CIK: 0001892770
Total reported value
$189.2M
Reporting period: 2026-06-30 · Number of holdings: 86
Knott David M Jr disclosed 86 holdings in its latest 13F filing for the period ending 2026-06-30, with total reported value of $189.2M and a quarterly turnover rate of 26.4%.
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Knott David M Jr's disclosed holdings carry a Herfindahl concentration index of 0.067 — mathematically equivalent to about 15 equally-sized positions, well below its 86 actual disclosed holdings. That gap points to a strategy built around a small core of high-conviction bets rather than broad diversification.
Position sizes vary widely across the portfolio (a coefficient of variation of 2.16), with a handful of outsized bets alongside many smaller positions.
No strong tilt toward either adding to existing winners or initiating outsized new positions was observed in the latest reported quarter.
Sector classification currently covers about 48% of this portfolio's disclosed value; the remainder includes holdings (e.g. unmapped tickers, options, or other security types) not yet covered by our sector mapping.
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Add TVTX
+4.7% $4.2M
New buy CLST
Sold out CPRX
Add GOOG
0.0% $6.1M
Sold out ACLXGBX
Sold out CYTK
Showing top 84 holdings (of 86 total)
| # | Ticker | Issuer | Asset Subclass | Weight | Weight Change | Shares Change | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | GOOG | Alphabet Inc-cl C | Stock-Comm Services | 17.07% | +1.46% | — | |
| 2 | APO | Apollo Global Management Inc | Stock-Financials | 14.07% | -0.85% | — | |
| 3 | SNDX | Syndax Pharmaceuticals Inc | Stock-Other | 5.05% | -0.82% | +3.61% | |
| 4 | XERS | Xeris Biopharma Holdings Inc | Stock-Other | 4.44% | +0.78% | — | |
| 5 | TVTX | Travere Therapeutics Inc | Stock-Other | 4.42% | +1.93% | +4.73% | |
| 6 | PTGX | Protagonist Therapeutics Inc | Stock-Other | 4.08% | +0.13% | — | |
| 7 | BBIO | Bridgebio Pharma Inc | Stock-Healthcare | 3.66% | -0.32% | +3.17% | |
| 8 | IOVA | Iovance Biotherapeutics Inc | Stock-Other | 3.52% | +0.18% | — | |
| 9 | ALKS | Alkermes plc | Stock-Healthcare | 3.37% | +0.84% | +1.47% | |
| 10 | JPM | Jpmorgan Chase & Co | Stock-Financials | 3.13% | -0.28% | -7.08% | |
| 11 | JAAA | Janus Henderson Aaa Clo ETF | ETF-Other | 2.50% | -0.30% | — | |
| 12 | ✓ | LPL Financial Holdings Inc. | Stock-Other | 2.46% | -0.49% | — | |
| 13 | COGT | Cogent Biosciences Inc | Stock-Other | 2.27% | -0.11% | +6.81% | |
| 14 | TGTX | Tg Therapeutics Inc | Stock-Healthcare | 1.94% | +0.16% | -25.74% | |
| 15 | CLST | Catalyst Bancorp Inc | Stock-Other | 1.89% | +1.89% | NEW | |
| 16 | AGIO | Agios Pharmaceuticals Inc | Stock-Other | 1.86% | -0.01% | +2.15% | |
| 17 | VRDN | Viridian Therapeutics Inc | Stock-Other | 1.76% | -0.35% | — | |
| 18 | RLMD | Relmada Therapeutics Inc | Stock-Other | 1.65% | -0.17% | +2.66% | |
| 19 | RCUS | Arcus Biosciences Inc | Stock-Other | 1.32% | +0.28% | — | |
| 20 | HELP | Cybin Inc | Stock-Other | 1.29% | +0.29% | +5.71% | |
| 21 | XBI | Ss Spdr S&p Biotech ETF | ETF-Tech | 1.25% | +0.11% | — | |
| 22 | RZLT | Rezolute Inc | Stock-Other | 1.02% | +0.35% | — | |
| 23 | AB | Alliancebernstein Holding LP | Stock-Other | 0.89% | -0.18% | — | |
| 24 | MDGL | Madrigal Pharmaceuticals Inc | Stock-Healthcare | 0.85% | +0.23% | +50.00% | |
| 25 | ATRC | Atricure Inc | Stock-Other | 0.76% | -0.11% | — | |
| 26 | DCGO | Docgo Inc | Stock-Other | 0.73% | -0.27% | — | |
| 27 | ARDX | Ardelyx Inc | Stock-Other | 0.71% | -0.03% | +27.13% | |
| 28 | RARE | Ultragenyx Pharmaceutical In | Stock-Other | 0.67% | +0.26% | +15.12% | |
| 29 | CLOZ | Eldridge Bbb-b Clo ETF | ETF-Other | 0.67% | -0.06% | — | |
| 30 | CGEM | Cullinan Therapeutics Inc | Stock-Other | 0.67% | +0.47% | +185.88% | |
| 31 | JNJ | Johnson & Johnson | Stock-Healthcare | 0.66% | -0.06% | — | |
| 32 | VERA | Vera Therapeutics Inc | Stock-Other | 0.59% | -0.03% | — | |
| 33 | OBIO | Orchestra Biomed Holdings In | Stock-Other | 0.58% | -0.06% | — | |
| 34 | SPRB | Spruce Biosciences Inc | Stock-Other | 0.57% | +0.57% | NEW | |
| 35 | ✓ | Connect Biopharma Hldgs LTD | Stock-Other | 0.56% | -0.04% | +14.70% | |
| 36 | IBB | Ishares Biotechnology ETF | ETF-Tech | 0.55% | — | — | |
| 37 | BIIB | Biogen Inc | Stock-Healthcare | 0.46% | +0.02% | — | |
| 38 | PFE | Pfizer Inc | Stock-Healthcare | 0.41% | -0.13% | — | |
| 39 | AAPL | Apple Inc | Stock-Tech | 0.38% | — | — | |
| 40 | CNQ | Canadian Natural Resources | Stock-Energy | 0.35% | -0.14% | — | |
| 41 | PTHS | Pelthos Therapeutics Inc | Stock-Other | 0.33% | +0.07% | +4.75% | |
| 42 | IBM | Intl Business Machines CORP | Stock-Tech | 0.32% | +0.01% | — | |
| 43 | MSFT | Microsoft CORP | Stock-Tech | 0.32% | -0.03% | — | |
| 44 | VSTM | Verastem Inc | Stock-Other | 0.31% | -0.02% | +49.04% | |
| 45 | KURA | Kura Oncology Inc | Stock-Other | 0.31% | +0.05% | — | |
| 46 | SLDB | Solid Biosciences Inc | Stock-Other | 0.30% | +0.10% | +19.23% | |
| 47 | ✓ | Stock-Other | 0.27% | +0.27% | NEW | ||
| 48 | INSM | Insmed Inc | Stock-Healthcare | 0.24% | +0.24% | NEW | |
| 49 | LBRX | Lb Pharmaceuticals Inc | Stock-Other | 0.22% | +0.22% | NEW | |
| 50 | CDNA | Caredx Inc | Stock-Other | 0.21% | +0.21% | NEW |
Performance for Q3 2026
+13.1%
Performance Last 4 Quarters
+61.6%
| Period | Holdings | Total value | Stability | Top holdings | |
|---|---|---|---|---|---|
| 2026 Q2 | 86 | $189.2M | 26 | ||
| 2026 Q1 | 88 | $168.0M | 54 | ||
| 2025 Q4 | 91 | $215.9M | 44 | ||
| 2025 Q3 | 92 | $248.0M | 50 | ||
| 2025 Q2 | 89 | $220.6M | 0 | ||
| 2025 Q1 | 88 | $212.0M | 0 | ||
| 2024 Q4 | 93 | $276.5M | 0 | ||
| 2024 Q3 | 99 | $253.9M | 0 | ||
| 2024 Q2 | 106 | $250.6M | 0 | ||
| 2024 Q1 | 114 | $282.8M | 0 | ||
| 2023 Q4 | 119 | $261.6M | 0 | ||
| 2023 Q3 | 135 | $261.9M | 0 | ||
| 2023 Q2 | 153 | $251.3M | 0 | ||
| 2023 Q1 | 154 | $254.5M | 0 | ||
| 2022 Q4 | 182 | $264.7M | 0 | ||
| 2022 Q3 | 192 | $237.6M | 0 | ||
| 2022 Q2 | 197 | $238.1M | 0 | ||
| 2022 Q1 | 180 | $314.0M | 0 | ||
| 2021 Q4 | 170 | $294.6M | 0 |
Knott David M Jr's most significant position changes for 2026-06-30: New buy: Catalyst Bancorp Inc (CLST); Sold out: Catalyst Pharmaceuticals Inc (CPRX); Sold out: Arcellx Inc (ACLXGBX); Sold out: Cytokinetics Inc (CYTK); Sold out: Centessa Pharmaceuticals-adr (260).
| # | Ticker | Issuer | Weight Change | Shares Change | Action |
|---|---|---|---|---|---|
| 1 | TVTX | Travere Therapeutics Inc | +1.9% | +4.73% | Add |
| 2 | CLST | Catalyst Bancorp Inc | +1.9% | NEW | New buy |
| 3 | GOOG | Alphabet Inc-cl C | +1.5% | — | Unchanged |
| 4 | ALKS | Alkermes plc | +0.8% | +1.47% | Add |
| 5 | XERS | Xeris Biopharma Holdings Inc | +0.8% | — | Unchanged |
| 6 | SPRB | Spruce Biosciences Inc | +0.6% | NEW | New buy |
| 7 | CGEM | Cullinan Therapeutics Inc | +0.5% | +185.88% | Add |
| 8 | RZLT | Rezolute Inc | +0.4% | — | Unchanged |
| 9 | HELP | Cybin Inc | +0.3% | +5.71% | Add |
| 10 | RCUS | Arcus Biosciences Inc | +0.3% | — | Unchanged |
| 11 | ✓ | +0.3% | NEW | New buy | |
| 12 | RARE | Ultragenyx Pharmaceutical In | +0.3% | +15.12% | Add |
| 13 | INSM | Insmed Inc | +0.2% | NEW | New buy |
| 14 | MDGL | Madrigal Pharmaceuticals Inc | +0.2% | +50.00% | Add |
| 15 | LBRX | Lb Pharmaceuticals Inc | +0.2% | NEW | New buy |
| 16 | CDNA | Caredx Inc | +0.2% | NEW | New buy |
| 17 | QTTB | Q32 Bio Inc | +0.2% | NEW | New buy |
| 18 | IOVA | Iovance Biotherapeutics Inc | +0.2% | — | Unchanged |
| 19 | ELVN | Enliven Therapeutics Inc | +0.2% | NEW | New buy |
| 20 | TGTX | Tg Therapeutics Inc | +0.2% | -25.74% | Trim |
| 21 | BSX | Boston Scientific CORP | +0.1% | NEW | New buy |
| 22 | PTGX | Protagonist Therapeutics Inc | +0.1% | — | Unchanged |
| 23 | XBI | Ss Spdr S&p Biotech ETF | +0.1% | — | Unchanged |
| 24 | SLDB | Solid Biosciences Inc | +0.1% | +19.23% | Add |
| 25 | PTHS | Pelthos Therapeutics Inc | +0.1% | +4.75% | Add |
| 26 | KURA | Kura Oncology Inc | +0.1% | — | Unchanged |
| 27 | RHP | Ryman Hospitality Properties | 0% | — | Unchanged |
| 28 | BIIB | Biogen Inc | 0% | — | Unchanged |
| 29 | URI | United Rentals Inc | 0% | — | Unchanged |
| 30 | FSK | Fs Kkr Capital CORP | 0% | NEW | New buy |
| 31 | IBM | Intl Business Machines CORP | 0% | — | Unchanged |
| 32 | AVGO | Broadcom Inc | 0% | — | Unchanged |
| 33 | NVDA | Nvidia CORP | 0% | — | Unchanged |
| 34 | PWR | Quanta Services Inc | 0% | — | Unchanged |
| 35 | LEGH | Legacy Housing CORP | 0% | — | Unchanged |
| 36 | GOOGL | Alphabet Inc-cl A | 0% | — | Unchanged |
| 37 | IBB | Ishares Biotechnology ETF | — | — | Unchanged |
| 38 | AAPL | Apple Inc | — | — | Unchanged |
| 39 | KMB | Kimberly-clark CORP | — | — | Unchanged |
| 40 | EBC | Eastern Bankshares Inc | — | — | Unchanged |
| 41 | IWP | Ishares Russell Mid-cap Grow | — | — | Unchanged |
| 42 | AMZN | Amazon.com Inc | — | — | Unchanged |
| 43 | UNH | Unitedhealth Group Inc | — | — | Unchanged |
| 44 | OXY-WS | Occidental Petroleum-cw27 | — | NEW | New buy |
| 45 | CRM | Salesforce Inc | — | — | Unchanged |
| 46 | KD | Kyndryl Holdings Inc | — | — | Unchanged |
| 47 | BX | Blackstone Inc | — | — | Unchanged |
| 48 | TMO | Thermo Fisher Scientific Inc | — | — | Unchanged |
| 49 | GEHC | GE Healthcare Technology | — | — | Unchanged |
| 50 | STWD | Starwood Property Trust Inc | — | — | Unchanged |
Knott David M Jr returned an annualized 27.5% over the trailing 36 months — outperforming the S&P 500 by 10.6 points — based on a reconstructed track record of its disclosed 13F positions, with a beta of 0.78 (less volatile than the market) and a 53% quarterly batting average against the index.
Its portfolio is broadly diversified and moderately active, with 35.5% of the portfolio concentrated in Financials.
Its turnover score has risen from 0 to 26 over the past 4 quarters — a shift toward more active trading.
It has added to its ALKS position over the past two quarters (+$3.7M, now $6.4M), while trimming WVE over the same stretch (-$1.3M, still holding $232.4K).
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