CIK: 0001306923
Total reported value
$653.9M
| # | Ticker | Issuer | Asset Subclass | Weight | Weight Change | Shares Change | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | INSM | Insmed INC | Stock-Healthcare | 11.86% | -1.47% | -0.47% | |
| 2 | AM6 | Amicus Therapeutics INC | Stock-Other | 10.32% | -7.86% | -3.02% | |
| 3 | PTCT | Ptc Therapeutics INC | Stock-Healthcare | 9.56% | +0.04% | +4.79% | |
| 4 | ACAD | Acadia Pharmaceuticals INC | Stock-Healthcare | 9.24% | +0.54% | +0.70% | |
| 5 | BMRN | Biomarin Pharmaceutical INC | Stock-Healthcare | 6.17% | -0.25% | -1.03% | |
| 6 | ANAB | Anaptysbio INC | Stock-Other | 4.66% | +0.75% | +2.45% | |
| 7 | BIIB | Biogen INC | Stock-Healthcare | 4.50% | -0.55% | -1.13% | |
| 8 | DYN | Dyne Therapeutics INC | Stock-Other | 4.01% | +0.57% | +16.59% | |
| 9 | UTHR | United Therapeutics CORP | Stock-Healthcare | 3.95% | +1.75% | — | |
| 10 | IRON | Disc Medicine INC | Stock-Other | 3.51% | +0.42% | +41.53% | |
| 11 | IOVA | Iovance Biotherapeutics INC | Stock-Other | 2.70% | +0.71% | -6.58% | |
| 12 | NVCR | NovoCure Limited | Stock-Healthcare | 2.34% | -0.21% | +3.41% | |
| 13 | SNDX | Syndax Pharmaceuticals INC | Stock-Other | 2.32% | +0.77% | +21.31% | |
| 14 | GOSS | Gossamer Bio INC | Stock-Other | 1.93% | -1.93% | EXIT | |
| 15 | CMPX | Compass Therapeutics INC | Stock-Other | 1.89% | -0.66% | — | |
| 16 | PRTA | Prothena Corporation plc | Stock-Other | 1.76% | +0.04% | -0.27% | |
| 17 | MIRM | Mirum Pharmaceuticals INC | Stock-Other | 1.72% | +2.87% | +141.76% | |
| 18 | ANNX | Annexon INC | Stock-Other | 1.67% | +0.83% | — | |
| 19 | RARE | Ultragenyx Pharmaceutical In | Stock-Other | 1.48% | +0.43% | +24.83% | |
| 20 | DNLI | Denali Therapeutics INC | Stock-Other | 1.47% | -0.78% | +57.16% | |
| 21 | CDNA | Caredx INC | Stock-Other | 1.25% | +0.16% | +51.24% | |
| 22 | EHTH | Ehealth INC | Stock-Other | 0.98% | -0.69% | -0.85% | |
| 23 | ALKS | Alkermes plc | Stock-Healthcare | 0.94% | +0.37% | +31.87% | |
| 24 | CAPR | Capricor Therapeutics INC | Stock-Other | 0.91% | +0.16% | — | |
| 25 | TSHA | Taysha Gene Therapies INC | Stock-Other | 0.91% | +0.04% | -5.04% | |
| 26 | ALGN | Align Technology INC | Stock-Healthcare | 0.90% | +0.19% | -9.22% | |
| 27 | AGIO | Agios Pharmaceuticals INC | Stock-Other | 0.81% | +0.30% | -19.96% | |
| 28 | BCAX | Bicara Therapeutics INC | Stock-Other | 0.70% | +0.97% | — | |
| 29 | NUVB | Nuvation Bio INC | Stock-Other | 0.67% | -0.34% | -47.28% | |
| 30 | ACRS | Aclaris Therapeutics INC | Stock-Other | 0.66% | +0.27% | — | |
| 31 | XENE | Xenon Pharmaceuticals INC | Stock-Other | 0.60% | -0.14% | — | |
| 32 | TVTX | Travere Therapeutics INC | Stock-Other | 0.59% | +0.46% | — | |
| 33 | EW | Edwards Lifesciences CORP | Stock-Healthcare | 0.40% | +0.01% | — | |
| 34 | NBIX | Neurocrine Biosciences INC | Stock-Healthcare | 0.36% | — | — | |
| 35 | STOK | Stoke Therapeutics INC | Stock-Other | 0.32% | +0.10% | -31.69% | |
| 36 | CRSP | CRISPR Therapeutics AG | Stock-Healthcare | 0.30% | -0.01% | — | |
| 37 | BNTX | Biontech Se-adr | Stock-Other | 0.26% | +0.01% | — | |
| 38 | ORKA | Oruka Therapeutics INC | Stock-Other | 0.25% | +0.20% | — | |
| 39 | BCYC | Bicycle Therapeutics Plc-adr | Stock-Other | 0.22% | -0.08% | — | |
| 40 | PYXS | Pyxis Oncology INC | Stock-Other | 0.17% | +0.06% | — | |
| 41 | ALDX | Aldeyra Therapeutics INC | Stock-Other | 0.16% | -0.12% | — | |
| 42 | HUM | Humana INC | Stock-Healthcare | 0.14% | -0.03% | — | |
| 43 | INSP | Inspire Medical Systems INC | Stock-Healthcare | 0.11% | -0.04% | — | |
| 44 | CMPS | Compass Pathways PLC | Stock-Other | 0.11% | -0.01% | — | |
| 45 | URGN | UroGen Pharma Ltd. | Stock-Other | 0.08% | -0.01% | — | |
| 46 | ABEO | Abeona Therapeutics INC | Stock-Other | 0.08% | — | — | |
| 47 | ✓ | Proqr Thrapeutics N V | Stock-Other | 0.05% | — | — | |
| 48 | ✓ | Stock-Other | 0.01% | — | — | ||
| 49 | ✓ | Akari Therapeutics PLC | Stock-Other | 0.01% | — | — |
| # | Ticker | Issuer | Weight Change | Shares Change | Action |
|---|---|---|---|---|---|
| 1 | AM6 | Amicus Therapeutics INC | +2.5% | -3.02% | Trim |
| 2 | DYN | Dyne Therapeutics INC | +1.1% | +16.59% | Add |
| 3 | ANAB | Anaptysbio INC | +0.8% | +2.45% | Add |
| 4 | MIRM | Mirum Pharmaceuticals INC | +0.8% | +141.76% | Add |
| 5 | IRON | Disc Medicine INC | +0.8% | +41.53% | Add |
| 6 | SNDX | Syndax Pharmaceuticals INC | +0.5% | +21.31% | Add |
| 7 | CDNA | Caredx INC | +0.4% | +51.24% | Add |
| 8 | DNLI | Denali Therapeutics INC | +0.4% | +57.16% | Add |
| 9 | TSHA | Taysha Gene Therapies INC | +0.2% | -5.04% | Trim |
| 10 | ACRS | Aclaris Therapeutics INC | +0.1% | — | Unchanged |
| 11 | TVTX | Travere Therapeutics INC | +0.1% | — | Unchanged |
| 12 | ORKA | Oruka Therapeutics INC | +0.1% | — | Unchanged |
| 13 | URGN | UroGen Pharma Ltd. | 0% | — | Unchanged |
| 14 | ✓ | Akari Therapeutics PLC | 0% | — | Unchanged |
| 15 | ✓ | Proqr Thrapeutics N V | 0% | — | Unchanged |
| 16 | NUVB | Nuvation Bio INC | 0% | -47.28% | Trim |
| 17 | HUM | Humana INC | -0.1% | — | Unchanged |
| 18 | ALKS | Alkermes plc | -0.1% | +31.87% | Add |
| 19 | EW | Edwards Lifesciences CORP | -0.1% | — | Unchanged |
| 20 | BCYC | Bicycle Therapeutics Plc-adr | -0.1% | — | Unchanged |
| 21 | BNTX | Biontech Se-adr | -0.1% | — | Unchanged |
| 22 | NBIX | Neurocrine Biosciences INC | -0.1% | — | Unchanged |
| 23 | STOK | Stoke Therapeutics INC | -0.1% | -31.69% | Trim |
| 24 | ALGN | Align Technology INC | -0.2% | -9.22% | Trim |
| 25 | CRSP | CRISPR Therapeutics AG | -0.2% | — | Unchanged |
| 26 | PTCT | Ptc Therapeutics INC | -0.2% | +4.79% | Add |
| 27 | EHTH | Ehealth INC | -0.3% | -0.85% | Trim |
| 28 | PYXS | Pyxis Oncology INC | -0.3% | — | Unchanged |
| 29 | BIIB | Biogen INC | -0.3% | -1.13% | Trim |
| 30 | IOVA | Iovance Biotherapeutics INC | -0.4% | -6.58% | Trim |
| 31 | ACAD | Acadia Pharmaceuticals INC | -0.5% | +0.70% | Add |
| 32 | UTHR | United Therapeutics CORP | -0.6% | — | Unchanged |
| 33 | RARE | Ultragenyx Pharmaceutical In | -0.6% | +24.83% | Add |
| 34 | PRTA | Prothena Corporation plc | -0.6% | -0.27% | Trim |
| 35 | NVCR | NovoCure Limited | -0.7% | +3.41% | Add |
| 36 | GOSS | Gossamer Bio INC | -0.7% | -18.17% | Trim |
| 37 | AGIO | Agios Pharmaceuticals INC | -1.2% | -19.96% | Trim |
| 38 | INSM | Insmed INC | -1.3% | -0.47% | Trim |
| 39 | BMRN | Biomarin Pharmaceutical INC | -1.4% | -1.03% | Trim |
| 40 | ALNY | Alnylam Pharmaceuticals INC | — | EXIT | Sold out |
| 41 | CMPX | Compass Therapeutics INC | — | NEW | New buy |
| 42 | ANNX | Annexon INC | — | NEW | New buy |
| 43 | CAPR | Capricor Therapeutics INC | — | NEW | New buy |
| 44 | BCAX | Bicara Therapeutics INC | — | NEW | New buy |
| 45 | RNAGBP | Avidity Biosciences INC | — | EXIT | Sold out |
| 46 | XENE | Xenon Pharmaceuticals INC | — | NEW | New buy |
| 47 | INSP | Inspire Medical Systems INC | — | NEW | New buy |
| 48 | CMPS | Compass Pathways PLC | — | NEW | New buy |
| 49 | GBIOGBX | Generation Bio Co | — | EXIT | Sold out |
| 50 | ✓ | — | NEW | New buy |