inc | 0% | — | Unchanged |
| 41 | JAZZ | Jazz Pharmaceuticals plc | 0% | — | Unchanged |
| 42 | INCY | Incyte CORP | 0% | — | Unchanged |
| 43 | SYK | Stryker CORP | 0% | +21.37% | Add |
| 44 | COGT | Cogent Biosciences Inc | 0% | +20.78% | Add |
| 45 | PRVA | Privia Health Group Inc | 0% | -11.06% | Trim |
| 46 | ABVX | Abivax Sa-adr | 0% | — | Unchanged |
| 47 | MEDP | Medpace Holdings Inc | 0% | — | Unchanged |
| 48 | BIIB | Biogen Inc | 0% | — | Unchanged |
| 49 | RPRX | Royalty Pharma plc | -0.1% | — | Unchanged |
| 50 | ABBV | Abbvie Inc | -0.1% | — | Unchanged |
1–50 of 92
Filing History
FAQ
What is Sectoral Asset Management Inc and what type of investor is it?
Sectoral Asset Management Inc is an investment manager that files SEC Form 13F quarterly, disclosing its U.S. public equity holdings to regulators. As of the most recent reporting period (2026-06-30), the firm manages a tracked equity portfolio valued at approximately $143.3M, spread across 82 disclosed positions.
What are Sectoral Asset Management Inc's largest equity positions?
Based on the latest 13F filing, Sectoral Asset Management Inc's top holdings by market value are:
1. Contineum Therapeutics Inc-a (CTNM) — $11.9M (8.3%)
2. Shoulder Innovations Inc (SI) — $8.7M (6.1%)
3. Eli Lilly & Co (LLY) — $7.6M (5.3%)
4. Unitedhealth Group Inc (UNH) — $5.5M (3.8%)
5. Johnson & Johnson (JNJ) — $4.6M (3.2%)
What changes did Sectoral Asset Management Inc make in its most recent portfolio filing?
In the latest reported quarter, Sectoral Asset Management Inc made 59 notable position adjustments: 15 new positions were initiated, 17 existing holdings were added to, 17 positions were partially reduced, and 10 were completely exited. The largest of these moves: Sold out: Evommune Inc (EVMN); New buy: Oruka Therapeutics Inc (ORKA); New buy: Definium Therapeutics Inc (DFTX); New buy: Irhythm Holdings Inc (IRTC); New buy: Avalo Therapeutics Inc (AVTX)
What sectors does Sectoral Asset Management Inc focus on?
Sectoral Asset Management Inc is concentrated in the following sectors based on its current disclosed equity portfolio:
• Health Care: 100.0%
Investment Profile
Sectoral Asset Management Inc returned an annualized 13.8% over the trailing 36 months — underperforming the S&P 500 by 1.3 points — based on a reconstructed track record of its disclosed 13F positions, with a beta of 0.83 (less volatile than the market) and a 36% quarterly batting average against the index.
Its portfolio is broadly diversified and fast-trading, with 100.0% of the portfolio concentrated in Health Care.
Its turnover score has risen from 0 to 60 over the past 4 quarters — a shift toward more active trading.
It has added to its CTNM position over the past two quarters (+$2.8M, now $11.9M), while trimming REGN over the same stretch (-$1.5M, still holding $1.4M).
Peer Institutions
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IC
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CIK 0001608826
Total reported value
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57 stks
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Concentration29.0
Portfolio Stability19.8
Sector conviction0.0
AUM within 0.0% of this institution
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JP
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CIK 0002051108
Total reported value
$143.4M
15 stks
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SL
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CIK 0001946733
Total reported value
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Concentration100.0
Portfolio Stability4.6
Sector conviction100.0
AUM within 0.1% of this institution
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Developer Access
Access Sectoral Asset Management Inc's institutional profile programmatically:
REST API
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