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CIK: 0002005245
Total reported value
$4.9B
$4.9B
115 檔
17.8%
During the Q3 2025 filing period, Siren, L.L.C. (CIK: 0002005245) submitted its Form 13F report to the U.S. SEC, disclosing a tracked public equity portfolio valued at $4.9B across 115 reported positions.
Siren, L.L.C. executed strategic sector rebalancing during Q3 2025, establishing 32 new positions while fully exiting 33 holdings and trimming 20 positions.
| # | Ticker | Issuer | Asset Subclass | Weight | Weight Change | Shares Change | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | SRRK | Scholar Rock Holding CORP | Stock-Other | 13.48% | -4.09% | — | |
| 2 | KYMR | Kymera Therapeutics Inc | Stock-Other | 7.59% | -0.55% | — | |
| 3 | ONC | Beone Medicines Ltd-adr | Stock-Other | 6.57% | -1.15% | -3.33% | |
| 4 | ARWR | Arrowhead Pharmaceuticals In | Stock-Healthcare | 3.60% | +0.02% | — | |
| 5 | BCAX | Bicara Therapeutics Inc | Stock-Other | 3.22% | +0.17% | — | |
| 6 | 260 | Centessa Pharmaceuticals-adr | Stock-Other | 3.06% | -1.16% | EXIT | |
| 7 | CRNX | Crinetics Pharmaceuticals In | Stock-Other | 2.75% | -0.84% | — | |
| 8 | EWTX | Edgewise Therapeutics Inc | Stock-Other | 2.47% | -1.25% | +23.31% | |
| 9 | IRON | Disc Medicine Inc | Stock-Other | 2.36% | -0.43% | -16.92% | |
| 10 | DYN | Dyne Therapeutics Inc | Stock-Other | 2.34% | -0.16% | -2.22% | |
| 11 | APLSUSD | Apellis Pharmaceuticals Inc | Stock-Other | 2.28% | — | — | |
| 12 | RNAGBP | Avidity Biosciences Inc | Stock-Other | 2.19% | — | +15.76% | |
| 13 | STOK | Stoke Therapeutics Inc | Stock-Other | 2.07% | -0.48% | — | |
| 14 | LXRX | Lexicon Pharmaceuticals Inc | Stock-Other | 2.06% | +0.23% | — | |
| 15 | RYTM | Rhythm Pharmaceuticals Inc | Stock-Other | 1.98% | +0.80% | +22.02% | |
| 16 | TNGX | Tango Therapeutics Inc | Stock-Other | 1.93% | +0.63% | +74.84% | |
| 17 | RVMD | Revolution Medicines Inc | Stock-Healthcare | 1.91% | +0.41% | +11.18% | |
| 18 | ASND | Ascendis Pharma A/S | Stock-Other | 1.83% | — | -4.10% | |
| 19 | RZLT | Rezolute Inc | Stock-Other | 1.79% | +0.07% | — | |
| 20 | SLDB | Solid Biosciences Inc | Stock-Other | 1.79% | +0.02% | — | |
| 21 | SEPN | Septerna Inc | Stock-Other | 1.62% | -0.04% | — | |
| 22 | RCUS | Arcus Biosciences Inc | Stock-Other | 1.55% | -0.29% | +80.64% | |
| 23 | TSHA | Taysha Gene Therapies Inc | Stock-Other | 1.41% | +0.27% | — | |
| 24 | TBLA | Taboola.com Ltd. | Stock-Other | 1.33% | -0.01% | — | |
| 25 | XENE | Xenon Pharmaceuticals Inc | Stock-Other | 1.28% | -0.52% | — | |
| 26 | SLNOEUR | Soleno Therapeutics Inc | Stock-Other | 1.24% | — | — | |
| 27 | RAPP | Rapport Therapeutics Inc | Stock-Other | 1.22% | -0.02% | +178.35% | |
| 28 | GPCR | Structure Therapeutics Inc | Stock-Other | 1.12% | -0.83% | — | |
| 29 | WVE | Wave Life Sciences Ltd. | Stock-Other | 1.06% | -0.49% | EXIT | |
| 30 | RELY | Remitly Global Inc | Stock-Other | 1.03% | +0.03% | +213.95% | |
| 31 | COGT | Cogent Biosciences Inc | Stock-Other | 0.97% | -0.36% | +101.82% | |
| 32 | TRVI | Trevi Therapeutics Inc | Stock-Other | 0.91% | +0.08% | -35.59% | |
| 33 | NAMS | NewAmsterdam Pharma Company N.V. | Stock-Other | 0.85% | — | -35.88% | |
| 34 | KRRO | Korro Bio Inc | Stock-Other | 0.78% | -0.02% | — | |
| 35 | ERAS | Erasca Inc | Stock-Other | 0.75% | -0.81% | — | |
| 36 | IHS | IHS Holding Limited | Stock-Other | 0.63% | — | — | |
| 37 | QURE | uniQure N.V. | Stock-Other | 0.63% | -0.45% | EXIT | |
| 38 | BCYC | Bicycle Therapeutics Plc-adr | Stock-Other | 0.61% | -0.20% | EXIT | |
| 39 | SLN | Silence Therapeutics Plc-adr | Stock-Other | 0.59% | +0.31% | — | |
| 40 | RAPT | Rapt Therapeutics Inc | Stock-Other | 0.59% | — | — | |
| 41 | UPB | Upstream Bio Inc | Stock-Other | 0.58% | — | — | |
| 42 | GOSS | Gossamer Bio Inc | Stock-Other | 0.54% | -0.03% | — | |
| 43 | AVBP | Arrivent Biopharma Inc | Stock-Other | 0.51% | — | — | |
| 44 | AMZN | Amazon.com Inc | Stock-Consumer Disc | 0.50% | -0.11% | +3.54% | |
| 45 | ORIC | Oric Pharmaceuticals Inc | Stock-Other | 0.47% | -0.39% | — | |
| 46 | DNLI | Denali Therapeutics Inc | Stock-Other | 0.47% | -0.01% | — | |
| 47 | IONQ | Ionq Inc | Stock-Tech | 0.41% | +0.04% | — | |
| 48 | SION | Sionna Therapeutics Inc | Stock-Other | 0.37% | +0.21% | — | |
| 49 | CRWD | Crowdstrike Holdings Inc - A | Stock-Tech | 0.35% | -0.10% | — | |
| 50 | MSFT | Microsoft CORP | Stock-Tech | 0.35% | +0.04% | +6.19% |
| # | Ticker | Issuer | Weight Change | Shares Change | Action |
|---|---|---|---|---|---|
| 1 | KYMR | Kymera Therapeutics Inc | +2.6% | — | Add |
| 2 | TNGX | Tango Therapeutics Inc | +1.7% | +74.84% | Add |
| 3 | ARWR | Arrowhead Pharmaceuticals In | +1.7% | — | Unchanged |
| 4 | STOK | Stoke Therapeutics Inc | +1.2% | — | Unchanged |
| 5 | RYTM | Rhythm Pharmaceuticals Inc | +1.2% | +22.02% | Add |
| 6 | LXRX | Lexicon Pharmaceuticals Inc | +1.1% | — | Unchanged |
| 7 | RAPP | Rapport Therapeutics Inc | +1% | +178.35% | Add |
| 8 | SEPN | Septerna Inc | +0.9% | — | Unchanged |
| 9 | TSHA | Taysha Gene Therapies Inc | +0.9% | — | Add |
| 10 | RCUS | Arcus Biosciences Inc | +0.8% | +80.64% | Add |
| 11 | BCAX | Bicara Therapeutics Inc | +0.8% | — | Add |
| 12 | RVMD | Revolution Medicines Inc | +0.8% | +11.18% | Add |
| 13 | DYN | Dyne Therapeutics Inc | +0.7% | -2.22% | Add |
| 14 | 260 | Centessa Pharmaceuticals-adr | +0.7% | -6.72% | Add |
| 15 | RELY | Remitly Global Inc | +0.5% | +213.95% | Add |
| 16 | KRRO | Korro Bio Inc | +0.4% | — | Unchanged |
| 17 | EWTX | Edgewise Therapeutics Inc | +0.4% | +23.31% | Add |
| 18 | RNAGBP | Avidity Biosciences Inc | +0.3% | +15.76% | Add |
| 19 | UPB | Upstream Bio Inc | +0.3% | — | Unchanged |
| 20 | SLDB | Solid Biosciences Inc | +0.2% | — | Unchanged |
| 21 | GOSS | Gossamer Bio Inc | +0.2% | — | Unchanged |
| 22 | IONQ | Ionq Inc | +0.2% | — | Unchanged |
| 23 | SION | Sionna Therapeutics Inc | +0.2% | — | Unchanged |
| 24 | SLN | Silence Therapeutics Plc-adr | +0.2% | — | Add |
| 25 | ORIC | Oric Pharmaceuticals Inc | +0.2% | — | Unchanged |
| 26 | NBIS | Nebius Group N.V. | +0.2% | +42.35% | Trim |
| 27 | AGEN | Agenus Inc | +0.1% | — | Add |
| 28 | ELDN | Eledon Pharmaceuticals Inc | +0.1% | +200.33% | Add |
| 29 | ERAS | Erasca Inc | +0.1% | — | Unchanged |
| 30 | BDTX | Black Diamond Therapeutics I | +0.1% | — | Unchanged |
| 31 | NMRA | Neumora Therapeutics Inc | +0.1% | — | Unchanged |
| 32 | CRM | Salesforce Inc | +0.1% | +33.19% | Add |
| 33 | SGMT | Sagimet Biosciences Inc-a | +0.1% | — | Unchanged |
| 34 | TSM | Taiwan Semiconductor-sp Adr | 0% | -7.54% | Trim |
| 35 | LXEO | Lexeo Therapeutics Inc | 0% | — | Unchanged |
| 36 | WK | Workiva Inc | 0% | +7.14% | Add |
| 37 | ✓ | Proqr Therapeutics N.v. | 0% | — | Unchanged |
| 38 | BIOA | Bioage Labs Inc | 0% | — | Unchanged |
| 39 | NVDA | Nvidia CORP | — | -25.01% | Trim |
| 40 | PANW | Palo Alto Networks Inc | — | +16.96% | Add |
| 41 | CRBU | Caribou Biosciences Inc | — | — | Unchanged |
| 42 | IRWD | Ironwood Pharmaceuticals Inc | — | — | Unchanged |
| 43 | FHTX | Foghorn Therapeutics Inc | 0% | — | Unchanged |
| 44 | BEKE | Ke Holdings Inc-adr | 0% | +38.10% | Add |
| 45 | PCOR | Procore Technologies Inc | 0% | — | Unchanged |
| 46 | CYCN | Cyclerion Therapeutics Inc | 0% | — | Unchanged |
| 47 | QCOM | Qualcomm Inc | 0% | — | Unchanged |
| 48 | SEER | Seer Inc | 0% | — | Unchanged |
| 49 | FROG | JFrog Ltd. | 0% | — | Trim |
| 50 | DT | Dynatrace Inc | 0% | +33.23% | Add |
According to official SEC Form 13F filings, Siren, L.L.C. reported a total U.S. public equity portfolio value of $4.9B across 115 disclosed positions in Q3 2025.
During Q3 2025, Siren, L.L.C.'s top holdings by market value included SRRK (13.5%)、KYMR (7.6%)、ONC (6.6%). The largest single position, SRRK, represented 13.5% of total portfolio value.
Expert Analysis & Guides for Tracking Wall Street Smart Money Movements
Learn how SEC Form 13F filings work, the $100M threshold, 45-day reporting lag, and how to track top hedge fund holdings.
In terms of portfolio concentration, the top 5 core holdings (including SRRK, KYMR, ONC) accounted for 17.8% of total reported equity market value during Q3 2025.
Top New Position Initiated
RZLT
市值: $45.8M
Top Position Liquidated / Trimmed
2655787D
前期市值: $64.3M
In Q3 2025, Siren, L.L.C. made 110 total portfolio adjustments, initiating 32 new buys, adding to 25 positions, trimming 20 holdings, and fully liquidating 33 stocks.
All holding records on this page are fetched directly from the U.S. Securities and Exchange Commission (SEC) EDGAR system (Form 13F-HR). AlphaSMO parses CUSIP identifiers and formats data into Schema.org-compliant datasets.
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