CIK: 0001839948
Total reported value
$3.5B
Reporting period: 2026-03-31 · Number of holdings: 49
TCG Crossover Management, LLC disclosed 49 holdings in its latest 13F filing for the period ending 2026-03-31, with total reported value of $3.5B and a quarterly turnover rate of 57.6%.
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TCG Crossover Management, LLC's disclosed holdings carry a Herfindahl concentration index of 0.069 — mathematically equivalent to about 15 equally-sized positions, well below its 49 actual disclosed holdings. That gap points to a strategy built around a small core of high-conviction bets rather than broad diversification.
Position sizes vary widely across the portfolio (a coefficient of variation of 1.56), with a handful of outsized bets alongside many smaller positions.
No strong tilt toward either adding to existing winners or initiating outsized new positions was observed in the latest reported quarter.
Sector classification currently covers about 2% of this portfolio's disclosed value; the remainder includes holdings (e.g. unmapped tickers, options, or other security types) not yet covered by our sector mapping.
Trim ABVX
-8.9% -$237.4M
Add MIRM
+1611.6% $93.2M
Add TNGX
-17.5% $107.2M
Add CGON
0.0% $96.0M
Trim GPCR
-84.8% -$57.3M
Trim OCUL
-71.3% -$55.7M
| # | Ticker | Issuer | Asset Subclass | Weight | Weight Change | Shares Change | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | ABVX | Abivax Sa-adr | Stock-Other | 20.65% | -11.09% | -8.87% | |
| 2 | CGON | Cg Oncology INC | Stock-Other | 7.11% | +2.07% | — | |
| 3 | TNGX | Tango Therapeutics INC | Stock-Other | 6.30% | +2.56% | -17.48% | |
| 4 | COGT | Cogent Biosciences INC | Stock-Other | 5.45% | -1.45% | -15.70% | |
| 5 | 260 | Centessa Pharmaceuticals-adr | Stock-Other | 4.87% | +1.32% | — | |
| 6 | DNTH | Dianthus Therapeutics INC | Stock-Other | 4.03% | +1.74% | — | |
| 7 | TYRA | Tyra Biosciences INC | Stock-Other | 3.56% | +1.04% | +12.11% | |
| 8 | IMVT | Immunovant INC | Stock-Other | 3.17% | +1.77% | +168.40% | |
| 9 | BCRX | Biocryst Pharmaceuticals INC | Stock-Other | 3.00% | +3.00% | NEW | |
| 10 | MIRM | Mirum Pharmaceuticals INC | Stock-Other | 2.81% | +2.65% | +1611.63% | |
| 11 | VOR | Vor Biopharma INC | Stock-Other | 2.76% | +2.76% | NEW | |
| 12 | SYRE | Spyre Therapeutics INC | Stock-Other | 2.74% | +0.68% | — | |
| 13 | AMLX | Amylyx Pharmaceuticals INC | Stock-Other | 2.48% | -0.02% | — | |
| 14 | IRON | Disc Medicine INC | Stock-Other | 2.45% | +2.45% | NEW | |
| 15 | DYN | Dyne Therapeutics INC | Stock-Other | 2.39% | -0.60% | — | |
| 16 | GLUE | Monte Rosa Therapeutics INC | Stock-Other | 2.18% | -0.22% | — | |
| 17 | SVRA | Savara INC | Stock-Other | 1.93% | -0.54% | — | |
| 18 | RVMD | Revolution Medicines INC | Stock-Healthcare | 1.60% | +0.45% | +32.08% | |
| 19 | KOD | Kodiak Sciences INC | Stock-Other | 1.58% | +0.24% | — | |
| 20 | LBRX | Lb Pharmaceuticals INC | Stock-Other | 1.30% | +0.01% | +5.41% | |
| 21 | SRZN | Surrozen INC | Stock-Other | 1.23% | +1.23% | NEW | |
| 22 | ✓ | Adc Therapeutics SA | Stock-Other | 1.22% | -0.11% | — | |
| 23 | RLAY | Relay Therapeutics INC | Stock-Other | 1.22% | +0.32% | +32.71% | |
| 24 | FULC | Fulcrum Therapeutics INC | Stock-Other | 1.15% | -0.81% | — | |
| 25 | BHVN | Biohaven Ltd. | Stock-Other | 1.12% | -0.61% | — | |
| 26 | IPSC | Century Therapeutics INC | Stock-Other | 1.12% | +1.12% | NEW | |
| 27 | TECX | Tectonic Therapeutic INC | Stock-Other | 1.07% | +1.07% | NEW | |
| 28 | CATX | Perspective Therapeutics INC | Stock-Other | 0.94% | +0.94% | NEW | |
| 29 | XNCR | Xencor INC | Stock-Other | 0.85% | -0.39% | — | |
| 30 | TRDA | Entrada Therapeutics INC | Stock-Other | 0.83% | +0.12% | +9.53% | |
| 31 | ALXO | Alx Oncology Holdings INC | Stock-Other | 0.75% | +0.75% | NEW | |
| 32 | ARVN | Arvinas INC | Stock-Other | 0.72% | -0.33% | -10.46% | |
| 33 | JANX | Janux Therapeutics INC | Stock-Other | 0.71% | — | — | |
| 34 | AGMB | Agomab Therapeutics NV | Stock-Other | 0.62% | +0.62% | NEW | |
| 35 | ALEC | Alector INC | Stock-Other | 0.62% | +0.10% | — | |
| 36 | MBX | Mbx Biosciences INC | Stock-Other | 0.56% | — | — | |
| 37 | SLN | Silence Therapeutics Plc-adr | Stock-Other | 0.46% | -0.15% | — | |
| 38 | LQDA | Liquidia CORP | Stock-Other | 0.44% | -1.51% | -76.43% | |
| 39 | OCUL | Ocular Therapeutix INC | Stock-Other | 0.40% | -1.91% | -71.29% | |
| 40 | AVTX | Avalo Therapeutics INC | Stock-Other | 0.32% | +0.03% | +52.87% | |
| 41 | URGN | UroGen Pharma Ltd. | Stock-Other | 0.21% | -0.35% | -43.49% | |
| 42 | MNPR | Monopar Therapeutics INC | Stock-Other | 0.21% | -0.10% | -6.91% | |
| 43 | CNTX | Context Therapeutics INC | Stock-Other | 0.20% | +0.20% | NEW | |
| 44 | GPCR | Structure Therapeutics INC | Stock-Other | 0.19% | -1.93% | -84.75% | |
| 45 | CGEM | Cullinan Therapeutics INC | Stock-Other | 0.17% | +0.17% | NEW | |
| 46 | KRRO | Korro Bio INC | Stock-Other | 0.13% | +0.02% | — | |
| 47 | LONA | Leonabio INC | Stock-Other | 0.13% | — | — | |
| 48 | UPB | Upstream Bio INC | Stock-Other | 0.05% | -0.62% | -75.66% | |
| 49 | VTGN | Vistagen Therapeutics INC | Stock-Other | 0.04% | — | — |
Performance for Q3 2026
+15.5%
Performance Last 4 Quarters
+132.2%
Based on 76% of reported portfolio value with available pricing
| Period | Holdings | Total value | Stability | Top holdings |
|---|---|---|---|---|
| 2026-03-31 | 49 | $3.5B | 58 | |
| 2025-12-31 | 43 | $3.0B | 56 | |
| 2025-09-30 | 40 | $2.0B | 100 | |
| 2025-06-30 | 38 | $875.5M | 0 | |
| 2025-03-31 | 38 | $733.1M | 0 | |
| 2024-12-31 | 38 | $1.0B | 0 | |
| 2024-09-30 | 36 | $1.2B | 0 | |
| 2024-06-30 | 32 | $959.5M | 0 | |
| 2024-03-31 | 33 | $1.3B | 0 | |
| 2023-12-31 | 29 | $901.7M | 0 | |
| 2023-09-30 | 26 | $679.1M | 0 | |
| 2023-06-30 | 22 | $609.8M | 0 | |
| 2023-03-31 | 22 | $513.0M | 0 | |
| 2022-12-31 | 21 | $566.6M | 0 | |
| 2022-09-30 | 21 | $333.4M | 0 | |
| 2022-06-30 | 22 | $235.4M | 0 | |
| 2022-03-31 | 20 | $249.1M | 0 | |
| 2021-12-31 | 15 | $213.6M | 0 |
TCG Crossover Management, LLC's most significant position changes for 2026-03-31: New buy: Biocryst Pharmaceuticals INC (BCRX); New buy: Vor Biopharma INC (VOR); Sold out: Rapt Therapeutics INC (RAPT); New buy: Disc Medicine INC (IRON); Sold out: Eyepoint INC (EYPT).
| # | Ticker | Issuer | Weight Change | Shares Change | Action |
|---|---|---|---|---|---|
| 1 | MIRM | Mirum Pharmaceuticals INC | +2.7% | +1611.63% | Add |
| 2 | TNGX | Tango Therapeutics INC | +2.6% | -17.48% | Trim |
| 3 | CGON | Cg Oncology INC | +2.1% | — | Unchanged |
| 4 | IMVT | Immunovant INC | +1.8% | +168.40% | Add |
| 5 | DNTH | Dianthus Therapeutics INC | +1.7% | — | Unchanged |
| 6 | 260 | Centessa Pharmaceuticals-adr | +1.3% | — | Unchanged |
| 7 | TYRA | Tyra Biosciences INC | +1% | +12.11% | Add |
| 8 | SYRE | Spyre Therapeutics INC | +0.7% | — | Unchanged |
| 9 | RVMD | Revolution Medicines INC | +0.5% | +32.08% | Add |
| 10 | RLAY | Relay Therapeutics INC | +0.3% | +32.71% | Add |
| 11 | KOD | Kodiak Sciences INC | +0.2% | — | Unchanged |
| 12 | TRDA | Entrada Therapeutics INC | +0.1% | +9.53% | Add |
| 13 | ALEC | Alector INC | +0.1% | — | Unchanged |
| 14 | AVTX | Avalo Therapeutics INC | 0% | +52.87% | Add |
| 15 | KRRO | Korro Bio INC | 0% | — | Unchanged |
| 16 | LBRX | Lb Pharmaceuticals INC | 0% | +5.41% | Add |
| 17 | AMLX | Amylyx Pharmaceuticals INC | 0% | — | Unchanged |
| 18 | MNPR | Monopar Therapeutics INC | -0.1% | -6.91% | Trim |
| 19 | ✓ | Adc Therapeutics SA | -0.1% | — | Unchanged |
| 20 | SLN | Silence Therapeutics Plc-adr | -0.2% | — | Unchanged |
| 21 | GLUE | Monte Rosa Therapeutics INC | -0.2% | — | Unchanged |
| 22 | ARVN | Arvinas INC | -0.3% | -10.46% | Trim |
| 23 | URGN | UroGen Pharma Ltd. | -0.4% | -43.49% | Trim |
| 24 | XNCR | Xencor INC | -0.4% | — | Unchanged |
| 25 | SVRA | Savara INC | -0.5% | — | Unchanged |
| 26 | DYN | Dyne Therapeutics INC | -0.6% | — | Unchanged |
| 27 | BHVN | Biohaven Ltd. | -0.6% | — | Unchanged |
| 28 | UPB | Upstream Bio INC | -0.6% | -75.66% | Trim |
| 29 | FULC | Fulcrum Therapeutics INC | -0.8% | — | Unchanged |
| 30 | COGT | Cogent Biosciences INC | -1.5% | -15.70% | Trim |
| 31 | LQDA | Liquidia CORP | -1.5% | -76.43% | Trim |
| 32 | OCUL | Ocular Therapeutix INC | -1.9% | -71.29% | Trim |
| 33 | GPCR | Structure Therapeutics INC | -1.9% | -84.75% | Trim |
| 34 | ABVX | Abivax Sa-adr | -11.1% | -8.87% | Trim |
| 35 | BCRX | Biocryst Pharmaceuticals INC | — | NEW | New buy |
| 36 | VOR | Vor Biopharma INC | — | NEW | New buy |
| 37 | RAPT | Rapt Therapeutics INC | — | EXIT | Sold out |
| 38 | IRON | Disc Medicine INC | — | NEW | New buy |
| 39 | EYPT | Eyepoint INC | — | EXIT | Sold out |
| 40 | SRZN | Surrozen INC | — | NEW | New buy |
| 41 | IPSC | Century Therapeutics INC | — | NEW | New buy |
| 42 | TECX | Tectonic Therapeutic INC | — | NEW | New buy |
| 43 | CATX | Perspective Therapeutics INC | — | NEW | New buy |
| 44 | AGIO | Agios Pharmaceuticals INC | — | EXIT | Sold out |
| 45 | ALXO | Alx Oncology Holdings INC | — | NEW | New buy |
| 46 | AGMB | Agomab Therapeutics NV | — | NEW | New buy |
| 47 | MAZE | Maze Therapeutics INC | — | EXIT | Sold out |
| 48 | CNTX | Context Therapeutics INC | — | NEW | New buy |
| 49 | CGEM | Cullinan Therapeutics INC | — | NEW | New buy |
| 50 | VTYXUSD | Ventyx Biosciences INC | — | EXIT | Sold out |
| Period | Filed | Type | EDGAR |
|---|---|---|---|
| 2026-03-31 | 2026-05-15 | 13F-HR | View on EDGAR |
| 2025-12-31 | 2026-02-17 | 13F-HR | View on EDGAR |
| 2025-09-30 | 2025-11-17 | 13F-HR | View on EDGAR |
| 2025-06-30 | 2025-08-14 | 13F-HR | View on EDGAR |
| 2025-03-31 | 2025-05-14 | 13F-HR | View on EDGAR |
| 2024-12-31 | 2025-02-14 | 13F-HR | View on EDGAR |
| 2024-09-30 | 2024-11-14 | 13F-HR | View on EDGAR |
| 2024-06-30 | 2024-08-14 | 13F-HR | View on EDGAR |
| 2024-03-31 | 2024-05-15 | 13F-HR | View on EDGAR |
| 2023-12-31 | 2024-02-14 | 13F-HR | View on EDGAR |
| 2023-09-30 | 2023-11-14 | 13F-HR | View on EDGAR |
| 2023-06-30 | 2023-08-14 | 13F-HR | View on EDGAR |
| 2023-03-31 | 2023-05-15 | 13F-HR | View on EDGAR |
| 2022-12-31 | 2023-02-14 | 13F-HR | View on EDGAR |
| 2022-09-30 | 2022-11-14 | 13F-HR | View on EDGAR |
| 2022-06-30 | 2022-08-15 | 13F-HR | View on EDGAR |
| 2022-03-31 | 2022-05-16 | 13F-HR | View on EDGAR |
| 2021-12-31 | 2022-02-18 | 13F-HR | View on EDGAR |
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