CIK: 0002011932
Total reported value
$193.3M
Reporting period: 2026-03-31 · Number of holdings: 56
Exome Asset Management LLC disclosed 56 holdings in its latest 13F filing for the period ending 2026-03-31, with total reported value of $193.3M and a quarterly turnover rate of 80.3%.
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Exome Asset Management LLC's disclosed holdings carry a Herfindahl concentration index of 0.029 — mathematically equivalent to about 35 equally-sized positions, close to its 56 actual disclosed holdings. Value is spread relatively evenly across the portfolio rather than concentrated in a handful of names.
Position sizes are fairly uniform across the portfolio (a coefficient of variation of 0.78), suggesting a disciplined, rules-based approach to how much capital goes into each idea.
No strong tilt toward either adding to existing winners or initiating outsized new positions was observed in the latest reported quarter.
Sector classification currently covers about 36% of this portfolio's disclosed value; the remainder includes holdings (e.g. unmapped tickers, options, or other security types) not yet covered by our sector mapping.
Add ELVN
-1.0% $5.2M
Add ALMS
-4.5% $3.3M
Trim 89422G957
-73.2% -$2.3M
Add 022307952
+97.4% $1.8M
Add UNH
+120.4% $1.6M
Trim GH
-15.7% -$2.4M
Showing top 55 holdings (of 56 total)
| # | Ticker | Issuer | Asset Subclass | Weight | Weight Change | Shares Change | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | PRAX | Praxis Precision Medicines I | Stock-Other | 7.58% | -0.61% | -21.77% | |
| 2 | COGT | Cogent Biosciences INC | Stock-Other | 5.54% | — | -8.85% | |
| 3 | ELVN | Enliven Therapeutics INC | Stock-Other | 4.46% | +2.82% | -1.00% | |
| 4 | IONS | Ionis Pharmaceuticals INC | Stock-Healthcare | 4.27% | — | -5.54% | |
| 5 | XBI | Ss Spdr S&p Biotech ETF | ETF-Tech | 3.96% | +3.96% | NEW | |
| 6 | GH | Guardant Health INC | Stock-Healthcare | 3.95% | -0.84% | -15.73% | |
| 7 | CYTK | Cytokinetics INC | Stock-Healthcare | 3.54% | — | -16.86% | |
| 8 | LLY | Eli Lilly & Co | Stock-Healthcare | 3.34% | -0.69% | -10.70% | |
| 9 | ALMS | Alumis INC | Stock-Other | 3.18% | +1.82% | -4.47% | |
| 10 | BBIO | Bridgebio Pharma INC | Stock-Healthcare | 2.59% | — | -16.39% | |
| 11 | VERA | Vera Therapeutics INC | Stock-Other | 2.39% | -0.62% | -7.56% | |
| 12 | INSM | Insmed INC | Stock-Healthcare | 2.25% | +2.25% | NEW | |
| 13 | ELV | Elevance Health INC | Stock-Healthcare | 2.22% | -0.66% | -14.62% | |
| 14 | AGIO | Agios Pharmaceuticals INC | Stock-Other | 2.19% | — | -8.68% | |
| 15 | UTHR | United Therapeutics CORP | Stock-Healthcare | 2.16% | — | -8.22% | |
| 16 | MLTX | Moonlake Immunotherapeutics | Stock-Other | 2.08% | +2.08% | NEW | |
| 17 | ✓ | Cytokinetics INC | Stock-Other | 2.05% | +2.05% | NEW | |
| 18 | NTRA | Natera INC | Stock-Healthcare | 1.93% | — | — | |
| 19 | RYTM | Rhythm Pharmaceuticals INC | Stock-Other | 1.83% | +1.83% | NEW | |
| 20 | UNH | Unitedhealth Group INC | Stock-Healthcare | 1.80% | +0.88% | +120.43% | |
| 21 | APLSUSD | Apellis Pharmaceuticals INC | Stock-Other | 1.78% | — | -37.05% | |
| 22 | VSTM | Verastem INC | Stock-Other | 1.75% | — | +58.48% | |
| 23 | TXG | 10x Genomics Inc-class A | Stock-Other | 1.69% | — | -5.78% | |
| 24 | BSX | Boston Scientific CORP | Stock-Healthcare | 1.57% | +1.57% | NEW | |
| 25 | ALKS | Alkermes plc | Stock-Healthcare | 1.54% | +1.54% | NEW | |
| 26 | ✓ | Beigene LTD | Stock-Other | 1.54% | +1.54% | NEW | |
| 27 | GLUE | Monte Rosa Therapeutics INC | Stock-Other | 1.53% | +1.53% | NEW | |
| 28 | ISRG | Intuitive Surgical INC | Stock-Healthcare | 1.52% | — | — | |
| 29 | ADAG | Adagene Inc-adr | Stock-Other | 1.49% | — | -30.50% | |
| 30 | ARWR | Arrowhead Pharmaceuticals In | Stock-Healthcare | 1.48% | — | -8.11% | |
| 31 | ✓ | Crescent Biopharma INC. | Stock-Other | 1.46% | +1.46% | NEW | |
| 32 | RLAY | Relay Therapeutics INC | Stock-Other | 1.43% | +1.43% | NEW | |
| 33 | ✓ | Ideaya Biosciences INC | Stock-Other | 1.38% | +1.38% | NEW | |
| 34 | MAZE | Maze Therapeutics INC | Stock-Other | 1.37% | +1.37% | NEW | |
| 35 | CTMX | Cytomx Therapeutics INC | Stock-Other | 1.27% | — | -30.03% | |
| 36 | AVTX | Avalo Therapeutics INC | Stock-Other | 1.23% | +1.23% | NEW | |
| 37 | ✓ | Alumis INC | Stock-Other | 1.20% | +0.95% | +97.37% | |
| 38 | GKOS | Glaukos CORP | Stock-Healthcare | 1.16% | -0.54% | -33.67% | |
| 39 | CRBP | Corbus Pharmaceuticals Holdi | Stock-Other | 1.14% | — | +67.79% | |
| 40 | PEN | Penumbra INC | Stock-Healthcare | 1.07% | — | -30.00% | |
| 41 | SLNOEUR | Soleno Therapeutics INC | Stock-Other | 1.07% | +1.07% | NEW | |
| 42 | LQDA | Liquidia CORP | Stock-Other | 0.89% | -0.61% | -49.76% | |
| 43 | ZBIO | Zenas Biopharma INC | Stock-Other | 0.82% | +0.82% | NEW | |
| 44 | ✓ | Liquidia Corporation | Stock-Other | 0.78% | +0.78% | NEW | |
| 45 | NBP | Novabridge Biosciences | Stock-Other | 0.73% | — | +15.49% | |
| 46 | ✓ | Centessa Pharmaceuticals PLC | Stock-Other | 0.71% | +0.71% | NEW | |
| 47 | FDMT | 4d Molecular Therapeutics In | Stock-Other | 0.63% | +0.63% | NEW | |
| 48 | NXTC | Nextcure INC | Stock-Other | 0.63% | — | -30.00% | |
| 49 | PALI | Palisade Bio INC | Stock-Other | 0.54% | — | -20.87% | |
| 50 | ✓ | Establishment Labs Hldgs INC | Stock-Other | 0.38% | — | — |
Performance for Q3 2026
+21.1%
Performance Last 4 Quarters
+120.4%
Based on 73% of reported portfolio value with available pricing
| Period | Holdings | Total value | Stability | Top holdings |
|---|---|---|---|---|
| 2026-03-31 | 56 | $193.3M | 80 | |
| 2025-12-31 | 60 | $209.1M | 89 | |
| 2025-09-30 | 68 | $165.1M | 95 | |
| 2025-06-30 | 63 | $134.5M | 0 | |
| 2025-03-31 | 59 | $112.5M | 0 | |
| 2024-12-31 | 59 | $133.1M | 0 | |
| 2024-09-30 | 59 | $147.9M | 0 | |
| 2024-06-30 | 52 | $112.3M | 0 | |
| 2024-03-31 | 53 | $116.8M | 0 | |
| 2023-12-31 | 52 | $101.1M | 0 |
Exome Asset Management LLC's most significant position changes for 2026-03-31: New buy: Ss Spdr S&p Biotech ETF (XBI); Sold out: Wave Life Sciences Ltd. (WVE); Sold out: Astrazeneca Plc-spons Adr (AZNN); Sold out: Jazz Pharmaceuticals plc (JAZZ); New buy: Insmed INC (INSM).
| # | Ticker | Issuer | Weight Change | Shares Change | Action |
|---|---|---|---|---|---|
| 1 | ELVN | Enliven Therapeutics INC | +2.8% | -1.00% | Trim |
| 2 | ALMS | Alumis INC | +1.8% | -4.47% | Trim |
| 3 | ✓ | Alumis INC | +1% | +97.37% | Add |
| 4 | UNH | Unitedhealth Group INC | +0.9% | +120.43% | Add |
| 5 | GKOS | Glaukos CORP | -0.5% | -33.67% | Trim |
| 6 | PRAX | Praxis Precision Medicines I | -0.6% | -21.77% | Trim |
| 7 | LQDA | Liquidia CORP | -0.6% | -49.76% | Trim |
| 8 | VERA | Vera Therapeutics INC | -0.6% | -7.56% | Trim |
| 9 | ELV | Elevance Health INC | -0.7% | -14.62% | Trim |
| 10 | LLY | Eli Lilly & Co | -0.7% | -10.70% | Trim |
| 11 | GH | Guardant Health INC | -0.8% | -15.73% | Trim |
| 12 | ✓ | Travere Therapeutics INC | -1.1% | -73.23% | Trim |
| 13 | XBI | Ss Spdr S&p Biotech ETF | — | NEW | New buy |
| 14 | WVE | Wave Life Sciences Ltd. | — | EXIT | Sold out |
| 15 | AZNN | Astrazeneca Plc-spons Adr | — | EXIT | Sold out |
| 16 | JAZZ | Jazz Pharmaceuticals plc | — | EXIT | Sold out |
| 17 | INSM | Insmed INC | — | NEW | New buy |
| 18 | IMVT | Immunovant INC | — | EXIT | Sold out |
| 19 | MLTX | Moonlake Immunotherapeutics | — | NEW | New buy |
| 20 | ✓ | Cytokinetics INC | — | NEW | New buy |
| 21 | UHS | Universal Health Services-b | — | EXIT | Sold out |
| 22 | IRON | Disc Medicine INC | — | EXIT | Sold out |
| 23 | RYTM | Rhythm Pharmaceuticals INC | — | NEW | New buy |
| 24 | CELC | Celcuity INC | — | EXIT | Sold out |
| 25 | TVTX | Travere Therapeutics INC | — | EXIT | Sold out |
| 26 | DXCM | Dexcom INC | — | EXIT | Sold out |
| 27 | BSX | Boston Scientific CORP | — | NEW | New buy |
| 28 | ALKS | Alkermes plc | — | NEW | New buy |
| 29 | ✓ | Beigene LTD | — | NEW | New buy |
| 30 | GLUE | Monte Rosa Therapeutics INC | — | NEW | New buy |
| 31 | ✓ | Crescent Biopharma INC. | — | NEW | New buy |
| 32 | RLAY | Relay Therapeutics INC | — | NEW | New buy |
| 33 | ✓ | Ideaya Biosciences INC | — | NEW | New buy |
| 34 | IMCR | Immunocore Holdings Plc-adr | — | EXIT | Sold out |
| 35 | MAZE | Maze Therapeutics INC | — | NEW | New buy |
| 36 | EWTX | Edgewise Therapeutics INC | — | EXIT | Sold out |
| 37 | AVTX | Avalo Therapeutics INC | — | NEW | New buy |
| 38 | BLTE | Belite Bio INC - Adr | — | EXIT | Sold out |
| 39 | WAY | Waystar Holding CORP | — | EXIT | Sold out |
| 40 | IRWD | Ironwood Pharmaceuticals INC | — | EXIT | Sold out |
| 41 | KPTI | Karyopharm Therapeutics INC | — | EXIT | Sold out |
| 42 | SLNOEUR | Soleno Therapeutics INC | — | NEW | New buy |
| 43 | UPB | Upstream Bio INC | — | EXIT | Sold out |
| 44 | ZBIO | Zenas Biopharma INC | — | NEW | New buy |
| 45 | ✓ | Liquidia Corporation | — | NEW | New buy |
| 46 | GOSS | Gossamer Bio INC | — | EXIT | Sold out |
| 47 | ✓ | Centessa Pharmaceuticals PLC | — | NEW | New buy |
| 48 | ✓ | Disc Medicine INC | — | EXIT | Sold out |
| 49 | IKT | Inhibikase Therapeutics INC | — | EXIT | Sold out |
| 50 | FDMT | 4d Molecular Therapeutics In | — | NEW | New buy |
| Period | Filed | Type | EDGAR |
|---|---|---|---|
| 2026-03-31 | 2026-05-15 | 13F-HR | View on EDGAR |
| 2025-12-31 | 2026-02-13 | 13F-HR | View on EDGAR |
| 2025-09-30 | 2025-11-14 | 13F-HR | View on EDGAR |
| 2025-06-30 | 2025-08-15 | Amendment | View on EDGAR |
| 2025-06-30 | 2025-08-14 | 13F-HR | View on EDGAR |
| 2025-03-31 | 2025-05-16 | Amendment | View on EDGAR |
| 2025-03-31 | 2025-05-15 | 13F-HR | View on EDGAR |
| 2024-12-31 | 2025-02-14 | 13F-HR | View on EDGAR |
| 2024-09-30 | 2024-12-13 | Amendment | View on EDGAR |
| 2024-09-30 | 2024-11-14 | 13F-HR | View on EDGAR |
| 2024-06-30 | 2024-10-03 | Amendment | View on EDGAR |
| 2024-06-30 | 2024-08-14 | 13F-HR | View on EDGAR |
| 2024-03-31 | 2024-05-15 | 13F-HR | View on EDGAR |
| 2023-12-31 | 2024-02-15 | 13F-HR | View on EDGAR |
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