CIK: 0001224962
Total reported value
$5.1B
| # | Ticker | Issuer | Asset Subclass | Weight | Weight Change | Shares Change | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | RYTM | Rhythm Pharmaceuticals INC | Stock-Other | 8.33% | -0.83% | +17230.57% | |
| 2 | ASND | Ascendis Pharma A/S | Stock-Other | 6.25% | +2.73% | +12.93% | |
| 3 | ACLXGBX | Arcellx INC | Stock-Other | 5.85% | -1.70% | EXIT | |
| 4 | CELC | Celcuity INC | Stock-Other | 4.22% | +1.35% | +81.01% | |
| 5 | NUVL | Nuvalent Inc-a | Stock-Other | 3.90% | — | +13.61% | |
| 6 | ✓ | Merus N V | Stock-Other | 3.68% | — | +91.07% | |
| 7 | AMLX | Amylyx Pharmaceuticals INC | Stock-Other | 3.51% | — | +13.29% | |
| 8 | ROIV | Roivant Sciences Ltd. | Stock-Healthcare | 3.22% | +1.39% | +121.18% | |
| 9 | MGTX | MeiraGTx Holdings plc | Stock-Other | 3.00% | — | — | |
| 10 | INSM | Insmed INC | Stock-Healthcare | 2.92% | — | +7.98% | |
| 11 | TVTX | Travere Therapeutics INC | Stock-Other | 2.62% | -0.51% | +354.85% | |
| 12 | AORT | Artivion INC | Stock-Other | 2.47% | -0.23% | -27.69% | |
| 13 | PRAX | Praxis Precision Medicines I | Stock-Other | 2.39% | +2.33% | +107.80% | |
| 14 | ✓ | Immatics NV | Stock-Other | 2.31% | — | — | |
| 15 | 260 | Centessa Pharmaceuticals-adr | Stock-Other | 2.17% | +2.78% | +170.36% | |
| 16 | SLDB | Solid Biosciences INC | Stock-Other | 2.11% | +0.49% | -0.61% | |
| 17 | PTGX | Protagonist Therapeutics INC | Stock-Other | 1.98% | — | -4.12% | |
| 18 | NBIX | Neurocrine Biosciences INC | Stock-Healthcare | 1.82% | -0.67% | +76.46% | |
| 19 | EWTX | Edgewise Therapeutics INC | Stock-Other | 1.78% | +0.75% | -18.19% | |
| 20 | VRNA | Verona Pharma PLC - Adr | Stock-Other | 1.61% | — | -90.48% | |
| 21 | PEN | Penumbra INC | Stock-Healthcare | 1.61% | -0.61% | EXIT | |
| 22 | AKRO | Akero Therapeutics INC | Stock-Other | 1.56% | — | +24.01% | |
| 23 | APGE | Apogee Therapeutics INC | Stock-Other | 1.55% | -0.61% | +14.37% | |
| 24 | OMDA | Omada Health INC | Stock-Other | 1.53% | -0.48% | -1.24% | |
| 25 | AM6 | Amicus Therapeutics INC | Stock-Other | 1.45% | -1.62% | EXIT | |
| 26 | CATBUSD | Astria Therapeutics INC | Stock-Other | 1.36% | -1.51% | EXIT | |
| 27 | INBX | Inhibrx Biosciences INC | Stock-Other | 1.29% | — | +35.77% | |
| 28 | RGEN | Repligen CORP | Stock-Healthcare | 1.04% | -0.27% | +62.91% | |
| 29 | ZYME | Zymeworks INC | Stock-Other | 1.03% | — | +63.94% | |
| 30 | SION | Sionna Therapeutics INC | Stock-Other | 1.00% | -0.34% | -3.04% | |
| 31 | CAI | Caris Life Sciences INC | Stock-Other | 0.96% | -0.55% | EXIT | |
| 32 | ABVX | Abivax Sa-adr | Stock-Other | 0.95% | -0.38% | — | |
| 33 | VRDN | Viridian Therapeutics INC | Stock-Other | 0.91% | -1.24% | +226.79% | |
| 34 | CTMX | Cytomx Therapeutics INC | Stock-Other | 0.89% | — | +38.41% | |
| 35 | BSX | Boston Scientific CORP | Stock-Healthcare | 0.87% | -1.66% | EXIT | |
| 36 | ALDX | Aldeyra Therapeutics INC | Stock-Other | 0.79% | -0.39% | EXIT | |
| 37 | DRUG | Bright Minds Biosciences INC | Stock-Other | 0.79% | — | +6.80% | |
| 38 | IMVT | Immunovant INC | Stock-Other | 0.74% | — | -25.73% | |
| 39 | EXK | Exact Sciences CORP | Stock-Materials | 0.74% | -2.17% | EXIT | |
| 40 | PVLA | Palvella Therapeutics INC | Stock-Other | 0.72% | -0.50% | EXIT | |
| 41 | ORKA | Oruka Therapeutics INC | Stock-Other | 0.70% | +0.54% | — | |
| 42 | ISRG | Intuitive Surgical INC | Stock-Healthcare | 0.67% | — | +15.51% | |
| 43 | IRTC | Irhythm Holdings INC | Stock-Healthcare | 0.61% | — | — | |
| 44 | AQST | Aquestive Therapeutics INC | Stock-Other | 0.61% | — | +71.66% | |
| 45 | SYRE | Spyre Therapeutics INC | Stock-Other | 0.60% | +1.94% | -19.61% | |
| 46 | ADGM | Adagio Medical Holdings INC | Stock-Other | 0.55% | — | — | |
| 47 | AXSM | Axsome Therapeutics INC | Stock-Healthcare | 0.52% | — | -25.00% | |
| 48 | ADMA | Adma Biologics INC | Stock-Healthcare | 0.49% | — | -11.51% | |
| 49 | ✓ | Engene Holdings INC | Stock-Other | 0.41% | — | — | |
| 50 | OBIO | Orchestra Biomed Holdings In | Stock-Other | 0.38% | — | +15.24% |
| # | Ticker | Issuer | Weight Change | Shares Change | Action |
|---|---|---|---|---|---|
| 1 | RYTM | Rhythm Pharmaceuticals INC | +3.6% | +17230.57% | Add |
| 2 | CELC | Celcuity INC | +3.4% | +81.01% | Add |
| 3 | ✓ | Merus N V | +2.7% | +91.07% | Add |
| 4 | AMLX | Amylyx Pharmaceuticals INC | +2.5% | +13.29% | Add |
| 5 | INSM | Insmed INC | +1.6% | +7.98% | Add |
| 6 | NBIX | Neurocrine Biosciences INC | +1.4% | +76.46% | Add |
| 7 | PRAX | Praxis Precision Medicines I | +1.1% | +107.80% | Add |
| 8 | ✓ | Immatics NV | +0.8% | — | Unchanged |
| 9 | INBX | Inhibrx Biosciences INC | +0.8% | +35.77% | Add |
| 10 | 260 | Centessa Pharmaceuticals-adr | +0.6% | +170.36% | Add |
| 11 | VRDN | Viridian Therapeutics INC | +0.6% | +226.79% | Add |
| 12 | SLDB | Solid Biosciences INC | +0.6% | -0.61% | Trim |
| 13 | SION | Sionna Therapeutics INC | +0.5% | -3.04% | Trim |
| 14 | RGEN | Repligen CORP | +0.5% | +62.91% | Add |
| 15 | AKRO | Akero Therapeutics INC | +0.4% | +24.01% | Add |
| 16 | BSX | Boston Scientific CORP | +0.4% | +10.71% | Add |
| 17 | PTGX | Protagonist Therapeutics INC | +0.1% | -4.12% | Trim |
| 18 | AORT | Artivion INC | +0.1% | -27.69% | Trim |
| 19 | MGTX | MeiraGTx Holdings plc | — | — | Add |
| 20 | NUVL | Nuvalent Inc-a | -0.2% | +13.61% | Trim |
| 21 | DYN | Dyne Therapeutics INC | -0.7% | -75.95% | Trim |
| 22 | JANX | Janux Therapeutics INC | -0.7% | — | Trim |
| 23 | SYRE | Spyre Therapeutics INC | -0.7% | -19.61% | Trim |
| 24 | BBNX | Beta Bionics INC | -0.8% | -82.56% | Trim |
| 25 | AXSM | Axsome Therapeutics INC | -0.9% | -25.00% | Trim |
| 26 | IMVT | Immunovant INC | -1% | -25.73% | Trim |
| 27 | ALDX | Aldeyra Therapeutics INC | -1.1% | +28.89% | Trim |
| 28 | EWTX | Edgewise Therapeutics INC | -3.7% | -18.19% | Trim |
| 29 | AM6 | Amicus Therapeutics INC | -4.7% | -14.06% | Trim |
| 30 | VRNA | Verona Pharma PLC - Adr | -13.1% | -90.48% | Trim |
| 31 | ASND | Ascendis Pharma A/S | — | NEW | New buy |
| 32 | ROIV | Roivant Sciences Ltd. | — | NEW | New buy |
| 33 | SLNOEUR | Soleno Therapeutics INC | — | EXIT | Sold out |
| 34 | ITCIEUR | Intra-cellular Therapies INC | — | EXIT | Sold out |
| 35 | TVTX | Travere Therapeutics INC | — | NEW | New buy |
| 36 | PEN | Penumbra INC | — | NEW | New buy |
| 37 | OMDA | Omada Health INC | — | NEW | New buy |
| 38 | EOLS | Evolus INC | — | EXIT | Sold out |
| 39 | IOVA | Iovance Biotherapeutics INC | — | EXIT | Sold out |
| 40 | ARGX | Argenx Se - Adr | — | EXIT | Sold out |
| 41 | CAI | Caris Life Sciences INC | — | NEW | New buy |
| 42 | ABVX | Abivax Sa-adr | — | NEW | New buy |
| 43 | CTMX | Cytomx Therapeutics INC | — | NEW | New buy |
| 44 | PCVX | Vaxcyte INC | — | EXIT | Sold out |
| 45 | EXK | Exact Sciences CORP | — | NEW | New buy |
| 46 | PVLA | Palvella Therapeutics INC | — | NEW | New buy |
| 47 | ORKA | Oruka Therapeutics INC | — | NEW | New buy |
| 48 | IRTC | Irhythm Holdings INC | — | NEW | New buy |
| 49 | PODD | Insulet CORP | — | EXIT | Sold out |
| 50 | MDGL | Madrigal Pharmaceuticals INC | — | EXIT | Sold out |