| BlackRock, Inc. | $138.3M | 0.00% |
| Redmile Group, LLC | $119.9M | 7.94% |
| Vestal Point Capital, LP | $100.8M | 2.82% |
| Deep Track Capital, LP | $98.4M | 1.61% |
| FMR LLC | $85.9M | 0.00% |
| STATE STREET CORP | $79.7M | 0.00% |
| MORGAN STANLEY | $76.4M | 0.00% |
| BAKER BROS. ADVISORS LP | $72.2M | 0.41% |
| VANGUARD CAPITAL MANAGEMENT LLC | $68.6M | 0.00% |
| GENERAL ATLANTIC, L.P. | $63.6M | 2.96% |
| PERCEPTIVE ADVISORS LLC | $57.5M | 1.12% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $51.0M | 0.01% |
| Pictet Asset Management Holding SA | $42.3M | 0.04% |
| GEODE CAPITAL MANAGEMENT, LLC | $39.1M | 0.00% |
| Rubric Capital Management LP | $38.3M | 0.41% |
| DEUTSCHE BANK AG\ | $35.6M | 0.01% |
| Commodore Capital LP | $35.3M | 2.04% |
| BRAIDWELL LP | $27.1M | 0.91% |
| Trails Edge Capital Partners, LP | $27.0M | 6.19% |
| ARK Investment Management LLC | $26.7M | 0.21% |
| Longaeva Partners L.P. | $23.1M | 0.86% |
| CITADEL ADVISORS LLC | $21.4M | 0.00% |
| GOLDMAN SACHS GROUP INC | $20.4M | 0.00% |
| EVENTIDE ASSET MANAGEMENT, LLC | $20.1M | 0.33% |
| Kynam Capital Management, LP | $18.5M | 1.14% |
| Sumitomo Mitsui Trust Group, Inc. | $18.3M | 0.01% |
| Amova Asset Management Americas, Inc. | $18.3M | 0.26% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $17.1M | 0.00% |
| UBS Group AG | $15.1M | 0.00% |
| Affinity Asset Advisors, LLC | $15.0M | 0.77% |
| Soleus Capital Management, L.P. | $14.5M | 0.59% |
| Woodline Partners LP | $14.3M | 0.05% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $14.3M | 0.00% |
| Capital World Investors | $13.8M | 0.00% |
| NORTHERN TRUST CORP | $13.2M | 0.00% |
| Nuveen, LLC | $12.6M | 0.00% |
| BANK OF AMERICA CORP /DE/ | $12.4M | 0.00% |
| DIMENSIONAL FUND ADVISORS LP | $12.1M | 0.00% |
| Integral Health Asset Management, LLC | $10.9M | 0.52% |
| VANGUARD FIDUCIARY TRUST CO | $9.8M | 0.00% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | $9.6M | 0.04% |
| KENNEDY CAPITAL MANAGEMENT LLC | $8.7M | 0.18% |
| Handelsbanken Fonder AB | $8.5M | 0.03% |
| MILLENNIUM MANAGEMENT LLC | $8.5M | 0.00% |
| Candriam S.C.A. | $8.3M | 0.04% |
| Qube Research & Technologies Ltd | $7.5M | 0.01% |
| CITIGROUP INC | $7.4M | 0.00% |
| Elmind Capital, LP | $7.1M | 2.02% |
| Point72 Asset Management, L.P. | $7.0M | 0.01% |
| Fisher Asset Management, LLC | $6.0M | 0.00% |
| D. E. Shaw & Co., Inc. | $5.3M | 0.00% |
| RAYMOND JAMES FINANCIAL INC | $5.2M | 0.00% |
| WELLINGTON MANAGEMENT GROUP LLP | $5.0M | 0.00% |
| STEMPOINT CAPITAL LP | $4.9M | 0.94% |
| ArrowMark Colorado Holdings LLC | $4.9M | 0.13% |
| Rhenman & Partners Asset Management AB | $4.9M | 0.60% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $4.8M | 0.00% |
| BESSEMER GROUP INC | $4.7M | 0.01% |
| Bank of New York Mellon Corp | $4.6M | 0.00% |
| Foresite Capital Management V, LLC | $4.1M | 1.52% |
| WestHill Financial Advisors, Inc. | $3.5M | 0.68% |
| HighVista Strategies LLC | $3.5M | 0.97% |
| Squarepoint Ops LLC | $3.5M | 0.00% |
| Trexquant Investment LP | $3.3M | 0.02% |
| Invesco Ltd. | $3.2M | 0.00% |
| TD Asset Management Inc | $2.9M | 0.00% |
| Abu Dhabi Investment Council Co P.J.S.C | $2.9M | 0.29% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $2.8M | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $2.4M | 0.00% |
| Swiss National Bank | $2.3M | 0.00% |
| Rafferty Asset Management, LLC | $2.3M | 0.01% |
| RHUMBLINE ADVISERS | $1.9M | 0.00% |
| ALLIANCEBERNSTEIN L.P. | $1.9M | 0.00% |
| Burkehill Global Management, LP | $1.8M | 0.09% |
| RENAISSANCE TECHNOLOGIES LLC | $1.8M | 0.00% |
| Susquehanna Portfolio Strategies, LLC | $1.7M | 0.02% |
| Boxer Capital Management, LLC | $1.6M | 0.20% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $1.5M | 0.00% |
| Jasper Ridge Partners, L.P. | $1.5M | 0.03% |
| EDMOND DE ROTHSCHILD HOLDING S.A. | $1.4M | 0.02% |
| Jump Financial, LLC | $1.4M | 0.02% |
| Vienna Powszechne Towarzystwo Emerytalne S.A. Vienna Insurance Group | $1.3M | 0.50% |
| Verdad Advisers, LP | $1.3M | 1.46% |
| SEI INVESTMENTS CO | $1.3M | 0.00% |
| Russell Investments Group, Ltd. | $1.3M | 0.00% |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | $1.3M | 0.10% |
| FLAX POND CAPITAL, LLC | $1.2M | 1.00% |
| AMERICAN CENTURY COMPANIES INC | $1.2M | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $1.2M | 0.00% |
| Legal & General Group Plc | $1.1M | 0.00% |
| PROFUND ADVISORS LLC | $1.0M | 0.04% |
| ExodusPoint Capital Management, LP | $968.8K | 0.01% |
| AMERIPRISE FINANCIAL INC | $958.3K | 0.00% |
| VICTORY CAPITAL MANAGEMENT INC | $957.5K | 0.00% |
| Polymer Capital Management (HK) LTD | $912.9K | 0.08% |
| WELLS FARGO & COMPANY/MN | $870.1K | 0.00% |
| ADAR1 Capital Management, LLC | $869.1K | 0.05% |
| MetLife Investment Management, LLC | $867.2K | 0.00% |
| Y-Intercept (Hong Kong) Ltd | $854.6K | 0.02% |
| ALGERT GLOBAL LLC | $796.0K | 0.01% |
| JPMORGAN CHASE & CO | $738.7K | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | $721.7K | 0.00% |
| Cinctive Capital Management LP | $700.2K | 0.05% |
| Connor, Clark & Lunn Investment Management Ltd. | $697.1K | 0.00% |
| PRUDENTIAL FINANCIAL INC | $685.1K | 0.00% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | $660.3K | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $634.4K | 0.00% |
| XTX Topco Ltd | $626.0K | 0.01% |
| JANUS HENDERSON GROUP PLC | $610.1K | 0.00% |
| Vanguard Global Advisers, LLC | $574.0K | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | $570.2K | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | $533.5K | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | $489.7K | 0.00% |
| AXQ CAPITAL, LP | $457.8K | 0.06% |
| PSP Research LLC | $444.9K | 0.31% |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | $420.8K | 0.00% |
| Police & Firemen's Retirement System of New Jersey | $414.3K | 0.00% |
| Brevan Howard Capital Management LP | $410.8K | 0.00% |
| Mariner, LLC | $406.7K | 0.00% |
| State of New Jersey Common Pension Fund D | $402.7K | 0.00% |
| AlphaCentric Advisors LLC | $396.4K | 0.40% |
| BARCLAYS PLC | $374.8K | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | $353.6K | 0.00% |
| Quantinno Capital Management LP | $343.1K | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | $323.7K | 0.00% |
| Headlands Technologies LLC | $312.2K | 0.04% |
| Vanguard Investments Australia, Ltd. | $310.0K | 0.00% |
| ProShare Advisors LLC | $299.8K | 0.00% |
| Creative Planning | $296.4K | 0.00% |
| SG Americas Securities, LLC | $294.0K | 0.00% |
| E Fund Management Co., Ltd. | $291.3K | 0.01% |
| China Universal Asset Management Co., Ltd. | $282.9K | 0.02% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $273.0K | 0.00% |
| RAM Investment Partners, LLC | $267.9K | 0.05% |
| AQR CAPITAL MANAGEMENT LLC | $254.3K | 0.00% |
| KLP KAPITALFORVALTNING AS | $251.1K | 0.00% |
| Velan Capital Investment Management LP | $248.0K | 0.16% |
| Tower Research Capital LLC (TRC) | $238.7K | 0.01% |
| Virtus Investment Advisers, LLC | $221.6K | 0.06% |
| FOX RUN MANAGEMENT, L.L.C. | $212.6K | 0.04% |
| Allspring Global Investments Holdings, LLC | $207.6K | 0.00% |
| Cerity Partners LLC | $206.6K | 0.00% |
| Virtu Financial LLC | $205.0K | 0.01% |
| JANE STREET GROUP, LLC | $190.2K | 0.00% |
| TWO SIGMA SECURITIES, LLC | $179.1K | 0.02% |
| 49 WEALTH MANAGEMENT, LLC | $155.3K | 0.01% |
| Ameritas Investment Partners, Inc. | $126.1K | 0.00% |
| SIMPLEX TRADING, LLC | $125.8K | 0.00% |
| Mirae Asset Global Investments Co., Ltd. | $83.1K | 0.00% |
| Rockefeller Capital Management L.P. | $82.4K | 0.00% |