CIK: 0001816307
Total reported value
$962.2M
Reporting period: 2026-06-30 · Number of holdings: 73
SILVERARC CAPITAL MANAGEMENT, LLC disclosed 73 holdings in its latest 13F filing for the period ending 2026-06-30, with total reported value of $962.2M and a quarterly turnover rate of 87.9%.
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Silverarc Capital Management, LLC's disclosed holdings carry a Herfindahl concentration index of 0.028 — mathematically equivalent to about 36 equally-sized positions, well below its 73 actual disclosed holdings. That gap points to a strategy built around a small core of high-conviction bets rather than broad diversification.
Position sizes are fairly uniform across the portfolio (a coefficient of variation of 1.01), suggesting a disciplined, rules-based approach to how much capital goes into each idea.
No strong tilt toward either adding to existing winners or initiating outsized new positions was observed in the latest reported quarter.
Sector classification currently covers about 4% of this portfolio's disclosed value; the remainder includes holdings (e.g. unmapped tickers, options, or other security types) not yet covered by our sector mapping.
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Sold out 78464A950
Sold out 4XC1
New buy K08588103
Sold out NUVL
Sold out ASND
Add ORKA
+133.8% $26.2M
| # | Ticker | Issuer | Asset Subclass | Weight | Weight Change | Shares Change | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | ✓ | Ascendis Pharma A/s | Stock-Other | 5.72% | +5.72% | NEW | |
| 2 | CELC | Celcuity Inc | Stock-Other | 5.45% | +1.28% | +39.98% | |
| 3 | COGT | Cogent Biosciences Inc | Stock-Other | 5.15% | -0.01% | -2.55% | |
| 4 | URGN | UroGen Pharma Ltd. | Stock-Other | 4.98% | +2.22% | -13.38% | |
| 5 | IMNM | Immunome Inc | Stock-Other | 4.44% | +0.31% | +9.01% | |
| 6 | DNTH | Dianthus Therapeutics Inc | Stock-Other | 3.95% | -1.66% | -40.43% | |
| 7 | RYTM | Rhythm Pharmaceuticals Inc | Stock-Other | 3.59% | +0.87% | +1.78% | |
| 8 | ORKA | Oruka Therapeutics Inc | Stock-Other | 3.49% | +2.73% | +133.79% | |
| 9 | GLUE | Monte Rosa Therapeutics Inc | Stock-Other | 2.79% | -0.57% | -44.64% | |
| 10 | SNDX | Syndax Pharmaceuticals Inc | Stock-Other | 2.76% | +0.64% | +36.60% | |
| 11 | ELVN | Enliven Therapeutics Inc | Stock-Other | 2.58% | +2.58% | NEW | |
| 12 | IMVT | Immunovant Inc | Stock-Other | 2.48% | +1.43% | +49.45% | |
| 13 | ERAS | Erasca Inc | Stock-Other | 2.40% | -0.66% | -31.80% | |
| 14 | SGMT | Sagimet Biosciences Inc-a | Stock-Other | 2.35% | +2.35% | NEW | |
| 15 | ABVX | Abivax Sa-adr | Stock-Other | 2.35% | -1.09% | -43.94% | |
| 16 | PRAX | Praxis Precision Medicines I | Stock-Other | 2.29% | -0.06% | -8.21% | |
| 17 | KOD | Kodiak Sciences Inc | Stock-Other | 2.21% | -1.65% | -44.93% | |
| 18 | ✓ | Ark ETF Tr | ETF-Other | 2.19% | +2.19% | NEW | |
| 19 | DFTX | Definium Therapeutics Inc | Stock-Other | 1.96% | +1.96% | NEW | |
| 20 | VCYT | Veracyte Inc | Stock-Other | 1.94% | +1.35% | +76.96% | |
| 21 | ✓ | Syndax Pharmaceuticals Inc | Stock-Other | 1.58% | +0.82% | +116.75% | |
| 22 | GH | Guardant Health Inc | Stock-Healthcare | 1.56% | +0.63% | +1.33% | |
| 23 | CCCC | C4 Therapeutics Inc | Stock-Other | 1.47% | +0.96% | +58.60% | |
| 24 | ZBIO | Zenas Biopharma Inc | Stock-Other | 1.34% | -0.93% | -55.12% | |
| 25 | TRVI | Trevi Therapeutics Inc | Stock-Other | 1.31% | +0.69% | +32.67% | |
| 26 | ✓ | Helix Acquisition CORP Iii | Stock-Other | 1.30% | +0.05% | -2.58% | |
| 27 | ALXO | Alx Oncology Holdings Inc | Stock-Other | 1.24% | +1.24% | NEW | |
| 28 | MANE | Veradermics Inc | Stock-Other | 1.21% | +1.21% | NEW | |
| 29 | XENE | Xenon Pharmaceuticals Inc | Stock-Other | 1.17% | — | -5.53% | |
| 30 | ✓ | Stock-Other | 1.13% | +1.13% | NEW | ||
| 31 | BIIB | Biogen Inc | Stock-Healthcare | 1.08% | +0.13% | -5.62% | |
| 32 | ACRS | Aclaris Therapeutics Inc | Stock-Other | 1.07% | +1.07% | NEW | |
| 33 | CERS | Cerus CORP | Stock-Other | 1.05% | +0.46% | +9.32% | |
| 34 | AVTX | Avalo Therapeutics Inc | Stock-Other | 0.96% | +0.96% | NEW | |
| 35 | BNTC | Benitec Biopharma Inc | Stock-Other | 0.95% | +0.17% | -5.28% | |
| 36 | PCVX | Vaxcyte Inc | Stock-Other | 0.88% | +0.02% | +0.01% | |
| 37 | WGS | Genedx Holdings CORP | Stock-Other | 0.87% | +0.87% | NEW | |
| 38 | SVRA | Savara Inc | Stock-Other | 0.87% | +0.07% | -5.28% | |
| 39 | OVID | Ovid Therapeutics Inc | Stock-Other | 0.87% | +0.64% | +210.11% | |
| 40 | ORIC | Oric Pharmaceuticals Inc | Stock-Other | 0.83% | -0.59% | -32.83% | |
| 41 | ✓ | Oric Pharmaceuticals Inc | Stock-Other | 0.77% | +0.77% | NEW | |
| 42 | ✓ | Monte Rosa Therapeutics Inc | Stock-Other | 0.75% | +0.75% | NEW | |
| 43 | CMPS | Compass Pathways PLC | Stock-Other | 0.74% | +0.57% | +67.79% | |
| 44 | ✓ | Compugen LTD | Stock-Other | 0.71% | -0.01% | -3.97% | |
| 45 | SLDB | Solid Biosciences Inc | Stock-Other | 0.69% | +0.69% | NEW | |
| 46 | ✓ | Abivax SA | Stock-Other | 0.69% | +0.69% | NEW | |
| 47 | IBIO | Ibio Inc | Stock-Other | 0.64% | +0.60% | +1457.74% | |
| 48 | IRON | Disc Medicine Inc | Stock-Other | 0.63% | -0.65% | -57.76% | |
| 49 | ALKS | Alkermes plc | Stock-Healthcare | 0.62% | -1.04% | -75.34% | |
| 50 | SYRE | Spyre Therapeutics Inc | Stock-Other | 0.55% | -0.41% | -67.87% |
Performance for Q3 2026
+10.6%
Performance Last 4 Quarters
+16.1%
Based on 73% of reported portfolio value with available pricing
| Period | Holdings | Total value | Stability | Top holdings | |
|---|---|---|---|---|---|
| 2026 Q2 | 73 | $962.2M | 88 | ||
| 2026 Q1 | 73 | $979.8M | 76 | ||
| 2025 Q4 | 68 | $720.1M | 89 | ||
| 2025 Q3 | 82 | $741.6M | 100 | ||
| 2025 Q2 | 65 | $542.3M | 0 | ||
| 2025 Q1 | 69 | $489.0M | 100 | ||
| 2024 Q4 | 61 | $457.2M | 0 | ||
| 2024 Q3 | 71 | $445.3M | 0 | ||
| 2024 Q2 | 70 | $423.9M | 0 | ||
| 2024 Q1 | 77 | $360.1M | 0 | ||
| 2023 Q4 | 67 | $336.0M | 0 | ||
| 2023 Q3 | 80 | $329.8M | 0 | ||
| 2023 Q2 | 82 | $323.3M | 0 | ||
| 2023 Q1 | 72 | $242.3M | 0 | ||
| 2022 Q4 | 90 | $349.6M | 0 | ||
| 2022 Q3 | 79 | $295.6M | 0 | ||
| 2022 Q2 | 70 | $324.8M | 0 | ||
| 2022 Q1 | 69 | $241.6M | 0 | ||
| 2021 Q4 | 71 | $246.8M | 0 | ||
| 2021 Q3 | 82 | $176.9M | 0 | ||
| 2021 Q2 | 96 | $224.2M | 91 | ||
| 2021 Q1 | 91 | $183.3M | 79 | ||
| 2020 Q4 | 85 | $172.1M | — |
Silverarc Capital Management, LLC's most significant position changes for 2026-06-30: Sold out: Spdr Series Trust; Sold out: Kalvista Pharmaceuticals Inc (4XC1); New buy: Ascendis Pharma A/s; Sold out: Nuvalent Inc-a (NUVL); Sold out: Ascendis Pharma A/S (ASND).
| # | Ticker | Issuer | Weight Change | Shares Change | Action |
|---|---|---|---|---|---|
| 1 | ✓ | Ascendis Pharma A/s | +5.7% | NEW | New buy |
| 2 | ORKA | Oruka Therapeutics Inc | +2.7% | +133.79% | Add |
| 3 | ELVN | Enliven Therapeutics Inc | +2.6% | NEW | New buy |
| 4 | SGMT | Sagimet Biosciences Inc-a | +2.4% | NEW | New buy |
| 5 | URGN | UroGen Pharma Ltd. | +2.2% | -13.38% | Trim |
| 6 | ✓ | Ark ETF Tr | +2.2% | NEW | New buy |
| 7 | DFTX | Definium Therapeutics Inc | +2% | NEW | New buy |
| 8 | IMVT | Immunovant Inc | +1.4% | +49.45% | Add |
| 9 | VCYT | Veracyte Inc | +1.4% | +76.96% | Add |
| 10 | CELC | Celcuity Inc | +1.3% | +39.98% | Add |
| 11 | ALXO | Alx Oncology Holdings Inc | +1.2% | NEW | New buy |
| 12 | MANE | Veradermics Inc | +1.2% | NEW | New buy |
| 13 | ✓ | +1.1% | NEW | New buy | |
| 14 | ACRS | Aclaris Therapeutics Inc | +1.1% | NEW | New buy |
| 15 | AVTX | Avalo Therapeutics Inc | +1% | NEW | New buy |
| 16 | CCCC | C4 Therapeutics Inc | +1% | +58.60% | Add |
| 17 | WGS | Genedx Holdings CORP | +0.9% | NEW | New buy |
| 18 | RYTM | Rhythm Pharmaceuticals Inc | +0.9% | +1.78% | Add |
| 19 | ✓ | Syndax Pharmaceuticals Inc | +0.8% | +116.75% | Add |
| 20 | ✓ | Oric Pharmaceuticals Inc | +0.8% | NEW | New buy |
| 21 | ✓ | Monte Rosa Therapeutics Inc | +0.8% | NEW | New buy |
| 22 | SLDB | Solid Biosciences Inc | +0.7% | NEW | New buy |
| 23 | ✓ | Abivax SA | +0.7% | NEW | New buy |
| 24 | TRVI | Trevi Therapeutics Inc | +0.7% | +32.67% | Add |
| 25 | OVID | Ovid Therapeutics Inc | +0.6% | +210.11% | Add |
| 26 | SNDX | Syndax Pharmaceuticals Inc | +0.6% | +36.60% | Add |
| 27 | GH | Guardant Health Inc | +0.6% | +1.33% | Add |
| 28 | IBIO | Ibio Inc | +0.6% | +1457.74% | Add |
| 29 | CMPS | Compass Pathways PLC | +0.6% | +67.79% | Add |
| 30 | ARTV | Artiva Biotherapeutics Inc | +0.5% | NEW | New buy |
| 31 | QURE | uniQure N.V. | +0.5% | NEW | New buy |
| 32 | CERS | Cerus CORP | +0.5% | +9.32% | Add |
| 33 | ✓ | +0.4% | NEW | New buy | |
| 34 | IMNM | Immunome Inc | +0.3% | +9.01% | Add |
| 35 | KPTI | Karyopharm Therapeutics Inc | +0.3% | NEW | New buy |
| 36 | ✓ | Kymera Therapeutics Inc | +0.3% | NEW | New buy |
| 37 | RVMD | Revolution Medicines Inc | +0.2% | NEW | New buy |
| 38 | ✓ | Absci Corporation | +0.2% | NEW | New buy |
| 39 | BNTC | Benitec Biopharma Inc | +0.2% | -5.28% | Trim |
| 40 | ACHV | Achieve Life Sciences Inc | +0.2% | NEW | New buy |
| 41 | ✓ | Connect Biopharma Hldgs LTD | +0.1% | NEW | New buy |
| 42 | BIIB | Biogen Inc | +0.1% | -5.62% | Trim |
| 43 | CTNM | Contineum Therapeutics Inc-a | +0.1% | -1.85% | Trim |
| 44 | CLRB | Cellectar Biosciences Inc | +0.1% | NEW | New buy |
| 45 | ABEO | Abeona Therapeutics Inc | +0.1% | -5.94% | Trim |
| 46 | SVRA | Savara Inc | +0.1% | -5.28% | Trim |
| 47 | GUTS | Fractyl Health Inc | +0.1% | -3.74% | Trim |
| 48 | ✓ | Helix Acquisition CORP Iii | +0.1% | -2.58% | Trim |
| 49 | SION | Sionna Therapeutics Inc | 0% | +7.77% | Add |
| 50 | TELA | Tela Bio Inc | 0% | -5.40% | Trim |
Silverarc Capital Management, LLC returned an annualized 17.6% over the trailing 30 months — outperforming the S&P 500 by 4.7 points — based on a reconstructed track record of its disclosed 13F positions, with a beta of 1.00 (roughly in line with the market) and a 40% quarterly batting average against the index.
Its portfolio is broadly diversified and fast-trading, with 100.0% of the portfolio concentrated in Health Care.
Its turnover score has risen from 0 to 88 over the past 4 quarters — a shift toward more active trading.
It has added to its RYTM position over the past two quarters (+$20.0M, now $34.6M), while trimming ABVX over the same stretch (-$34.3M, still holding $22.6M).
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