| Frazier Life Sciences Management, L.P. | $198.6M | 5.11% |
| ORBIMED ADVISORS LLC | $108.6M | 2.23% |
| NEA Management Company, LLC | $107.9M | 6.13% |
| WELLINGTON MANAGEMENT GROUP LLP | $95.3M | 0.02% |
| BlackRock, Inc. | $87.8M | 0.00% |
| FMR LLC | $87.7M | 0.00% |
| Deep Track Capital, LP | $82.3M | 1.34% |
| NVP ASSOCIATES, LLC | $63.8M | 36.20% |
| Polar Capital Holdings Plc | $48.4M | 0.17% |
| BRAIDWELL LP | $44.6M | 1.49% |
| VANGUARD CAPITAL MANAGEMENT LLC | $44.1M | 0.00% |
| Aaron Wealth Advisors LLC | $34.9M | 1.98% |
| Cormorant Asset Management, LP | $33.4M | 1.68% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $30.7M | 0.00% |
| Driehaus Capital Management LLC | $30.4M | 0.22% |
| CITADEL ADVISORS LLC | $28.9M | 0.00% |
| Kynam Capital Management, LP | $27.9M | 1.72% |
| Woodline Partners LP | $26.9M | 0.10% |
| EVENTIDE ASSET MANAGEMENT, LLC | $26.6M | 0.44% |
| Caligan Partners LP | $25.3M | 1.69% |
| Parkman Healthcare Partners LLC | $23.9M | 2.46% |
| STATE STREET CORP | $23.5M | 0.00% |
| EcoR1 Capital, LLC | $23.2M | 0.98% |
| GEODE CAPITAL MANAGEMENT, LLC | $20.0M | 0.00% |
| TCG Crossover Management, LLC | $19.4M | 0.56% |
| MILLENNIUM MANAGEMENT LLC | $16.8M | 0.01% |
| STEMPOINT CAPITAL LP | $14.9M | 2.85% |
| GOLDMAN SACHS GROUP INC | $13.7M | 0.00% |
| UBS Group AG | $10.4M | 0.00% |
| Candriam S.C.A. | $8.8M | 0.05% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $8.8M | 0.00% |
| D. E. Shaw & Co., Inc. | $8.6M | 0.01% |
| Rock Springs Capital Management LP | $8.6M | 0.51% |
| Opaleye Management Inc. | $7.8M | 1.02% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $6.4M | 0.00% |
| Elmind Capital, LP | $6.3M | 1.79% |
| NORTHERN TRUST CORP | $6.3M | 0.00% |
| BOOTHBAY FUND MANAGEMENT, LLC | $6.2M | 0.08% |
| Soleus Capital Management, L.P. | $5.3M | 0.22% |
| DAFNA Capital Management LLC | $5.2M | 1.19% |
| VANGUARD FIDUCIARY TRUST CO | $5.1M | 0.00% |
| Goelzer Investment Management, Inc. | $4.9M | 0.24% |
| Affinity Asset Advisors, LLC | $4.5M | 0.23% |
| Tetragon Partners GP Ltd | $4.3M | 0.84% |
| JPMORGAN CHASE & CO | $4.0M | 0.00% |
| Schonfeld Strategic Advisors LLC | $3.7M | 0.03% |
| KVP Capital Advisors, LP | $3.6M | 2.71% |
| TD Asset Management Inc | $3.5M | 0.00% |
| TWO SIGMA INVESTMENTS, LP | $3.4M | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $3.1M | 0.00% |
| Burkehill Global Management, LP | $3.0M | 0.15% |
| Squarepoint Ops LLC | $2.9M | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $2.7M | 0.00% |
| Nuveen, LLC | $2.4M | 0.00% |
| Bank of New York Mellon Corp | $2.4M | 0.00% |
| PFM Health Sciences, LP | $2.1M | 0.20% |
| VICTORY CAPITAL MANAGEMENT INC | $2.1M | 0.00% |
| MARSHALL WACE, LLP | $1.9M | 0.00% |
| XTX Topco Ltd | $1.6M | 0.03% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | $1.5M | 0.00% |
| DIMENSIONAL FUND ADVISORS LP | $1.4M | 0.00% |
| Swiss National Bank | $1.3M | 0.00% |
| PLATINUM INVESTMENT MANAGEMENT LTD | $1.3M | 0.33% |
| JANE STREET GROUP, LLC | $1.2M | 0.00% |
| ALPS ADVISORS INC | $1.1M | 0.01% |
| ALGERT GLOBAL LLC | $1.1M | 0.02% |
| Creative Planning | $1.1M | 0.00% |
| EXCHANGE TRADED CONCEPTS, LLC | $1.0M | 0.01% |
| RHUMBLINE ADVISERS | $1.0M | 0.00% |
| ALLIANCEBERNSTEIN L.P. | $962.0K | 0.00% |
| MORGAN STANLEY | $942.1K | 0.00% |
| BANK OF AMERICA CORP /DE/ | $858.2K | 0.00% |
| ExodusPoint Capital Management, LP | $838.4K | 0.01% |
| Invesco Ltd. | $821.6K | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | $817.5K | 0.00% |
| DEUTSCHE BANK AG\ | $685.1K | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $679.5K | 0.00% |
| Swiss Life Asset Management Ltd | $657.2K | 0.00% |
| Cerity Partners LLC | $631.7K | 0.00% |
| Legal & General Group Plc | $577.8K | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | $575.0K | 0.00% |
| Koa Wealth Management, LLC | $534.7K | 0.39% |
| Engineers Gate Manager LP | $518.8K | 0.01% |
| Qube Research & Technologies Ltd | $513.0K | 0.00% |
| Vanguard Global Advisers, LLC | $478.4K | 0.00% |
| MetLife Investment Management, LLC | $478.1K | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | $440.3K | 0.00% |
| Optimize Financial Inc | $433.1K | 0.21% |
| CITIGROUP INC | $402.9K | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $397.8K | 0.00% |
| Jump Financial, LLC | $379.1K | 0.01% |
| BARCLAYS PLC | $353.4K | 0.00% |
| HighVista Strategies LLC | $342.4K | 0.09% |
| CANADA PENSION PLAN INVESTMENT BOARD | $325.4K | 0.00% |
| WELLS FARGO & COMPANY/MN | $321.2K | 0.00% |
| JANUS HENDERSON GROUP PLC | $308.2K | 0.00% |
| Verition Fund Management LLC | $305.1K | 0.00% |
| Aquatic Capital Management LLC | $303.1K | 0.01% |
| Virtus Investment Advisers, LLC | $272.6K | 0.08% |
| NEW YORK STATE COMMON RETIREMENT FUND | $268.7K | 0.00% |
| ACT CAPITAL MANAGEMENT, LLC | $268.7K | 0.21% |
| SEI INVESTMENTS CO | $268.3K | 0.00% |
| Tidal Investments LLC | $265.0K | 0.00% |
| Tema ETFs LLC | $265.0K | 0.02% |
| ACADIAN ASSET MANAGEMENT LLC | $262.0K | 0.00% |
| AMERICAN CENTURY COMPANIES INC | $260.5K | 0.00% |
| PROFUND ADVISORS LLC | $250.4K | 0.01% |
| China Universal Asset Management Co., Ltd. | $237.8K | 0.02% |
| Orion Porfolio Solutions, LLC | $237.3K | 0.00% |
| State of New Jersey Common Pension Fund D | $229.0K | 0.00% |
| Police & Firemen's Retirement System of New Jersey | $224.5K | 0.00% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | $223.9K | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $216.1K | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | $204.3K | 0.00% |
| GROUP ONE TRADING LLC | $186.6K | 0.00% |
| Vanguard Investments Australia, Ltd. | $182.2K | 0.00% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $167.2K | 0.00% |
| KLP KAPITALFORVALTNING AS | $146.3K | 0.00% |
| Russell Investments Group, Ltd. | $115.1K | 0.00% |
| SG Americas Securities, LLC | $101.0K | 0.00% |
| Rockefeller Capital Management L.P. | $96.2K | 0.00% |
| Mirae Asset Global Investments Co., Ltd. | $69.9K | 0.00% |
| Ameritas Investment Partners, Inc. | $69.0K | 0.00% |
| Cygnus Capital Advisors, LLC | $54.0K | 0.04% |
| CWM, LLC | $52.9K | 0.00% |
| STRS OHIO | $47.8K | 0.00% |
| NISA INVESTMENT ADVISORS, LLC | $47.5K | 0.00% |
| Tower Research Capital LLC (TRC) | $42.1K | 0.00% |
| SIMPLEX TRADING, LLC | $39.0K | 0.00% |
| GF FUND MANAGEMENT CO. LTD. | $30.1K | 0.00% |
| Sterling Capital Management LLC | $28.3K | 0.00% |
| KBC Group NV | $24.0K | 0.00% |
| ROYAL BANK OF CANADA | $22.0K | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $14.0K | 0.00% |
| GAMMA Investing LLC | $8.9K | 0.00% |
| US BANCORP \DE\ | $8.5K | 0.00% |
| OSAIC HOLDINGS, INC. | $8.0K | 0.00% |
| PNC FINANCIAL SERVICES GROUP, INC. | $6.2K | 0.00% |
| SIGNATUREFD, LLC | $5.3K | 0.00% |
| FIL Ltd | $5.3K | 0.00% |
| Physician Wealth Advisors, Inc. | $3.3K | 0.00% |
| BNP PARIBAS FINANCIAL MARKETS | $3.1K | 0.00% |
| JONES FINANCIAL COMPANIES LLLP | $2.3K | 0.00% |
| Allworth Financial LP | $2.1K | 0.00% |
| Parallel Advisors, LLC | $1.8K | 0.00% |
| Larson Financial Group LLC | $1.5K | 0.00% |
| Cornerstone Financial Management LLC | $1.0K | 0.00% |
| EverSource Wealth Advisors, LLC | $746.0 | 0.00% |
| ROTHSCHILD INVESTMENT LLC | $716.0 | 0.00% |
| Versant Capital Management, Inc | $716.0 | 0.00% |