CIK: 0001306923
Total reported value
$653.9M
| # | Ticker | Issuer | Asset Subclass | Weight | Weight Change | Shares Change | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | INSM | Insmed INC | Stock-Healthcare | 18.52% | -1.47% | -12.36% | |
| 2 | ACAD | Acadia Pharmaceuticals INC | Stock-Healthcare | 11.76% | +0.54% | -3.78% | |
| 3 | BMRN | Biomarin Pharmaceutical INC | Stock-Healthcare | 9.83% | -0.25% | -15.21% | |
| 4 | AM6 | Amicus Therapeutics INC | Stock-Other | 6.84% | -7.86% | -23.61% | |
| 5 | UTHR | United Therapeutics CORP | Stock-Healthcare | 5.84% | +1.75% | -9.26% | |
| 6 | BIIB | Biogen INC | Stock-Healthcare | 5.50% | -0.55% | +0.41% | |
| 7 | ALNY | Alnylam Pharmaceuticals INC | Stock-Healthcare | 5.24% | — | -9.53% | |
| 8 | PTCT | Ptc Therapeutics INC | Stock-Healthcare | 4.22% | +0.04% | +0.56% | |
| 9 | ANAB | Anaptysbio INC | Stock-Other | 3.84% | +0.75% | -20.37% | |
| 10 | NVCR | NovoCure Limited | Stock-Healthcare | 3.64% | -0.21% | -3.96% | |
| 11 | STAA | Staar Surgical Co | Stock-Other | 2.83% | — | +50.83% | |
| 12 | AGIO | Agios Pharmaceuticals INC | Stock-Other | 1.90% | +0.30% | -2.82% | |
| 13 | PRTA | Prothena Corporation plc | Stock-Other | 1.65% | +0.04% | -23.20% | |
| 14 | IRON | Disc Medicine INC | Stock-Other | 1.64% | +0.42% | — | |
| 15 | ALGN | Align Technology INC | Stock-Healthcare | 1.52% | +0.19% | — | |
| 16 | GOSS | Gossamer Bio INC | Stock-Other | 1.50% | -1.93% | EXIT | |
| 17 | EHTH | Ehealth INC | Stock-Other | 1.46% | -0.69% | -6.32% | |
| 18 | ALKS | Alkermes plc | Stock-Healthcare | 1.35% | +0.37% | -0.22% | |
| 19 | IOVA | Iovance Biotherapeutics INC | Stock-Other | 1.25% | +0.71% | +6.79% | |
| 20 | SNDX | Syndax Pharmaceuticals INC | Stock-Other | 0.89% | +0.77% | — | |
| 21 | RNAGBP | Avidity Biosciences INC | Stock-Other | 0.72% | — | — | |
| 22 | DNLI | Denali Therapeutics INC | Stock-Other | 0.71% | -0.78% | — | |
| 23 | MIRM | Mirum Pharmaceuticals INC | Stock-Other | 0.70% | +2.87% | — | |
| 24 | EW | Edwards Lifesciences CORP | Stock-Healthcare | 0.66% | +0.01% | — | |
| 25 | TSHA | Taysha Gene Therapies INC | Stock-Other | 0.61% | +0.04% | -12.22% | |
| 26 | BNTX | Biontech Se-adr | Stock-Other | 0.57% | +0.01% | — | |
| 27 | DYN | Dyne Therapeutics INC | Stock-Other | 0.54% | +0.57% | -20.52% | |
| 28 | CRSP | CRISPR Therapeutics AG | Stock-Healthcare | 0.46% | -0.01% | — | |
| 29 | ACRS | Aclaris Therapeutics INC | Stock-Other | 0.42% | +0.27% | +79.12% | |
| 30 | RARE | Ultragenyx Pharmaceutical In | Stock-Other | 0.38% | +0.43% | — | |
| 31 | BCYC | Bicycle Therapeutics Plc-adr | Stock-Other | 0.37% | -0.08% | — | |
| 32 | NBIX | Neurocrine Biosciences INC | Stock-Healthcare | 0.36% | — | — | |
| 33 | TVTX | Travere Therapeutics INC | Stock-Other | 0.35% | +0.46% | — | |
| 34 | NUVB | Nuvation Bio INC | Stock-Other | 0.32% | -0.34% | — | |
| 35 | STOK | Stoke Therapeutics INC | Stock-Other | 0.30% | +0.10% | — | |
| 36 | PYXS | Pyxis Oncology INC | Stock-Other | 0.24% | +0.06% | — | |
| 37 | HUM | Humana INC | Stock-Healthcare | 0.21% | -0.03% | — | |
| 38 | ALDX | Aldeyra Therapeutics INC | Stock-Other | 0.18% | -0.12% | — | |
| 39 | KPTI | Karyopharm Therapeutics INC | Stock-Other | 0.17% | — | — | |
| 40 | VYNE | Vyne Therapeutics INC | Stock-Other | 0.16% | — | — | |
| 41 | ABEO | Abeona Therapeutics INC | Stock-Other | 0.13% | — | — | |
| 42 | ALMS | Alumis INC | Stock-Other | 0.09% | — | — | |
| 43 | URGN | UroGen Pharma Ltd. | Stock-Other | 0.07% | -0.01% | — | |
| 44 | ✓ | Akari Therapeutics PLC | Stock-Other | 0.04% | — | — | |
| 45 | GBIOGBX | Generation Bio Co | Stock-Other | 0.01% | — | — |