SO
Sr One Capital Management, LP SEC 13F Holdings (Q2 2026) — Top Position: VERADERMICS INC
Sr One Capital Management, LPCIK: 0001910264
Sector-focusedContrarianHigh-turnover trader
Total reported value
$1.0B
Reporting period: 2026-06-30 · Number of holdings: 15
SR ONE CAPITAL MANAGEMENT, LP disclosed 15 holdings in its latest 13F filing for the period ending 2026-06-30, with total reported value of $1.0B and a quarterly turnover rate of 76.3%.
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Personality snowflake
- Concentration
- 55.94
- Portfolio Stability
- 76.34
- Momentum
- 0
- Sector conviction
- 100
- Diversification
- 30
- Sizing Uniformity
- 89.15
Sr One Capital Management, LP's disclosed holdings carry a Herfindahl concentration index of 0.140 — mathematically equivalent to about 7 equally-sized positions, well below its 15 actual disclosed holdings. That gap points to a strategy built around a small core of high-conviction bets rather than broad diversification.
Position sizes are fairly uniform across the portfolio (a coefficient of variation of 1.08), suggesting a disciplined, rules-based approach to how much capital goes into each idea.
No strong tilt toward either adding to existing winners or initiating outsized new positions was observed in the latest reported quarter.
Sector classification currently covers about 11% of this portfolio's disclosed value; the remainder includes holdings (e.g. unmapped tickers, options, or other security types) not yet covered by our sector mapping.
Source and citation information
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Recent moves
View source Form 13F filing on SEC.govSold out ACLXGBX
Add MANE
0.0% $143.6M
New buy 05348Y105
New buy 67613T104
New buy 60705V103
Sold out ORKA
Holdings Map
New buyAddUnchangedTrim
Top 10 holdings by weight
Full holdings list this quarter
| # | Ticker | Issuer | Asset Subclass | Weight | Weight Change | Shares Change | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | MANE | Veradermics Inc | Stock-Other | 28.42% | +11.85% | — | |
| 2 | ZBIO | Zenas Biopharma Inc | Stock-Other | 12.31% | +1.55% | — | |
| 3 | CRSP | CRISPR Therapeutics AG | Stock-Healthcare | 10.70% | +0.11% | — | |
| 4 | ✓ | Stock-Other | 10.48% | +10.48% | NEW | ||
| 5 | DSGN | Design Therapeutics Inc | Stock-Other | 9.09% | +1.50% | — | |
| 6 | ✓ | Stock-Other | 6.83% | +6.83% | NEW | ||
| 7 | ALMS | Alumis Inc | Stock-Other | 5.31% | +0.59% | — | |
| 8 | ORIC | Oric Pharmaceuticals Inc | Stock-Other | 4.81% | -1.58% | +2.23% | |
| 9 | MLYS | Mineralys Therapeutics Inc | Stock-Other | 4.06% | -0.57% | — | |
| 10 | SPRY | Ars Pharmaceuticals Inc | Stock-Other | 3.09% | -0.43% | — | |
| 11 | ✓ | Stock-Other | 2.56% | +2.56% | NEW | ||
| 12 | NKTX | Nkarta Inc | Stock-Other | 0.91% | +0.14% | — | |
| 13 | OCS | Oculis Holding AG | Stock-Other | 0.86% | -1.00% | — | |
| 14 | RARE | Ultragenyx Pharmaceutical In | Stock-Other | 0.44% | +0.12% | — | |
| 15 | ✓ | Engene Holdings Inc | Stock-Other | 0.12% | -0.44% | — |
Portfolio Performance
Performance for Q3 2026
+13.3%
Performance Last 4 Quarters
+63.6%
Based on 70% of reported portfolio value with available pricing
- Stdev
- +43.8%
- Beta
- +0.52
- Alpha
- +23%
- Max Drawdown
- -30.5%
- Annualized Perf
- +27%
- Batting Avg vs S&P
- +44.4%
- Sortino
- +1.53
- Stutzer
- +0.23
- Treynor
- +0.63
- Sterling
- +0.83
- Calmar
- +0.88
- Information Ratio
- +0.32
- Tracking Error
- +43.7%
- Stdev Down
- +21.4%
- Winning Months %
- +51.9%
- Losing Months %
- +48.1%
- Best 12 Months
- +128%
- Worst 12 Months
- -14.1%
- Efficiency Ratio
- +0.27
- Sharpe
- +0.75
- Stdev Sectors
- 0%
- Skewness
- +0.73
- Kurtosis
- +0.54
- Upside Potential
- +3.55
Reported value over time
Sector allocation
Sector allocation over time
Quarterly history
| Period | Holdings | Total value | Stability | Top holdings | |
|---|---|---|---|---|---|
| 2026 Q2 | 15 | $1.0B | 76 | ||
| 2026 Q1 | 14 | $915.4M | 57 | ||
| 2025 Q4 | 13 | $706.4M | 32 | ||
| 2025 Q3 | 12 | $691.4M | 59 | ||
| 2025 Q2 | 13 | $461.4M | 0 | ||
| 2025 Q1 | 12 | $389.3M | 0 | ||
| 2024 Q4 | 11 | $410.1M | 0 | ||
| 2024 Q3 | 11 | $498.7M | 0 | ||
| 2024 Q2 | 9 | $319.4M | 0 | ||
| 2024 Q1 | 6 | $364.1M | 0 | ||
| 2023 Q4 | 5 | $238.2M | 0 | ||
| 2023 Q3 | 6 | $195.1M | 0 | ||
| 2023 Q2 | 6 | $231.9M | 0 | ||
| 2023 Q1 | 6 | $268.5M | 0 | ||
| 2022 Q4 | 5 | $273.9M | 0 | ||
| 2022 Q3 | 4 | $218.7M | 0 | ||
| 2022 Q2 | 4 | $204.3M | 0 | ||
| 2022 Q1 | 3 | $195.3M | 0 | ||
| 2021 Q4 | 2 | $177.0M | 0 | 1DSGN228202V |
Holding changes this quarter
Sr One Capital Management, LP's most significant position changes for 2026-06-30: Sold out: Arcellx Inc (ACLXGBX); New buy: ; New buy: ; New buy: ; Sold out: Oruka Therapeutics Inc (ORKA).
| # | Ticker | Issuer | Weight Change | Shares Change | Action |
|---|---|---|---|---|---|
| 1 | MANE | Veradermics Inc | +11.9% | — | Unchanged |
| 2 | ✓ | +10.5% | NEW | New buy | |
| 3 | ✓ | +6.8% | NEW | New buy | |
| 4 | ✓ | +2.6% | NEW | New buy | |
| 5 | ZBIO | Zenas Biopharma Inc | +1.6% | — | Unchanged |
| 6 | DSGN | Design Therapeutics Inc | +1.5% | — | Unchanged |
| 7 | ALMS | Alumis Inc | +0.6% | — | Unchanged |
| 8 | NKTX | Nkarta Inc | +0.1% | — | Unchanged |
| 9 | RARE | Ultragenyx Pharmaceutical In | +0.1% | — | Unchanged |
| 10 | CRSP | CRISPR Therapeutics AG | +0.1% | — | Unchanged |
| 11 | SPRY | Ars Pharmaceuticals Inc | -0.4% | — | Unchanged |
| 12 | ✓ | Engene Holdings Inc | -0.4% | — | Unchanged |
| 13 | MLYS | Mineralys Therapeutics Inc | -0.6% | — | Unchanged |
| 14 | OCS | Oculis Holding AG | -1% | — | Unchanged |
| 15 | ORIC | Oric Pharmaceuticals Inc | -1.6% | +2.23% | Add |
| 16 | ORKA | Oruka Therapeutics Inc | -2.3% | EXIT | Sold out |
| 17 | ACLXGBX | Arcellx Inc | -29.4% | EXIT | Sold out |
Filing History
FAQ
What is Sr One Capital Management, LP and what type of investor is it?
Sr One Capital Management, LP is an investment manager that files SEC Form 13F quarterly, disclosing its U.S. public equity holdings to regulators. As of the most recent reporting period (2026-06-30), the firm manages a tracked equity portfolio valued at approximately $1.0B, spread across 15 disclosed positions.
What are Sr One Capital Management, LP's largest equity positions?
Based on the latest 13F filing, Sr One Capital Management, LP's top holdings by market value are:
1. Veradermics Inc (MANE) — $295.3M (28.4%)
2. Zenas Biopharma Inc (ZBIO) — $127.9M (12.3%)
3. CRISPR Therapeutics AG (CRSP) — $111.2M (10.7%)
4. — $108.9M (10.5%)
5. Design Therapeutics Inc (DSGN) — $94.4M (9.1%)
What changes did Sr One Capital Management, LP make in its most recent portfolio filing?
In the latest reported quarter, Sr One Capital Management, LP made 6 notable position adjustments: 3 new positions were initiated, 1 existing holdings were added to, 0 positions were partially reduced, and 2 were completely exited. The largest of these moves: Sold out: Arcellx Inc (ACLXGBX); New buy: ; New buy: ; New buy: ; Sold out: Oruka Therapeutics Inc (ORKA)
What sectors does Sr One Capital Management, LP focus on?
Sr One Capital Management, LP is concentrated in the following sectors based on its current disclosed equity portfolio:
• Health Care: 100.0%
* This report is exclusively curated by the AlphaSMO team. AlphaSMO is the web's most authoritative 13F / Inside Trader database, delivering precise insider trading and institutional holdings insights.
Investment Profile
Sr One Capital Management, LP returned an annualized 27.0% over the trailing 27 months — outperforming the S&P 500 by 23.0 points — based on a reconstructed track record of its disclosed 13F positions, with a beta of 0.52 (less volatile than the market) and a 44% quarterly batting average against the index.
Its portfolio is moderately concentrated and fast-trading, with 100.0% of the portfolio concentrated in Health Care.
Its turnover score has risen from 0 to 76 over the past 4 quarters — a shift toward more active trading.
It has added to its ALMS position over the past two quarters (+$36.0M, now $55.2M), while trimming SPRY over the same stretch (-$14.6M, still holding $32.1M).
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Developer Access
Access Sr One Capital Management, LP's institutional profile programmatically:
REST API
curl https://alphasmo.com/api/v1/institutions/sr-one-capital-management-lpCLI
npx alphasmo institutions get sr-one-capital-management-lp