VA
Venrock Adviser, LLC — 13F Portfolio Changes & Top Buys (Q2 2026)
Venrock Adviser, LLCCIK: 0001615982
Momentum followerQuality / disciplined sizing
Total reported value
$3.3B
Reporting period: 2026-06-30 · Number of holdings: 33
Venrock Adviser, LLC disclosed 33 holdings in its latest 13F filing for the period ending 2026-06-30, with total reported value of $3.3B and a quarterly turnover rate of 41.6%.
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Personality snowflake
- Concentration
- 61.73
- Portfolio Stability
- 41.56
- Momentum
- 100
- Sector conviction
- 0
- Diversification
- 66
- Sizing Uniformity
- 79.46
Sector classification currently covers about 0% of this portfolio's disclosed value; the remainder includes holdings (e.g. unmapped tickers, options, or other security types) not yet covered by our sector mapping.
Source and citation information
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Recent moves
View source Form 13F filing on SEC.govAdd APGE
0.0% $412.4M
Sold out 4XC1
Add ORKA
0.0% $191.3M
Trim ELVN
-69.5% -$41.0M
Sold out 29286M105
Trim CTMX
-50.1% -$28.2M
Holdings Map
New buyAddUnchangedTrim
Top 10 holdings by weight
Full holdings list this quarter
| # | Ticker | Issuer | Asset Subclass | Weight | Weight Change | Shares Change | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | APGE | Apogee Therapeutics Inc | Stock-Other | 34.18% | +7.50% | — | |
| 2 | ORKA | Oruka Therapeutics Inc | Stock-Other | 11.97% | +4.37% | — | |
| 3 | ERAS | Erasca Inc | Stock-Other | 9.94% | +0.05% | +9.21% | |
| 4 | SYRE | Spyre Therapeutics Inc | Stock-Other | 8.04% | +1.10% | -18.99% | |
| 5 | DNTH | Dianthus Therapeutics Inc | Stock-Other | 3.49% | -0.21% | — | |
| 6 | OCUL | Ocular Therapeutix Inc | Stock-Other | 3.08% | -0.19% | — | |
| 7 | DMRA | Damora Therapeutics Inc | Stock-Other | 2.84% | -0.64% | — | |
| 8 | SVRA | Savara Inc | Stock-Other | 2.75% | -0.05% | +7.32% | |
| 9 | JBIO | Jade Biosciences Inc | Stock-Other | 2.17% | +0.48% | — | |
| 10 | COGT | Cogent Biosciences Inc | Stock-Other | 1.93% | -0.94% | -17.89% | |
| 11 | VRDN | Viridian Therapeutics Inc | Stock-Other | 1.81% | -1.02% | -16.09% | |
| 12 | VOR | Vor Biopharma Inc | Stock-Other | 1.70% | -0.33% | — | |
| 13 | DYN | Dyne Therapeutics Inc | Stock-Other | 1.46% | -0.01% | — | |
| 14 | MAZE | Maze Therapeutics Inc | Stock-Other | 1.45% | -0.33% | — | |
| 15 | RLMD | Relmada Therapeutics Inc | Stock-Other | 1.44% | +0.18% | +41.31% | |
| 16 | ORIC | Oric Pharmaceuticals Inc | Stock-Other | 1.42% | -0.62% | — | |
| 17 | ✓ | Crescent Biopharma Inc. | Stock-Other | 1.16% | -0.30% | — | |
| 18 | ✓ | Zura Bio LTD | Stock-Other | 1.15% | -0.28% | — | |
| 19 | ANL | Adlai Nortye Ltd-adr | Stock-Other | 1.12% | +0.29% | — | |
| 20 | ELVN | Enliven Therapeutics Inc | Stock-Other | 0.81% | -1.72% | -69.51% | |
| 21 | HELP | Cybin Inc | Stock-Other | 0.77% | +0.08% | — | |
| 22 | CGEM | Cullinan Therapeutics Inc | Stock-Other | 0.76% | +0.03% | — | |
| 23 | IPSC | Century Therapeutics Inc | Stock-Other | 0.65% | -0.08% | — | |
| 24 | ARTV | Artiva Biotherapeutics Inc | Stock-Other | 0.60% | +0.21% | +26.97% | |
| 25 | CTMX | Cytomx Therapeutics Inc | Stock-Other | 0.57% | -1.18% | -50.09% | |
| 26 | ACHV | Achieve Life Sciences Inc | Stock-Other | 0.54% | +0.54% | NEW | |
| 27 | ✓ | Stock-Other | 0.52% | +0.52% | NEW | ||
| 28 | SRZN | Surrozen Inc | Stock-Other | 0.50% | -0.19% | — | |
| 29 | KRRO | Korro Bio Inc | Stock-Other | 0.40% | -0.03% | — | |
| 30 | ANRO | Alto Neuroscience Inc | Stock-Other | 0.40% | -0.02% | — | |
| 31 | XFOR | X4 Pharmaceuticals Inc | Stock-Other | 0.27% | +0.22% | +485.21% | |
| 32 | ✓ | Stock-Other | 0.10% | +0.10% | NEW | ||
| 33 | INM | Inmed Pharmaceuticals Inc | Stock-Other | — | — | NEW |
Portfolio Performance
Performance for Q3 2026
+36.4%
Performance Last 4 Quarters
+187.9%
- Stdev
- +45.8%
- Beta
- +0.9
- Alpha
- +39.8%
- Max Drawdown
- -45%
- Annualized Perf
- +60.2%
- Batting Avg vs S&P
- +55.6%
- Sortino
- +2.66
- Stutzer
- +0.38
- Treynor
- +0.64
- Sterling
- +1.88
- Calmar
- +1.34
- Information Ratio
- +0.85
- Tracking Error
- +44.3%
- Stdev Down
- +21.7%
- Winning Months %
- +58.3%
- Losing Months %
- +41.7%
- Best 12 Months
- +239.4%
- Worst 12 Months
- -45%
- Efficiency Ratio
- +0.82
- Sharpe
- +1.26
- Stdev Sectors
- —
- Skewness
- +0.21
- Kurtosis
- -0.34
- Upside Potential
- +4.24
Reported value over time
Sector allocation
Not enough sector-mapped data yet
Sector allocation over time
Quarterly history
| Period | Holdings | Total value | Stability | Top holdings | |
|---|---|---|---|---|---|
| 2026 Q2 | 33 | $3.3B | 42 | ||
| 2026 Q1 | 33 | $2.7B | 41 | ||
| 2025 Q4 | 27 | $2.0B | 65 | ||
| 2025 Q3 | 33 | $1.8B | 53 | ||
| 2025 Q2 | 31 | $1.3B | 0 | ||
| 2025 Q1 | 37 | $1.2B | 100 | ||
| 2024 Q4 | 37 | $1.5B | 0 | ||
| 2024 Q3 | 38 | $1.9B | 0 | ||
| 2024 Q2 | 35 | $1.6B | 0 | ||
| 2024 Q1 | 38 | $2.1B | 0 | ||
| 2023 Q4 | 36 | $1.5B | 0 | ||
| 2023 Q3 | 37 | $949.9M | 0 | ||
| 2023 Q2 | 30 | $625.4M | 0 | ||
| 2023 Q1 | 25 | $512.2M | 0 | ||
| 2022 Q4 | 28 | $593.6M | 0 | ||
| 2022 Q3 | 31 | $648.1M | 0 | ||
| 2022 Q2 | 27 | $507.8M | 0 | ||
| 2022 Q1 | 27 | $617.2M | 0 | ||
| 2021 Q4 | 26 | $731.5M | 0 | ||
| 2021 Q3 | 26 | $778.5M | 0 | ||
| 2021 Q2 | 29 | $824.4M | 100 | ||
| 2021 Q1 | 28 | $921.8M | 75 | ||
| 2020 Q4 | 25 | $680.1M | 88 | ||
| 2020 Q3 | 22 | $511.2M | 74 | ||
| 2020 Q2 | 16 | $417.6M | 94 | ||
| 2020 Q1 | 16 | $369.2M | 0 |
Holding changes this quarter
Venrock Adviser, LLC's most significant position changes for 2026-06-30: Sold out: Kalvista Pharmaceuticals Inc (4XC1); Sold out: Engene Holdings Inc; Sold out: Tenax Therapeutics Inc (TENX); New buy: Achieve Life Sciences Inc (ACHV); New buy: .
| # | Ticker | Issuer | Weight Change | Shares Change | Action |
|---|---|---|---|---|---|
| 1 | APGE | Apogee Therapeutics Inc | +7.5% | — | Unchanged |
| 2 | ORKA | Oruka Therapeutics Inc | +4.4% | — | Unchanged |
| 3 | SYRE | Spyre Therapeutics Inc | +1.1% | -18.99% | Trim |
| 4 | ACHV | Achieve Life Sciences Inc | +0.5% | NEW | New buy |
| 5 | ✓ | +0.5% | NEW | New buy | |
| 6 | JBIO | Jade Biosciences Inc | +0.5% | — | Unchanged |
| 7 | ANL | Adlai Nortye Ltd-adr | +0.3% | — | Unchanged |
| 8 | XFOR | X4 Pharmaceuticals Inc | +0.2% | +485.21% | Add |
| 9 | ARTV | Artiva Biotherapeutics Inc | +0.2% | +26.97% | Add |
| 10 | RLMD | Relmada Therapeutics Inc | +0.2% | +41.31% | Add |
| 11 | ✓ | +0.1% | NEW | New buy | |
| 12 | HELP | Cybin Inc | +0.1% | — | Unchanged |
| 13 | ERAS | Erasca Inc | +0.1% | +9.21% | Add |
| 14 | CGEM | Cullinan Therapeutics Inc | 0% | — | Unchanged |
| 15 | INM | Inmed Pharmaceuticals Inc | — | NEW | New buy |
| 16 | DYN | Dyne Therapeutics Inc | 0% | — | Unchanged |
| 17 | ANRO | Alto Neuroscience Inc | 0% | — | Unchanged |
| 18 | KRRO | Korro Bio Inc | 0% | — | Unchanged |
| 19 | SVRA | Savara Inc | -0.1% | +7.32% | Add |
| 20 | IPSC | Century Therapeutics Inc | -0.1% | — | Unchanged |
| 21 | OCUL | Ocular Therapeutix Inc | -0.2% | — | Unchanged |
| 22 | SRZN | Surrozen Inc | -0.2% | — | Unchanged |
| 23 | DNTH | Dianthus Therapeutics Inc | -0.2% | — | Unchanged |
| 24 | ✓ | Zura Bio LTD | -0.3% | — | Unchanged |
| 25 | ✓ | Crescent Biopharma Inc. | -0.3% | — | Unchanged |
| 26 | VOR | Vor Biopharma Inc | -0.3% | — | Unchanged |
| 27 | MAZE | Maze Therapeutics Inc | -0.3% | — | Unchanged |
| 28 | SEPN | Septerna Inc | -0.5% | EXIT | Sold out |
| 29 | ORIC | Oric Pharmaceuticals Inc | -0.6% | — | Unchanged |
| 30 | DMRA | Damora Therapeutics Inc | -0.6% | — | Unchanged |
| 31 | COGT | Cogent Biosciences Inc | -0.9% | -17.89% | Trim |
| 32 | TENX | Tenax Therapeutics Inc | -1% | EXIT | Sold out |
| 33 | VRDN | Viridian Therapeutics Inc | -1% | -16.09% | Trim |
| 34 | CTMX | Cytomx Therapeutics Inc | -1.2% | -50.09% | Trim |
| 35 | ✓ | Engene Holdings Inc | -1.2% | EXIT | Sold out |
| 36 | ELVN | Enliven Therapeutics Inc | -1.7% | -69.51% | Trim |
| 37 | 4XC1 | Kalvista Pharmaceuticals Inc | -4.9% | EXIT | Sold out |
💡
Data Source Notice: AlphaSMO is the web's most authoritative 13F / Inside Trader database. Institutional holdings and insider trades presented here are precisely computed to deliver accurate portfolio reporting.
Filing History
FAQ
What is Venrock Adviser, LLC and what type of investor is it?
Venrock Adviser, LLC is an investment manager that files SEC Form 13F quarterly, disclosing its U.S. public equity holdings to regulators. As of the most recent reporting period (2026-06-30), the firm manages a tracked equity portfolio valued at approximately $3.3B, spread across 33 disclosed positions.
What are Venrock Adviser, LLC's largest equity positions?
Based on the latest 13F filing, Venrock Adviser, LLC's top holdings by market value are:
1. Apogee Therapeutics Inc (APGE) — $1.1B (34.2%)
2. Oruka Therapeutics Inc (ORKA) — $394.8M (12.0%)
3. Erasca Inc (ERAS) — $327.8M (9.9%)
4. Spyre Therapeutics Inc (SYRE) — $265.0M (8.0%)
5. Dianthus Therapeutics Inc (DNTH) — $115.0M (3.5%)
What changes did Venrock Adviser, LLC make in its most recent portfolio filing?
In the latest reported quarter, Venrock Adviser, LLC made 18 notable position adjustments: 4 new positions were initiated, 5 existing holdings were added to, 5 positions were partially reduced, and 4 were completely exited. The largest of these moves: Sold out: Kalvista Pharmaceuticals Inc (4XC1); Sold out: Engene Holdings Inc; Sold out: Tenax Therapeutics Inc (TENX); New buy: Achieve Life Sciences Inc (ACHV); New buy:
What sectors does Venrock Adviser, LLC focus on?
Sector breakdown data is not yet available for Venrock Adviser, LLC. Check back after the next 13F processing cycle.
Investment Profile
Venrock Adviser, LLC returned an annualized 60.2% over the trailing 36 months — outperforming the S&P 500 by 39.8 points — based on a reconstructed track record of its disclosed 13F positions, with a beta of 0.90 (less volatile than the market) and a 56% quarterly batting average against the index.
Its portfolio is moderately concentrated and moderately active.
Its turnover score has risen from 0 to 42 over the past 4 quarters — a shift toward more active trading.
It has added to its APGE position over the past two quarters (+$486.2M, now $1.1B), while trimming VRDN over the same stretch (-$61.0M, still holding $59.8M).
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Developer Access
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REST API
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