Across its top 20 institutional holders, KPTI's holder base skews toward low-concentration, high-turnover investors on average (avg. concentration score 17/100, avg. turnover score 58/100).

Quarterly Activity

Recent Activity

+$127.6M

Total Buy Value

$488.6M

Total Sell Value

New buy26

Trim8

Add34

Sold out13

Net Buyers

Net Sellers

Smart Money Convergence

KPTI does not currently have enough recent insider (Form 4) trading activity to compute a convergence signal against its 13F institutional flows.

13F data as of 2026-06-30 quarterly filings. Note: many large institutions file close to the 45-day post-quarter deadline, so early-quarter flow figures can shift substantially as more filings arrive.

Insider Trading (Form 4)

Form 144 Pre-Sale Notices

No Form 144 planned sale filings in the last 90 days

Beneficial Ownership (13D/13G)

No Schedule 13D/13G filings for this ticker

Material Events (8-K)

Filings (14d)

Data as of 2026-07-17

2026-07-17

Karyopharm Therapeutics announced a retention program for its top executives, awarding lump-sum cash payments totaling over $3.7 million in place of the 2026 annual bonus. The payments are subject to clawback if the executive leaves voluntarily or is fired for cause within 12 months. The program aims to keep key talent during a period of expected catalysts.

View Full Filing (SEC EDGAR)

View all Form 8-K filings

CUSIP

48576U205

FAQ

Who are the top institutional investors holding KARYOPHARM THERAPEUTICS INC (KPTI)?

Major stakeholders currently include Ikarian Capital, LLC ($14.3M), Commodore Capital LP ($10.9M), Ra Capital Management, L.p. ($10.7M). Based on the latest 13F filings, there are a total of 83 tracked investment funds and institutions maintaining positions in KPTI.

What is the overall institutional sentiment toward KPTI recently?

Institutional sentiment appears Bullish (Net Buying). During the most recent reporting quarter, the stock experienced a net inflow of $64.8M, driven by 60 managers accumulating shares while 21 reduced their exposure.

Which institutions have been selling or reducing their KPTI positions?

In the latest period, 8 funds trimmed their holdings, and 13 managers completely exited their positions. The aggregate reported sell value was $488.6M.

Are there any notable investors adding KPTI to their portfolios?

Yes, buying activity remains notable. 26 institutions opened new positions in {ticker}, and 34 existing holders added to their shares. The total reported buy value for the quarter amounted to $127.6M.