CIK: 0001306923
Total reported value
$653.9M
| # | Ticker | Issuer | Asset Subclass | Weight | Weight Change | Shares Change | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | INSM | Insmed INC | Stock-Healthcare | 13.11% | -1.47% | -43.15% | |
| 2 | PTCT | Ptc Therapeutics INC | Stock-Healthcare | 9.80% | +0.04% | +112.22% | |
| 3 | ACAD | Acadia Pharmaceuticals INC | Stock-Healthcare | 9.74% | +0.54% | -3.77% | |
| 4 | AM6 | Amicus Therapeutics INC | Stock-Other | 7.83% | -7.86% | -4.33% | |
| 5 | BMRN | Biomarin Pharmaceutical INC | Stock-Healthcare | 7.56% | -0.25% | -10.29% | |
| 6 | BIIB | Biogen INC | Stock-Healthcare | 4.81% | -0.55% | -9.77% | |
| 7 | UTHR | United Therapeutics CORP | Stock-Healthcare | 4.51% | +1.75% | -39.06% | |
| 8 | ANAB | Anaptysbio INC | Stock-Other | 3.82% | +0.75% | -17.14% | |
| 9 | IOVA | Iovance Biotherapeutics INC | Stock-Other | 3.06% | +0.71% | +122.15% | |
| 10 | NVCR | NovoCure Limited | Stock-Healthcare | 3.00% | -0.21% | +30.52% | |
| 11 | DYN | Dyne Therapeutics INC | Stock-Other | 2.96% | +0.57% | +376.52% | |
| 12 | IRON | Disc Medicine INC | Stock-Other | 2.74% | +0.42% | +53.96% | |
| 13 | ALNY | Alnylam Pharmaceuticals INC | Stock-Healthcare | 2.73% | — | -57.21% | |
| 14 | GOSS | Gossamer Bio INC | Stock-Other | 2.66% | -1.93% | EXIT | |
| 15 | PRTA | Prothena Corporation plc | Stock-Other | 2.39% | +0.04% | +3.87% | |
| 16 | RARE | Ultragenyx Pharmaceutical In | Stock-Other | 2.06% | +0.43% | +658.01% | |
| 17 | AGIO | Agios Pharmaceuticals INC | Stock-Other | 1.97% | +0.30% | -1.22% | |
| 18 | SNDX | Syndax Pharmaceuticals INC | Stock-Other | 1.86% | +0.77% | +47.38% | |
| 19 | EHTH | Ehealth INC | Stock-Other | 1.23% | -0.69% | -2.11% | |
| 20 | DNLI | Denali Therapeutics INC | Stock-Other | 1.10% | -0.78% | +70.14% | |
| 21 | ALGN | Align Technology INC | Stock-Healthcare | 1.06% | +0.19% | +21.08% | |
| 22 | ALKS | Alkermes plc | Stock-Healthcare | 1.02% | +0.37% | -16.78% | |
| 23 | RNAGBP | Avidity Biosciences INC | Stock-Other | 0.89% | — | -7.62% | |
| 24 | MIRM | Mirum Pharmaceuticals INC | Stock-Other | 0.88% | +2.87% | — | |
| 25 | CDNA | Caredx INC | Stock-Other | 0.85% | +0.16% | — | |
| 26 | TSHA | Taysha Gene Therapies INC | Stock-Other | 0.75% | +0.04% | — | |
| 27 | NUVB | Nuvation Bio INC | Stock-Other | 0.70% | -0.34% | +32.08% | |
| 28 | ACRS | Aclaris Therapeutics INC | Stock-Other | 0.55% | +0.27% | +12.72% | |
| 29 | CRSP | CRISPR Therapeutics AG | Stock-Healthcare | 0.49% | -0.01% | -7.62% | |
| 30 | TVTX | Travere Therapeutics INC | Stock-Other | 0.49% | +0.46% | — | |
| 31 | EW | Edwards Lifesciences CORP | Stock-Healthcare | 0.48% | +0.01% | -14.78% | |
| 32 | NBIX | Neurocrine Biosciences INC | Stock-Healthcare | 0.47% | — | +35.87% | |
| 33 | STOK | Stoke Therapeutics INC | Stock-Other | 0.46% | +0.10% | -16.24% | |
| 34 | PYXS | Pyxis Oncology INC | Stock-Other | 0.43% | +0.06% | — | |
| 35 | BNTX | Biontech Se-adr | Stock-Other | 0.36% | +0.01% | -22.19% | |
| 36 | BCYC | Bicycle Therapeutics Plc-adr | Stock-Other | 0.32% | -0.08% | -11.19% | |
| 37 | ALDX | Aldeyra Therapeutics INC | Stock-Other | 0.22% | -0.12% | — | |
| 38 | HUM | Humana INC | Stock-Healthcare | 0.19% | -0.03% | — | |
| 39 | ORKA | Oruka Therapeutics INC | Stock-Other | 0.15% | +0.20% | — | |
| 40 | ABEO | Abeona Therapeutics INC | Stock-Other | 0.11% | — | — | |
| 41 | URGN | UroGen Pharma Ltd. | Stock-Other | 0.09% | -0.01% | — | |
| 42 | ✓ | Proqr Thrapeutics N V | Stock-Other | 0.07% | — | — | |
| 43 | ✓ | Akari Therapeutics PLC | Stock-Other | 0.03% | — | — | |
| 44 | GBIOGBX | Generation Bio Co | Stock-Other | 0.02% | — | -90.00% |
| # | Ticker | Issuer | Weight Change | Shares Change | Action |
|---|---|---|---|---|---|
| 1 | PTCT | Ptc Therapeutics INC | +5.9% | +112.22% | Add |
| 2 | DYN | Dyne Therapeutics INC | +2.3% | +376.52% | Add |
| 3 | GOSS | Gossamer Bio INC | +1.4% | -4.79% | Trim |
| 4 | ACAD | Acadia Pharmaceuticals INC | +1.3% | -3.77% | Trim |
| 5 | IOVA | Iovance Biotherapeutics INC | +1% | +122.15% | Add |
| 6 | SNDX | Syndax Pharmaceuticals INC | +0.8% | +47.38% | Add |
| 7 | NUVB | Nuvation Bio INC | +0.4% | +32.08% | Add |
| 8 | AGIO | Agios Pharmaceuticals INC | +0.4% | -1.22% | Trim |
| 9 | TSHA | Taysha Gene Therapies INC | +0.4% | — | Trim |
| 10 | MIRM | Mirum Pharmaceuticals INC | +0.3% | — | Unchanged |
| 11 | ACRS | Aclaris Therapeutics INC | +0.3% | +12.72% | Add |
| 12 | STOK | Stoke Therapeutics INC | +0.3% | -16.24% | Trim |
| 13 | PYXS | Pyxis Oncology INC | +0.2% | — | Unchanged |
| 14 | ANAB | Anaptysbio INC | +0.2% | -17.14% | Trim |
| 15 | NBIX | Neurocrine Biosciences INC | +0.2% | +35.87% | Add |
| 16 | TVTX | Travere Therapeutics INC | +0.1% | — | Unchanged |
| 17 | URGN | UroGen Pharma Ltd. | 0% | — | Unchanged |
| 18 | ABEO | Abeona Therapeutics INC | 0% | — | Unchanged |
| 19 | ✓ | Akari Therapeutics PLC | — | — | Unchanged |
| 20 | ALDX | Aldeyra Therapeutics INC | 0% | — | Unchanged |
| 21 | EW | Edwards Lifesciences CORP | -0.1% | -14.78% | Trim |
| 22 | BCYC | Bicycle Therapeutics Plc-adr | -0.1% | -11.19% | Trim |
| 23 | BNTX | Biontech Se-adr | -0.1% | -22.19% | Trim |
| 24 | ALGN | Align Technology INC | -0.1% | +21.08% | Add |
| 25 | ALKS | Alkermes plc | -0.4% | -16.78% | Trim |
| 26 | NVCR | NovoCure Limited | -0.4% | +30.52% | Add |
| 27 | BIIB | Biogen INC | -0.5% | -9.77% | Trim |
| 28 | EHTH | Ehealth INC | -0.9% | -2.11% | Trim |
| 29 | INSM | Insmed INC | -1.2% | -43.15% | Trim |
| 30 | PRTA | Prothena Corporation plc | -1.5% | +3.87% | Trim |
| 31 | ALNY | Alnylam Pharmaceuticals INC | -1.6% | -57.21% | Trim |
| 32 | UTHR | United Therapeutics CORP | -1.7% | -39.06% | Trim |
| 33 | AM6 | Amicus Therapeutics INC | -3.6% | -4.33% | Trim |
| 34 | BMRN | Biomarin Pharmaceutical INC | -5.8% | -10.29% | Trim |
| 35 | IRON | Disc Medicine INC | — | NEW | New buy |
| 36 | SRPT | Sarepta Therapeutics INC | — | EXIT | Sold out |
| 37 | RARE | Ultragenyx Pharmaceutical In | — | NEW | New buy |
| 38 | STAA | Staar Surgical Co | — | EXIT | Sold out |
| 39 | DNLI | Denali Therapeutics INC | — | NEW | New buy |
| 40 | RNAGBP | Avidity Biosciences INC | — | NEW | New buy |
| 41 | CDNA | Caredx INC | — | NEW | New buy |
| 42 | ✓ | Acelyrin INC | — | EXIT | Sold out |
| 43 | CRSP | CRISPR Therapeutics AG | — | NEW | New buy |
| 44 | ✓ | Verve Therapeutics INC | — | EXIT | Sold out |
| 45 | KPTIEUR | Karyopharm Therapeutics INC | — | EXIT | Sold out |
| 46 | ORKA | Oruka Therapeutics INC | — | NEW | New buy |
| 47 | VYNE | Vyne Therapeutics INC | — | EXIT | Sold out |
| 48 | ✓ | Proqr Thrapeutics N V | — | NEW | New buy |
| 49 | TIL | Instil Bio INC | — | EXIT | Sold out |
| 50 | RLMD | Relmada Therapeutics INC | — | EXIT | Sold out |