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CIK: 0001442756
Total reported value
$1.2B
$1.2B
77 檔
24.8%
The Q4 2025 SEC filing reveals that PFM Health Sciences, LP held a total portfolio value of $1.2B, covering 77 public equity positions.
PFM Health Sciences, LP executed strategic sector rebalancing during Q4 2025, establishing 30 new positions while fully exiting 23 holdings and trimming 34 positions.
In terms of portfolio concentration, the top 5 core holdings (including THC, LLY, AXSM) accounted for 24.8% of total reported equity market value during Q4 2025.
| # | Ticker | Issuer | Asset Subclass | Weight | Weight Change | Shares Change | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | THC | Tenet Healthcare CORP | Stock-Healthcare | 7.88% | -4.83% | -13.84% | |
| 2 | LLY | Eli Lilly & Co | Stock-Healthcare | 7.32% | -1.48% | -69.67% | |
| 3 | AXSM | Axsome Therapeutics Inc | Stock-Healthcare | 4.58% | +0.54% | -52.57% | |
| 4 | CNC | Centene CORP | Stock-Healthcare | 4.50% | +1.07% | +91.12% | |
| 5 | PEN | Penumbra Inc | Stock-Healthcare | 4.50% | -2.56% | -25.59% | |
| 6 | ASND | Ascendis Pharma A/S | Stock-Other | 3.78% | -3.64% | EXIT | |
| 7 | UTHR | United Therapeutics CORP | Stock-Healthcare | 3.29% | -4.03% | -29.18% | |
| 8 | BBIO | Bridgebio Pharma Inc | Stock-Healthcare | 2.34% | -0.13% | -6.32% | |
| 9 | ADMA | Adma Biologics Inc | Stock-Healthcare | 2.31% | — | +7.61% | |
| 10 | NBIX | Neurocrine Biosciences Inc | Stock-Healthcare | 2.31% | +0.50% | +185.08% | |
| 11 | GKOS | Glaukos CORP | Stock-Healthcare | 2.27% | -2.12% | EXIT | |
| 12 | TMO | Thermo Fisher Scientific Inc | Stock-Healthcare | 2.19% | +0.57% | +1538.50% | |
| 13 | EW | Edwards Lifesciences CORP | Stock-Healthcare | 2.10% | +0.08% | -35.27% | |
| 14 | ICLR | ICON Public Limited Company | Stock-Healthcare | 2.10% | +1.45% | -13.72% | |
| 15 | INBX | Inhibrx Biosciences Inc | Stock-Other | 2.09% | +0.64% | +10.80% | |
| 16 | MDT | Medtronic plc | Stock-Healthcare | 2.05% | — | — | |
| 17 | NEO | Neogenomics Inc | Stock-Healthcare | 1.99% | -1.21% | EXIT | |
| 18 | MRK | Merck & Co. Inc. | Stock-Healthcare | 1.97% | +1.40% | NEW | |
| 19 | AMRX | Amneal Pharmaceuticals Inc | Stock-Other | 1.84% | -0.34% | +311.86% | |
| 20 | SYK | Stryker CORP | Stock-Healthcare | 1.78% | +0.87% | — | |
| 21 | UNH | Unitedhealth Group Inc | Stock-Healthcare | 1.66% | +1.72% | — | |
| 22 | WAT | Waters CORP | Stock-Healthcare | 1.64% | +0.85% | +40.51% | |
| 23 | ASND 2.25 04-01-28Bond | Ascendis Pharma A/s | Bond | 1.51% | -1.54% | EXIT | |
| 24 | DXCM | Dexcom Inc | Stock-Healthcare | 1.50% | -0.86% | EXIT | |
| 25 | 260 | Centessa Pharmaceuticals-adr | Stock-Other | 1.48% | -1.91% | EXIT | |
| 26 | INDV | Indivior Pharmaceuticals, Inc. | Stock-Other | 1.29% | — | -35.77% | |
| 27 | CAH | Cardinal Health Inc | Stock-Healthcare | 1.28% | -0.62% | EXIT | |
| 28 | UHS | Universal Health Services-b | Stock-Healthcare | 1.25% | — | -50.62% | |
| 29 | TFX | Teleflex Inc | Stock-Healthcare | 1.25% | +0.87% | NEW | |
| 30 | RVMD | Revolution Medicines Inc | Stock-Healthcare | 1.20% | +1.05% | -54.25% | |
| 31 | SLNOEUR | Soleno Therapeutics Inc | Stock-Other | 1.14% | -0.76% | EXIT | |
| 32 | PRAX | Praxis Precision Medicines I | Stock-Other | 0.92% | +0.07% | -48.56% | |
| 33 | ISRG | Intuitive Surgical Inc | Stock-Healthcare | 0.87% | — | -80.09% | |
| 34 | GILD | Gilead Sciences Inc | Stock-Healthcare | 0.87% | +0.98% | NEW | |
| 35 | JAZZ | Jazz Pharmaceuticals plc | Stock-Healthcare | 0.86% | +0.25% | — | |
| 36 | CVS | Cvs Health CORP | Stock-Healthcare | 0.85% | +1.22% | NEW | |
| 37 | SNY | Sanofi-adr | Stock-Healthcare | 0.85% | — | — | |
| 38 | IQV | Iqvia Holdings Inc | Stock-Healthcare | 0.85% | — | — | |
| 39 | ITGR | Integer Holdings CORP | Stock-Healthcare | 0.83% | -0.06% | — | |
| 40 | COO | Cooper Cos Inc/the | Stock-Healthcare | 0.82% | +0.25% | +35.55% | |
| 41 | VEEV | Veeva Systems Inc-class A | Stock-Healthcare | 0.72% | — | -21.72% | |
| 42 | OSCR | Oscar Health Inc - Class A | Stock-Healthcare | 0.72% | +0.75% | -39.09% | |
| 43 | BLLN | Billiontoone Inc Cl A | Stock-Other | 0.71% | -0.63% | EXIT | |
| 44 | CGON | Cg Oncology Inc | Stock-Other | 0.68% | -0.24% | +3.86% | |
| 45 | VKTX | Viking Therapeutics Inc | Stock-Healthcare | 0.66% | +0.07% | +2.95% | |
| 46 | ALGN | Align Technology Inc | Stock-Healthcare | 0.66% | — | — | |
| 47 | HCA | Hca Healthcare Inc | Stock-Healthcare | 0.65% | -0.49% | -78.92% | |
| 48 | PSNL | Personalis Inc | Stock-Other | 0.64% | -0.51% | EXIT | |
| 49 | VERA | Vera Therapeutics Inc | Stock-Other | 0.54% | +0.19% | -79.04% | |
| 50 | CMPS | Compass Pathways PLC | Stock-Other | 0.54% | -0.39% | -53.12% |
| # | Ticker | Issuer | Weight Change | Shares Change | Action |
|---|---|---|---|---|---|
| 1 | CNC | Centene CORP | +2.9% | +91.12% | Add |
| 2 | TMO | Thermo Fisher Scientific Inc | +2.1% | +1538.50% | Add |
| 3 | NBIX | Neurocrine Biosciences Inc | +1.7% | +185.08% | Add |
| 4 | AMRX | Amneal Pharmaceuticals Inc | +1.6% | +311.86% | Add |
| 5 | ASND | Ascendis Pharma A/S | +1.6% | +22.28% | Add |
| 6 | INBX | Inhibrx Biosciences Inc | +1.5% | +10.80% | Add |
| 7 | BBIO | Bridgebio Pharma Inc | +1% | -6.32% | Trim |
| 8 | ADMA | Adma Biologics Inc | +1% | +7.61% | Add |
| 9 | WAT | Waters CORP | +0.9% | +40.51% | Add |
| 10 | PEN | Penumbra Inc | +0.7% | -25.59% | Trim |
| 11 | NEO | Neogenomics Inc | +0.7% | -23.30% | Trim |
| 12 | THC | Tenet Healthcare CORP | +0.7% | -13.84% | Trim |
| 13 | PRAX | Praxis Precision Medicines I | +0.7% | -48.56% | Trim |
| 14 | MRK | Merck & Co. Inc. | +0.4% | -20.57% | Trim |
| 15 | COO | Cooper Cos Inc/the | +0.4% | +35.55% | Add |
| 16 | ICLR | ICON Public Limited Company | +0.3% | -13.72% | Trim |
| 17 | ASND 2.25 04-01-28Bond | Ascendis Pharma A/s | +0.3% | -7.47% | Trim |
| 18 | VKTX | Viking Therapeutics Inc | +0.3% | +2.95% | Add |
| 19 | INDV | Indivior Pharmaceuticals, Inc. | +0.3% | -35.77% | Trim |
| 20 | 260 | Centessa Pharmaceuticals-adr | +0.2% | -11.20% | Trim |
| 21 | GPCR | Structure Therapeutics Inc | +0.2% | -40.69% | Trim |
| 22 | UTHR | United Therapeutics CORP | +0.2% | -29.18% | Trim |
| 23 | SNDX | Syndax Pharmaceuticals Inc | +0.2% | -5.27% | Trim |
| 24 | DNTH | Dianthus Therapeutics Inc | +0.2% | +46.78% | Add |
| 25 | CGON | Cg Oncology Inc | +0.2% | +3.86% | Add |
| 26 | RYTM | Rhythm Pharmaceuticals Inc | +0.1% | -16.51% | Trim |
| 27 | RVMD | Revolution Medicines Inc | 0% | -54.25% | Trim |
| 28 | ARGX | Argenx Se - Adr | 0% | -34.37% | Trim |
| 29 | MBX | Mbx Biosciences Inc | -0.1% | -64.19% | Trim |
| 30 | IRON | Disc Medicine Inc | -0.1% | -66.19% | Trim |
| 31 | CRBU | Caribou Biosciences Inc | -0.1% | -29.51% | Trim |
| 32 | QURE | uniQure N.V. | -0.1% | -14.79% | Trim |
| 33 | SLNOEUR | Soleno Therapeutics Inc | -0.1% | +1.85% | Add |
| 34 | EW | Edwards Lifesciences CORP | -0.2% | -35.27% | Trim |
| 35 | CMPS | Compass Pathways PLC | -0.2% | -53.12% | Trim |
| 36 | VEEV | Veeva Systems Inc-class A | -0.2% | -21.72% | Trim |
| 37 | RZLT | Rezolute Inc | -0.3% | -54.44% | Trim |
| 38 | AMLX | Amylyx Pharmaceuticals Inc | -0.3% | -69.15% | Trim |
| 39 | AXSM | Axsome Therapeutics Inc | -0.4% | -52.57% | Trim |
| 40 | OSCR | Oscar Health Inc - Class A | -0.5% | -39.09% | Trim |
| 41 | UHS | Universal Health Services-b | -0.6% | -50.62% | Trim |
| 42 | VERA | Vera Therapeutics Inc | -0.6% | -79.04% | Trim |
| 43 | CVS | Cvs Health CORP | -1.2% | -68.91% | Trim |
| 44 | HCA | Hca Healthcare Inc | -1.5% | -78.92% | Trim |
| 45 | OM | Outset Medical Inc | -1.7% | -69.32% | Trim |
| 46 | ISRG | Intuitive Surgical Inc | -1.8% | -80.09% | Trim |
| 47 | LLY | Eli Lilly & Co | -5.9% | -69.67% | Trim |
| 48 | XBI | Ss Spdr S&p Biotech ETF | — | EXIT | Sold out |
| 49 | MCK | Mckesson CORP | — | EXIT | Sold out |
| 50 | HUM | Humana Inc | — | EXIT | Sold out |
According to official SEC Form 13F filings, PFM Health Sciences, LP reported a total U.S. public equity portfolio value of $1.2B across 77 disclosed positions in Q4 2025.
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Top New Position Initiated
GKOS
市值: $22.8M
Top Position Liquidated / Trimmed
XBI
前期市值: $71.9M
During Q4 2025, PFM Health Sciences, LP's top holdings by market value included THC (7.9%)、LLY (7.3%)、AXSM (4.6%). The largest single position, THC, represented 7.9% of total portfolio value.
In Q4 2025, PFM Health Sciences, LP made 100 total portfolio adjustments, initiating 30 new buys, adding to 13 positions, trimming 34 holdings, and fully liquidating 23 stocks.
All holding records on this page are fetched directly from the U.S. Securities and Exchange Commission (SEC) EDGAR system (Form 13F-HR). AlphaSMO parses CUSIP identifiers and formats data into Schema.org-compliant datasets.
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