| Frazier Life Sciences Management, L.P. | $709.4M | 18.25% |
| JANUS HENDERSON GROUP PLC | $641.8M | 0.31% |
| BlackRock, Inc. | $355.3M | 0.01% |
| VANGUARD CAPITAL MANAGEMENT LLC | $223.1M | 0.01% |
| FMR LLC | $181.6M | 0.01% |
| STATE STREET CORP | $179.6M | 0.01% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $158.7M | 0.02% |
| BVF INC/IL | $146.4M | 4.66% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $132.3M | 0.01% |
| EVENTIDE ASSET MANAGEMENT, LLC | $130.1M | 2.15% |
| WELLINGTON MANAGEMENT GROUP LLP | $123.3M | 0.02% |
| NOVO HOLDINGS A/S | $122.4M | 9.92% |
| GEODE CAPITAL MANAGEMENT, LLC | $116.4M | 0.01% |
| TANG CAPITAL MANAGEMENT LLC | $114.2M | 5.80% |
| CITADEL ADVISORS LLC | $98.3M | 0.02% |
| TCG Crossover Management, LLC | $98.1M | 2.81% |
| Rock Springs Capital Management LP | $74.9M | 4.42% |
| TWO SIGMA INVESTMENTS, LP | $71.6M | 0.06% |
| Capital World Investors | $66.9M | 0.01% |
| BANK OF AMERICA CORP /DE/ | $66.7M | 0.00% |
| FRANKLIN RESOURCES INC | $66.0M | 0.02% |
| Clearbridge Investments, LLC | $62.1M | 0.05% |
| GOLDMAN SACHS GROUP INC | $61.2M | 0.01% |
| Paradigm Biocapital Advisors LP | $57.7M | 1.18% |
| LORD, ABBETT & CO. LLC | $57.0M | 0.19% |
| Bank of New York Mellon Corp | $54.0M | 0.01% |
| RENAISSANCE TECHNOLOGIES LLC | $53.8M | 0.08% |
| Woodline Partners LP | $52.5M | 0.20% |
| Balyasny Asset Management L.P. | $49.8M | 0.06% |
| MORGAN STANLEY | $48.5M | 0.00% |
| FEDERATED HERMES, INC. | $46.8M | 0.08% |
| UBS Group AG | $45.7M | 0.01% |
| Connor, Clark & Lunn Investment Management Ltd. | $44.3M | 0.10% |
| LOOMIS SAYLES & CO L P | $43.9M | 0.06% |
| Nuveen, LLC | $43.8M | 0.01% |
| Candriam S.C.A. | $42.9M | 0.22% |
| BAKER BROS. ADVISORS LP | $41.2M | 0.24% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $39.5M | 0.01% |
| Pictet Asset Management Holding SA | $39.1M | 0.04% |
| BOONE CAPITAL MANAGEMENT LLC | $38.9M | 11.92% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | $37.4M | 0.06% |
| First Turn Management, LLC | $37.0M | 4.13% |
| Soleus Capital Management, L.P. | $37.0M | 1.50% |
| EMERALD ADVISERS, LLC | $36.7M | 1.16% |
| NORTHERN TRUST CORP | $36.5M | 0.00% |
| NEXT CENTURY GROWTH INVESTORS LLC | $35.6M | 2.58% |
| TimesSquare Capital Management, LLC | $34.8M | 0.59% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $34.6M | 0.05% |
| MILLENNIUM MANAGEMENT LLC | $34.0M | 0.01% |
| Point72 Asset Management, L.P. | $32.7M | 0.04% |
| Octagon Capital Advisors LP | $31.3M | 3.46% |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | $31.0M | 0.10% |
| VANGUARD FIDUCIARY TRUST CO | $30.8M | 0.01% |
| Trails Edge Capital Partners, LP | $30.8M | 7.05% |
| Palo Alto Investors LP | $30.0M | 4.59% |
| RA CAPITAL MANAGEMENT, L.P. | $29.4M | 0.31% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | $26.5M | 0.01% |
| Hood River Capital Management LLC | $26.4M | 0.26% |
| Invesco Ltd. | $26.4M | 0.00% |
| Polar Capital Holdings Plc | $26.2M | 0.09% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $24.5M | 0.03% |
| Penn Capital Management Company, LLC | $23.8M | 1.84% |
| EMERALD MUTUAL FUND ADVISERS TRUST | $23.1M | 1.12% |
| NAN FUNG TRINITY (HK) LTD | $21.5M | 2.36% |
| Patient Square Capital LP | $21.2M | 3.77% |
| RAYMOND JAMES FINANCIAL INC | $21.1M | 0.01% |
| AMERIPRISE FINANCIAL INC | $20.3M | 0.00% |
| Ensign Peak Advisors, Inc | $18.7M | 0.03% |
| NEW YORK STATE COMMON RETIREMENT FUND | $18.6M | 0.03% |
| Logos Global Management LP | $18.5M | 0.92% |
| Erste Asset Management GmbH | $18.5M | 0.17% |
| Russell Investments Group, Ltd. | $18.2M | 0.02% |
| Handelsbanken Fonder AB | $17.9M | 0.06% |
| SEGALL BRYANT & HAMILL, LLC | $16.2M | 0.23% |
| D. E. Shaw & Co., Inc. | $15.5M | 0.01% |
| Legal & General Group Plc | $14.2M | 0.00% |
| CITIGROUP INC | $14.2M | 0.01% |
| FIRST TRUST ADVISORS LP | $14.0M | 0.01% |
| Voleon Capital Management LP | $13.9M | 0.30% |
| RICE HALL JAMES & ASSOCIATES, LLC | $13.6M | 0.76% |
| PDT Partners, LLC | $13.4M | 0.79% |
| Nicholas Investment Partners, LP | $12.1M | 0.88% |
| PANAGORA ASSET MANAGEMENT INC | $11.9M | 0.04% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $11.8M | 0.00% |
| Highlander Partners, L.P. | $11.4M | 4.45% |
| ESSEX INVESTMENT MANAGEMENT CO LLC | $10.0M | 1.58% |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | $9.6M | 0.04% |
| Atle Fund Management AB | $9.4M | 3.03% |
| Caption Management, LLC | $9.2M | 0.05% |
| VICTORY CAPITAL MANAGEMENT INC | $8.8M | 0.01% |
| Hennion & Walsh Asset Management, Inc. | $8.6M | 0.29% |
| Fisher Asset Management, LLC | $8.6M | 0.00% |
| Rhenman & Partners Asset Management AB | $8.6M | 1.06% |
| ExodusPoint Capital Management, LP | $8.1M | 0.07% |
| JPMORGAN CHASE & CO | $8.0M | 0.00% |
| SEI INVESTMENTS CO | $7.5M | 0.01% |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | $7.5M | 0.05% |
| NEUBERGER BERMAN GROUP LLC | $7.4M | 0.01% |
| Swiss National Bank | $6.9M | 0.00% |
| PICTON MAHONEY ASSET MANAGEMENT | $6.8M | 0.05% |
| VOYA INVESTMENT MANAGEMENT LLC | $6.4M | 0.01% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | $6.3M | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $6.2M | 0.00% |
| Squarepoint Ops LLC | $5.7M | 0.01% |
| Hillsdale Investment Management Inc. | $5.5M | 0.15% |
| PRINCIPAL FINANCIAL GROUP INC | $5.3M | 0.00% |
| Thrivent Financial for Lutherans | $5.3M | 0.01% |
| BANK OF MONTREAL /CAN/ | $5.2M | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $5.1M | 0.00% |
| RHUMBLINE ADVISERS | $4.8M | 0.00% |
| F/m Investments LLC | $4.7M | 0.31% |
| DEUTSCHE BANK AG\ | $4.6M | 0.00% |
| Rafferty Asset Management, LLC | $4.5M | 0.02% |
| ALPS ADVISORS INC | $4.5M | 0.02% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $4.1M | 0.00% |
| Secure Asset Management, LLC | $4.0M | 0.64% |
| Informed Momentum Co LLC | $4.0M | 0.46% |
| ALLIANCEBERNSTEIN L.P. | $3.9M | 0.00% |
| Legato Capital Management LLC | $3.9M | 0.35% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $3.7M | 0.01% |
| Lisanti Capital Growth, LLC | $3.6M | 0.91% |
| Cinctive Capital Management LP | $3.6M | 0.23% |
| ZACKS INVESTMENT MANAGEMENT | $3.4M | 0.03% |
| STATE OF WISCONSIN INVESTMENT BOARD | $3.2M | 0.01% |
| Alyeska Investment Group, L.P. | $3.1M | 0.01% |
| TD Asset Management Inc | $3.1M | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | $2.9M | 0.00% |
| Allianz Asset Management GmbH | $2.9M | 0.00% |
| Creative Planning | $2.8M | 0.00% |
| Sofinnova Investments, Inc. | $2.5M | 0.10% |
| MACKENZIE FINANCIAL CORP | $2.5M | 0.00% |
| Faithward Advisors, LLC | $2.5M | 0.36% |
| Pathstone Holdings, LLC | $2.4M | 0.01% |
| VANGUARD ASSET MANAGEMENT, Ltd | $2.3M | 0.00% |
| Knights of Columbus Asset Advisors LLC | $2.2M | 0.12% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $2.1M | 0.00% |
| MetLife Investment Management, LLC | $2.1M | 0.01% |
| MARTINGALE ASSET MANAGEMENT L P | $2.1M | 0.05% |
| ENVESTNET ASSET MANAGEMENT INC | $2.1M | 0.00% |
| PROFUND ADVISORS LLC | $2.0M | 0.08% |
| Vanguard Global Advisers, LLC | $2.0M | 0.00% |
| POLEN CAPITAL MANAGEMENT LLC | $1.9M | 0.01% |
| ROYAL BANK OF CANADA | $1.9M | 0.00% |
| CenterBook Partners LP | $1.8M | 0.10% |
| CAPITAL FUND MANAGEMENT S.A. | $1.8M | 0.01% |
| NOMURA HOLDINGS INC | $1.8M | 0.01% |
| BARCLAYS PLC | $1.8M | 0.00% |
| Ascentis Independent Advisors | $1.8M | 0.14% |
| XTX Topco Ltd | $1.8M | 0.03% |
| WELLS FARGO & COMPANY/MN | $1.6M | 0.00% |