| SUVRETTA CAPITAL MANAGEMENT, LLC | $263.3M | 6.72% |
| SR One Capital Management, LP | $151.7M | 16.57% |
| CITADEL ADVISORS LLC | $115.3M | 0.02% |
| FMR LLC | $113.2M | 0.01% |
| VIKING GLOBAL INVESTORS LP | $106.8M | 0.30% |
| Siren, L.L.C. | $95.1M | 2.64% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $69.5M | 0.11% |
| Aberdeen Group plc | $66.6M | 0.11% |
| JPMORGAN CHASE & CO | $59.4M | 0.00% |
| INFINITUM ASSET MANAGEMENT, LLC | $46.2M | 5.77% |
| VANGUARD CAPITAL MANAGEMENT LLC | $44.2M | 0.00% |
| MARSHALL WACE, LLP | $41.3M | 0.04% |
| Balyasny Asset Management L.P. | $33.7M | 0.04% |
| Paradigm Biocapital Advisors LP | $33.2M | 0.68% |
| AMERIPRISE FINANCIAL INC | $32.5M | 0.01% |
| Woodline Partners LP | $31.6M | 0.12% |
| Deep Track Capital, LP | $31.6M | 0.52% |
| WELLINGTON MANAGEMENT GROUP LLP | $30.2M | 0.01% |
| UBS Group AG | $21.9M | 0.00% |
| Vivo Capital, LLC | $18.9M | 1.57% |
| STIFEL FINANCIAL CORP | $18.6M | 0.02% |
| BlackRock, Inc. | $17.8M | 0.00% |
| FRANKLIN RESOURCES INC | $12.6M | 0.00% |
| GEODE CAPITAL MANAGEMENT, LLC | $11.3M | 0.00% |
| Catalio Capital Management, LP | $11.0M | 2.29% |
| GOLDMAN SACHS GROUP INC | $10.7M | 0.00% |
| Ensign Peak Advisors, Inc | $9.5M | 0.02% |
| Kalehua Capital Management LLC | $9.2M | 6.51% |
| JENNISON ASSOCIATES LLC | $9.0M | 0.01% |
| D. E. Shaw & Co., Inc. | $8.5M | 0.01% |
| EMERALD ADVISERS, LLC | $8.4M | 0.26% |
| MILLENNIUM MANAGEMENT LLC | $7.8M | 0.00% |
| MYDA Advisors LLC | $7.6M | 1.25% |
| EMERALD MUTUAL FUND ADVISERS TRUST | $6.9M | 0.33% |
| Jones Hill Capital LP | $6.4M | 1.37% |
| MASTERS CAPITAL MANAGEMENT LLC | $6.3M | 0.21% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $6.2M | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | $6.2M | 0.00% |
| SEVEN GRAND MANAGERS, LLC | $4.7M | 0.32% |
| STATE STREET CORP | $4.7M | 0.00% |
| Sofinnova Investments, Inc. | $4.6M | 0.18% |
| Affinity Asset Advisors, LLC | $4.4M | 0.23% |
| BANK OF AMERICA CORP /DE/ | $4.1M | 0.00% |
| BAMCO INC /NY/ | $3.8M | 0.01% |
| MORGAN STANLEY | $3.3M | 0.00% |
| Monashee Investment Management LLC | $3.2M | 1.72% |
| Polymer Capital Management (HK) LTD | $2.6M | 0.23% |
| BARCLAYS PLC | $2.3M | 0.00% |
| NORTHERN TRUST CORP | $2.2M | 0.00% |
| Brevan Howard Capital Management LP | $1.9M | 0.02% |
| Logos Global Management LP | $1.6M | 0.08% |
| Centiva Capital, LP | $1.3M | 0.01% |
| FIRST TRUST ADVISORS LP | $1.2M | 0.00% |
| Shay Capital LLC | $1.1M | 0.09% |
| Squarepoint Ops LLC | $1.0M | 0.00% |
| Penserra Capital Management LLC | $928.0K | 0.01% |
| FORMULA GROWTH LTD | $884.1K | 0.40% |
| TORONTO DOMINION BANK | $848.0K | 0.00% |
| CIBC Bancorp USA Inc. | $827.3K | 0.00% |
| XTX Topco Ltd | $726.9K | 0.01% |
| Hudson Bay Capital Management LP | $699.6K | 0.00% |
| CITIGROUP INC | $675.1K | 0.00% |
| Persistent Asset Partners Ltd | $580.4K | 0.22% |
| Legal & General Group Plc | $448.7K | 0.00% |
| Vanguard Global Advisers, LLC | $426.1K | 0.00% |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | $423.8K | 0.03% |
| Burkehill Global Management, LP | $315.8K | 0.02% |
| Private Advisor Group, LLC | $315.8K | 0.00% |
| Ghisallo Capital Management LLC | $315.8K | 0.01% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $315.8K | 0.00% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $286.5K | 0.00% |
| Schonfeld Strategic Advisors LLC | $246.3K | 0.00% |
| Bank of New York Mellon Corp | $231.6K | 0.00% |
| US BANCORP \DE\ | $29.7K | 0.00% |
| Allworth Financial LP | $3.2K | 0.00% |
| NVWM, LLC | $2.2K | 0.00% |
| SBI Securities Co., Ltd. | $1.3K | 0.00% |
| ROYAL BANK OF CANADA | $1.0K | 0.00% |
| JONES FINANCIAL COMPANIES LLLP | $655.0 | 0.00% |
| Tower Research Capital LLC (TRC) | $632.0 | 0.00% |