CIK: 0001892770
Total reported value
$168.0M
Reporting period: 2026-03-31 · Number of holdings: 88
Knott David M Jr disclosed 88 holdings in its latest 13F filing for the period ending 2026-03-31, with total reported value of $168.0M and a quarterly turnover rate of 54.5%.
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Knott David M Jr's disclosed holdings carry a Herfindahl concentration index of 0.064 — mathematically equivalent to about 16 equally-sized positions, well below its 88 actual disclosed holdings. That gap points to a strategy built around a small core of high-conviction bets rather than broad diversification.
Position sizes vary widely across the portfolio (a coefficient of variation of 2.11), with a handful of outsized bets alongside many smaller positions.
No strong tilt toward either adding to existing winners or initiating outsized new positions was observed in the latest reported quarter.
Sector classification currently covers about 51% of this portfolio's disclosed value; the remainder includes holdings (e.g. unmapped tickers, options, or other security types) not yet covered by our sector mapping.
Add GOOG
0.0% -$2.5M
Add SNDX
+1.7% $1.1M
Add AGIO
+417.0% $2.7M
Add ALKS
+26.3% $1.6M
Add TGTX
+100.0% $1.6M
Add PTGX
-13.7% $264.4K
Showing top 85 holdings (of 88 total)
| # | Ticker | Issuer | Asset Subclass | Weight | Weight Change | Shares Change | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | GOOG | Alphabet Inc-cl C | Stock-Comm Services | 15.61% | +2.33% | — | |
| 2 | APO | Apollo Global Management INC | Stock-Financials | 14.92% | -0.16% | — | |
| 3 | SNDX | Syndax Pharmaceuticals INC | Stock-Other | 5.87% | +1.83% | +1.69% | |
| 4 | BBIO | Bridgebio Pharma INC | Stock-Healthcare | 3.98% | — | +5.88% | |
| 5 | PTGX | Protagonist Therapeutics INC | Stock-Other | 3.95% | +1.00% | -13.70% | |
| 6 | XERS | Xeris Biopharma Holdings INC | Stock-Other | 3.66% | +0.13% | +9.28% | |
| 7 | JPM | Jpmorgan Chase & Co | Stock-Financials | 3.41% | +0.50% | — | |
| 8 | IOVA | Iovance Biotherapeutics INC | Stock-Other | 3.34% | +3.34% | NEW | |
| 9 | ✓ | LPL Financial Holdings Inc. | Stock-Other | 2.95% | +2.95% | NEW | |
| 10 | JAAA | Janus Henderson Aaa Clo ETF | ETF-Other | 2.80% | — | — | |
| 11 | ALKS | Alkermes plc | Stock-Healthcare | 2.53% | +1.30% | +26.32% | |
| 12 | TVTX | Travere Therapeutics INC | Stock-Other | 2.49% | -0.80% | -24.39% | |
| 13 | COGT | Cogent Biosciences INC | Stock-Other | 2.38% | +0.70% | +1.96% | |
| 14 | VRDN | Viridian Therapeutics INC | Stock-Other | 2.11% | +0.02% | +24.83% | |
| 15 | AGIO | Agios Pharmaceuticals INC | Stock-Other | 1.87% | +1.64% | +416.99% | |
| 16 | RLMD | Relmada Therapeutics INC | Stock-Other | 1.82% | +1.82% | NEW | |
| 17 | TGTX | Tg Therapeutics INC | Stock-Healthcare | 1.78% | +1.16% | +100.00% | |
| 18 | CPRX | Catalyst Pharmaceuticals INC | Stock-Healthcare | 1.77% | -0.27% | -36.51% | |
| 19 | ✓ | Arcellx INC Common Stock | Stock-Other | 1.33% | +0.55% | -24.39% | |
| 20 | XBI | Ss Spdr S&p Biotech ETF | ETF-Tech | 1.14% | +0.41% | +15.38% | |
| 21 | AB | Alliancebernstein Holding LP | Stock-Other | 1.07% | — | — | |
| 22 | RCUS | Arcus Biosciences INC | Stock-Other | 1.04% | -0.30% | -32.99% | |
| 23 | DCGO | Docgo INC | Stock-Other | 1.00% | -0.09% | — | |
| 24 | HELP | Cybin INC | Stock-Other | 1.00% | -0.08% | +22.73% | |
| 25 | CYTK | Cytokinetics INC | Stock-Healthcare | 0.93% | -0.07% | -30.46% | |
| 26 | 260 | Centessa Pharmaceuticals-adr | Stock-Other | 0.92% | +0.87% | +875.00% | |
| 27 | ATRC | Atricure INC | Stock-Other | 0.87% | -0.07% | — | |
| 28 | ARDX | Ardelyx INC | Stock-Other | 0.74% | +0.74% | NEW | |
| 29 | CLOZ | Eldridge Bbb-b Clo ETF | ETF-Other | 0.73% | — | — | |
| 30 | JNJ | Johnson & Johnson | Stock-Healthcare | 0.72% | — | -28.89% | |
| 31 | RZLT | Rezolute INC | Stock-Other | 0.67% | +0.30% | +8.82% | |
| 32 | OBIO | Orchestra Biomed Holdings In | Stock-Other | 0.64% | — | +1.46% | |
| 33 | MDGL | Madrigal Pharmaceuticals INC | Stock-Healthcare | 0.62% | — | — | |
| 34 | VERA | Vera Therapeutics INC | Stock-Other | 0.62% | +0.01% | — | |
| 35 | ✓ | Connect Biopharma Hldgs LTD | Stock-Other | 0.60% | +0.34% | +93.92% | |
| 36 | IBB | Ishares Biotechnology ETF | ETF-Tech | 0.55% | — | — | |
| 37 | PFE | Pfizer INC | Stock-Healthcare | 0.54% | — | — | |
| 38 | BMY | Bristol-myers Squibb Co | Stock-Healthcare | 0.49% | -0.06% | -38.08% | |
| 39 | CNQ | Canadian Natural Resources | Stock-Energy | 0.49% | +0.23% | — | |
| 40 | BIIB | Biogen INC | Stock-Healthcare | 0.44% | -0.05% | -33.33% | |
| 41 | RARE | Ultragenyx Pharmaceutical In | Stock-Other | 0.41% | +0.20% | +65.30% | |
| 42 | AAPL | Apple INC | Stock-Tech | 0.38% | — | — | |
| 43 | MSFT | Microsoft CORP | Stock-Tech | 0.35% | — | — | |
| 44 | VSTM | Verastem INC | Stock-Other | 0.33% | +0.33% | NEW | |
| 45 | ADMA | Adma Biologics INC | Stock-Healthcare | 0.32% | -0.19% | — | |
| 46 | IBM | Intl Business Machines CORP | Stock-Tech | 0.31% | — | — | |
| 47 | ✓ | Biohaven Pharmaceutical Holding Co. Ltd | Stock-Other | 0.31% | +0.31% | NEW | |
| 48 | PTHS | Pelthos Therapeutics INC | Stock-Other | 0.26% | — | +9.29% | |
| 49 | KURA | Kura Oncology INC | Stock-Other | 0.26% | — | +34.58% | |
| 50 | ✓ | Evolus INC | Stock-Other | 0.24% | -0.07% | — |
Performance for Q3 2026
+11.2%
Performance Last 4 Quarters
+62.8%
Based on 86% of reported portfolio value with available pricing
| Period | Holdings | Total value | Stability | Top holdings |
|---|---|---|---|---|
| 2026-03-31 | 88 | $168.0M | 54 | |
| 2025-12-31 | 91 | $215.9M | 44 | |
| 2025-09-30 | 92 | $248.0M | 50 | |
| 2025-06-30 | 89 | $220.6M | 0 | |
| 2025-03-31 | 88 | $212.0M | 0 | |
| 2024-12-31 | 93 | $276.5M | 0 | |
| 2024-09-30 | 99 | $284.6M | 0 | |
| 2024-06-30 | 106 | $250.6M | 0 | |
| 2024-03-31 | 114 | $282.8M | 0 | |
| 2023-12-31 | 119 | $261.6M | 0 | |
| 2023-09-30 | 135 | $261.9M | 0 | |
| 2023-06-30 | 153 | $251.3M | 0 | |
| 2023-03-31 | 154 | $254.5M | 0 | |
| 2022-12-31 | 182 | $264.7M | 0 | |
| 2022-09-30 | 192 | $237.6M | 0 | |
| 2022-06-30 | 197 | $238.1M | 0 | |
| 2022-03-31 | 180 | $314.0M | 0 | |
| 2021-12-31 | 170 | $294.6M | 0 |
Knott David M Jr's most significant position changes for 2026-03-31: Sold out: Calumet INC (CLMT); New buy: Iovance Biotherapeutics INC (IOVA); New buy: LPL Financial Holdings Inc.; New buy: Relmada Therapeutics INC (RLMD); Sold out: Tectonic Therapeutic INC (TECX).
| # | Ticker | Issuer | Weight Change | Shares Change | Action |
|---|---|---|---|---|---|
| 1 | GOOG | Alphabet Inc-cl C | +2.3% | — | Unchanged |
| 2 | SNDX | Syndax Pharmaceuticals INC | +1.8% | +1.69% | Add |
| 3 | AGIO | Agios Pharmaceuticals INC | +1.6% | +416.99% | Add |
| 4 | ALKS | Alkermes plc | +1.3% | +26.32% | Add |
| 5 | TGTX | Tg Therapeutics INC | +1.2% | +100.00% | Add |
| 6 | PTGX | Protagonist Therapeutics INC | +1% | -13.70% | Trim |
| 7 | 260 | Centessa Pharmaceuticals-adr | +0.9% | +875.00% | Add |
| 8 | COGT | Cogent Biosciences INC | +0.7% | +1.96% | Add |
| 9 | ✓ | Arcellx INC Common Stock | +0.6% | -24.39% | Trim |
| 10 | JPM | Jpmorgan Chase & Co | +0.5% | — | Unchanged |
| 11 | XBI | Ss Spdr S&p Biotech ETF | +0.4% | +15.38% | Add |
| 12 | ✓ | Connect Biopharma Hldgs LTD | +0.3% | +93.92% | Add |
| 13 | RZLT | Rezolute INC | +0.3% | +8.82% | Add |
| 14 | CNQ | Canadian Natural Resources | +0.2% | — | Unchanged |
| 15 | RARE | Ultragenyx Pharmaceutical In | +0.2% | +65.30% | Add |
| 16 | XERS | Xeris Biopharma Holdings INC | +0.1% | +9.28% | Add |
| 17 | VRDN | Viridian Therapeutics INC | 0% | +24.83% | Add |
| 18 | VERA | Vera Therapeutics INC | 0% | — | Unchanged |
| 19 | BIIB | Biogen INC | -0.1% | -33.33% | Trim |
| 20 | BMY | Bristol-myers Squibb Co | -0.1% | -38.08% | Trim |
| 21 | CYTK | Cytokinetics INC | -0.1% | -30.46% | Trim |
| 22 | ATRC | Atricure INC | -0.1% | — | Unchanged |
| 23 | ✓ | Evolus INC | -0.1% | — | Unchanged |
| 24 | HELP | Cybin INC | -0.1% | +22.73% | Add |
| 25 | DCGO | Docgo INC | -0.1% | — | Unchanged |
| 26 | APO | Apollo Global Management INC | -0.2% | — | Unchanged |
| 27 | ADMA | Adma Biologics INC | -0.2% | — | Unchanged |
| 28 | SLDB | Solid Biosciences INC | -0.2% | -70.98% | Trim |
| 29 | LENZ | Lenz Therapeutics INC | -0.2% | -37.22% | Trim |
| 30 | CPRX | Catalyst Pharmaceuticals INC | -0.3% | -36.51% | Trim |
| 31 | RCUS | Arcus Biosciences INC | -0.3% | -32.99% | Trim |
| 32 | WVE | Wave Life Sciences Ltd. | -0.5% | -55.56% | Trim |
| 33 | TVTX | Travere Therapeutics INC | -0.8% | -24.39% | Trim |
| 34 | CLMT | Calumet INC | — | EXIT | Sold out |
| 35 | IOVA | Iovance Biotherapeutics INC | — | NEW | New buy |
| 36 | ✓ | LPL Financial Holdings Inc. | — | NEW | New buy |
| 37 | RLMD | Relmada Therapeutics INC | — | NEW | New buy |
| 38 | TECX | Tectonic Therapeutic INC | — | EXIT | Sold out |
| 39 | BHVN | Biohaven Ltd. | — | EXIT | Sold out |
| 40 | ARDX | Ardelyx INC | — | NEW | New buy |
| 41 | NKTR | Nektar Therapeutics | — | EXIT | Sold out |
| 42 | SRRK | Scholar Rock Holding CORP | — | EXIT | Sold out |
| 43 | VSTM | Verastem INC | — | NEW | New buy |
| 44 | ✓ | Biohaven Pharmaceutical Holding Co. Ltd | — | NEW | New buy |
| 45 | XENE | Xenon Pharmaceuticals INC | — | EXIT | Sold out |
| 46 | MRSN | Mersana Therapeutics INC | — | EXIT | Sold out |
| 47 | FATE | Fate Therapeutics INC | — | EXIT | Sold out |
| 48 | CGEM | Cullinan Therapeutics INC | — | NEW | New buy |
| 49 | RAIN | Rain Enhancement Techno-cl A | — | NEW | New buy |
| 50 | DAWNGBX | Day One Biopharmaceuticals I | — | EXIT | Sold out |
| Period | Filed | Type | EDGAR |
|---|---|---|---|
| 2026-03-31 | 2026-05-14 | 13F-HR | View on EDGAR |
| 2025-12-31 | 2026-02-12 | 13F-HR | View on EDGAR |
| 2025-09-30 | 2025-11-12 | 13F-HR | View on EDGAR |
| 2025-06-30 | 2025-08-11 | 13F-HR | View on EDGAR |
| 2025-03-31 | 2025-05-12 | 13F-HR | View on EDGAR |
| 2024-12-31 | 2025-02-12 | 13F-HR | View on EDGAR |
| 2024-09-30 | 2024-11-13 | 13F-HR | View on EDGAR |
| 2024-06-30 | 2024-08-12 | 13F-HR | View on EDGAR |
| 2024-03-31 | 2024-05-14 | 13F-HR | View on EDGAR |
| 2023-12-31 | 2024-02-13 | 13F-HR | View on EDGAR |
| 2023-09-30 | 2023-11-13 | 13F-HR | View on EDGAR |
| 2023-06-30 | 2023-08-11 | 13F-HR | View on EDGAR |
| 2023-03-31 | 2023-05-11 | 13F-HR | View on EDGAR |
| 2022-12-31 | 2023-02-13 | 13F-HR | View on EDGAR |
| 2022-09-30 | 2022-11-10 | 13F-HR | View on EDGAR |
| 2022-06-30 | 2022-08-11 | 13F-HR | View on EDGAR |
| 2022-03-31 | 2022-05-16 | 13F-HR | View on EDGAR |
| 2021-12-31 | 2022-02-11 | 13F-HR | View on EDGAR |
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