AC
Acuta Capital Partners, LLC 13F Portfolio & Top Holdings (Q2 2026)
Acuta Capital Partners, LLCCIK: 0001582844
Sector-focusedContrarianQuality / disciplined sizing
Total reported value
$143.5M
Reporting period: 2026-06-30 · Number of holdings: 23
ACUTA CAPITAL PARTNERS, LLC disclosed 23 holdings in its latest 13F filing for the period ending 2026-06-30, with total reported value of $143.5M and a quarterly turnover rate of 63.9%.
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Personality snowflake
- Concentration
- 35.08
- Portfolio Stability
- 63.93
- Momentum
- 0
- Sector conviction
- 100
- Diversification
- 46
- Sizing Uniformity
- 89.69
Acuta Capital Partners, LLC's disclosed holdings carry a Herfindahl concentration index of 0.088 — mathematically equivalent to about 11 equally-sized positions, well below its 23 actual disclosed holdings. That gap points to a strategy built around a small core of high-conviction bets rather than broad diversification.
Position sizes are fairly uniform across the portfolio (a coefficient of variation of 1.03), suggesting a disciplined, rules-based approach to how much capital goes into each idea.
No strong tilt toward either adding to existing winners or initiating outsized new positions was observed in the latest reported quarter.
Sector classification currently covers about 4% of this portfolio's disclosed value; the remainder includes holdings (e.g. unmapped tickers, options, or other security types) not yet covered by our sector mapping.
Source and citation information
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Recent moves
View source Form 13F filing on SEC.govSold out 430
Add WHWK
+37.4% $9.7M
New buy AVBP
New buy FDMT
New buy 05348Y105
Trim CMPX
-29.9% -$3.2M
Holdings Map
New buyAddUnchangedTrim
Top 10 holdings by weight
Full holdings list this quarter
| # | Ticker | Issuer | Asset Subclass | Weight | Weight Change | Shares Change | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | PRAX | Praxis Precision Medicines I | Stock-Other | 19.32% | -0.13% | -2.48% | |
| 2 | WHWK | Whitehawk Therapeutics Inc | Stock-Other | 14.96% | +6.59% | +37.40% | |
| 3 | TNGX | Tango Therapeutics Inc | Stock-Other | 8.52% | +1.95% | -11.52% | |
| 4 | STRO | Sutro Biopharma Inc | Stock-Other | 6.25% | +1.48% | +0.31% | |
| 5 | AVBP | Arrivent Biopharma Inc | Stock-Other | 5.29% | +5.29% | NEW | |
| 6 | FDMT | 4d Molecular Therapeutics In | Stock-Other | 4.71% | +4.71% | NEW | |
| 7 | DRUG | Bright Minds Biosciences Inc | Stock-Other | 4.54% | -1.27% | -17.19% | |
| 8 | OCUL | Ocular Therapeutix Inc | Stock-Other | 3.64% | +0.07% | -10.07% | |
| 9 | ERAS | Erasca Inc | Stock-Other | 3.39% | -0.69% | -25.21% | |
| 10 | SRZN | Surrozen Inc | Stock-Other | 3.14% | -0.44% | +0.32% | |
| 11 | ARGX | Argenx Se - Adr | Stock-Healthcare | 3.04% | +0.60% | +0.32% | |
| 12 | MLTX | Moonlake Immunotherapeutics | Stock-Other | 2.93% | +0.39% | +12.46% | |
| 13 | DSGN | Design Therapeutics Inc | Stock-Other | 2.85% | +1.75% | +93.67% | |
| 14 | NERV | Minerva Neurosciences Inc | Stock-Other | 2.74% | -0.30% | — | |
| 15 | TSHA | Taysha Gene Therapies Inc | Stock-Other | 2.67% | +1.27% | +27.84% | |
| 16 | ✓ | Stock-Other | 2.64% | +2.64% | NEW | ||
| 17 | AVTX | Avalo Therapeutics Inc | Stock-Other | 2.40% | +1.75% | +206.39% | |
| 18 | AMLX | Amylyx Pharmaceuticals Inc | Stock-Other | 2.10% | +0.61% | +11.29% | |
| 19 | ARTV | Artiva Biotherapeutics Inc | Stock-Other | 1.76% | +1.76% | NEW | |
| 20 | CMPX | Compass Therapeutics Inc | Stock-Other | 0.91% | -2.28% | -29.90% | |
| 21 | UTHR | United Therapeutics CORP | Stock-Healthcare | 0.84% | -0.10% | — | |
| 22 | CTNM | Contineum Therapeutics Inc-a | Stock-Other | 0.72% | +0.72% | NEW | |
| 23 | LBRX | Lb Pharmaceuticals Inc | Stock-Other | 0.65% | +0.14% | — |
Portfolio Performance
Performance for Q3 2026
+3.1%
Performance Last 4 Quarters
+78.6%
Based on 80% of reported portfolio value with available pricing
- Stdev
- +45.1%
- Beta
- +1.15
- Alpha
- +22.7%
- Max Drawdown
- -29.8%
- Annualized Perf
- +43.3%
- Batting Avg vs S&P
- +52.8%
- Sortino
- +2.07
- Stutzer
- +0.31
- Treynor
- +0.4
- Sterling
- +1.33
- Calmar
- +1.45
- Information Ratio
- +0.6
- Tracking Error
- +42.6%
- Stdev Down
- +22%
- Winning Months %
- +66.7%
- Losing Months %
- +33.3%
- Best 12 Months
- +130%
- Worst 12 Months
- -24.5%
- Efficiency Ratio
- +0.6
- Sharpe
- +1.01
- Stdev Sectors
- 0%
- Skewness
- +1.06
- Kurtosis
- +4.21
- Upside Potential
- +3.5
Reported value over time
Sector allocation
Sector allocation over time
Quarterly history
| Period | Holdings | Total value | Stability | Top holdings | |
|---|---|---|---|---|---|
| 2026 Q2 | 23 | $143.5M | 64 | ||
| 2026 Q1 | 27 | $140.6M | 62 | ||
| 2025 Q4 | 30 | $147.3M | 78 | ||
| 2025 Q3 | 28 | $96.8M | 100 | ||
| 2025 Q2 | 28 | $71.6M | 0 | ||
| 2025 Q1 | 34 | $86.2M | 100 | ||
| 2024 Q4 | 39 | $99.4M | 0 | ||
| 2024 Q3 | 41 | $123.5M | 0 | ||
| 2024 Q2 | 33 | $118.7M | 0 | ||
| 2024 Q1 | 33 | $153.9M | 0 | ||
| 2023 Q4 | 39 | $177.7M | 0 | ||
| 2023 Q3 | 46 | $149.2M | 0 | ||
| 2023 Q2 | 35 | $147.6M | 0 | ||
| 2023 Q1 | 35 | $135.7M | 0 | ||
| 2022 Q4 | 34 | $162.5M | 0 | ||
| 2022 Q3 | 47 | $232.2M | 0 | ||
| 2022 Q2 | 43 | $179.5M | 0 | ||
| 2022 Q1 | 41 | $214.0M | 0 | ||
| 2021 Q4 | 36 | $237.9M | 0 | ||
| 2021 Q3 | 47 | $283.4M | 0 | ||
| 2021 Q2 | 38 | $250.2M | 100 | ||
| 2021 Q1 | 46 | $277.3M | 81 | ||
| 2020 Q4 | 51 | $367.5M | 81 | ||
| 2020 Q3 | 43 | $368.2M | 100 | ||
| 2020 Q2 | 46 | $346.1M | 94 | ||
| 2020 Q1 | 32 | $206.3M | 100 | ||
| 2019 Q4 | 38 | $403.8M | 100 | ||
| 2019 Q3 | 31 | $138.5M | 89 | ||
| 2019 Q2 | 30 | $281.2M | 89 | ||
| 2019 Q1 | 33 | $210.3M | 66 | ||
| 2018 Q4 | 21 | $131.1M | 82 | ||
| 2018 Q3 | 31 | $280.4M | 74 | ||
| 2018 Q2 | 59 | $561.7M | 64 | ||
| 2018 Q1 | 59 | $612.3M | 62 | ||
| 2017 Q4 | 74 | $529.7M | 51 | ||
| 2017 Q3 | 64 | $558.0M | 71 | ||
| 2017 Q2 | 60 | $357.3M | 75 | ||
| 2017 Q1 | 67 | $421.8M | 82 | ||
| 2016 Q4 | 50 | $268.9M | 62 | ||
| 2016 Q3 | 67 | $266.3M | 61 | ||
| 2016 Q2 | 65 | $208.1M | 71 | ||
| 2016 Q1 | 40 | $178.8M | 75 | ||
| 2015 Q4 | 53 | $209.1M | 95 | ||
| 2015 Q3 | 59 | $172.7M | 77 | ||
| 2015 Q2 | 51 | $161.7M | 86 | ||
| 2015 Q1 | 51 | $118.7M | 100 | ||
| 2014 Q4 | 64 | $148.0M | 0 |
Holding changes this quarter
Acuta Capital Partners, LLC's most significant position changes for 2026-06-30: Sold out: Terns Pharmaceuticals Inc (430); New buy: Arrivent Biopharma Inc (AVBP); New buy: 4d Molecular Therapeutics In (FDMT); New buy: ; Sold out: Oculis Holding AG (OCS).
| # | Ticker | Issuer | Weight Change | Shares Change | Action |
|---|---|---|---|---|---|
| 1 | WHWK | Whitehawk Therapeutics Inc | +6.6% | +37.40% | Add |
| 2 | AVBP | Arrivent Biopharma Inc | +5.3% | NEW | New buy |
| 3 | FDMT | 4d Molecular Therapeutics In | +4.7% | NEW | New buy |
| 4 | ✓ | +2.6% | NEW | New buy | |
| 5 | TNGX | Tango Therapeutics Inc | +2% | -11.52% | Trim |
| 6 | ARTV | Artiva Biotherapeutics Inc | +1.8% | NEW | New buy |
| 7 | DSGN | Design Therapeutics Inc | +1.8% | +93.67% | Add |
| 8 | AVTX | Avalo Therapeutics Inc | +1.8% | +206.39% | Add |
| 9 | STRO | Sutro Biopharma Inc | +1.5% | +0.31% | Add |
| 10 | TSHA | Taysha Gene Therapies Inc | +1.3% | +27.84% | Add |
| 11 | CTNM | Contineum Therapeutics Inc-a | +0.7% | NEW | New buy |
| 12 | AMLX | Amylyx Pharmaceuticals Inc | +0.6% | +11.29% | Add |
| 13 | ARGX | Argenx Se - Adr | +0.6% | +0.32% | Add |
| 14 | MLTX | Moonlake Immunotherapeutics | +0.4% | +12.46% | Add |
| 15 | LBRX | Lb Pharmaceuticals Inc | +0.1% | — | Unchanged |
| 16 | OCUL | Ocular Therapeutix Inc | +0.1% | -10.07% | Trim |
| 17 | UTHR | United Therapeutics CORP | -0.1% | — | Unchanged |
| 18 | PRAX | Praxis Precision Medicines I | -0.1% | -2.48% | Trim |
| 19 | UNCY | Unicycive Therapeutics Inc | -0.3% | EXIT | Sold out |
| 20 | NERV | Minerva Neurosciences Inc | -0.3% | — | Unchanged |
| 21 | MAZE | Maze Therapeutics Inc | -0.4% | EXIT | Sold out |
| 22 | SRZN | Surrozen Inc | -0.4% | +0.32% | Add |
| 23 | ERAS | Erasca Inc | -0.7% | -25.21% | Trim |
| 24 | TRDA | Entrada Therapeutics Inc | -0.8% | EXIT | Sold out |
| 25 | IDYA | Ideaya Biosciences Inc | -1.2% | EXIT | Sold out |
| 26 | DRUG | Bright Minds Biosciences Inc | -1.3% | -17.19% | Trim |
| 27 | ✓ | 4d Molecular Therapeutics Inc | -1.6% | EXIT | Sold out |
| 28 | RVMD | Revolution Medicines Inc | -1.8% | EXIT | Sold out |
| 29 | OCS | Oculis Holding AG | -1.9% | EXIT | Sold out |
| 30 | CMPX | Compass Therapeutics Inc | -2.3% | -29.90% | Trim |
| 31 | 430 | Terns Pharmaceuticals Inc | -18.6% | EXIT | Sold out |
Filing History
FAQ
What is Acuta Capital Partners, LLC and what type of investor is it?
Acuta Capital Partners, LLC is an investment manager that files SEC Form 13F quarterly, disclosing its U.S. public equity holdings to regulators. As of the most recent reporting period (2026-06-30), the firm manages a tracked equity portfolio valued at approximately $143.5M, spread across 23 disclosed positions.
What are Acuta Capital Partners, LLC's largest equity positions?
Based on the latest 13F filing, Acuta Capital Partners, LLC's top holdings by market value are:
1. Praxis Precision Medicines I (PRAX) — $27.7M (19.3%)
2. Whitehawk Therapeutics Inc (WHWK) — $21.5M (15.0%)
3. Tango Therapeutics Inc (TNGX) — $12.2M (8.5%)
4. Sutro Biopharma Inc (STRO) — $9.0M (6.3%)
5. Arrivent Biopharma Inc (AVBP) — $7.6M (5.3%)
What changes did Acuta Capital Partners, LLC make in its most recent portfolio filing?
In the latest reported quarter, Acuta Capital Partners, LLC made 28 notable position adjustments: 5 new positions were initiated, 9 existing holdings were added to, 6 positions were partially reduced, and 8 were completely exited. The largest of these moves: Sold out: Terns Pharmaceuticals Inc (430); New buy: Arrivent Biopharma Inc (AVBP); New buy: 4d Molecular Therapeutics In (FDMT); New buy: ; Sold out: Oculis Holding AG (OCS)
What sectors does Acuta Capital Partners, LLC focus on?
Acuta Capital Partners, LLC is concentrated in the following sectors based on its current disclosed equity portfolio:
• Health Care: 100.0%
Investment Profile
Acuta Capital Partners, LLC returned an annualized 43.3% over the trailing 36 months — outperforming the S&P 500 by 22.7 points — based on a reconstructed track record of its disclosed 13F positions, with a beta of 1.15 (more volatile than the market) and a 53% quarterly batting average against the index.
Its portfolio is moderately concentrated and fast-trading, with 100.0% of the portfolio concentrated in Health Care.
Its turnover score has risen from 0 to 64 over the past 4 quarters — a shift toward more active trading.
It has added to its WHWK position over the past two quarters (+$13.2M, now $21.5M), while trimming CMPX over the same stretch (-$4.6M, still holding $1.3M).
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